[go: up one dir, main page]

PE20181178A1 - Compuestos carbocilicos novedosos como moduladores de ror gamma - Google Patents

Compuestos carbocilicos novedosos como moduladores de ror gamma

Info

Publication number
PE20181178A1
PE20181178A1 PE2018000317A PE2018000317A PE20181178A1 PE 20181178 A1 PE20181178 A1 PE 20181178A1 PE 2018000317 A PE2018000317 A PE 2018000317A PE 2018000317 A PE2018000317 A PE 2018000317A PE 20181178 A1 PE20181178 A1 PE 20181178A1
Authority
PE
Peru
Prior art keywords
alkyl
compounds
haloalkyl
hydroxyl
carbocylic
Prior art date
Application number
PE2018000317A
Other languages
English (en)
Inventor
Sanjib Das
Laxmikant Atmaram Gharat
Rajendra Laxman Harde
Dnyaneshwar Eknath Shelke
Shailesh Ramesh Pardeshi
Abraham Thomas
Neelima Khairatkar-Joshi
Daisy Manish Shah
Malini Bajpai
Original Assignee
Glenmark Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa
Publication of PE20181178A1 publication Critical patent/PE20181178A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Referido a compuestos carbociclicos de formula (I), en donde R1 es amino, hidroxilo, alquilo C1-8 y alcoxi C1-8; R2 es alquilo C1-8, haloalquilo C1-8, hidroxialquilo C1-8, entre otros; R3 es hidrogeno, alquilo C1-8, haloalquilo C1-8, entre otros; R4 es alquilo C1-8, alcoxi C1-8, haloalquilo C1-8, entre otros; R5 es halogeno, hidroxilo, ciano, alquilo C1-8, entre otros; R6 es halogeno, ciano, hidroxilo, alquilo C1-8 y cicloalquilo C3-6; cada uno de Ra y Rb son, independientemente, hidrogeno, alquilo C1-8; o juntos pueden formar un oxo; n es 1, 2, 3 o 4; m es 0, 1 o 2; y p es 0 o 1. Dichos compuestos son moduladores del receptor huerfano gamma t vinculado a retinoides (RORyt), siendo utiles para el tratamiento de enfermedades, trastornos, sindromes o afecciones mediados por RORyt, tales como dolor, inflamacion, EPOC, asma, artritis reumatoide, colitis, esclerosis multiple, psoriasis, enfermedades neurodegenerativas y cancer
PE2018000317A 2015-08-28 2016-08-26 Compuestos carbocilicos novedosos como moduladores de ror gamma PE20181178A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN3299MU2015 2015-08-28

Publications (1)

Publication Number Publication Date
PE20181178A1 true PE20181178A1 (es) 2018-07-20

Family

ID=58186928

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2018000317A PE20181178A1 (es) 2015-08-28 2016-08-26 Compuestos carbocilicos novedosos como moduladores de ror gamma

Country Status (16)

Country Link
US (2) US10189775B2 (es)
EP (1) EP3341357A4 (es)
JP (1) JP2018526372A (es)
KR (1) KR20180044384A (es)
CN (1) CN108026039A (es)
AU (1) AU2016314547A1 (es)
CA (1) CA2996017A1 (es)
CL (1) CL2018000504A1 (es)
EA (1) EA201890330A1 (es)
HK (1) HK1257756A1 (es)
IL (1) IL257525A (es)
MX (1) MX2018002478A (es)
PE (1) PE20181178A1 (es)
PH (1) PH12018500411A1 (es)
WO (1) WO2017037595A1 (es)
ZA (1) ZA201801268B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018042342A1 (en) * 2016-08-30 2018-03-08 Glenmark Pharmaceuticals S.A. 1,2,3-benzotriazole derivatives as ror gamma t modulators
WO2018193297A1 (en) 2017-04-21 2018-10-25 Cadila Healthcare Limited Novel compounds as ror-gamma modulators
CN113880774B (zh) * 2020-07-02 2023-12-08 沈阳中化农药化工研发有限公司 一种苯基异恶唑啉类化合物的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6174905B1 (en) * 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
JP2002179651A (ja) * 1998-06-19 2002-06-26 Wakamoto Pharmaceut Co Ltd ベンズアニリド誘導体及び医薬組成物
DE10306250A1 (de) * 2003-02-14 2004-09-09 Aventis Pharma Deutschland Gmbh Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2011156655A2 (en) * 2010-06-09 2011-12-15 Receptos, Inc. Novel glp-1 receptor stabilizers and modulators
WO2012028100A1 (en) 2010-09-01 2012-03-08 Glaxo Group Limited Novel compounds
WO2012027965A1 (en) 2010-09-01 2012-03-08 Glaxo Group Limited Novel compounds
US8772562B2 (en) 2010-11-10 2014-07-08 Exxonmobil Research And Engineering Company Process for making basestocks from renewable feedstocks
WO2012100732A1 (en) 2011-01-24 2012-08-02 Glaxo Group Limited Retinoid-related orphan receptor gamma modulators, composition containing them and uses thereof
WO2012100734A1 (en) 2011-01-24 2012-08-02 Glaxo Group Limited Compounds useful as retinoid-related orphan receptor gamma modulators
EP2511263A1 (en) 2011-04-14 2012-10-17 Phenex Pharmaceuticals AG Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (RORgamma, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases
WO2013171729A2 (en) * 2013-01-08 2013-11-21 Glenmark Pharmaceuticals S.A. Aryl and heteroaryl amide compounds as rorgamat modulator
WO2015008234A1 (en) * 2013-07-17 2015-01-22 Glenmark Pharmaceuticals S.A. Bicyclic heterocyclic compounds as ror gamma modulators

Also Published As

Publication number Publication date
EA201890330A1 (ru) 2018-07-31
HK1257756A1 (zh) 2019-10-25
PH12018500411A1 (en) 2018-08-29
ZA201801268B (en) 2019-05-29
KR20180044384A (ko) 2018-05-02
US10336688B2 (en) 2019-07-02
US20190144375A1 (en) 2019-05-16
MX2018002478A (es) 2018-06-15
EP3341357A4 (en) 2019-03-27
JP2018526372A (ja) 2018-09-13
AU2016314547A1 (en) 2018-03-22
EP3341357A1 (en) 2018-07-04
WO2017037595A1 (en) 2017-03-09
CL2018000504A1 (es) 2018-07-06
US10189775B2 (en) 2019-01-29
CA2996017A1 (en) 2017-03-09
US20180237382A1 (en) 2018-08-23
CN108026039A (zh) 2018-05-11
IL257525A (en) 2018-04-30

Similar Documents

Publication Publication Date Title
MX2020001361A (es) Compuestos nuevos como moduladores de ror gamma.
EA201691491A1 (ru) Арильные и гетероарильные эфиры в качестве модуляторов ror-гамма
PE20161572A1 (es) Compuestos como moduladores de ror gamma
ECSP17047155A (es) Productos farmacéuticos y composiciones líquidas estables de anticuerpos contra il-17
CL2024001474A1 (es) Compuestos derivados de heterociclos sustituidos, activadores akt3; composición farmacéutica; y uso
CL2015002655A1 (es) Moduladores de p2x7
ECSP16061758A (es) Moduladores de tetrahidropiridopirazinas de gpr6
CR20140493A (es) Compuestos novedosos
CL2015002125A1 (es) Moduladores de receptores nmda de espiro-lactama y sus usos.
CL2016002348A1 (es) Agonistas del receptor muscarínico
CL2016001579A1 (es) Nuevas indazolcarboxamidas, procedimientos para su preparación, preparaciones farmacéuticas que las contienen, así como su uso para la preparación de medicamentos.
ECSP20061469A (es) Anticuerpos Anti-Trem-1 y Usos de los Mismos
UY36037A (es) Derivados de indazol y 2-metil-pirazol-piridina sustituidos como inhibidores de la tirosina quinasa (syk) del bazo y composiciones farmacéuticas que las contienen
PE20160687A1 (es) Analogos de heteroaril indol biciclico utiles como moduladores de ror
PE20180119A1 (es) Sulfonas triciclicas como moduladores del receptor huerfano relacionado con retinoide gamma (rorgamma)
MX2016015630A (es) Nuevos compuestos.
PE20181178A1 (es) Compuestos carbocilicos novedosos como moduladores de ror gamma
DOP2016000311A (es) Nuevos compuestos
CL2017002405A1 (es) Compuestos bicíclicos fusionados, composición farmacéutica que los comprende y su uso para el tratamiento de enfermedades o desordenes relacionados con el fxr.
MX2014014751A (es) Compuestos de heteroarilo y metodos de uso de los mismos.
CL2016002321A1 (es) Compuestos derivados del ácido 2-8-5-cloropirimidin-2-ilamino-6,7,8,9-tetrahidro-5h-pirido3,2-bindol-5-ilacético, moduladores del receptor de prostaglandina d2 composición farmacéutica y su uso para el tratamiento de enfermedadestrastornos alérgicosinmunitarios.
MX2019005090A (es) Derivados de piridazina como moduladores de receptor gamma huerfano relacionado a acido retinoico (rorc).
CL2017001231A1 (es) Espiro-tiazolonas
UY36398A (es) NUEVOS MODULADORES DEL RECEPTOR GAMMA HUERFANO RELACIONADO CON RETINOIDE (RORy)