PE35296A1 - EXCITATION SYNTHETIC AMINO ACID - Google Patents
EXCITATION SYNTHETIC AMINO ACIDInfo
- Publication number
- PE35296A1 PE35296A1 PE27612495A PE27612495A PE35296A1 PE 35296 A1 PE35296 A1 PE 35296A1 PE 27612495 A PE27612495 A PE 27612495A PE 27612495 A PE27612495 A PE 27612495A PE 35296 A1 PE35296 A1 PE 35296A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- formula
- carboxi
- co2r4
- protective group
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title abstract 2
- 230000005284 excitation Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 230000001681 protective effect Effects 0.000 abstract 3
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- -1 CARBOXYL GROUPS Chemical group 0.000 abstract 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 230000005540 biological transmission Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE AL COMPUESTO DE FORMULA I DONDE: X ES (CH2)n; R2 ES CO2R4 Y R3 ES H; o R2 ES H y R3 ES CO2R4; R1 y R4 SON INDEPENDIENTEMENTE H, C1-C10 ALQUILO, C2-C10 ALQUENILO, ARILO o ARILALQUILO, DE PREFERENCIA ES H o C1-C4 ALQUILO. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE OBTENCION QUE COMPRENDE: a) LA HIDROLISIS DE UN COMPUESTO DE FORMULA (A) DONDE X ES (CH2)n, n ES 1, R2a ES CO2R4a y R3a ES H, R2a ES H y R3a ES CO2R4 y R4a ES UN GRUPO PROTECTOR DE CARBOXI; b) LA REACCION DE UN COMPUESTO DE FORMULA (B) DONDE X, R2a y R3a YA SE DEFINIERON, CON CIANURO DE METAL ALCALINO Y UNA SAL DE AMONIO E HIDROLIZANDO EL INTERMEDIO RESULTANTE; c) LA HIDROLISIS DE UN COMPUESTO DE FORMULA (C) DONDE R1a ES UN GRUPO PROTECTOR DE CARBOXI y X, R2a y R3a COMO SE DEFINIERON; d) OPCIONALMENTE RETIRAR EL GRUPO PROTECTOR DE CARBOXI; e) OPCIONALMENTE ESTERIFICAR UNO O AMBOS GRUPOS CARBOXILO; f) OPCIONALMENTE SEPARAR LOS DIASTEROISOMEROS Y/O RESOLVER LOS ENANTIOMEROS. ESTE COMPUESTO ES UTILIZADO EN EL TRATAMIENTO DE TRANSTORNOS NEUROLOGICOS ASOCIADO CON LA ESTIMULACION EXCESIVA O INAPROPIADA DE LA TRANSMISION DEL AMINOACIDO EXITATORIOREFERS TO COMPOUND OF FORMULA I WHERE: X IS (CH2) n; R2 IS CO2R4 AND R3 IS H; or R2 IS H and R3 IS CO2R4; R1 and R4 ARE INDEPENDENTLY H, C1-C10 ALKYL, C2-C10 ALKYNYL, ARYL or ARYALKYL, OF PREFERENCE IS H or C1-C4 ALKYL. IT ALSO REFERS TO THE PROCEDURE FOR OBTAINING THAT INCLUDES: a) THE HYDROLYSIS OF A COMPOUND OF FORMULA (A) WHERE X IS (CH2) n, n ES 1, R2a IS CO2R4a and R3a IS H, R2a IS H and R3a IS CO2R4 and R4a IS A CARBOXI PROTECTIVE GROUP; b) THE REACTION OF A COMPOUND OF FORMULA (B) WHERE X, R2a and R3a HAVE ALREADY BEEN DEFINED, WITH ALKALINE METAL CYANIDE AND AMMONIUM SALT AND HYDROLYZING THE RESULTING INTERMEDIATE; c) THE HYDROLYSIS OF A COMPOUND OF FORMULA (C) WHERE R1a IS A PROTECTIVE GROUP OF CARBOXI and X, R2a and R3a AS DEFINED; d) OPTIONALLY WITHDRAW THE CARBOXI PROTECTIVE GROUP; e) OPTIONALLY ESTERIFY ONE OR BOTH CARBOXYL GROUPS; f) OPTIONALLY SEPARATE THE DIASTEROISOMERS AND / OR SOLVE THE ENANTIOMERS. THIS COMPOUND IS USED IN THE TREATMENT OF NEUROLOGICAL DISORDERS ASSOCIATED WITH THE EXCESSIVE OR INAPPROPRIATE STIMULATION OF THE TRANSMISSION OF THE EXITATORY AMINO ACID
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33734994A | 1994-11-10 | 1994-11-10 | |
| US08/496,643 US5750566A (en) | 1994-08-12 | 1995-06-29 | Synthetic excitatory amino acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE35296A1 true PE35296A1 (en) | 1996-10-04 |
Family
ID=52272708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE27612495A PE35296A1 (en) | 1994-11-10 | 1995-08-16 | EXCITATION SYNTHETIC AMINO ACID |
Country Status (1)
| Country | Link |
|---|---|
| PE (1) | PE35296A1 (en) |
-
1995
- 1995-08-16 PE PE27612495A patent/PE35296A1/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |