PE20190397A1 - Virus de enteritis de pato y usos del mismo - Google Patents
Virus de enteritis de pato y usos del mismoInfo
- Publication number
- PE20190397A1 PE20190397A1 PE2018003339A PE2018003339A PE20190397A1 PE 20190397 A1 PE20190397 A1 PE 20190397A1 PE 2018003339 A PE2018003339 A PE 2018003339A PE 2018003339 A PE2018003339 A PE 2018003339A PE 20190397 A1 PE20190397 A1 PE 20190397A1
- Authority
- PE
- Peru
- Prior art keywords
- enteritis virus
- duck enteritis
- virus
- vep
- duck
- Prior art date
Links
- 241001492342 Anatid alphaherpesvirus 1 Species 0.000 title abstract 2
- 241000271566 Aves Species 0.000 abstract 1
- 241000287828 Gallus gallus Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 235000013330 chicken meat Nutrition 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 244000144977 poultry Species 0.000 abstract 1
- 235000013594 poultry meat Nutrition 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/869—Herpesviral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
- C12N2710/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
- C12N2710/16341—Use of virus, viral particle or viral elements as a vector
- C12N2710/16343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
- C12N2710/16361—Methods of inactivation or attenuation
- C12N2710/16362—Methods of inactivation or attenuation by genetic engineering
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/10011—Birnaviridae
- C12N2720/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Referido a un virus de enteritis de pato (VEP), en el que dicho virus tiene los genes US4 y US5 inactivos, los cuales estan, independientemente uno del otro, mutados, eliminados o interrumpidos. Tambien se refiere a una composicion y un kit de vacunacion que comprende el citado VEP para la inmunizacion de aves de corral, preferentemente pollos, contra patogenos aviarios.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16176834.6A EP3263129A1 (en) | 2016-06-29 | 2016-06-29 | Duck enteritis virus and the uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20190397A1 true PE20190397A1 (es) | 2019-03-13 |
Family
ID=56321768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2018003339A PE20190397A1 (es) | 2016-06-29 | 2017-06-28 | Virus de enteritis de pato y usos del mismo |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10821170B2 (es) |
| EP (2) | EP3263129A1 (es) |
| JP (1) | JP6990814B2 (es) |
| CN (1) | CN109789199B (es) |
| BR (1) | BR112018077210A8 (es) |
| CA (1) | CA3029108A1 (es) |
| MX (1) | MX388489B (es) |
| PE (1) | PE20190397A1 (es) |
| RU (1) | RU2771165C2 (es) |
| UA (1) | UA123682C2 (es) |
| WO (1) | WO2018002133A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX381252B (es) | 2015-06-30 | 2025-03-11 | Ceva Sante Animale | Virus de la enteritis del pato y usos del mismo. |
| CN113249340B (zh) * | 2020-08-19 | 2022-07-19 | 浙江省农业科学院 | 一株双色荧光蛋白标记鸭瘟病毒及其构建方法和应用 |
| CN112852760A (zh) * | 2021-03-04 | 2021-05-28 | 温氏食品集团股份有限公司 | 重组鸭肠炎病毒及其应用 |
| CN114196639B (zh) * | 2021-11-18 | 2023-09-19 | 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) | 表达3型鸭甲型肝炎病毒p1和3c基因的重组鸭瘟病毒及其构建方法和用途 |
| CN114480301B (zh) * | 2022-01-21 | 2024-04-19 | 中国农业大学 | 预防或治疗禽病毒感染症的疫苗 |
| WO2025044922A2 (en) * | 2023-08-25 | 2025-03-06 | Boehringer Ingelheim Vetmedica (China) Co., Ltd. | Vectored dev avian influenza h9 vaccines |
| WO2025044920A2 (en) * | 2023-08-25 | 2025-03-06 | Boehringer Ingelheim Vetmedica (China) Co., Ltd. | New dev vectors for avian vaccines |
| WO2025044919A2 (en) * | 2023-08-25 | 2025-03-06 | Boehringer Ingelheim Vetmedica (China) Co., Ltd. | New dev vectors |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1987004463A1 (en) | 1986-01-27 | 1987-07-30 | Syntro Corporation | Attenuated herpesviruses, herpesviruses which include foreign dna encoding an amino acid sequence and vaccine containing same |
| BE1004877A3 (fr) | 1991-05-27 | 1993-02-16 | Solvay | Virus de l'avipox recombinant, culture de cellules infectees par ce virus et vaccins pour la volaille derives de ce virus. |
| US5853733A (en) | 1993-02-26 | 1998-12-29 | Syntro Corporation | Recombinant herpesvirus of turkeys and uses thereof |
| FR2728795B1 (fr) | 1994-12-30 | 1997-03-21 | Rhone Merieux | Vaccin vivant recombinant aviaire, utilisant comme vecteur un virus herpes aviaire |
| FR2757061B1 (fr) | 1996-12-16 | 1999-03-26 | Rhone Merieux | Vaccin vivant recombinant aviaire, utilisant comme vecteur le virus de la laryngotracheite infectieuse aviaire |
| EP2140879A1 (en) | 2001-05-09 | 2010-01-06 | M'S Science Corporation | Composition and method for treating cancer using herpes virus |
| US6764684B2 (en) | 2001-09-28 | 2004-07-20 | Zeon Corporation | Avian herpesvirus-based recombinant infectious bursal disease vaccine |
| US6866852B2 (en) | 2002-01-31 | 2005-03-15 | Zeon Corporation | Recombinant herpesvirus of turkeys and use thereof |
| US20050214316A1 (en) * | 2003-11-13 | 2005-09-29 | Brown Thomas P | Methods of characterizing infectious bursal disease virus |
| JP2005287422A (ja) | 2004-03-31 | 2005-10-20 | Nippon Zeon Co Ltd | 組み換えヘルペスウイルス及び多価ワクチン |
| CN102657861A (zh) * | 2010-08-16 | 2012-09-12 | 郑州金森生物科技工程有限公司 | 单纯疱疹病毒ⅰ型基因重组减毒活疫苗及其制备方法 |
| CN102373180B (zh) * | 2011-09-26 | 2013-06-19 | 中国农业科学院哈尔滨兽医研究所 | 表达禽流感病毒血凝素(ha)基因的重组鸭病毒性肠炎病毒疫苗株及其构建方法和应用 |
| CN102732545B (zh) | 2012-05-08 | 2014-09-24 | 四川农业大学 | 鸭瘟病毒转移载体pUC-ΔgC-EGFP及gC缺失重组株DPV-ΔgC-EGFP |
| WO2014036735A1 (zh) | 2012-09-10 | 2014-03-13 | 中国农业科学院哈尔滨兽医研究所 | 鸭病毒性肠炎病毒疫苗株作为表达载体在制备预防鸡形目禽类疾病的重组病毒疫苗中的应用 |
| AR097029A1 (es) * | 2013-07-26 | 2016-02-17 | Intervet Int Bv | Aceleración de la respuesta inmune inducida por virus vectorial en aves, composición, uso, método para la vacunación y método para acelerar la respuesta inmune |
| CN104312982A (zh) | 2014-09-17 | 2015-01-28 | 中国农业科学院哈尔滨兽医研究所 | 表达增强型绿色荧光蛋白基因的鸭瘟病毒重组疫苗株rDEVTK-EGFP及其构建方法和应用 |
| CN104480142A (zh) * | 2014-12-16 | 2015-04-01 | 青岛蔚蓝生物股份有限公司 | 一种鸭瘟病毒基因缺失转移载体及其应用 |
| MX381252B (es) * | 2015-06-30 | 2025-03-11 | Ceva Sante Animale | Virus de la enteritis del pato y usos del mismo. |
| CN105385663A (zh) | 2015-11-26 | 2016-03-09 | 中国兽医药品监察所 | 鸭肠炎病毒gE、gI双基因缺失病毒株的构建及其应用 |
-
2016
- 2016-06-29 EP EP16176834.6A patent/EP3263129A1/en not_active Withdrawn
-
2017
- 2017-06-28 EP EP17736602.8A patent/EP3478318A1/en active Pending
- 2017-06-28 PE PE2018003339A patent/PE20190397A1/es unknown
- 2017-06-28 BR BR112018077210A patent/BR112018077210A8/pt unknown
- 2017-06-28 RU RU2019102170A patent/RU2771165C2/ru active
- 2017-06-28 CA CA3029108A patent/CA3029108A1/en active Pending
- 2017-06-28 UA UAA201900802A patent/UA123682C2/uk unknown
- 2017-06-28 JP JP2019521512A patent/JP6990814B2/ja active Active
- 2017-06-28 CN CN201780040729.3A patent/CN109789199B/zh active Active
- 2017-06-28 US US16/313,174 patent/US10821170B2/en active Active
- 2017-06-28 WO PCT/EP2017/065987 patent/WO2018002133A1/en not_active Ceased
- 2017-06-28 MX MX2018016306A patent/MX388489B/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2019102170A (ru) | 2020-07-29 |
| CN109789199A (zh) | 2019-05-21 |
| RU2019102170A3 (es) | 2020-09-08 |
| MX388489B (es) | 2025-03-20 |
| BR112018077210A8 (pt) | 2022-05-17 |
| BR112018077210A2 (pt) | 2019-04-09 |
| CA3029108A1 (en) | 2018-01-04 |
| US20190151439A1 (en) | 2019-05-23 |
| RU2771165C2 (ru) | 2022-04-27 |
| EP3263129A1 (en) | 2018-01-03 |
| EP3478318A1 (en) | 2019-05-08 |
| US10821170B2 (en) | 2020-11-03 |
| UA123682C2 (uk) | 2021-05-12 |
| WO2018002133A1 (en) | 2018-01-04 |
| JP2019524154A (ja) | 2019-09-05 |
| JP6990814B2 (ja) | 2022-01-12 |
| MX2018016306A (es) | 2019-08-29 |
| CN109789199B (zh) | 2022-11-18 |
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