PE64598A1 - SUBSTITUTED INDAZOL DERIVATIVES AND RELATED COMPOUNDS - Google Patents
SUBSTITUTED INDAZOL DERIVATIVES AND RELATED COMPOUNDSInfo
- Publication number
- PE64598A1 PE64598A1 PE1997000330A PE00033097A PE64598A1 PE 64598 A1 PE64598 A1 PE 64598A1 PE 1997000330 A PE1997000330 A PE 1997000330A PE 00033097 A PE00033097 A PE 00033097A PE 64598 A1 PE64598 A1 PE 64598A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- compounds
- preference
- related compounds
- double link
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical class C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 abstract 2
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 abstract 2
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I) Y A COMPUESTOS INTERMEDIOS DE FORMULA (XV) Y (XIX), EN DONDE: R ES H, ALQUILO C1-C6 O (CH2)n(CICLOALQUILO C3-C7), ENTRE OTROS, EN DONDE: n ES 0; 1 o 2; SIENDO DE PREFERENCIA R UN CICLOHEXILO O CICLOPENTILO; R1 ES DE PREFERENCIA ETILO; R2 ES DE PREFERENCIA (Ia), EN DONDE LAS LINEAS DISCONTINUAS SON UN ENLACE SENCILLO O DOBLE, CON LA CONDICION DE QUE SI R5 ESTA AUSENTE CUANDO LA LINEA DISCONTINUA EN LA FORMULA (Ia) ES UN DOBLE ENLACE; R3 ES H O CN, ENTRE OTROS; R4 ES CARBOXI, CH2OH O CH2CONH2, ENTRE OTROS; R5 ES R9, OR9 O CH2OR9, ENTRE OTROS; O R4 Y R5 SE UNEN PARA FORMAR =O o =R8; R8 ES =NCN O =NCR9R10(ALQUENILO C2-C6), ENTRE OTROS; R9 Y R10 SON H O ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO HASTA CON 3 FLUOR. ESTOS COMPUESTOS ACTUAN COMO INHIBIDORES SELECTIVOS DE LA FOSFODIESTERASA (PDE) TIPO IV Y DE LA PRODUCCION DEL FACTOR DE NECROSIS TUMORAL, SIENDO UTIL EN EL TRATAMIENTO DEL ASMA, DE LA ARTRITIS REUMATOIDEA, ENTRE OTROSTHEY REFER TO COMPOUNDS OF FORMULA (I) AND INTERMEDIATE COMPOUNDS OF FORMULA (XV) AND (XIX), WHERE: R ES H, ALQUILO C1-C6 O (CH2) n (CICLOALQUILO C3-C7), AMONG OTHERS, WHERE : n IS 0; 1 or 2; BEING OF PREFERENCE R A CYCLOHEXILO OR CICLOPENTILO; R1 IS PREFERRED ETHYL; R2 IS OF PREFERENCE (Ia), WHERE THE DISCONTINUOUS LINES ARE A SIMPLE OR DOUBLE LINK, WITH THE CONDITION THAT IF R5 IS ABSENT WHEN THE DISCONTINUOUS LINE IN THE FORMULA (Ia) IS A DOUBLE LINK; R3 IS H O CN, AMONG OTHERS; R4 IS CARBOXY, CH2OH OR CH2CONH2, AMONG OTHERS; R5 IS R9, OR9 OR CH2OR9, AMONG OTHERS; OR R4 AND R5 JOIN TO FORM = O or = R8; R8 ES = NCN O = NCR9R10 (C2-C6 ALKYNYLL), AMONG OTHERS; R9 AND R10 ARE H OR C1-C4 ALKYL OPTIONALLY REPLACED UP TO 3 FLUORESCENT. THESE COMPOUNDS ACT AS SELECTIVE INHIBITORS OF TYPE IV PHOSPHODIESTERASE (PDE) AND OF THE PRODUCTION OF THE TUMOR NECROSIS FACTOR, BEING USEFUL IN THE TREATMENT OF ASTHMA, RHEUMATOID ARTHRITIS, AMONG OTHERS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1686196P | 1996-05-03 | 1996-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE64598A1 true PE64598A1 (en) | 1998-10-26 |
Family
ID=21779401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997000330A PE64598A1 (en) | 1996-05-03 | 1997-04-30 | SUBSTITUTED INDAZOL DERIVATIVES AND RELATED COMPOUNDS |
Country Status (41)
| Country | Link |
|---|---|
| US (2) | US6211222B1 (en) |
| EP (1) | EP0912521B1 (en) |
| JP (1) | JP3148254B2 (en) |
| KR (1) | KR100339935B1 (en) |
| CN (2) | CN1112359C (en) |
| AP (4) | AP2001002304A0 (en) |
| AR (1) | AR006906A1 (en) |
| AT (1) | ATE292626T1 (en) |
| AU (1) | AU725576B2 (en) |
| BG (1) | BG64211B1 (en) |
| BR (1) | BR9709051A (en) |
| CA (2) | CA2252982C (en) |
| CO (1) | CO4650038A1 (en) |
| CZ (1) | CZ292825B6 (en) |
| DE (1) | DE69732966T2 (en) |
| DZ (1) | DZ2217A1 (en) |
| EA (1) | EA002272B1 (en) |
| ES (1) | ES2238079T3 (en) |
| GT (1) | GT199700043A (en) |
| HN (1) | HN1997000046A (en) |
| HR (1) | HRP970227B1 (en) |
| HU (1) | HUP9902459A3 (en) |
| ID (1) | ID16856A (en) |
| IL (2) | IL152083A0 (en) |
| IS (1) | IS4871A (en) |
| MA (1) | MA24158A1 (en) |
| MY (1) | MY132499A (en) |
| NO (1) | NO312959B1 (en) |
| NZ (1) | NZ332240A (en) |
| OA (1) | OA10904A (en) |
| PE (1) | PE64598A1 (en) |
| PL (1) | PL329836A1 (en) |
| SK (1) | SK148298A3 (en) |
| TN (1) | TNSN97070A1 (en) |
| TR (1) | TR199802202T2 (en) |
| TW (1) | TW449585B (en) |
| UA (1) | UA65536C2 (en) |
| UY (1) | UY24532A1 (en) |
| WO (1) | WO1997042174A1 (en) |
| YU (1) | YU16397A (en) |
| ZA (1) | ZA973804B (en) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6005118A (en) * | 1996-05-03 | 1999-12-21 | Caron; Stephane | Methods of preparing 4-cyano-4 (substituted indazole) cyclohexane-carboxylic acids useful as PDE4 inhibitors |
| AP2001002304A0 (en) * | 1996-05-03 | 2001-12-31 | Pfizer | Substituted indazole derivatives and related compounds |
| EP2223920A3 (en) | 1996-06-19 | 2011-09-28 | Aventis Pharma Limited | Substituted azabicyclic compounds |
| WO1998050367A1 (en) * | 1997-05-08 | 1998-11-12 | Pfizer Products Inc. | Processes and intermediates for preparing substituted indazole derivatives |
| TR200001256T2 (en) * | 1997-11-04 | 2000-11-21 | Pfizer Products Inc. | Therapeutically active compositions. |
| IL126745A (en) | 1997-11-04 | 2003-09-17 | Pfizer Prod Inc | Methods of preparing 4-cyano-4- (substituted indazole) cyclohexanecarboxylic acids useful as pde4 inhibitors |
| ID23921A (en) * | 1997-11-04 | 2000-05-25 | Pfizer Prod Inc | REPLACEMENT OF INDAZOLA BIOISOSTERE CATEGOL IN ACTIVE COMPOUNDS FOR THERAPY |
| IL132407A0 (en) * | 1998-10-21 | 2001-03-19 | Pfizer Prod Inc | Method for treating congestive heart failure |
| JP2000198734A (en) * | 1998-12-30 | 2000-07-18 | Pfizer Inc | Motility enhancers for the treatment of gastric motility impairment and related disorders |
| US6303782B1 (en) * | 1999-04-20 | 2001-10-16 | Pfizer Inc | Process for preparing benzylnitriles |
| US6362213B1 (en) | 1999-12-23 | 2002-03-26 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| AU770918B2 (en) * | 1999-12-23 | 2004-03-11 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| US7211594B2 (en) * | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
| US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| US6953774B2 (en) | 2000-08-11 | 2005-10-11 | Applied Research Systems Ars Holding N.V. | Methods of inducing ovulation |
| IL162506A0 (en) | 2001-12-14 | 2005-11-20 | Applied Research Systems | Ovulation induction |
| US20040034084A1 (en) * | 2002-05-24 | 2004-02-19 | Celgene Corporation | Methods for using JNK inhibitors for treating or preventing disease-related wasting |
| US7196082B2 (en) * | 2002-11-08 | 2007-03-27 | Merck & Co. Inc. | Ophthalmic compositions for treating ocular hypertension |
| US20050019366A1 (en) * | 2002-12-31 | 2005-01-27 | Zeldis Jerome B. | Drug-coated stents and methods of use therefor |
| DE10318610A1 (en) | 2003-04-24 | 2004-11-11 | Elbion Ag | 7-azaindoles and their use as therapeutic agents |
| US7601847B2 (en) | 2004-10-26 | 2009-10-13 | Wyeth | Preparation and purification of 4-(indazol-3-yl)phenols |
| US20070004777A1 (en) * | 2005-03-23 | 2007-01-04 | Bhagwat Shripad S | Methods for treating or preventing acute myelogenous leukemia |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| EP1942879A1 (en) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| AU2007240355B2 (en) * | 2006-04-21 | 2013-09-26 | Centocor, Inc. | CXCL13 antagonists and their use for the treatment of inflammatory diseases |
| JP2009536669A (en) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | Neurogenesis by angiotensin regulation |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| KR20200104291A (en) | 2017-11-06 | 2020-09-03 | 랩트 테라퓨틱스, 인크. | Anticancer drugs |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3994890A (en) * | 1974-01-31 | 1976-11-30 | Chugai Seiyaku Kabushiki Kaisha | 1-Aminoalkyl, 3-phenyl indazoles |
| JPS5654437A (en) * | 1979-10-09 | 1981-05-14 | Konishiroku Photo Ind Co Ltd | Direct positive image forming method |
| GB8707051D0 (en) * | 1986-04-15 | 1987-04-29 | Ici America Inc | Heterocyclic carboxamides |
| JP2525286B2 (en) * | 1990-11-26 | 1996-08-14 | 日本原子力研究所 | Method for producing super heat resistant silicon carbide fiber |
| TW223004B (en) * | 1991-11-25 | 1994-05-01 | Sumitomo Chemical Co | |
| US5444038A (en) * | 1992-03-09 | 1995-08-22 | Zeneca Limited | Arylindazoles and their use as herbicides |
| PT630367E (en) * | 1992-03-09 | 2000-10-31 | Zeneca Ltd | NEW ARILINDAZOLES AND ITS USE AS HERBICIDES |
| AU677776B2 (en) * | 1992-04-02 | 1997-05-08 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
| US5554620A (en) * | 1993-09-14 | 1996-09-10 | Sterling Winthrop Inc. | Substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizinium salts and compositions and methods of use thereof |
| US5440038A (en) * | 1993-12-07 | 1995-08-08 | Miles Inc. | Process for the purification of substituted 4-amino-1,2,4-triazine-5-ones |
| PL319758A1 (en) * | 1994-10-20 | 1997-08-18 | Pfizer | Bicyclic tetrahydropyrasole pyridines and their application as medicines |
| DE69516298T2 (en) * | 1994-10-21 | 2000-12-28 | Elisha Technologies Co. L.L.C., Moberly | CORROSION-PREVENTING BUFFER SYSTEM FOR METAL PRODUCTS |
| AP2001002304A0 (en) * | 1996-05-03 | 2001-12-31 | Pfizer | Substituted indazole derivatives and related compounds |
| WO1998050367A1 (en) * | 1997-05-08 | 1998-11-12 | Pfizer Products Inc. | Processes and intermediates for preparing substituted indazole derivatives |
-
1996
- 1996-05-03 AP AP2001002304A patent/AP2001002304A0/en unknown
- 1996-05-03 AP APAP/P/2001/002294A patent/AP1147A/en active
-
1997
- 1997-01-04 UA UA98105434A patent/UA65536C2/en unknown
- 1997-04-01 HU HU9902459A patent/HUP9902459A3/en unknown
- 1997-04-01 SK SK1482-98A patent/SK148298A3/en unknown
- 1997-04-01 AU AU19373/97A patent/AU725576B2/en not_active Ceased
- 1997-04-01 EA EA199800882A patent/EA002272B1/en not_active IP Right Cessation
- 1997-04-01 IL IL15208397A patent/IL152083A0/en unknown
- 1997-04-01 EP EP97907247A patent/EP0912521B1/en not_active Expired - Lifetime
- 1997-04-01 NZ NZ332240A patent/NZ332240A/en unknown
- 1997-04-01 JP JP53967097A patent/JP3148254B2/en not_active Expired - Fee Related
- 1997-04-01 CN CN97194356A patent/CN1112359C/en not_active Expired - Fee Related
- 1997-04-01 AT AT97907247T patent/ATE292626T1/en not_active IP Right Cessation
- 1997-04-01 CZ CZ19983492A patent/CZ292825B6/en not_active IP Right Cessation
- 1997-04-01 CA CA002252982A patent/CA2252982C/en not_active Expired - Fee Related
- 1997-04-01 ES ES97907247T patent/ES2238079T3/en not_active Expired - Lifetime
- 1997-04-01 TR TR1998/02202T patent/TR199802202T2/en unknown
- 1997-04-01 TW TW086104176A patent/TW449585B/en active
- 1997-04-01 DE DE69732966T patent/DE69732966T2/en not_active Expired - Fee Related
- 1997-04-01 PL PL97329836A patent/PL329836A1/en unknown
- 1997-04-01 BR BR9709051A patent/BR9709051A/en active Search and Examination
- 1997-04-01 WO PCT/IB1997/000323 patent/WO1997042174A1/en not_active Ceased
- 1997-04-01 CA CA002389918A patent/CA2389918A1/en not_active Abandoned
- 1997-04-01 AP APAP/P/2001/002304A patent/AP0102304A0/en unknown
- 1997-04-01 IL IL12654797A patent/IL126547A/en not_active IP Right Cessation
- 1997-04-01 KR KR1019980708867A patent/KR100339935B1/en not_active Expired - Fee Related
- 1997-04-04 HN HN1997000046A patent/HN1997000046A/en unknown
- 1997-04-10 GT GT199700043A patent/GT199700043A/en unknown
- 1997-04-28 UY UY24532A patent/UY24532A1/en not_active IP Right Cessation
- 1997-04-29 AR ARP970101769A patent/AR006906A1/en not_active Application Discontinuation
- 1997-04-29 YU YU16397A patent/YU16397A/en unknown
- 1997-04-30 PE PE1997000330A patent/PE64598A1/en not_active Application Discontinuation
- 1997-04-30 TN TNTNSN97070A patent/TNSN97070A1/en unknown
- 1997-04-30 AP APAP/P/1997/000975A patent/AP1146A/en active
- 1997-04-30 DZ DZ970064A patent/DZ2217A1/en active
- 1997-04-30 MA MA24577A patent/MA24158A1/en unknown
- 1997-05-02 MY MYPI97001923A patent/MY132499A/en unknown
- 1997-05-02 ZA ZA973804A patent/ZA973804B/en unknown
- 1997-05-02 HR HR970227A patent/HRP970227B1/en not_active IP Right Cessation
- 1997-05-02 ID IDP971466A patent/ID16856A/en unknown
- 1997-05-05 CO CO97023872A patent/CO4650038A1/en unknown
- 1997-11-04 US US08/963,904 patent/US6211222B1/en not_active Expired - Fee Related
-
1998
- 1998-10-16 IS IS4871A patent/IS4871A/en unknown
- 1998-10-23 OA OA9800201A patent/OA10904A/en unknown
- 1998-11-02 NO NO19985095A patent/NO312959B1/en not_active IP Right Cessation
- 1998-11-23 BG BG102946A patent/BG64211B1/en unknown
-
1999
- 1999-09-27 US US09/406,220 patent/US6127398A/en not_active Expired - Fee Related
-
2002
- 2002-11-08 CN CN02149950A patent/CN1422849A/en active Pending
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