PE20181956A1 - Polipeptidos que inhiben cd40l - Google Patents
Polipeptidos que inhiben cd40lInfo
- Publication number
- PE20181956A1 PE20181956A1 PE2018001013A PE2018001013A PE20181956A1 PE 20181956 A1 PE20181956 A1 PE 20181956A1 PE 2018001013 A PE2018001013 A PE 2018001013A PE 2018001013 A PE2018001013 A PE 2018001013A PE 20181956 A1 PE20181956 A1 PE 20181956A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- nos
- amino acid
- cd40l
- group
- Prior art date
Links
- 108010029697 CD40 Ligand Proteins 0.000 title abstract 4
- 102100032937 CD40 ligand Human genes 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 208000005777 Lupus Nephritis Diseases 0.000 abstract 1
- 102000007562 Serum Albumin Human genes 0.000 abstract 1
- 108010071390 Serum Albumin Proteins 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
Abstract
Referido a un polipeptido que comprende al menos un dominio variable unico de inmunoglobulina (ISVD) que se une especificamente a CD40L, y opcionalmente comprende una albumina de suero que se une a ISDV y/o una extension C-terminal, en el que la union a CD40L inhibe una actividad de CD40L. El ISVD consiste esencialmente en 4 regiones macro (FR1 a FR4, respectivamente) y 3 regiones determinantes de complementariedad (CDR1 a CDR3 respectivamente), en las que: (i) CDR1 se elige del grupo que consiste en las SEQ ID Nos: 33, 61, 40 y 68; y secuencias de aminoacidos que tienen 1, 2 o 3 diferencias de aminoacidos con las SEQ ID Nos: 33, 61, 40 o 68; (ii) CDR2 se elige del grupo que consiste en las SEQ ID Nos: 35, 63, 42 y 70; y secuencias de aminoacidos que tienen 1, 2 o 3 diferencias de aminoacidos con las SEQ ID Nos: 35, 63, 42 o 70; y (iii) CDR3 se elige del grupo que consiste en las SEQ ID Nos: 37, 65, 44 y 72; y secuencias de aminoacidos que tienen 1, 2, 3 o 4 diferencias de aminoacidos con las SEQ ID Nos: 37, 65, 44 o 72. El polipeptido tiene al menos 80%, 90%, 95% o 100% de identidad de secuencia con SEQ ID NO: 9 o SEQ ID NO: 78. Tambien se refiere a metodos para preparar tales polipeptidos y composiciones farmaceuticas que los comprenden, para el uso en el tratamiento o prevencion de un sintoma de una enfermedad autoinmune, nefritis lupica, entre otros.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562260411P | 2015-11-27 | 2015-11-27 | |
| US201662345967P | 2016-06-06 | 2016-06-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20181956A1 true PE20181956A1 (es) | 2018-12-17 |
Family
ID=57471837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2018001013A PE20181956A1 (es) | 2015-11-27 | 2016-11-28 | Polipeptidos que inhiben cd40l |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US11248055B2 (es) |
| EP (2) | EP3380517B1 (es) |
| JP (1) | JP7256011B2 (es) |
| KR (1) | KR20180080337A (es) |
| CN (1) | CN108473561B (es) |
| AU (1) | AU2016360987A1 (es) |
| BR (1) | BR112018010802A2 (es) |
| CA (1) | CA3006398A1 (es) |
| CL (1) | CL2018001400A1 (es) |
| CO (1) | CO2018005921A2 (es) |
| DO (1) | DOP2018000128A (es) |
| EC (1) | ECSP18046820A (es) |
| GT (1) | GT201800102A (es) |
| IL (1) | IL259249A (es) |
| MA (1) | MA43302A (es) |
| MX (1) | MX2018006377A (es) |
| PE (1) | PE20181956A1 (es) |
| PH (1) | PH12018501114A1 (es) |
| RU (1) | RU2018122255A (es) |
| SG (2) | SG10201913503VA (es) |
| TN (1) | TN2018000180A1 (es) |
| WO (1) | WO2017089618A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3551656A1 (en) | 2016-12-07 | 2019-10-16 | Ablynx NV | Improved serum albumin binding immunoglobulin single variable domains |
| SG11201906264YA (en) | 2017-01-17 | 2019-08-27 | Ablynx Nv | Improved serum albumin binders |
| US11897944B2 (en) | 2017-01-17 | 2024-02-13 | Ablynx N.V. | Immunoglobulin single variable domain (ISVD) capable of binding to serum albumin |
| US11673954B2 (en) * | 2017-11-17 | 2023-06-13 | Nanjing Legend Biotech Co., Ltd. | Single-domain antibodies and variants thereof against PD-L1 |
| AU2020400938A1 (en) * | 2019-12-09 | 2022-07-28 | Ablynx Nv | Polypeptides comprising immunoglobulin single variable domains targeting IL-13 and TSLP |
| CN114149508B (zh) * | 2021-11-25 | 2023-04-28 | 苏州普乐康医药科技有限公司 | 一种结合cd40l的融合蛋白及其应用 |
| US20240415974A1 (en) | 2022-12-23 | 2024-12-19 | Ablynx N.V. | Protein-based conjugation carriers |
| TW202448926A (zh) | 2023-02-17 | 2024-12-16 | 比利時商艾伯霖克斯公司 | 結合新生兒fc受體之多肽 |
| WO2025133166A1 (en) | 2023-12-22 | 2025-06-26 | Ablynx Nv | Protein-based carriers for site-specific amine conjugation |
| WO2025133253A2 (en) | 2023-12-22 | 2025-06-26 | Ablynx Nv | Protein-based conjugation carriers for intranuclear delivery |
| WO2025235683A1 (en) | 2024-05-07 | 2025-11-13 | Eledon Pharmaceuticals, Inc. | Methods and compositions for prevention of transplant rejection |
| WO2025235670A1 (en) | 2024-05-07 | 2025-11-13 | Eledon Pharmaceuticals, Inc. | Use of anti-cd40 ligand antibodies for immunosuppression in islet cell transplantation |
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| KR20070084170A (ko) | 2004-10-13 | 2007-08-24 | 아블린쓰 엔.브이. | 알쯔하이머병 등의 퇴행성 신경 질환의 치료 및 진단을위한 단일 도메인 카멜리드 항-아밀로이드 베타 항체 및이를 포함하는 폴리펩타이드 |
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| SMT202000091T1 (it) | 2011-10-13 | 2020-05-08 | Bristol Myers Squibb Co | Polipeptidi anticorpali che antagonizzano cd40l |
| ES2779123T3 (es) | 2013-09-26 | 2020-08-13 | Ablynx Nv | Nanobodies biespecíficos |
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| US10669343B2 (en) | 2015-08-05 | 2020-06-02 | Janssen Biotech, Inc. | Anti-CD154 antibodies and methods of using them |
-
2016
- 2016-11-28 MA MA043302A patent/MA43302A/fr unknown
- 2016-11-28 WO PCT/EP2016/079048 patent/WO2017089618A1/en not_active Ceased
- 2016-11-28 KR KR1020187018169A patent/KR20180080337A/ko not_active Withdrawn
- 2016-11-28 US US15/778,677 patent/US11248055B2/en active Active
- 2016-11-28 RU RU2018122255A patent/RU2018122255A/ru unknown
- 2016-11-28 EP EP16805359.3A patent/EP3380517B1/en active Active
- 2016-11-28 JP JP2018527745A patent/JP7256011B2/ja active Active
- 2016-11-28 AU AU2016360987A patent/AU2016360987A1/en not_active Abandoned
- 2016-11-28 EP EP21179221.3A patent/EP3932945A1/en not_active Withdrawn
- 2016-11-28 CN CN201680068704.XA patent/CN108473561B/zh active Active
- 2016-11-28 PE PE2018001013A patent/PE20181956A1/es unknown
- 2016-11-28 SG SG10201913503VA patent/SG10201913503VA/en unknown
- 2016-11-28 MX MX2018006377A patent/MX2018006377A/es unknown
- 2016-11-28 TN TNP/2018/000180A patent/TN2018000180A1/en unknown
- 2016-11-28 BR BR112018010802A patent/BR112018010802A2/pt not_active Application Discontinuation
- 2016-11-28 CA CA3006398A patent/CA3006398A1/en not_active Abandoned
- 2016-11-28 SG SG11201803976VA patent/SG11201803976VA/en unknown
-
2018
- 2018-05-09 IL IL259249A patent/IL259249A/en unknown
- 2018-05-21 GT GT201800102A patent/GT201800102A/es unknown
- 2018-05-22 DO DO2018000128A patent/DOP2018000128A/es unknown
- 2018-05-24 CL CL2018001400A patent/CL2018001400A1/es unknown
- 2018-05-25 PH PH12018501114A patent/PH12018501114A1/en unknown
- 2018-06-08 CO CONC2018/0005921A patent/CO2018005921A2/es unknown
- 2018-06-21 EC ECSENADI201846820A patent/ECSP18046820A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL259249A (en) | 2018-07-31 |
| US20180355050A1 (en) | 2018-12-13 |
| EP3932945A1 (en) | 2022-01-05 |
| CL2018001400A1 (es) | 2018-10-26 |
| BR112018010802A2 (pt) | 2018-11-27 |
| RU2018122255A (ru) | 2019-12-19 |
| MA43302A (fr) | 2021-03-17 |
| CN108473561B (zh) | 2022-12-16 |
| CA3006398A1 (en) | 2017-06-01 |
| PH12018501114A1 (en) | 2019-01-28 |
| ECSP18046820A (es) | 2018-07-31 |
| SG11201803976VA (en) | 2018-06-28 |
| EP3380517A1 (en) | 2018-10-03 |
| WO2017089618A1 (en) | 2017-06-01 |
| US11248055B2 (en) | 2022-02-15 |
| SG10201913503VA (en) | 2020-03-30 |
| JP7256011B2 (ja) | 2023-04-11 |
| JP2019504822A (ja) | 2019-02-21 |
| EP3380517B1 (en) | 2021-08-04 |
| RU2018122255A3 (es) | 2020-04-06 |
| MX2018006377A (es) | 2018-09-05 |
| GT201800102A (es) | 2019-08-15 |
| AU2016360987A1 (en) | 2018-06-07 |
| DOP2018000128A (es) | 2018-09-30 |
| CO2018005921A2 (es) | 2018-06-20 |
| CN108473561A (zh) | 2018-08-31 |
| TN2018000180A1 (en) | 2019-10-04 |
| KR20180080337A (ko) | 2018-07-11 |
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