PE20191499A1 - Imidazopirrolopiridina como inhibidores de la familia de quinasas jak - Google Patents
Imidazopirrolopiridina como inhibidores de la familia de quinasas jakInfo
- Publication number
- PE20191499A1 PE20191499A1 PE2019001273A PE2019001273A PE20191499A1 PE 20191499 A1 PE20191499 A1 PE 20191499A1 PE 2019001273 A PE2019001273 A PE 2019001273A PE 2019001273 A PE2019001273 A PE 2019001273A PE 20191499 A1 PE20191499 A1 PE 20191499A1
- Authority
- PE
- Peru
- Prior art keywords
- imidazopyrrolopyridine
- inhibitors
- kinases
- jak
- jak family
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 102000015617 Janus Kinases Human genes 0.000 abstract 3
- 108010024121 Janus Kinases Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- FBMPIPDDIOMXIM-UHFFFAOYSA-N 2-[3-[4-(cyanomethyl)cyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]-N-(pyrimidin-4-ylmethyl)acetamide Chemical compound O=C(Cc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1)NCc1ccncn1 FBMPIPDDIOMXIM-UHFFFAOYSA-N 0.000 abstract 1
- ZRWAPJQBKMIZOF-UHFFFAOYSA-N 2-cyano-N-[[3-[4-(cyanomethyl)cyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]methyl]ethanesulfonamide Chemical compound O=S(=O)(CCC#N)NCc1nc2cnc3[nH]ccc3c2n1C1CCC(CC#N)CC1 ZRWAPJQBKMIZOF-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invencion se refiere a compuestos derivados de imidazopirrolopiridina o sales farmaceuticamente aceptables de los mismos, seleccionados de: 2-ciano-N - ((1 - ((1r, 4r) -4- (cianometil) ciclohexil) - 1, 6-dihidroimidazo [4,5-d] pirrolo [2,3-b] piridin-2-il ) metil) etanosulfonamida; 2- (1 - ((1r, 4r) -4- (cianometil) ciclohexil) -1, 6-dihidroimidazo [4,5-d] pirrolo [2,3-b] piridin-2-il) -N- ( pirimidin-4-ilmetil) acetamida; entre otros. Dichos compuestos son inhibidores de la proteina Janus quinasa (JAK), siendo utiles en el tratamiento de estados de enfermedad, trastornos y afecciones mediadas por JAK.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662435639P | 2016-12-16 | 2016-12-16 | |
| US201762592747P | 2017-11-30 | 2017-11-30 | |
| US201762596636P | 2017-12-08 | 2017-12-08 | |
| PCT/US2017/066754 WO2018112382A1 (en) | 2016-12-16 | 2017-12-15 | Imidazopyrrolopyridine as inhibitors of the jak family of kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20191499A1 true PE20191499A1 (es) | 2019-10-22 |
Family
ID=60937954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019001273A PE20191499A1 (es) | 2016-12-16 | 2017-12-15 | Imidazopirrolopiridina como inhibidores de la familia de quinasas jak |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US10981911B2 (es) |
| EP (1) | EP3555096B1 (es) |
| JP (2) | JP7153647B2 (es) |
| KR (1) | KR102565224B1 (es) |
| CN (2) | CN114685505A (es) |
| AU (2) | AU2017377072B2 (es) |
| CA (1) | CA3047311A1 (es) |
| CL (1) | CL2019001633A1 (es) |
| CO (1) | CO2019006858A2 (es) |
| EC (1) | ECSP19047936A (es) |
| ES (1) | ES2935392T3 (es) |
| IL (2) | IL295461A (es) |
| JO (1) | JOP20190144A1 (es) |
| MX (2) | MX386481B (es) |
| MY (1) | MY196805A (es) |
| NI (1) | NI201900061A (es) |
| PE (1) | PE20191499A1 (es) |
| PH (1) | PH12019501355A1 (es) |
| UA (1) | UA123689C2 (es) |
| WO (1) | WO2018112382A1 (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3433256T (pt) | 2016-10-24 | 2019-10-31 | Astrazeneca | Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f]isoquinolina úteis no tratamento do cancro |
| TWI831738B (zh) | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
| ES2922379T3 (es) * | 2016-12-16 | 2022-09-14 | Janssen Pharmaceutica Nv | Compuestos de imidazo[4,5,D]pirrolo[2,3,B]piridina como inhibidores de Janus quinasas |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| SI3568396T1 (sl) | 2017-01-11 | 2021-04-30 | Leo Pharma A/S | Novi derivati amino-imidazopiridina koz zaviralci Janus kinaze in njihova farmacevtska uporaba |
| KR102246668B1 (ko) | 2017-01-30 | 2021-04-29 | 아스트라제네카 아베 | 에스트로겐 수용체 조절인자 |
| US11180575B2 (en) | 2018-12-28 | 2021-11-23 | Corn Products Development, Inc. | Thermally inhibited starch and process for making |
| TW202016110A (zh) * | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| BR112020025605A2 (pt) | 2018-06-15 | 2021-03-23 | Reata Pharmaceuticals, Inc. | compostos de pirazol e imidazol para inibição de il-17 e rorgama |
| EP3810141A1 (en) | 2018-06-20 | 2021-04-28 | Reata Pharmaceuticals, Inc. | Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith |
| CN114128028B (zh) | 2019-07-30 | 2024-06-11 | 株式会社Lg化学 | 用于电化学装置的复合隔板和包括该复合隔板的电化学装置 |
| KR20220088699A (ko) | 2019-09-27 | 2022-06-28 | 디스크 메디슨, 인크. | 골수섬유증 및 관련 상태의 치료 방법 |
| GB201914779D0 (en) * | 2019-10-11 | 2019-11-27 | Oxford Medical Products Ltd | Polymer compositions |
| IL297216A (en) | 2020-04-24 | 2022-12-01 | Astrazeneca Ab | Dosage regimen for the treatment of cancer |
| PE20221838A1 (es) | 2020-04-24 | 2022-11-29 | Astrazeneca Ab | Formulaciones farmaceuticas |
| KR20230012539A (ko) | 2020-05-13 | 2023-01-26 | 디스크 메디슨, 인크. | 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체 |
| WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
| WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
| WO2022006457A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| US11767323B2 (en) | 2020-07-02 | 2023-09-26 | Incyte Corporation | Tricyclic pyridone compounds as JAK2 V617F inhibitors |
| WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
| WO2022182839A1 (en) | 2021-02-25 | 2022-09-01 | Incyte Corporation | Spirocyclic lactams as jak2 v617f inhibitors |
| AU2022233254A1 (en) | 2021-03-11 | 2023-10-26 | Janssen Pharmaceutica Nv | Lorpucitinib for use in the treatment of jak mediated disorders |
| CN113292561A (zh) * | 2021-05-22 | 2021-08-24 | 中国药科大学 | 一种二吡咯并吡啶结构的化合物、制备方法和医药用途 |
| JP2025509672A (ja) | 2022-03-17 | 2025-04-11 | インサイト・コーポレイション | Ｊａｋ２ ｖ６１７ｆ阻害剤としての三環式尿素化合物 |
| WO2023194841A1 (en) * | 2022-04-05 | 2023-10-12 | Unichem Laboratories Limited | Substituted tricyclic compounds and their use in ulcerative colitis |
| WO2023194842A1 (en) * | 2022-04-05 | 2023-10-12 | Unichem Laboratories Limited | Substituted tricyclic compounds and their use in rheumatoid arthritis |
| WO2023194840A1 (en) * | 2022-04-05 | 2023-10-12 | Unichem Laboratories Limited | Substituted tricyclic compounds and their use in covid-19 |
| WO2023248010A2 (en) | 2022-06-23 | 2023-12-28 | Synovo Gmbh | Targeted modulators of jak3 for treatment of inflammatory and autoimmune diseases |
| CN117924326B (zh) * | 2024-01-23 | 2025-01-21 | 英矽智能科技(上海)有限公司 | 一类抑制jak和phd的三并环类化合物 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6080747A (en) | 1999-03-05 | 2000-06-27 | Hughes Institute | JAK-3 inhibitors for treating allergic disorders |
| CO5170421A1 (es) | 1999-04-23 | 2002-06-27 | Smithkline Beecham Plc | Nuevo compuesto farmaceutico maleico |
| AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| PE20040538A1 (es) | 2002-05-31 | 2004-08-30 | Schering Corp | Polimorfos inhibidores de xantina fosfodiesterasa v |
| GB0319935D0 (en) | 2003-08-26 | 2003-09-24 | Cipla Ltd | Polymorphs |
| US7737279B2 (en) | 2005-05-10 | 2010-06-15 | Bristol-Myers Squibb Company | 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same |
| KR20080028386A (ko) | 2005-07-01 | 2008-03-31 | 와이어쓰 | 4-[(2,4-디클로로-5-메톡시페닐)아미노]-6-메톡시-7-[3-(4-메틸-1-피페라지닐)프로폭시]-3-퀴놀린카르보니트릴의결정형 형태 및 그의 제조 방법 |
| EP2251341A1 (en) | 2005-07-14 | 2010-11-17 | Astellas Pharma Inc. | Heterocyclic Janus kinase 3 inhibitors |
| KR20080026654A (ko) | 2005-07-14 | 2008-03-25 | 아스텔라스세이야쿠 가부시키가이샤 | 헤테로시클릭 야누스 키나제 3 억제제 |
| AU2012201894A1 (en) * | 2005-12-13 | 2012-04-19 | Incyte Holdings Corporation | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors |
| GB0526246D0 (en) * | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| US8461163B2 (en) * | 2008-03-31 | 2013-06-11 | Takeda Pharmaceutical Company Limited | Substituted N-(pyrazolo[1,5-a]pyrimidin-5-yl)amides as inhibitors of apoptosis signal-regulating kinase 1 |
| HUE028347T2 (en) | 2008-06-10 | 2016-12-28 | Abbvie Inc | Tricyclic compounds |
| DK2473510T3 (da) | 2009-09-03 | 2014-10-20 | Bristol Myers Squibb Co | Jak-2-hæmmere og anvendelse heraf til behandling af myeloproliferativesygdomme og cancer |
| HUE033099T2 (en) * | 2009-12-01 | 2017-11-28 | Abbvie Inc | Novel tricyclic compounds |
| WO2011068899A1 (en) | 2009-12-01 | 2011-06-09 | Abbott Laboratories | Novel tricyclic compounds |
| KR20140015162A (ko) * | 2010-01-12 | 2014-02-06 | 에프. 호프만-라 로슈 아게 | 트라이사이클릭 헤테로사이클릭 화합물, 조성물 및 이의 사용 방법 |
| AU2011214254B2 (en) | 2010-02-10 | 2016-06-09 | Genon Biotechnologies Oy | Dual activity kinase domains and uses thereof |
| WO2013007765A1 (en) | 2011-07-13 | 2013-01-17 | F. Hoffmann-La Roche Ag | Fused tricyclic compounds for use as inhibitors of janus kinases |
| GB201212081D0 (en) | 2012-07-06 | 2012-08-22 | Kalvista Pharmaceuticals Ltd | New polymorph |
| ES2755130T3 (es) | 2013-02-08 | 2020-04-21 | Nissan Chemical Corp | Compuesto de pirrolopiridina tricíclico, e inhibidor de JAK |
| EP2924026A1 (en) | 2014-03-28 | 2015-09-30 | Novartis Tiergesundheit AG | Aminosulfonylmethylcyclohexanes as JAK inhibitors |
| ES2744213T3 (es) | 2014-05-14 | 2020-02-24 | Nissan Chemical Corp | Compuesto tricíclico e inhibidor de JAK |
| PL3303348T3 (pl) | 2015-05-28 | 2020-02-28 | Theravance Biopharma R&D Ip, Llc | Związki naftyrydyny jako inhibitory kinazy JAK |
| US20180321235A1 (en) | 2015-11-04 | 2018-11-08 | Mayo Foundation For Medical Education And Research | Methods and materials for treating autoimmune conditions |
| JOP20190053A1 (ar) | 2016-09-23 | 2019-03-21 | Novartis Ag | مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط |
| PT3433256T (pt) | 2016-10-24 | 2019-10-31 | Astrazeneca | Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f]isoquinolina úteis no tratamento do cancro |
| ES2922379T3 (es) | 2016-12-16 | 2022-09-14 | Janssen Pharmaceutica Nv | Compuestos de imidazo[4,5,D]pirrolo[2,3,B]piridina como inhibidores de Janus quinasas |
| CN110072867B (zh) | 2016-12-16 | 2022-07-08 | 伊莱利利公司 | 作为突变体idh1和idh2抑制剂的7-苯基乙基氨基-4h-嘧啶并[4,5-d][1,3]噁嗪-2-酮化合物 |
| WO2018109074A1 (en) | 2016-12-16 | 2018-06-21 | Nestec Sa | Oligosaccharides for flavour generation |
| AU2017374860B2 (en) | 2016-12-16 | 2021-09-02 | Pfizer Inc. | GLP-1 receptor agonists and uses thereof |
| AU2017374992A1 (en) | 2016-12-16 | 2019-06-20 | Basf Se | Pesticidal compounds |
| JOP20190144A1 (ar) * | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| SI3568396T1 (sl) | 2017-01-11 | 2021-04-30 | Leo Pharma A/S | Novi derivati amino-imidazopiridina koz zaviralci Janus kinaze in njihova farmacevtska uporaba |
| KR102246668B1 (ko) | 2017-01-30 | 2021-04-29 | 아스트라제네카 아베 | 에스트로겐 수용체 조절인자 |
| KR102668371B1 (ko) | 2017-04-21 | 2024-05-28 | 이케나 온콜로지, 인코포레이티드 | 인돌 ahr 억제제 및 이의 용도 |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| WO2020216936A1 (en) * | 2019-04-24 | 2020-10-29 | Janssen Pharmaceutica Nv | Non-clinical liquid formulations of pan-jak inhibitor |
| AU2022233254A1 (en) * | 2021-03-11 | 2023-10-26 | Janssen Pharmaceutica Nv | Lorpucitinib for use in the treatment of jak mediated disorders |
-
2017
- 2017-06-16 JO JOP/2019/0144A patent/JOP20190144A1/ar unknown
- 2017-12-15 CN CN202210363548.7A patent/CN114685505A/zh active Pending
- 2017-12-15 ES ES17826097T patent/ES2935392T3/es active Active
- 2017-12-15 AU AU2017377072A patent/AU2017377072B2/en active Active
- 2017-12-15 PE PE2019001273A patent/PE20191499A1/es unknown
- 2017-12-15 EP EP17826097.2A patent/EP3555096B1/en active Active
- 2017-12-15 US US16/469,939 patent/US10981911B2/en active Active
- 2017-12-15 CA CA3047311A patent/CA3047311A1/en active Pending
- 2017-12-15 JP JP2019531906A patent/JP7153647B2/ja active Active
- 2017-12-15 IL IL295461A patent/IL295461A/en unknown
- 2017-12-15 MY MYPI2019003415A patent/MY196805A/en unknown
- 2017-12-15 WO PCT/US2017/066754 patent/WO2018112382A1/en not_active Ceased
- 2017-12-15 IL IL267215A patent/IL267215B/en unknown
- 2017-12-15 CN CN201780086744.1A patent/CN110312719B/zh active Active
- 2017-12-15 UA UAA201908084A patent/UA123689C2/uk unknown
- 2017-12-15 KR KR1020197020735A patent/KR102565224B1/ko active Active
- 2017-12-15 MX MX2019007084A patent/MX386481B/es unknown
-
2019
- 2019-06-13 CL CL2019001633A patent/CL2019001633A1/es unknown
- 2019-06-14 MX MX2021011438A patent/MX2021011438A/es unknown
- 2019-06-14 PH PH12019501355A patent/PH12019501355A1/en unknown
- 2019-06-14 NI NI201900061A patent/NI201900061A/es unknown
- 2019-06-26 CO CONC2019/0006858A patent/CO2019006858A2/es unknown
- 2019-07-05 EC ECSENADI201947936A patent/ECSP19047936A/es unknown
-
2021
- 2021-03-16 US US17/202,887 patent/US11827638B2/en active Active
- 2021-11-24 AU AU2021273566A patent/AU2021273566B2/en active Active
-
2022
- 2022-04-26 JP JP2022072068A patent/JP7441264B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20191499A1 (es) | Imidazopirrolopiridina como inhibidores de la familia de quinasas jak | |
| PE20191105A1 (es) | Inhibidores de moleculas pequenas de lafamilia de quinasas jak | |
| PE20190811A1 (es) | Derivados de pirazolopirimidinas como inhibidor de quinasa | |
| HUE053643T2 (hu) | (S)-N-(5 -((R)-2-(2,5-difluor-fenil)-pirrolidin-1-il)-pirazolo[1,5-A] pirimidin-3-il)-3-hidroxi-pirrolidin-1-karboxamid elõkészítése | |
| MX381849B (es) | Compuestos a base de pirazol[1,5-a]pirimidina, composiciones que los comprenden, y métodos para su uso. | |
| EA201790995A1 (ru) | ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-a]ПИРИМИДИНЫ И ИХ ПРИМЕНЕНИЕ ПРИ ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ | |
| MX2018016419A (es) | Derivados de n-(sustituida-fenil)-sulfonamida como inhibidores de quinasa n-(sustituida-fenil)-sulfonamida. | |
| ECSP10010429A (es) | Derivados bicíclicos heterocíclicos o espirobicíclicos heterocíclicos enlazados, de pirazolo[1,5-a]pirimidinas, procedimientos para su preparación y usos de los mismos | |
| PE20170327A1 (es) | 2-AMINO-6-METIL-4,4a,5,6-TETRAHIDROPIRANO[3,4d] [1,3] TIAZIN-8a(8H)-IL-1,3-TIAZOL-4-ILAMIDAS | |
| MX2016015874A (es) | Derivados radiomarcadores de un compuesto de 2-amino-6-fluoro-n-[5 -fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-carboxamida util como inhibidor de ataxia telangiectasia mutada y rad3 relacionado (atr) cinasa, preparacion de tal compuesto y diferentes formas solidas del mismo. | |
| CU20160183A7 (es) | Sales del clorhidrato de n-(cianometil)-4-(2-(4-morfolinofenilamino)pirimidin-4-il)benzamida | |
| SA519401322B1 (ar) | مركبات أريل كربوكساميد غير متجانسة كمثطبات لكيناز بروتين سيرين/ ثريونين متداخل مع المستقبل 2 | |
| NI202000100A (es) | Inhibidores de moléculas pequeñas de la familia de quinasa jak | |
| CL2014002847A1 (es) | Compuestos triazolo derivados, inhibidores de pde10; procedimiento de preparacion; uso para el tratamiento y/o profilaxis de trastornos psicoticos, esquizofrenia, ansiedad, adicciona a drogas, enfermedad de parkinson, entre otras. | |
| AR114969A1 (es) | Inhibidores de moléculas pequeñas de la familia de quinasas jak | |
| EA201991473A1 (ru) | Имидазопирролопиридин в качестве ингибиторов киназ семейства jak | |
| EA202190047A1 (ru) | Низкомолекулярные ингибиторы киназ семейства jak | |
| TH1901003656A (th) | สารยับยั้งที่มีโมเลกุลขนาดเล็กของวงศ์ jak ของไคเนส | |
| EA201991472A1 (ru) | Низкомолекулярные ингибиторы киназ семейства jak | |
| CU20100174A7 (es) | Derivados bicíclicos heterocíclicos o espirobicíclicos heterocíclicos enlazados de pirazol[1,5-a]pirimidinas, procedimiento para su preparación y usos de los mismos |