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PE20230684A1 - 2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS AS RNA POLYMERASE INHIBITORS - Google Patents

2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS AS RNA POLYMERASE INHIBITORS

Info

Publication number
PE20230684A1
PE20230684A1 PE2022003082A PE2022003082A PE20230684A1 PE 20230684 A1 PE20230684 A1 PE 20230684A1 PE 2022003082 A PE2022003082 A PE 2022003082A PE 2022003082 A PE2022003082 A PE 2022003082A PE 20230684 A1 PE20230684 A1 PE 20230684A1
Authority
PE
Peru
Prior art keywords
rna polymerase
nucleoside analogs
fluoro substituted
polymerase inhibitors
substituted carba
Prior art date
Application number
PE2022003082A
Other languages
Spanish (es)
Inventor
Aesop Cho
Choung Kim
Adrian Ray
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47748238&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20230684(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US12/885,917 external-priority patent/US7973013B2/en
Priority claimed from US13/050,820 external-priority patent/US8455451B2/en
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of PE20230684A1 publication Critical patent/PE20230684A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Referido a analogos de carba-nucleosidos sustituidos con 2'-fluoro como inhibidores de la ARN polimerasa que consiste en el grupo A. Tambien se refiere a metodo de sintesis de estos compuestos, una composicion farmaceutica que comprende dichos compuestos y su uso en el tratamiento de las infecciones cronicas por virus de la hepatitis C (VHC) en humanos.Referring to analogues of 2'-fluoro-substituted carba-nucleosides as inhibitors of RNA polymerase consisting of group A. It also refers to the method of synthesis of these compounds, a pharmaceutical composition comprising said compounds and their use in the treatment of chronic hepatitis C virus (HCV) infections in humans.

PE2022003082A 2010-09-20 2011-03-22 2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS AS RNA POLYMERASE INHIBITORS PE20230684A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/885,917 US7973013B2 (en) 2009-09-21 2010-09-20 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
US13/050,820 US8455451B2 (en) 2009-09-21 2011-03-17 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
PCT/US2011/029441 WO2012039791A1 (en) 2010-09-20 2011-03-22 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment

Publications (1)

Publication Number Publication Date
PE20230684A1 true PE20230684A1 (en) 2023-04-21

Family

ID=47748238

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2022003082A PE20230684A1 (en) 2010-09-20 2011-03-22 2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS AS RNA POLYMERASE INHIBITORS
PE2017001530A PE20171624A1 (en) 2010-09-20 2011-03-22 2'-FLUORINE SUBSTITUTED CARBA-NUCLEOSID ANALOGS FOR ANTIVIRAL TREATMENT
PE2013000530A PE20131165A1 (en) 2010-09-20 2011-03-22 2'-FLUORINE SUBSTITUTED CARBA-NUCLEOSID ANALOGS FOR ANTIVIRAL TREATMENT

Family Applications After (2)

Application Number Title Priority Date Filing Date
PE2017001530A PE20171624A1 (en) 2010-09-20 2011-03-22 2'-FLUORINE SUBSTITUTED CARBA-NUCLEOSID ANALOGS FOR ANTIVIRAL TREATMENT
PE2013000530A PE20131165A1 (en) 2010-09-20 2011-03-22 2'-FLUORINE SUBSTITUTED CARBA-NUCLEOSID ANALOGS FOR ANTIVIRAL TREATMENT

Country Status (22)

Country Link
EP (1) EP2619206A1 (en)
JP (4) JP2013538230A (en)
KR (1) KR101879887B1 (en)
CN (1) CN103108876A (en)
AP (1) AP3699A (en)
AU (1) AU2011306066B2 (en)
BR (1) BR112013008017A2 (en)
CA (1) CA2807496C (en)
CL (1) CL2013000727A1 (en)
CO (1) CO6680669A2 (en)
CR (1) CR20130172A (en)
EA (1) EA026523B1 (en)
EC (1) ECSP13012560A (en)
IL (1) IL225221A0 (en)
MA (1) MA34593B1 (en)
MX (1) MX2013003179A (en)
NZ (1) NZ608070A (en)
PE (3) PE20230684A1 (en)
PH (1) PH12013500311B1 (en)
SG (1) SG188223A1 (en)
WO (1) WO2012039791A1 (en)
ZA (1) ZA201301042B (en)

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EP3651734B1 (en) 2017-07-11 2024-11-13 Gilead Sciences, Inc. Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections
ES2995458T3 (en) 2017-12-07 2025-02-10 Univ Emory N4-hydroxycytidine derivative and anti-viral uses related thereto
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Also Published As

Publication number Publication date
PH12013500311A1 (en) 2013-04-22
WO2012039791A1 (en) 2012-03-29
CL2013000727A1 (en) 2013-08-23
JP2019014726A (en) 2019-01-31
PE20171624A1 (en) 2017-11-02
PE20131165A1 (en) 2013-10-14
CR20130172A (en) 2013-05-29
NZ608070A (en) 2015-11-27
JP2016074732A (en) 2016-05-12
PH12013500311B1 (en) 2017-11-08
EP2619206A1 (en) 2013-07-31
BR112013008017A2 (en) 2016-06-14
CN103108876A (en) 2013-05-15
CA2807496A1 (en) 2012-03-29
JP2013538230A (en) 2013-10-10
MA34593B1 (en) 2013-10-02
AU2011306066B2 (en) 2015-01-29
AP2013006767A0 (en) 2013-03-31
SG188223A1 (en) 2013-04-30
IL225221A0 (en) 2013-06-27
AU2011306066A1 (en) 2013-02-28
KR20130110168A (en) 2013-10-08
ECSP13012560A (en) 2013-06-28
KR101879887B1 (en) 2018-07-18
EA201390141A1 (en) 2013-09-30
ZA201301042B (en) 2014-07-30
CO6680669A2 (en) 2013-05-31
CA2807496C (en) 2019-01-22
JP2017119726A (en) 2017-07-06
MX2013003179A (en) 2013-04-24
EA026523B1 (en) 2017-04-28
JP6475280B2 (en) 2019-02-27
AP3699A (en) 2016-05-31

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