PE20220219A1 - Analogos de 3-(5-metil-1,3-tiazol-2-il)-n-{(1r)-1-[2-(trifluor-metil)pirimidin-5-il]etil}benzamida - Google Patents
Analogos de 3-(5-metil-1,3-tiazol-2-il)-n-{(1r)-1-[2-(trifluor-metil)pirimidin-5-il]etil}benzamidaInfo
- Publication number
- PE20220219A1 PE20220219A1 PE2021002216A PE2021002216A PE20220219A1 PE 20220219 A1 PE20220219 A1 PE 20220219A1 PE 2021002216 A PE2021002216 A PE 2021002216A PE 2021002216 A PE2021002216 A PE 2021002216A PE 20220219 A1 PE20220219 A1 PE 20220219A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- benzamide
- pyrimidin
- ethyl
- thiazol
- Prior art date
Links
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title abstract 4
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 1,3-THIAZOL-2-YL Chemical group 0.000 abstract 1
- 102100040460 P2X purinoceptor 3 Human genes 0.000 abstract 1
- 101710189970 P2X purinoceptor 3 Proteins 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 230000001272 neurogenic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A COMPUESTOS DE BENZAMIDA SUSTITUIDOS CON 1,3-TIAZOL-2-ILO DE FORMULA (I) DONDE R1 ES METILO; R2 ES ALQUILO C3-C4 SUSTITUIDO CON DOS SUSTITUYENTES SELECCIONADOS DE OH Y -COOH, O HETEROCICLOALQUILO DE 5 MIEMBROS SUSTITUIDO CON OXO Y OH. SON COMPUESTOS PREFERIDOS: 3-{[(2R)-1,4-DIHIDROXIBUTAN-2-IL]OXI}-5-(5-METIL-1,3-TIAZOL-2-IL)-N-{(1R)-1-[2-(TRIFLUORMETIL)PIRIMIDIN-5-IL]ETIL}BENZAMIDA; REL-3-{[(3R,5R)-5-HIDROXITETRAHIDROFURAN-3-IL]OXI}-5-(5-METIL-1,3-TIAZOL-2-IL)-N-{(1R)-1-[2-(TRIFLUORMETIL)PIRIMIDIN-5-IL]ETIL}BENZAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DEL RECEPTOR P2X3 SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS NEUROGENICOS.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19182797.1A EP3757103A1 (en) | 2019-06-27 | 2019-06-27 | Analogues of 3-(5-methyl-1,3-thiazol-2-yl)-n-{(1r)-1-[2-(trifluoro-methyl)pyrimidin-5-yl]ethyl}benzamide for the treatment of neurogenic diseases |
| PCT/EP2020/067828 WO2020260463A1 (en) | 2019-06-27 | 2020-06-25 | Analogues of 3-(5-methyl-1,3-thiazol-2-yl)-n-{(1r)-1-[2-(trifluoro-methyl)pyrimidin-5-yl]ethyl}benzamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20220219A1 true PE20220219A1 (es) | 2022-02-02 |
Family
ID=67105828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2021002216A PE20220219A1 (es) | 2019-06-27 | 2020-06-25 | Analogos de 3-(5-metil-1,3-tiazol-2-il)-n-{(1r)-1-[2-(trifluor-metil)pirimidin-5-il]etil}benzamida |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20230013419A1 (es) |
| EP (2) | EP3757103A1 (es) |
| JP (1) | JP2022538270A (es) |
| KR (1) | KR20220027860A (es) |
| CN (1) | CN114026086A (es) |
| AU (1) | AU2020303269A1 (es) |
| BR (1) | BR112021024325A2 (es) |
| CA (1) | CA3145204A1 (es) |
| CL (1) | CL2021003455A1 (es) |
| CO (1) | CO2021017435A2 (es) |
| CR (1) | CR20210686A (es) |
| EC (1) | ECSP21088111A (es) |
| IL (1) | IL289161A (es) |
| JO (1) | JOP20210338A1 (es) |
| MA (1) | MA56383A (es) |
| MX (1) | MX2021015853A (es) |
| PE (1) | PE20220219A1 (es) |
| PH (1) | PH12021553202A1 (es) |
| WO (1) | WO2020260463A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6544665B2 (ja) | 2014-12-09 | 2019-07-17 | バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | １，３−チアゾール−２−イル置換ベンズアミド |
| CN114072399B (zh) * | 2020-05-25 | 2024-11-29 | 中国医药研究开发中心有限公司 | 芳甲酰胺类化合物及其制备方法和医药用途 |
| WO2022063205A1 (zh) * | 2020-09-24 | 2022-03-31 | 中国医药研究开发中心有限公司 | 芳基甲酰胺类化合物及其制备方法和医药用途 |
| IL301667A (en) * | 2020-09-30 | 2023-05-01 | Humanwell Healthcare Group Co Ltd | Benzamide compound and use thereof |
| CN114591317A (zh) * | 2020-12-04 | 2022-06-07 | 武汉人福创新药物研发中心有限公司 | P2x3抑制剂及其用途 |
| WO2023185931A1 (zh) * | 2022-03-29 | 2023-10-05 | 人福医药集团股份公司 | 一种p2x3抑制剂化合物及其盐、多晶型和用途 |
| TW202525285A (zh) * | 2023-12-29 | 2025-07-01 | 大陸商人福醫藥集團股份公司 | Ｐ２ｘ３受體拮抗劑的固體分散體及其製備方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8501933B2 (en) * | 2006-11-09 | 2013-08-06 | Roche Palo Alto Llc | Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists |
| KR101165936B1 (ko) * | 2006-11-09 | 2012-07-19 | 에프. 호프만-라 로슈 아게 | 티아졸 및 옥사졸-치환된 아릴아마이드 |
| BRPI0820377A2 (pt) * | 2007-11-08 | 2015-05-19 | Sirtris Pharmaceutical Inc | Tiazolopiridinas solubilizadas |
| US8946439B2 (en) * | 2008-02-29 | 2015-02-03 | Evotec Ag | Amide compounds, compositions and uses thereof |
| BRPI0922645A2 (pt) * | 2008-12-16 | 2019-09-24 | Hoffmann La Roche | "arilamidas tiadiazol substituídas". |
| EP2675440B1 (en) | 2011-02-14 | 2020-03-25 | Merck Sharp & Dohme Corp. | Cathepsin cysteine protease inhibitors |
| US10183937B2 (en) * | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| JP6544665B2 (ja) | 2014-12-09 | 2019-07-17 | バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | １，３−チアゾール−２−イル置換ベンズアミド |
| KR20210009341A (ko) * | 2018-05-15 | 2021-01-26 | 바이엘 악티엔게젤샤프트 | 신경 섬유 감작과 연관된 질환의 치료를 위한 1,3-티아졸-2-일 치환된 벤즈아미드 |
| MA52616A (fr) * | 2018-05-15 | 2021-03-24 | Bayer Ag | Benzamides à substitution 1,3-thiazol-2-yl pour le traitement de maladies associées à la sensibilisation de fibres nerveuses |
-
2019
- 2019-06-27 EP EP19182797.1A patent/EP3757103A1/en not_active Withdrawn
-
2020
- 2020-06-25 MA MA056383A patent/MA56383A/fr unknown
- 2020-06-25 PH PH1/2021/553202A patent/PH12021553202A1/en unknown
- 2020-06-25 CA CA3145204A patent/CA3145204A1/en active Pending
- 2020-06-25 KR KR1020217042065A patent/KR20220027860A/ko not_active Withdrawn
- 2020-06-25 US US17/620,410 patent/US20230013419A1/en not_active Abandoned
- 2020-06-25 BR BR112021024325A patent/BR112021024325A2/pt not_active IP Right Cessation
- 2020-06-25 PE PE2021002216A patent/PE20220219A1/es unknown
- 2020-06-25 WO PCT/EP2020/067828 patent/WO2020260463A1/en not_active Ceased
- 2020-06-25 JO JOP/2021/0338A patent/JOP20210338A1/ar unknown
- 2020-06-25 EP EP20734210.6A patent/EP3990453A1/en not_active Withdrawn
- 2020-06-25 JP JP2021577052A patent/JP2022538270A/ja active Pending
- 2020-06-25 CN CN202080046297.9A patent/CN114026086A/zh active Pending
- 2020-06-25 AU AU2020303269A patent/AU2020303269A1/en not_active Abandoned
- 2020-06-25 MX MX2021015853A patent/MX2021015853A/es unknown
- 2020-06-25 CR CR20210686A patent/CR20210686A/es unknown
-
2021
- 2021-12-03 EC ECSENADI202188111A patent/ECSP21088111A/es unknown
- 2021-12-20 CO CONC2021/0017435A patent/CO2021017435A2/es unknown
- 2021-12-20 IL IL289161A patent/IL289161A/en unknown
- 2021-12-23 CL CL2021003455A patent/CL2021003455A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL289161A (en) | 2022-02-01 |
| EP3757103A1 (en) | 2020-12-30 |
| KR20220027860A (ko) | 2022-03-08 |
| AU2020303269A1 (en) | 2022-02-03 |
| PH12021553202A1 (en) | 2022-10-24 |
| JOP20210338A1 (ar) | 2023-01-30 |
| US20230013419A1 (en) | 2023-01-19 |
| MA56383A (fr) | 2022-05-04 |
| CR20210686A (es) | 2022-02-09 |
| MX2021015853A (es) | 2022-02-03 |
| CO2021017435A2 (es) | 2022-01-17 |
| ECSP21088111A (es) | 2022-01-31 |
| CN114026086A (zh) | 2022-02-08 |
| JP2022538270A (ja) | 2022-09-01 |
| CA3145204A1 (en) | 2020-12-30 |
| EP3990453A1 (en) | 2022-05-04 |
| CL2021003455A1 (es) | 2022-08-05 |
| BR112021024325A2 (pt) | 2022-01-11 |
| WO2020260463A1 (en) | 2020-12-30 |
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