PE20240048A1 - Forma cristalina i del compuesto agonista de receptor de melanocortina y metodo de preparacion para la misma - Google Patents
Forma cristalina i del compuesto agonista de receptor de melanocortina y metodo de preparacion para la mismaInfo
- Publication number
- PE20240048A1 PE20240048A1 PE2023001494A PE2023001494A PE20240048A1 PE 20240048 A1 PE20240048 A1 PE 20240048A1 PE 2023001494 A PE2023001494 A PE 2023001494A PE 2023001494 A PE2023001494 A PE 2023001494A PE 20240048 A1 PE20240048 A1 PE 20240048A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation
- crystalline form
- melanocortin receptor
- receptor agonist
- agonist compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A LA FORMA CRISTALINA I DEL HIDRATO DE CLORHIDRATO DE N-((3S,5S)-1-((3S,4R)-1-(TER-BUTIL)-4-(4-CLOROFENIL)PIRROLIDIN-3-CARBONIL)-5-(MORFOLIN-4-CARBONIL)-PIRROLIDIN-3-IL)-N-((1S,4R)-4-METILCICLOHEXIL)ISOBUTIRAMIDA CUYO PATRON DE DIFRACCION DE POLVO DE RAYOS X PRESENTA PICOS CARACTERISTICOS CON LOS SIGUIENTES ANGULOS DE DIFRACCION (VALORES 2THETA) DE: 7.19±0.2°, 9.58±0.2°, 10.87±0.2°, 12.50±0.2°, 14.73±0.2°, 17.38±0.2°, 18.22±0.2°, 18.59±0.2°, 19.03±0.2°, 20.61±0.2°, 21.14±0.2°, 21.82±0.2°, 22.42±0.2°, 23.18±0.2°, 24.15±0.2°, 24.92±0.2°, 25.55±0.2°, 27.04±0.2°, 28.75±0.2° Y 29.85±0.2°. TAMBIEN SE REFIERE A UN METODO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA QUE LO COMPRENDE. DICHO COMPUESTO ES AGONISTA DE UN RECEPTOR DE MELANOCORTINA SIENDO UTIL EN EL TRATAMIENTO DE OBESIDAD, DIABETES.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20200142396 | 2020-10-29 | ||
| PCT/KR2021/015469 WO2022092909A1 (ko) | 2020-10-29 | 2021-10-29 | 멜라노코르틴 수용체 작용제 화합물의 결정형 i 및 이의 제조방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20240048A1 true PE20240048A1 (es) | 2024-01-09 |
Family
ID=81384109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2023001494A PE20240048A1 (es) | 2020-10-29 | 2021-10-29 | Forma cristalina i del compuesto agonista de receptor de melanocortina y metodo de preparacion para la misma |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20230373984A1 (es) |
| EP (1) | EP4219472A4 (es) |
| JP (2) | JP2023548327A (es) |
| KR (2) | KR102672624B1 (es) |
| CN (1) | CN116507615A (es) |
| AU (1) | AU2021367713B2 (es) |
| CA (1) | CA3195298A1 (es) |
| CL (1) | CL2023001223A1 (es) |
| CO (1) | CO2023006515A2 (es) |
| IL (1) | IL302427A (es) |
| MX (1) | MX2023004655A (es) |
| PE (1) | PE20240048A1 (es) |
| WO (1) | WO2022092909A1 (es) |
| ZA (1) | ZA202305594B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4249483A4 (en) * | 2020-12-22 | 2024-05-15 | Lg Chem, Ltd. | Crystalline form i of melanocortin receptor agonist compound and method for preparing same |
| EP4249485A4 (en) * | 2020-12-22 | 2024-05-15 | Lg Chem, Ltd. | CRYSTALLINE FORM III OF A MELANOCORTIN RECEPTOR AGONIST COMPOUND AND METHOD OF PREPARING THE SAME |
| EP4249484A4 (en) * | 2020-12-22 | 2024-05-15 | Lg Chem, Ltd. | Crystal type ii of melanocortin receptor agonist compound and method for preparing same |
| KR20220090450A (ko) * | 2020-12-22 | 2022-06-29 | 주식회사 엘지화학 | 멜라노코르틴-4 수용체의 선택적 항진제로서의 용도 |
| EP4317149A4 (en) * | 2021-05-06 | 2024-08-21 | Lg Chem, Ltd. | CRYSTALLINE FORM V OF A MELANOCORTIN RECEPTOR AGONIST COMPOUND AND PROCESS FOR ITS PREPARATION |
| CN117242063A (zh) * | 2021-05-07 | 2023-12-15 | 株式会社Lg化学 | 黑皮质素受体激动剂化合物与香兰素的共晶及其制备方法 |
| CN117255787A (zh) * | 2021-05-07 | 2023-12-19 | 株式会社Lg 化学 | 黑皮质素受体激动剂化合物的硫酸盐晶体及其制备方法 |
| JP2024517271A (ja) * | 2021-05-07 | 2024-04-19 | エルジー・ケム・リミテッド | メラノコルチン受容体アゴニスト化合物の有機酸塩の結晶形ｉｖおよびその製造方法 |
| TWI838114B (zh) * | 2022-02-08 | 2024-04-01 | 南韓商Ｌｇ化學股份有限公司 | 黑皮質素-4受體激動劑在預防或治療罕見遺傳性肥胖中的用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2377369A1 (en) * | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
| CA2433025A1 (en) * | 2001-01-23 | 2002-08-01 | Chaoyu Xie | Substituted piperidines/piperazines as melanocortin receptor agonists |
| AR044510A1 (es) | 2003-04-14 | 2005-09-14 | Merck & Co Inc | Procedimiento e intermedios para preparar acidos carboxilicos de pirrolidina |
| TWI341835B (en) * | 2003-11-12 | 2011-05-11 | Lg Life Sciences Ltd | Melanocortin receptor agonists |
| TWI332501B (en) * | 2006-07-14 | 2010-11-01 | Lg Life Sciences Ltd | Melanocortin receptor agonists |
| KR20080007046A (ko) * | 2006-07-14 | 2008-01-17 | 주식회사 엘지생명과학 | 멜라노코틴 수용체의 항진제 |
| UA99555C2 (en) | 2008-11-12 | 2012-08-27 | Элджи Лайф Саенсез Лтд. | Melanocortin receptor agonists |
| EP3580194A4 (en) | 2017-02-08 | 2020-12-30 | Tilray, Inc. | LOW PRESSURE RADIANT ENERGY CANNABIS TREATMENT METHODS AND APPARATUS |
| PL3953327T3 (pl) * | 2019-11-07 | 2024-05-06 | Lg Chem, Ltd. | Agoniści receptora melanokortyny-4 |
-
2021
- 2021-10-29 MX MX2023004655A patent/MX2023004655A/es unknown
- 2021-10-29 KR KR1020210146188A patent/KR102672624B1/ko active Active
- 2021-10-29 US US18/251,084 patent/US20230373984A1/en active Pending
- 2021-10-29 IL IL302427A patent/IL302427A/en unknown
- 2021-10-29 AU AU2021367713A patent/AU2021367713B2/en active Active
- 2021-10-29 PE PE2023001494A patent/PE20240048A1/es unknown
- 2021-10-29 EP EP21886903.0A patent/EP4219472A4/en active Pending
- 2021-10-29 CA CA3195298A patent/CA3195298A1/en active Pending
- 2021-10-29 JP JP2023526438A patent/JP2023548327A/ja active Pending
- 2021-10-29 WO PCT/KR2021/015469 patent/WO2022092909A1/ko not_active Ceased
- 2021-10-29 CN CN202180073226.2A patent/CN116507615A/zh active Pending
-
2023
- 2023-04-27 CL CL2023001223A patent/CL2023001223A1/es unknown
- 2023-05-17 CO CONC2023/0006515A patent/CO2023006515A2/es unknown
- 2023-05-24 ZA ZA2023/05594A patent/ZA202305594B/en unknown
-
2024
- 2024-05-31 KR KR1020240071408A patent/KR20240085230A/ko active Pending
-
2025
- 2025-06-04 JP JP2025093513A patent/JP2025131717A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023548327A (ja) | 2023-11-16 |
| WO2022092909A1 (ko) | 2022-05-05 |
| US20230373984A1 (en) | 2023-11-23 |
| JP2025131717A (ja) | 2025-09-09 |
| KR20220057470A (ko) | 2022-05-09 |
| EP4219472A1 (en) | 2023-08-02 |
| EP4219472A4 (en) | 2024-03-13 |
| ZA202305594B (en) | 2024-09-25 |
| KR20240085230A (ko) | 2024-06-14 |
| CN116507615A (zh) | 2023-07-28 |
| AU2021367713A1 (en) | 2023-06-01 |
| IL302427A (en) | 2023-06-01 |
| AU2021367713B2 (en) | 2024-01-25 |
| KR102672624B1 (ko) | 2024-06-07 |
| MX2023004655A (es) | 2023-05-18 |
| CL2023001223A1 (es) | 2023-11-03 |
| CO2023006515A2 (es) | 2023-07-31 |
| CA3195298A1 (en) | 2022-05-05 |
| AU2021367713A9 (en) | 2024-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20240048A1 (es) | Forma cristalina i del compuesto agonista de receptor de melanocortina y metodo de preparacion para la misma | |
| PE20240367A1 (es) | Forma cristalina iv del compuesto agonista de receptor de melanocortina y metodo de preparacion para la misma | |
| PE20240366A1 (es) | Forma cristalina iii del compuesto agonista de receptor de melanocortina y metodo de preparacion para la misma | |
| PE20240124A1 (es) | Forma cristalina ii del compuesto agonista de receptor de melanocortina y metodo de preparacion para la misma | |
| PE20220766A1 (es) | Agonistas de receptor de melanocortina-4 | |
| CL2019003619A1 (es) | Preparación sólida para administración oral. | |
| ZA202007671B (en) | Pharmaceutical combination, composition, and combination formulation containing glucokinase activator and biguanide hypoglycemic drug as well as preparation method and use thereof | |
| AR120703A1 (es) | Formas sólidas de sal de 1,3-dihidroxi-2-(hidroximetil)propan-2-amina de ácido 2-((4-((s)-2-(5-cloropiridin-2-il)-2-metilbenzo[d][1,3]dioxol-4-il)piperidin-1-il)metil)-1-(((s)-oxetan-2-il)metil)-1h-benzo[d]imidazol-6-carboxílico | |
| CL2008000127A1 (es) | Compuestos derivados de n-(heteroaril)-1-heteroaril-1h-indol-2-carboxamidas; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del dolor, inflamacion, trastornos urologicos | |
| ATE528005T1 (de) | 2s,4r ketoconazol zur behandlung von diabetes, metabolischem syndrom und anderen erkrankungen | |
| PE20121084A1 (es) | Forma de dosificacion farmaceutica para administracion oral de un inhibidor de la familia bcl-2 | |
| CL2021001325A1 (es) | Ureas cíclicas. | |
| HRP20110125T1 (hr) | Farmaceutski sastavi koji sadrže rosuvastatin-kalcij | |
| JP2010514832A5 (es) | ||
| CL2008000017A1 (es) | Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci | |
| PE20081878A1 (es) | Compuestos derivados de 1-(4-hidroxifenil sustituido)-4-ol-indazol | |
| PE20110060A1 (es) | Forma cristalina de (2s)-(-)-n-(6-cloro-2,3-dihidro-benzo[1,4]dioxin-2-ilmetil)-sulfamida | |
| CY1124616T1 (el) | Θεραπεια της μετα-βαριατρικης υπογλυκαιμιας με εξενδινη(9-39) | |
| AU2018251118A8 (en) | Pharmaceutical composition containing MOR agonist and KOR agonist, and uses thereof | |
| RU2010133483A (ru) | Новые кристаллические формы 4-{4-(2-адамантилкарбамоил)-5-третбутилпиразол-1-ил}бензойной кислоты | |
| EA201891413A1 (ru) | Фармацевтическая композиция, содержащая безводный дазатиниб | |
| SA521422467B1 (ar) | مركبات هالو-آلِّيلامين واستخدامها | |
| IL304563A (en) | The compound n-(benzoyl)-phenylalanine, a pharmaceutical composition containing it, and its use | |
| PH12019500287A1 (en) | Crystals of cyclic amine derivative and pharmaceutical use thereof | |
| ZA202005286B (en) | Crystalline forms of the cxcr7 receptor antagonist (3s,4s)-1-cyclopropylmethyl-4-{[5-(2,4-difluoro-phenyl)-isoxazole-3-carbonyl]-amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)-amide |