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PE20170303A1 - Derivados de la indolizina como inhibidores de las fosfoinositido-3 quinasas - Google Patents

Derivados de la indolizina como inhibidores de las fosfoinositido-3 quinasas

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Publication number
PE20170303A1
PE20170303A1 PE2016002720A PE2016002720A PE20170303A1 PE 20170303 A1 PE20170303 A1 PE 20170303A1 PE 2016002720 A PE2016002720 A PE 2016002720A PE 2016002720 A PE2016002720 A PE 2016002720A PE 20170303 A1 PE20170303 A1 PE 20170303A1
Authority
PE
Peru
Prior art keywords
indolizine
kinases
phosphoinositide
inhibitors
derivatives
Prior art date
Application number
PE2016002720A
Other languages
English (en)
Inventor
Alessandro Accetta
Matteo Biagetti
Michele Retini
Matilde Guala
Anna Maria Capelli
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of PE20170303A1 publication Critical patent/PE20170303A1/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

Se refiere a un compuesto derivado de indolizina de formula (I); en donde X1, X2, X3 y X4 son CH o al menos uno de ellos es un N y los otros son CH; R, cuando esta presente, es OR5, -SR5, entre otros; R1 es H, -OR6, entre otros; R2 es H, -OR9, entre otros; R3 y R4 son H, alquiloC1-C6, entre otros; Cy es arilo, heteroarilo, entre otros opcionalmente sustituido; Z es -O-, -NH, entre otros; m es 0 o 1; n es 1 o 2; p es 0, 1, 2 o 3; R5, R6 y R9 son H, alquiloC1-C6, entre otros. Un compuesto seleccionado es 9- [(3 -fenilindolizin-2-il)metil]-9H-purin-6-amina; entre otros. Tambien se refiere a una composicion farmaceutica. Dicho compuesto inhibe las fosfoinositido-3 quinasas (PI3K) siendo util en el tratamiento de enfermedades respiratorias tal como asma, EPOC, fibrosisi pulmonar, entre otras
PE2016002720A 2014-06-17 2015-06-16 Derivados de la indolizina como inhibidores de las fosfoinositido-3 quinasas PE20170303A1 (es)

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EP14172764 2014-06-17

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US (1) US9527869B2 (es)
EP (1) EP3157920B1 (es)
JP (1) JP6730200B2 (es)
KR (1) KR102420322B1 (es)
CN (1) CN106661019B (es)
AR (1) AR100879A1 (es)
AU (1) AU2015276264B2 (es)
BR (1) BR112016028845B1 (es)
CA (1) CA2952287C (es)
CL (1) CL2016003214A1 (es)
EA (1) EA031409B1 (es)
ES (1) ES2750791T3 (es)
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IL (1) IL249554A0 (es)
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PE (1) PE20170303A1 (es)
PH (1) PH12016502291A1 (es)
PL (1) PL3157920T3 (es)
SG (1) SG11201610473QA (es)
TN (1) TN2016000555A1 (es)
TW (1) TW201625611A (es)
WO (1) WO2015193263A1 (es)
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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2970196B1 (en) 2013-03-15 2020-11-25 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
KR101815193B1 (ko) * 2015-12-29 2018-01-30 (주)스파크바이오파마 PPARγ 인산화 저해제 및 이를 포함하는 약학적 조성물
WO2017123991A1 (en) 2016-01-15 2017-07-20 The Brigham And Women's Hospital, Inc. Pyridazine derivatives as eaat2 activators
US10189844B2 (en) * 2016-02-04 2019-01-29 Chiesi Farmaceutici S.P.A. Pyrazole derivatives as phosphoinositide 3-kinases inhibitors
JP7111733B2 (ja) 2017-03-16 2022-08-02 江蘇恒瑞医薬股▲ふん▼有限公司 ヘテロアリール［４，３－ｃ］ピリミジン－５－アミン誘導体、その製造方法、およびその医薬の使用
CN108129480A (zh) * 2018-03-11 2018-06-08 赵艳阳 一种含芳杂环亚甲基吲嗪衍生物的制备方法
WO2019236625A1 (en) 2018-06-04 2019-12-12 Ohio State Innovation Foundation Eaat2 activators and methods of using thereof
PL3947384T3 (pl) 2019-04-04 2024-03-25 Chiesi Farmaceutici S.P.A. Pochodne izochromenu jako inhibitory kinaz 3-fosfoinozytydów
CN110156785B (zh) * 2019-04-15 2020-08-28 浙江大学 吲唑类化合物及其制备方法和应用
WO2021003398A1 (en) * 2019-07-03 2021-01-07 Sanford Burnham Prebys Medical Discovery Institute Inhibitors of low molecular weight protein tyrosine phosphatase (lmptp) and uses thereof
PH12022550494A1 (en) 2019-09-19 2023-02-27 Totus Medicines Inc Therapeutic conjugates
EP4413000A1 (en) 2021-10-04 2024-08-14 FoRx Therapeutics AG N,n-dimethyl-4-(7-(n-(1-methylcyclopropyl)sulfamoyl)-imidazo[1,5-a]pyridin-5-yl)piperazine-1-carboxamide derivatives and the corresponding pyrazolo[1,5-a]pyridine derivatives as parg inhibitors for the treatment of cancer
KR102866487B1 (ko) 2023-01-06 2025-10-01 연세대학교 산학협력단 새로운 인돌리진-피롤로피리미딘 하이브리드 유도체 제조방법 및 이를 포함하는 항암제 조성물
WO2024186827A2 (en) * 2023-03-06 2024-09-12 The Regents Of The University Of California Novel host-directed therapeutic agent for the treatment of infectious diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY28931A1 (es) * 2004-06-03 2005-12-30 Bayer Pharmaceuticals Corp Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
EP2331541B1 (en) * 2008-09-04 2015-04-22 Boehringer Ingelheim International GmbH Indolizine inhibitors of leukotriene production
AR077428A1 (es) * 2009-07-29 2011-08-24 Sanofi Aventis (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos
US8759359B2 (en) * 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
EP2571357B1 (en) 2010-05-21 2016-07-06 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
UA111503C2 (uk) * 2011-09-27 2016-05-10 Новартіс Аг 3-піримідин-4-іл-оксазолідин-2-они як інгібітори мутантної idh

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