[go: up one dir, main page]

PE20181078A1 - Derivados de 8-[6-[3-(amino) propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cancer - Google Patents

Derivados de 8-[6-[3-(amino) propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cancer

Info

Publication number
PE20181078A1
PE20181078A1 PE2018000343A PE2018000343A PE20181078A1 PE 20181078 A1 PE20181078 A1 PE 20181078A1 PE 2018000343 A PE2018000343 A PE 2018000343A PE 2018000343 A PE2018000343 A PE 2018000343A PE 20181078 A1 PE20181078 A1 PE 20181078A1
Authority
PE
Peru
Prior art keywords
kinase
quinolin
pyridyl
isopropylimidazo
atm
Prior art date
Application number
PE2018000343A
Other languages
English (en)
Inventor
Bernard Christophe Barlaam
Kurt Gordon Pike
Thomas Anthony Hunt
Andrew John Eatherton
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20181078A1 publication Critical patent/PE20181078A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invencion refiere un derivado de 8-[6-[3-(amino)propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona de formula (I) o una sal farmaceuticamente aceptable de este, donde R1 es metilo; R2 es hidro o metilo; R3 es hidro o fluoro; R4 es hidro o metilo; y R5 es hidro o fluoro. Son compuestos preferidos: 8-[6-[3-(dimetilamino)propoxi]-3-piridil]-7-fluoro-1-isopropil-3-metilimidazo[4,5-c]quinolin-2-ona; 7-fluoro-1-isopropil-3-metil-8-[6-[3-(1-piperidil)propoxi]-3-piridil]imidazo[4,5-c]quinolin-2-ona; entre otros. La presente invencion es util para el tratamiento del cancer. Estos compuestos modulan selectivamente la cinasa de la ataxia telangiectasia mutada (ATM).
PE2018000343A 2015-09-17 2016-09-15 Derivados de 8-[6-[3-(amino) propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cancer PE20181078A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1516504.6A GB201516504D0 (en) 2015-09-17 2015-09-17 Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer

Publications (1)

Publication Number Publication Date
PE20181078A1 true PE20181078A1 (es) 2018-07-05

Family

ID=54544418

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2018000343A PE20181078A1 (es) 2015-09-17 2016-09-15 Derivados de 8-[6-[3-(amino) propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cancer

Country Status (37)

Country Link
US (5) US9856255B2 (es)
EP (2) EP3350180B1 (es)
JP (1) JP6605130B2 (es)
KR (2) KR102028848B1 (es)
CN (1) CN108137576B (es)
AR (1) AR106053A1 (es)
AU (1) AU2016323399B2 (es)
BR (1) BR112018004325B1 (es)
CA (1) CA2997399C (es)
CL (1) CL2018000677A1 (es)
CO (1) CO2018002829A2 (es)
CR (1) CR20180172A (es)
CY (1) CY1124680T1 (es)
DK (2) DK3350180T3 (es)
DO (1) DOP2018000065A (es)
EA (1) EA033284B1 (es)
ES (2) ES2920876T3 (es)
GB (1) GB201516504D0 (es)
HR (1) HRP20210149T1 (es)
HU (2) HUE053066T2 (es)
IL (1) IL257847B (es)
LT (1) LT3350180T (es)
MX (1) MX384930B (es)
MY (2) MY195669A (es)
NI (1) NI201800033A (es)
PE (1) PE20181078A1 (es)
PH (1) PH12018500532A1 (es)
PL (2) PL3683220T3 (es)
PT (2) PT3350180T (es)
RS (1) RS61435B1 (es)
SI (1) SI3350180T1 (es)
SM (1) SMT202100071T1 (es)
SV (1) SV2018005655A (es)
TN (1) TN2018000078A1 (es)
TW (2) TWI714631B (es)
WO (1) WO2017046216A1 (es)
ZA (1) ZA202209171B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201516504D0 (en) * 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
GB201608227D0 (en) * 2016-05-11 2016-06-22 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
JOP20190209A1 (ar) * 2017-03-16 2019-09-12 Astrazeneca Ab مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان
CN111344293A (zh) 2017-09-20 2020-06-26 阿斯利康(瑞典)有限公司 1，3-二氢咪唑并[4，5-c]噌啉-2-酮化合物及其在治疗癌症中的用途
EP4516318A3 (en) 2018-09-14 2025-04-30 Suzhou Zanrong Pharma Limited 1-isopropyl-3-methyl-8- (pyridin-3-yl) -1, 3-dihydro-2h-imidazo [4, 5-c] cinnolin-2-one as selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof
CN115003672A (zh) * 2020-01-09 2022-09-02 南京明德新药研发有限公司 喹啉并咪唑类化合物及其应用
US20230293507A1 (en) * 2020-03-04 2023-09-21 Pharos Ibio Co., Ltd Use of 2,3,5-substituted thiophene compound for preventing, ameliorating, or treating ovarian cancer
JP2023539715A (ja) * 2020-06-24 2023-09-19 アストラゼネカ ユーケー リミテッド 抗体－薬物コンジュゲートとａｔｍ阻害剤との組合わせ
CA3194102A1 (en) * 2020-09-28 2022-03-31 Chuanwu ZHAO A class of fused ring compounds, and preparation and use thereof
EP3992191A1 (en) 2020-11-03 2022-05-04 Deutsches Krebsforschungszentrum Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors
WO2022125614A1 (en) * 2020-12-09 2022-06-16 Stingray Therapeutics, Inc. Phosphonates as inhibitors of enpp1 and cdnp
WO2022193166A1 (en) * 2021-03-17 2022-09-22 Suzhou Zanrong Pharma Limited Selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof
CN115304598B (zh) * 2021-08-25 2024-05-31 石药集团中奇制药技术（石家庄）有限公司 一种杂环类化合物及其制备方法和用途
GB202114704D0 (en) 2021-10-14 2021-12-01 Univ Birmingham ATM inhibition
MX2024009184A (es) * 2022-01-26 2024-07-30 Chia Tai Tianqing Pharmaceutical Group Co Ltd Compuesto que contiene grupo hidrazino.
CA3245563A1 (en) * 2022-04-11 2023-10-19 Wei Zhong CRYSTALLINE FORM OF DERIVED 1-(3,3-DIFLUOROPIPERIDIN-4-YL)-IMIDAZO [4,5-C]QUINOLIN-2-ONE, CRYSTALLINE SALT FORM, PREPARATION AND APPLICATION
TW202529760A (zh) 2023-09-13 2025-08-01 瑞典商阿斯特捷利康公司 治療方法
WO2025190957A1 (en) 2024-03-13 2025-09-18 Astrazeneca Ab Azd1390, or a pharmaceutically acceptable salt thereof, in combination with radiation for use in a method of treatment of a central nervous system (cns) tumour

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006683A1 (en) 1990-10-22 1992-04-30 Research Corporation Technologies, Inc. Aryl and heteroaryl compounds having anti-retrovirus activity
TW301607B (es) 1993-03-09 1997-04-01 Takeda Pharm Industry Co Ltd
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
PT880508E (pt) 1996-02-13 2003-07-31 Astrazeneca Ab Derivados de quinazolina como inibidores de vegf
IL125954A (en) 1996-03-05 2003-06-24 Zeneca Ltd Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
US6632823B1 (en) 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
AU5509099A (en) 1998-08-03 2000-02-28 Basf Corporation Pyridinones for the treatment of sexual dysfunction
AU2871900A (en) 1999-02-04 2000-08-25 Millennium Pharmaceuticals, Inc. G-protein coupled heptahelical receptor binding compounds and methods of use thereof
US20020151712A1 (en) 1999-09-14 2002-10-17 Nan-Horng Lin 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission
EP1578341A4 (en) 2000-10-11 2005-09-28 Tularik Inc MODULATION OF THE CCR4 FUNCTION
WO2002030357A2 (en) 2000-10-11 2002-04-18 Chemocentryx, Inc. Compounds and methods for modulating ccr4 function
EP1217000A1 (en) 2000-12-23 2002-06-26 Aventis Pharma Deutschland GmbH Inhibitors of factor Xa and factor VIIa
AU2002303156A1 (en) 2001-03-23 2002-10-08 Bethesda Pharmaceuticals, Inc. Design and synthesis of optimized ligands for ppar
JP2002293745A (ja) 2001-03-29 2002-10-09 St Marianna Univ School Of Medicine 慢性関節リウマチ治療剤
EP1383799A4 (en) 2001-04-10 2008-08-06 Transtech Pharma Inc PROBES, SYSTEMS AND METHODS FOR DISCOVERING MEDICAMENTS
US20040116330A1 (en) 2001-04-27 2004-06-17 Kenichiro Naito Preventive/therapeutic method for cancer
WO2002094264A1 (en) 2001-05-23 2002-11-28 Tularik Inc. Ccr4 antagonists
EP1270535A3 (de) 2001-06-20 2004-02-18 Clariant GmbH Verfahren zur Herstellung von substituierten aromatischen Verbindungen
JP4082888B2 (ja) 2001-10-17 2008-04-30 広栄化学工業株式会社 ビアリール化合物の製造法
AU2003214873A1 (en) 2002-01-18 2003-09-02 Ceretek Llc Methods of treating conditions associated with an edg receptor
JP4167848B2 (ja) 2002-04-10 2008-10-22 広栄化学工業株式会社 ビアリール化合物の製造法
GB0211649D0 (en) 2002-05-21 2002-07-03 Novartis Ag Organic compounds
JPWO2004007472A1 (ja) 2002-07-10 2005-11-17 小野薬品工業株式会社 Ｃｃｒ４アンタゴニストおよびその医薬用途
CA2495903A1 (en) 2002-08-23 2004-03-04 University Of Connecticut Novel biphenyl and biphenyl-like cannabinoids
JP2006511460A (ja) 2002-08-23 2006-04-06 ユニバーシティ オブ コネチカット 治療適応を持つケトカンナビノイド
JP4787150B2 (ja) * 2003-03-06 2011-10-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｊｎｋ阻害剤
JPWO2004080943A1 (ja) 2003-03-11 2006-06-08 小野薬品工業株式会社 シンナミルアルコール誘導体化合物およびその化合物を有効成分として含有する薬剤
WO2004113258A1 (ja) 2003-06-20 2004-12-29 Shionogi & Co., Ltd. 炭素−炭素結合生成反応
JPWO2005023771A1 (ja) 2003-09-05 2006-11-02 小野薬品工業株式会社 ケモカインレセプターアンタゴニストおよびその医薬用途
JP2005170939A (ja) 2003-11-20 2005-06-30 Takeda Chem Ind Ltd 糖尿病の予防・治療剤
RU2006121646A (ru) 2003-11-21 2008-01-10 Новартис АГ (CH) Производные 1h-имидазохинолина в качестве ингибиторов протеинкиназы
WO2006038594A1 (ja) 2004-10-04 2006-04-13 Ono Pharmaceutical Co., Ltd. Ｎ型カルシウムチャネル阻害薬
PT1826197E (pt) 2004-12-13 2012-03-06 Ono Pharmaceutical Co Derivado de ácido aminocarboxílico e sua utilização medicinal
GB0510390D0 (en) * 2005-05-20 2005-06-29 Novartis Ag Organic compounds
US20070032522A1 (en) 2005-07-01 2007-02-08 Kumar Dange V Antiviral agents
EP1962861A2 (en) 2005-08-26 2008-09-03 Emory University Compounds and methods for modulating the silencing of a polynucleotide of interest
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
JP2009023986A (ja) 2006-11-08 2009-02-05 Pharma Ip 抗癌剤としてのビアリール誘導体
CL2008000191A1 (es) 2007-01-25 2008-08-22 Astrazeneca Ab Compuestos derivados de 4-amino-cinnotina-3-carboxamida; inhibidores de csf-1r quinasa; su proceso de preparacion; y su uso para tratar el cancer.
US9370508B2 (en) 2007-02-20 2016-06-21 Novartis Ag Imidazoquinolines as dual lipid kinase and mTOR inhibitors
EP2139887A2 (en) 2007-03-07 2010-01-06 Alantos Pharmaceuticals Holding, Inc. Metalloprotease inhibitors containing a heterocyclic moiety
US8039505B2 (en) 2007-04-11 2011-10-18 University Of Utah Research Foundation Compounds for modulating T-cells
PE20090717A1 (es) 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
US7928111B2 (en) 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US9321730B2 (en) 2007-08-21 2016-04-26 The Hong Kong Polytechnic University Method of making and administering quinoline derivatives as anti-cancer agents
MX338088B (es) 2008-03-26 2016-04-01 Novartis Ag Imidazoquinolinas y derivados de pirimidina como moduladores potentes de los procesos angiogenicos impulsados por el factor de crecimiento endotelial vascular (vegf).
WO2010003025A1 (en) 2008-07-01 2010-01-07 Genentech, Inc. Bicyclic heterocycles as mek kinase inhibitors
WO2010007756A1 (ja) 2008-07-14 2010-01-21 塩野義製薬株式会社 Ｔｔｋ阻害作用を有するピリジン誘導体
CA2735932C (en) 2008-09-30 2013-07-09 Pfizer Inc. Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions
WO2010077680A2 (en) 2008-12-08 2010-07-08 Vm Discovery Inc. Compositions of protein receptor tyrosine kinase inhibitors
WO2010114919A2 (en) 2009-04-02 2010-10-07 Stc.Unm Metnase and intnase inhibitors and their use in treating cancer
TW201041888A (en) 2009-05-06 2010-12-01 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
NZ596487A (en) * 2009-06-04 2012-11-30 Novartis Ag 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES AND THE USE THEREOF AS PI3K INHIBITORS
JP2012528829A (ja) * 2009-06-04 2012-11-15 ノバルティス アーゲー １Ｈ−イミダゾ［４，５−ｃ］キノリノン化合物
BR112012006802A2 (pt) 2009-09-28 2020-08-18 F.Hoffmann-La Roche Ag composto, composição farmacêutica, método para tratar câncer, usos de um composto, kit e invenção
GB0919423D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
CN102199152A (zh) 2010-03-25 2011-09-28 高大新 杂环咪唑类磷脂激酶抑制剂
CN102372711B (zh) * 2010-08-18 2014-09-17 山东轩竹医药科技有限公司 咪唑并喹啉类PI3K和mTOR双重抑制剂
US20120046272A1 (en) 2010-08-23 2012-02-23 Grunenthal Gmbh Novel Therapeutic Compounds
DE102010035744A1 (de) * 2010-08-28 2012-03-01 Merck Patent Gmbh Imidazolonylchinoline
CN102399218A (zh) * 2010-09-16 2012-04-04 和记黄埔医药（上海）有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
AR083267A1 (es) 2010-10-04 2013-02-13 Novartis Ag Combinaciones farmaceuticas
RU2013130224A (ru) 2010-12-03 2015-01-10 Новартис Аг Фармацевтические композиции
AR084731A1 (es) 2010-12-06 2013-06-05 Piramal Life Sciences Ltd Derivados de imidazoquinolina sustituidos
CN102603628B (zh) 2010-12-22 2016-08-17 香港理工大学 作为抗癌试剂的喹啉衍生物
WO2012092471A2 (en) 2010-12-29 2012-07-05 Development Center For Biotechnology Novel tubulin inhibitors and methods of using the same
JO3003B1 (ar) * 2011-01-14 2016-09-05 Lilly Co Eli مركب أيميدازو [4، 5 -c ] كينولين-2- واحد واستخدامه كمثبط كيناز PI3/mtor
AU2012240246A1 (en) 2011-04-04 2013-05-09 Netherlands Cancer Institute Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors
AU2012258977A1 (en) 2011-05-23 2014-01-16 Imago Pharmaceuticals, Inc. Inhibitors of LRRK2 kinase activity
US10533000B2 (en) 2011-05-26 2020-01-14 Sunovion Pharmaceuticals, Inc. Metabotrophic glutamate receptor 5 modulators and methods of use thereof
WO2013022740A2 (en) 2011-08-05 2013-02-14 Corning Incorporated Gpr35 ligands and the uses thereof
JP6042060B2 (ja) 2011-09-26 2016-12-14 サノフイ ピラゾロキノリノン誘導体、その調製および治療上の使用
US9580409B2 (en) 2011-11-07 2017-02-28 Sunovion Pharmaceuticals, Inc. Modulators of opioid receptors and methods of use thereof
WO2013074965A1 (en) 2011-11-16 2013-05-23 Microbiotix, Inc. Aminoalkyl phenol ether inhibitors of influenza a virus
WO2013157018A1 (en) 2012-04-18 2013-10-24 Indian Institute Of Technology Madras A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics
MX2014014969A (es) 2012-06-06 2015-03-13 Novartis Ag Combinacion de un inhibidor de la 17-alfa-hidroxilasa (c17,20-liasa) y un inhibidor especifico de la pi-3k para tratar una enfermedad tumoral.
US9957247B2 (en) 2012-06-07 2018-05-01 Georgia State University Research Foundation, Inc. SecA inhibitors and methods of making and using thereof
WO2013192367A1 (en) 2012-06-22 2013-12-27 Novartis Ag Neuroendocrine tumor treatment
US20150216870A1 (en) 2012-08-16 2015-08-06 Novartis Ag Combination of PI3K Inhibitor and C-Met Inhibitor
WO2014031872A2 (en) 2012-08-23 2014-02-27 The Broad Institute, Inc. Small molecule inhibitors for treating parasitic infections
AU2014248568B2 (en) 2013-03-12 2017-07-13 Curegenix, Inc. Compounds for treatment of cancer
GB201309180D0 (en) 2013-05-21 2013-07-03 Ucl Business Plc Compounds and Their Uses
US20160264570A1 (en) 2013-11-15 2016-09-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Method of blocking transmission of malarial parasite
WO2015084384A1 (en) * 2013-12-06 2015-06-11 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
NO2714752T3 (es) * 2014-05-08 2018-04-21
GB201409044D0 (en) 2014-05-21 2014-07-02 Ucl Business Plc New compounds
PT3560924T (pt) 2015-04-02 2021-07-02 Merck Patent Gmbh Imidazolinilquinolinas e a sua utilização como inibidores da cinase atm
CN104876912B (zh) 2015-04-08 2017-07-21 苏州云轩医药科技有限公司 Wnt信号通路抑制剂及其应用
US10858316B2 (en) 2015-07-10 2020-12-08 University Of Maryland, Baltimore Small molecule inhibitors of the MCL-1 oncoprotein and uses thereof
GB201516504D0 (en) * 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
FI3429591T3 (fi) 2016-03-16 2023-06-15 Kura Oncology Inc Substituoituja tieno[2,3-d]pyrimidiinijohdannaisia meniini-mll:n estäjinä ja käyttömenetelmiä

Also Published As

Publication number Publication date
HK1257413A1 (en) 2019-10-18
NZ741661A (en) 2024-04-26
KR20180052724A (ko) 2018-05-18
TW202124381A (zh) 2021-07-01
AU2016323399B2 (en) 2019-04-18
US10882858B2 (en) 2021-01-05
US10457679B2 (en) 2019-10-29
US20170081325A1 (en) 2017-03-23
CR20180172A (es) 2018-05-25
EP3350180A1 (en) 2018-07-25
EP3350180B1 (en) 2020-11-11
EP3683220B1 (en) 2022-04-13
PH12018500532A1 (en) 2018-08-29
IL257847A (en) 2018-04-30
HUE058884T2 (hu) 2022-09-28
ES2920876T3 (es) 2022-08-11
KR20190112852A (ko) 2019-10-07
LT3350180T (lt) 2021-02-25
MX2018003186A (es) 2018-05-17
US20180141943A1 (en) 2018-05-24
MX384930B (es) 2025-03-14
PT3683220T (pt) 2022-06-24
PL3350180T3 (pl) 2021-05-17
TN2018000078A1 (en) 2019-07-08
EA033284B1 (ru) 2019-09-30
HK1255408A1 (zh) 2019-08-16
BR112018004325A2 (es) 2018-10-02
TWI762109B (zh) 2022-04-21
GB201516504D0 (en) 2015-11-04
MY195669A (en) 2023-02-03
DK3683220T3 (da) 2022-07-04
SI3350180T1 (sl) 2021-03-31
JP2018531226A (ja) 2018-10-25
RS61435B1 (sr) 2021-03-31
DK3350180T3 (da) 2021-02-15
US11613539B2 (en) 2023-03-28
CA2997399C (en) 2024-02-20
CN108137576B (zh) 2020-09-22
DOP2018000065A (es) 2018-03-30
AU2016323399A1 (en) 2018-05-10
EP3683220A1 (en) 2020-07-22
CL2018000677A1 (es) 2018-08-17
EA201890650A1 (ru) 2018-10-31
ES2853924T3 (es) 2021-09-20
TW201722946A (zh) 2017-07-01
NI201800033A (es) 2018-10-18
US20230286981A1 (en) 2023-09-14
HUE053066T2 (hu) 2021-06-28
US9856255B2 (en) 2018-01-02
KR102028848B1 (ko) 2019-10-04
TWI714631B (zh) 2021-01-01
MY198813A (en) 2023-09-29
AR106053A1 (es) 2017-12-06
SV2018005655A (es) 2018-04-27
PT3350180T (pt) 2021-02-08
IL257847B (en) 2020-08-31
WO2017046216A1 (en) 2017-03-23
ZA202209171B (en) 2023-11-29
CO2018002829A2 (es) 2018-05-31
BR112018004325B1 (pt) 2023-10-17
CY1124680T1 (el) 2022-07-22
CN108137576A (zh) 2018-06-08
HRP20210149T1 (hr) 2021-03-19
PL3683220T3 (pl) 2022-08-01
KR102469153B1 (ko) 2022-11-22
JP6605130B2 (ja) 2019-11-13
US20200102302A1 (en) 2020-04-02
SMT202100071T1 (it) 2021-03-15
US20210147416A1 (en) 2021-05-20
CA2997399A1 (en) 2017-03-23

Similar Documents

Publication Publication Date Title
PE20181078A1 (es) Derivados de 8-[6-[3-(amino) propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) para el tratamiento del cancer
JOP20190070B1 (ar) مركبات بنزو[b] ثيوفين كناهضات محفزة لبروتين جينات الإنترفيرون
CR20170237A (es) Nuevos compuestos de 5-amino-6h-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituidos para el tratamiento y profilaxis de infecciones virales.
PE20191245A1 (es) Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim
PE20180508A1 (es) Amidas heterociclicas como inhibidores de quinasa
CO2017012267A2 (es) Compuestos de naftiridina como inhibidores de la quinasa jak
NI201600152A (es) Compuestos de heteroarilo o arilo bicíclicos fusionados y su uso como inhibidores de irak4
UY37310A (es) Compuestos de indol sustituidos con [1,2,4]triazolo[1,5-a]piridinilo
BR112018070602A2 (pt) composto, composição farmacêutica, uso do composto, e, método para tratar uma doença ou distúrbio
AR102204A1 (es) Compuestos derivados de amino-alquilbenzotiazepinas
UY35675A (es) Derivados sustituidos de quinazolin-4-ona
CR20140413A (es) Inhibidores de serina/treonina cinasa
TW201613872A (en) IRAK4 inhibiting agents
EA202192151A1 (ru) Применение пиразолпиримидиновых производных для лечения нарушений, связанных с pi3k
PE20151280A1 (es) Compuestos y metodos para la modulacion de quinasas y sus indicaciones
PE20180024A1 (es) Triazolopirazinonas como inhibidores de pde1
UY36170A (es) Compuestos de dihidroisoquinolinona sustituida
UY36226A (es) Ácidos carboxílicos heterocíclicos como activadores de guanilato ciclasa soluble
PE20160689A1 (es) Derivados del isocromeno como inhibidores de las fosfoinositido-3 quinasas
CU20160192A7 (es) Derivados de indano e indolina útiles como activadores de la guanilato ciclasa soluble
CO2019001181A2 (es) Compuestos de heteroarilcarboxamida como inhibidores de ripk2
CU20170007A7 (es) Compuestos de imidazopiridazina
CL2019000662A1 (es) Inhibidores de dopamina–b–hidroxilasa.
CL2019001023A1 (es) Derivados de naftiridinona y su uso en el tratamiento de la arritmia.
UY36228A (es) Derivados de heteroarilo como inhibidores de aldosterona sintasa (cyp11b2) y composiciones farmacéuticas que los contienen