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PE20251072A1 - Conjugados de anticuerpo-farmaco de compuestos antineoplasicos y metodos de uso de los mismos - Google Patents

Conjugados de anticuerpo-farmaco de compuestos antineoplasicos y metodos de uso de los mismos

Info

Publication number
PE20251072A1
PE20251072A1 PE2024002625A PE2024002625A PE20251072A1 PE 20251072 A1 PE20251072 A1 PE 20251072A1 PE 2024002625 A PE2024002625 A PE 2024002625A PE 2024002625 A PE2024002625 A PE 2024002625A PE 20251072 A1 PE20251072 A1 PE 20251072A1
Authority
PE
Peru
Prior art keywords
antibody
conjugates
antineoplastic
payload
cancer
Prior art date
Application number
PE2024002625A
Other languages
English (en)
Inventor
Matthew T Burger
Zhuoliang Chen
Joseph Anthony D'alessio
Gregory John Hollingworth
Claudia Judith Klinter
Jean-Baptiste Georges Armand Langlois
Eric Andrew Mcneill
Cornelia Anne Mundt
Katsumasa Nakajima
Richard Vaughan Newcombe
Katharina Madorin
Bing Yu
Qiang Zhang
Imre Fejes
Olivier Geneste
Ana Leticia Maragno
Stuart Ray
Francesca Rocchetti
Jerôme-Benoît Starck
Zoltan Szlavik
Vesela Kostova
Tibor Robert Novak
Original Assignee
Novartis Ag
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Servier Lab filed Critical Novartis Ag
Publication of PE20251072A1 publication Critical patent/PE20251072A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68037—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a camptothecin [CPT] or derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invencion se refiere a conjugados de anticuerpo-farmaco que se unen a antigenos diana de celulas cancerosas. Dichos conjugados se caracterizan porque comprenden un anticuerpo, o fragmento de union a antigeno del mismo, unido covalentemente a dos cargas utiles antineoplasticas mediante un conector dual, en donde la primera carga util es un mimetico de BH3, seleccionado de un inhibidor de Mcl-1, Bcl-2 o Bcl-xL, y la segunda carga util es un antineoplasico no mimetico de BH3 seleccionado de un inhibidor de topoisomerasa 1 como topotecan, exatecan, entre otros, o un farmaco antimitotico como monometil auristatina E (MMAE) o un taxano. Asimismo, dichos conjugados son de Formula (A) y en su estructura, Ab es un anticuerpo, o fragmento de union a antigeno del mismo, R1 es un grupo de union, L1 es un espaciador en puente, W es una unidad de ramificacion, L2' y L3' son independientemente entre si un conector, D1 y D2 son independientemente una carga util antineoplasica, y a es 1 a 16. Ademas, refiere a composiciones farmaceuticas que comprenden el conjugado de anticuerpo-farmaco y un vehiculo farmaceuticamente aceptable; al uso de dichos conjugados y composiciones farmaceuticas en la elaboracion de un medicamento para tratar a un sujeto que padece, o puede padecer, un cancer seleccionado de cancer de mama, cancer gastrico, leucemia mieloide aguda, entre otros, y metodos para su tratamiento.
PE2024002625A 2022-05-20 2023-05-19 Conjugados de anticuerpo-farmaco de compuestos antineoplasicos y metodos de uso de los mismos PE20251072A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202263344510P 2022-05-20 2022-05-20
PCT/US2023/022990 WO2023225359A1 (en) 2022-05-20 2023-05-19 Antibody-drug conjugates of antineoplastic compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
PE20251072A1 true PE20251072A1 (es) 2025-04-10

Family

ID=86861832

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2024002625A PE20251072A1 (es) 2022-05-20 2023-05-19 Conjugados de anticuerpo-farmaco de compuestos antineoplasicos y metodos de uso de los mismos

Country Status (16)

Country Link
EP (1) EP4525927A1 (es)
JP (1) JP2025517435A (es)
KR (1) KR20250027285A (es)
CN (1) CN120787162A (es)
AR (1) AR129380A1 (es)
AU (1) AU2023272448A1 (es)
CA (1) CA3255949A1 (es)
CL (1) CL2024003536A1 (es)
CO (1) CO2024017273A2 (es)
CR (1) CR20240553A (es)
DO (1) DOP2024000245A (es)
IL (1) IL317101A (es)
MX (1) MX2024014345A (es)
PE (1) PE20251072A1 (es)
TW (1) TW202408588A (es)
WO (1) WO2023225359A1 (es)

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Also Published As

Publication number Publication date
DOP2024000245A (es) 2025-03-31
CL2024003536A1 (es) 2025-05-16
JP2025517435A (ja) 2025-06-05
WO2023225359A1 (en) 2023-11-23
CR20240553A (es) 2025-05-02
CO2024017273A2 (es) 2025-03-06
AU2023272448A1 (en) 2024-12-12
AR129380A1 (es) 2024-08-21
CA3255949A1 (en) 2023-11-23
EP4525927A1 (en) 2025-03-26
KR20250027285A (ko) 2025-02-25
MX2024014345A (es) 2025-03-07
CN120787162A (zh) 2025-10-14
TW202408588A (zh) 2024-03-01
IL317101A (en) 2025-01-01

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