PE70398A1 - SALTS OF 10-AMINOALIFATIL-DIBENZ [B, F] OXEPINE WITH ANTINEURODEGENERATIVE ACTIVITY - Google Patents
SALTS OF 10-AMINOALIFATIL-DIBENZ [B, F] OXEPINE WITH ANTINEURODEGENERATIVE ACTIVITYInfo
- Publication number
- PE70398A1 PE70398A1 PE1997000433A PE00043397A PE70398A1 PE 70398 A1 PE70398 A1 PE 70398A1 PE 1997000433 A PE1997000433 A PE 1997000433A PE 00043397 A PE00043397 A PE 00043397A PE 70398 A1 PE70398 A1 PE 70398A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- compounds
- alkyl
- substituted
- salts
- Prior art date
Links
- 230000002555 anti-neurodegenerative effect Effects 0.000 title 1
- ATYBXHSAIOKLMG-UHFFFAOYSA-N oxepin Chemical compound O1C=CC=CC=C1 ATYBXHSAIOKLMG-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 3
- -1 AMINO GROUP Chemical group 0.000 abstract 2
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000006408 oxalic acid Nutrition 0.000 abstract 1
- 208000027232 peripheral nervous system disease Diseases 0.000 abstract 1
- 208000033808 peripheral neuropathy Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/14—[b,f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: ALK DE PREFERENCIA ES ALQUILIDENO INFERIOR; R ES UN GRUPO AMINO INSUSTITUIDO O SUSTITUIDO, POR ALQUILO C1-C4, POR FENILALQUILO C1-C4 (EN DONDE LA PARTE ALQUILICA ESTA SUSTITUIDA POR CARBOXI EVENTUALMENTE ESTERIFICADO), POR FENILALQUILENO C1-C4 O POR FENILALQUILO C1-C4-ALQUILENO C1-C4, ENTRE OTROS; R1, R2, R3 Y R4 SON H, ALQUILO C1-C4, ALCOXI C1-C4, HALOGENO, CF3. TAMBIEN SE REFIEREN A LAS SALES DE ADICION DE LOS COMPUESTOS DE FORMULA (I) Y AL PROCEDIMIENTO DE PREPARACION DE DICHA SAL, QUE COMPRENDE HACER REACCIONAR EL COMPUESTO DE FORMULA (I) EN FORMA LIBRE CON UN ACIDO ORGANICO TAL COMO EL ACIDO OXALICO, FUMARICO, MALEICO, SUCCINICO, DIMALEICO O DIFUMARICO, ENTRE OTROS. LOS COMPUESTOS DE FORMULA (I) Y SUS SALES DE ADICION SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS ESPECIALMENTE AQUELLAS RELACIONADAS A LA MUERTE CELULAR APOPTOTICA, TAL COMO ISQUEMIA CEREBRAL, LAS ENFERMEDADES DE ALZHEIMER, HUNTINGTON Y PARKINSON, LA ESCLEROSIS MULTIPLE Y LAS DIVERSAS CLASES DE GLAUCOMA, ASI COMO TAMBIEN EN EL TRATAMIENTO DE NEUROPATIAS PERIFERICAS GENERALES O DIABETICASTHEY REFER TO COMPOUNDS OF FORMULA (I), WHERE: ALK OF PREFERENCE IS LOWER ALKYLIDEN; R IS AN AMINO GROUP SUBSTITUTED OR SUBSTITUTED, BY C1-C4 ALKYL, BY C1-C4 PHENYLALKYL (WHERE THE PART ALKYL IS SUBSTITUTED BY EVENTUALLY ESTERIFIED CARBOXI), BY C1-C4 PHENYLALKYLENE-C1-C4 , AMONG OTHERS; R1, R2, R3 AND R4 ARE H, C1-C4 ALKYL, C1-C4 ALCOXY, HALOGEN, CF3. THEY ALSO REFER TO THE ADDITIONAL SALTS OF THE COMPOUNDS OF FORMULA (I) AND THE PROCEDURE OF PREPARATION OF SUCH SALT, WHICH INCLUDES REACTIONING THE COMPOUND OF FORMULA (I) WITH AN ORGANIC ACID SUCH AS OXALIC ACID, FUMIC , MALEICO, SUCCINICO, DIMALEICO OR DIFUMARICO, AMONG OTHERS. THE COMPOUNDS OF FORMULA (I) AND THEIR ADDITIONAL SALTS ARE USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES ESPECIALLY THOSE RELATED TO APOPTOTIC CELL DEATH, SUCH AS ISQUEMIA CEREBRAL, LAST, AND HUNGARY, HUNTING OF GLAUCOMA, AS WELL AS IN THE TREATMENT OF GENERAL PERIPHERAL NEUROPATHIES OR DIABETIC
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH135296 | 1996-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE70398A1 true PE70398A1 (en) | 1998-11-09 |
Family
ID=4208469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000433A PE70398A1 (en) | 1996-05-30 | 1997-05-28 | SALTS OF 10-AMINOALIFATIL-DIBENZ [B, F] OXEPINE WITH ANTINEURODEGENERATIVE ACTIVITY |
Country Status (10)
| Country | Link |
|---|---|
| AR (1) | AR008371A1 (en) |
| AU (1) | AU3030397A (en) |
| CO (1) | CO5080765A1 (en) |
| CZ (1) | CZ296134B6 (en) |
| ID (1) | ID18178A (en) |
| PE (1) | PE70398A1 (en) |
| PL (1) | PL191728B1 (en) |
| TR (1) | TR199802482T2 (en) |
| WO (1) | WO1997045422A1 (en) |
| ZA (1) | ZA974802B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1182200T3 (en) * | 1999-06-03 | 2005-12-27 | Nippon Suisan Kaisha Ltd | Tricyclic condensed heterocyclic compounds, processes for their preparation and use thereof |
| US7355042B2 (en) | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
| AU2003235799A1 (en) * | 2002-01-08 | 2003-07-24 | Nordic Bioscience A/S | Modulation of iamt (pimt or pcmt) in immune system |
| EP1589963A1 (en) * | 2003-01-29 | 2005-11-02 | Novartis AG | Use of 10-aminoaliphatyl-dibenz b,f oxepines for the tr eatment of degenerative ocular disorders |
| PE20050487A1 (en) * | 2003-11-06 | 2005-10-07 | Novartis Ag | STABILIZED PHARMACEUTICAL COMPOSITIONS |
| ATE542536T1 (en) | 2004-09-21 | 2012-02-15 | Hypnion Inc | 3-Ä4-(DIBENZOÄB,FÜÄ1,4ÜOXAZEPINE-11-YL)-PIPERAZI - 1-YLÜ-2,2-DIMETHYL PROPANOIC ACID FOR USE IN THE TREATMENT OF SLEEP DISORDERS |
| US7563785B2 (en) | 2004-10-29 | 2009-07-21 | Hypnion, Inc. | Quetiapine analogs and methods of use thereof |
| EP1757284A1 (en) | 2005-08-25 | 2007-02-28 | Santhera Pharmaceuticals (Schweiz) AG | Use of N-(dibenz(b,f)oxepin-10ylmethyl)-N-methyl-N-prop-2-ynylamine (omigapil) for the prophylaxis and/or treatment of muscular dystrophy |
| EP1842539A1 (en) * | 2006-04-05 | 2007-10-10 | Santhera Pharmaceuticals (Schweiz) AG | Use of N- (dibenz(b,f)oxepin-10-ylmethyl)N-methyl-N-prop-2-ynylamine (omigapil) for the prophylaxis and/or treatment of congenital muscular dystrophy or myopathy resulting from collagen VI deficiency |
| US9937144B2 (en) | 2013-01-30 | 2018-04-10 | The Johns Hopkins University | Treatment of drug abuse by preventing GAPDH nitrosylation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3100207A (en) * | 1959-07-08 | 1963-08-06 | Smith Kline French Lab | 10-aminoalkylbenzo[b,f]thiepin and -dibenz[b,f]oxepin derivatives |
| DE1493782B1 (en) * | 1964-06-29 | 1969-12-11 | Geigy Ag J R | Basically substituted dibenzo [b, f] -oxepines and their non-toxic salts |
| CH585747A5 (en) * | 1973-06-08 | 1977-03-15 | Hoffmann La Roche | |
| ES2160790T3 (en) * | 1995-02-08 | 2001-11-16 | Novartis Ag | 10-AMINOALIFATIL-DIBENZO (B, F) OXEPINS OF ANTINEURODEGENERATIVE ACTION. |
-
1997
- 1997-05-27 AR ARP970102247A patent/AR008371A1/en unknown
- 1997-05-28 AU AU30303/97A patent/AU3030397A/en not_active Abandoned
- 1997-05-28 WO PCT/EP1997/002794 patent/WO1997045422A1/en not_active Ceased
- 1997-05-28 PE PE1997000433A patent/PE70398A1/en not_active IP Right Cessation
- 1997-05-28 CZ CZ0387898A patent/CZ296134B6/en not_active IP Right Cessation
- 1997-05-28 PL PL330238A patent/PL191728B1/en unknown
- 1997-05-28 TR TR1998/02482T patent/TR199802482T2/en unknown
- 1997-05-29 CO CO97029926A patent/CO5080765A1/en unknown
- 1997-05-30 ID IDP971845A patent/ID18178A/en unknown
- 1997-05-30 ZA ZA974802A patent/ZA974802B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO5080765A1 (en) | 2001-09-25 |
| ZA974802B (en) | 1998-11-30 |
| PL330238A1 (en) | 1999-05-10 |
| CZ296134B6 (en) | 2006-01-11 |
| PL191728B1 (en) | 2006-06-30 |
| TR199802482T2 (en) | 1999-02-22 |
| AU3030397A (en) | 1998-01-05 |
| ID18178A (en) | 1998-03-12 |
| AR008371A1 (en) | 2000-01-19 |
| CZ387898A3 (en) | 1999-02-17 |
| WO1997045422A1 (en) | 1997-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| MK | Expiration of term |