PE20200698A1 - GEL INCLUDING CHLORHEXIDINE - Google Patents
GEL INCLUDING CHLORHEXIDINEInfo
- Publication number
- PE20200698A1 PE20200698A1 PE2020000181A PE2020000181A PE20200698A1 PE 20200698 A1 PE20200698 A1 PE 20200698A1 PE 2020000181 A PE2020000181 A PE 2020000181A PE 2020000181 A PE2020000181 A PE 2020000181A PE 20200698 A1 PE20200698 A1 PE 20200698A1
- Authority
- PE
- Peru
- Prior art keywords
- same
- chlorhexidine
- composition
- salt
- mixtures
- Prior art date
Links
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 title abstract 2
- 229960003260 chlorhexidine Drugs 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
- 229920002678 cellulose Polymers 0.000 abstract 2
- 239000001913 cellulose Substances 0.000 abstract 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 1
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 abstract 1
- 229920013820 alkyl cellulose Polymers 0.000 abstract 1
- 229960002152 chlorhexidine acetate Drugs 0.000 abstract 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 abstract 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 abstract 1
- 229960004504 chlorhexidine hydrochloride Drugs 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 229920002674 hyaluronan Polymers 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 210000000214 mouth Anatomy 0.000 abstract 1
- 229920001515 polyalkylene glycol Polymers 0.000 abstract 1
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UNA COMPOSICION DE GEL QUE COMPRENDE: A) DE 0,05% P/P A 1,5% P/P DE CLORHEXIDINA Y/O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LA MISMA EN RELACION CON EL PESO TOTAL DE LA COMPOSICION DE GEL, DONDE DICHA SAL SE SELECCIONA DE GLUCONATO DE CLORHEXIDINA, ACETATO DE CLORHEXIDINA, CLORHIDRATO DE CLORHEXIDINA Y MEZCLAS DE LOS MISMOS; B) DE 0,1% A 1,0% DE ACIDO HIALURONICO EN RELACION CON EL PESO TOTAL DE LA COMPOSICION; C) DE 1,0% A 5,0% DE UNA MATRIZ GELIFICANTE QUE COMPRENDE AGUA Y UN DERIVADO DE CELULOSA, DONDE DICHO DERIVADO DE CELULOSA COMPRENDE CARBOXI (C1-C3) ALQUILCELULOSA Y/O UNA SAL DE LA MISMA, LA CUAL ES CARBOXIMETILCELULOSA; Y D) UN SOLVENTE TAL COMO POLIALQUILENGLICOL, GLICERINA, PROPILENGLICOL Y MEZCLAS DE LOS MISMOS. DICHA COMPOSICION ES UTIL EN LA HIGIENE DE LA CAVIDAD ORALIT REFERS TO A GEL COMPOSITION THAT INCLUDES: A) 0.05% W / W 1.5% W / W CHLORHEXIDINE AND / OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME IN RELATION TO THE TOTAL WEIGHT OF THE GEL COMPOSITION , WHERE SAID SALT IS SELECTED FROM CHLORHEXIDINE GLUCONATE, CHLORHEXIDINE ACETATE, CHLORHEXIDINE HYDROCHLORIDE AND MIXTURES OF THE SAME; B) FROM 0.1% TO 1.0% OF HYALURONIC ACID IN RELATION TO THE TOTAL WEIGHT OF THE COMPOSITION; C) FROM 1.0% TO 5.0% OF A GELLING MATRIX THAT INCLUDES WATER AND A CELLULOSE DERIVATIVE, WHERE SAID CELLULOSE DERIVATIVE INCLUDES CARBOXI (C1-C3) ALKYL CELLULOSE AND / OR A SALT OF THE SAME, WHICH IS CARBOXIMETHYLCELLULOSE; AND D) A SOLVENT SUCH AS POLYALKYLENE GLYCOL, GLYCERIN, PROPYLENE GLYCOL, AND MIXTURES OF THE SAME. SUCH COMPOSITION IS USEFUL IN THE HYGIENE OF THE ORAL CAVITY
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17382547 | 2017-08-04 | ||
| IE20170230A IE87094B1 (en) | 2017-08-04 | 2017-11-02 | Gel comprising chlorhexidine |
| PCT/EP2018/071155 WO2019025599A1 (en) | 2017-08-04 | 2018-08-03 | Gel comprising chlorhexidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20200698A1 true PE20200698A1 (en) | 2020-06-16 |
Family
ID=63047391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2020000181A PE20200698A1 (en) | 2017-08-04 | 2018-08-03 | GEL INCLUDING CHLORHEXIDINE |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP3661480A1 (en) |
| CN (1) | CN110996891B (en) |
| BR (1) | BR112020002106B1 (en) |
| CL (1) | CL2020000293A1 (en) |
| CR (1) | CR20200058A (en) |
| IE (1) | IE87094B1 (en) |
| MX (1) | MX2020001363A (en) |
| NI (1) | NI202000007A (en) |
| PE (1) | PE20200698A1 (en) |
| PH (1) | PH12020550032A1 (en) |
| WO (1) | WO2019025599A1 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022538521A (en) * | 2019-06-14 | 2022-09-05 | ザ プロクター アンド ギャンブル カンパニー | Leave-in oral care composition |
| WO2020248232A1 (en) * | 2019-06-14 | 2020-12-17 | The Procter & Gamble Company | Leave-on oral care compositions |
| MX2021015126A (en) | 2019-06-14 | 2022-01-24 | Procter & Gamble | Leave-on oral care compositions. |
| WO2020248239A1 (en) * | 2019-06-14 | 2020-12-17 | The Procter & Gamble Company | Leave-on oral care compositions |
| JP7288090B2 (en) | 2019-06-14 | 2023-06-06 | ザ プロクター アンド ギャンブル カンパニー | Leave-in oral care composition |
| CN111494376A (en) * | 2020-06-15 | 2020-08-07 | 牡丹江医学院 | Medicine for treating gingivitis and preparation method thereof |
| IT202000029288A1 (en) | 2020-12-01 | 2022-06-01 | Altergon Sa | BIGUANIDINE MICROBIOCIDE SALTS WITH GLYCOSAMINOGLYCANS |
| CA3218883A1 (en) * | 2021-05-26 | 2022-12-01 | Murilo Nogueira NAKAJIMA | Oral care compositions |
| CN113440441B (en) * | 2021-07-29 | 2022-09-16 | 山东福瑞达生物股份有限公司 | Oral bacteriostatic composition containing essential oil and preparation method thereof |
| EP4483889A1 (en) | 2023-06-28 | 2025-01-01 | Igen Biolab Group AG | Postbiotic composition for oral administration for preventing or treating oral dysbiosis |
| GR1010853B (en) * | 2023-11-10 | 2025-01-10 | Ιουλια Τσετη | Composition of sodium hyaluronate and sucralphate for administration into the oral cavity |
| CN119033680A (en) * | 2024-08-28 | 2024-11-29 | 西南医科大学附属口腔医院 | Preparation method and application of hydrogel for oral mucosa injury |
| CN120309762A (en) * | 2025-04-29 | 2025-07-15 | 杭州三言生物科技有限公司 | A preparation method of chlorhexidine hyaluronic acid with antibacterial effect |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5192802A (en) | 1991-09-25 | 1993-03-09 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
| CH691030A5 (en) | 1995-09-26 | 2001-04-12 | Apr Applied Pharma Res Sa | A gel formulation, for topical use in the pharmaceutical, cosmetic, dietetic and veterinary industries |
| JPH1160505A (en) | 1997-05-20 | 1999-03-02 | Senju Pharmaceut Co Ltd | Antiseptic composition |
| US6117415A (en) | 1999-06-17 | 2000-09-12 | Alpharx Inc. | Toothpaste comprising bioadhesive submicron emulsion for improved delivery of antibacterial and anticaries agents |
| US8283135B2 (en) * | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
| RU2286764C1 (en) | 2005-06-16 | 2006-11-10 | Георгий Георгиевич Ростиашвили | Agent of prolonged action for treatment of mouth cavity inflammation diseases |
| US8609634B2 (en) | 2007-05-16 | 2013-12-17 | Mcneil-Ppc, Inc. | Preserved compositions containing hyaluronic acid or a pharmaceutically-acceptable salt thereof and related methods |
| US20090068122A1 (en) * | 2007-09-06 | 2009-03-12 | Shira Pilch | Dentifrice Compositions for Treating Xerostomia |
| EP2520279A1 (en) * | 2011-05-02 | 2012-11-07 | TERES S.r.l. | Thermoreversible gel pharamaceutical compositions for odontoiatric use |
| CN104474582A (en) * | 2014-12-17 | 2015-04-01 | 安徽省健源医疗器械设备有限公司 | Hyaluronic-acid-containing hemostatic gauze and preparation method thereof |
| WO2016112998A1 (en) * | 2015-05-08 | 2016-07-21 | Curasept Ads S.R.L. | Improved mouthwash preparation |
| CN105342939A (en) * | 2015-12-15 | 2016-02-24 | 山东消博士消毒科技股份有限公司 | Disinfectant bath wash capable of reducing operative incision infection and preparation technology of disinfectant bath wash |
| CN106540281A (en) * | 2016-12-08 | 2017-03-29 | 邓丽萍 | B ultrasonic couplant and its preparation technology |
-
2017
- 2017-11-02 IE IE20170230A patent/IE87094B1/en unknown
-
2018
- 2018-08-03 CN CN201880052414.5A patent/CN110996891B/en active Active
- 2018-08-03 MX MX2020001363A patent/MX2020001363A/en unknown
- 2018-08-03 EP EP18746958.0A patent/EP3661480A1/en active Pending
- 2018-08-03 CR CR20200058A patent/CR20200058A/en unknown
- 2018-08-03 PE PE2020000181A patent/PE20200698A1/en unknown
- 2018-08-03 WO PCT/EP2018/071155 patent/WO2019025599A1/en not_active Ceased
- 2018-08-03 BR BR112020002106-7A patent/BR112020002106B1/en active IP Right Grant
-
2020
- 2020-01-21 PH PH12020550032A patent/PH12020550032A1/en unknown
- 2020-01-28 NI NI202000007A patent/NI202000007A/en unknown
- 2020-01-31 CL CL2020000293A patent/CL2020000293A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112020002106A2 (en) | 2020-08-04 |
| IE87094B1 (en) | 2020-05-13 |
| BR112020002106A8 (en) | 2020-12-01 |
| CN110996891B (en) | 2023-02-28 |
| CR20200058A (en) | 2020-03-28 |
| PH12020550032A1 (en) | 2021-02-15 |
| EP3661480A1 (en) | 2020-06-10 |
| BR112020002106B1 (en) | 2023-04-18 |
| WO2019025599A1 (en) | 2019-02-07 |
| NI202000007A (en) | 2020-07-31 |
| CN110996891A (en) | 2020-04-10 |
| MX2020001363A (en) | 2020-03-20 |
| CL2020000293A1 (en) | 2020-08-14 |
| IE20170230A1 (en) | 2019-02-06 |
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