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PE20151164A1 - Anticuerpos bmp-6 - Google Patents

Anticuerpos bmp-6

Info

Publication number
PE20151164A1
PE20151164A1 PE2015001017A PE2015001017A PE20151164A1 PE 20151164 A1 PE20151164 A1 PE 20151164A1 PE 2015001017 A PE2015001017 A PE 2015001017A PE 2015001017 A PE2015001017 A PE 2015001017A PE 20151164 A1 PE20151164 A1 PE 20151164A1
Authority
PE
Peru
Prior art keywords
antibodies
bmp
antigen
binding fragments
anemia
Prior art date
Application number
PE2015001017A
Other languages
English (en)
Inventor
Stephanie Marie Eaton Truhlar
Neungseon Seo
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49918813&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20151164(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20151164A1 publication Critical patent/PE20151164A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)

Abstract

La invencion se refiere a anticuerpos, o fragmentos de los mismos de union al antigeno, que se unen a BMP-6 humano, composiciones que comprenden tales anticuerpos, o fragmentos de los mismos de union al antigeno, y metodos para usar el mismo para tratamiento de anemia de enfermedad cronica
PE2015001017A 2012-12-17 2013-12-05 Anticuerpos bmp-6 PE20151164A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261737859P 2012-12-17 2012-12-17

Publications (1)

Publication Number Publication Date
PE20151164A1 true PE20151164A1 (es) 2015-08-19

Family

ID=49918813

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2015001017A PE20151164A1 (es) 2012-12-17 2013-12-05 Anticuerpos bmp-6

Country Status (33)

Country Link
US (2) US8795665B2 (es)
EP (1) EP2931748B1 (es)
JP (1) JP6033459B2 (es)
KR (1) KR20150083918A (es)
CN (1) CN104870473B (es)
AP (1) AP2015008600A0 (es)
AR (1) AR093620A1 (es)
AU (1) AU2013363548A1 (es)
BR (1) BR112015012708A2 (es)
CA (1) CA2892911C (es)
CL (1) CL2015001639A1 (es)
CY (1) CY1118254T1 (es)
DK (1) DK2931748T3 (es)
EA (1) EA201590918A1 (es)
ES (1) ES2608381T3 (es)
HR (1) HRP20161587T1 (es)
HU (1) HUE032431T2 (es)
IL (1) IL239242A0 (es)
LT (1) LT2931748T (es)
MA (1) MA38161A1 (es)
ME (1) ME02515B (es)
MX (1) MX2015007831A (es)
PE (1) PE20151164A1 (es)
PH (1) PH12015501360A1 (es)
PL (1) PL2931748T3 (es)
PT (1) PT2931748T (es)
RS (1) RS55413B1 (es)
SG (1) SG11201504695QA (es)
SI (1) SI2931748T1 (es)
TN (1) TN2015000277A1 (es)
TW (1) TW201439118A (es)
WO (1) WO2014099391A1 (es)
ZA (1) ZA201504282B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR093620A1 (es) * 2012-12-17 2015-06-10 Lilly Co Eli Anticuerpos bmp-6
UY36449A (es) 2014-12-19 2016-07-29 Novartis Ag Composiciones y métodos para anticuerpos dirigidos a bmp6
GB2550114A (en) 2016-05-03 2017-11-15 Kymab Ltd Methods, regimens, combinations & antagonists
AU2017283787B2 (en) * 2016-06-15 2020-09-17 Novartis Ag Methods for treating disease using inhibitors of bone morphogenetic protein 6 (BMP6)
GB201815629D0 (en) 2018-09-25 2018-11-07 Kymab Ltd Antagonists
CA3141266A1 (en) * 2019-06-12 2020-12-17 Sarah J. Hatsell Human antibodies to bone morphogenetic protein 6
CN114761013A (zh) 2019-09-27 2022-07-15 迪斯克医药公司 治疗骨髓纤维化和相关病症的方法
CN115243762A (zh) 2020-04-07 2022-10-25 迈威(美国)生物治疗有限公司 抗tmprss6抗体及其用途
JP2023528223A (ja) 2020-05-13 2023-07-04 ディスク・メディシン・インコーポレイテッド 骨髄線維症を処置するための抗ヘモジュベリン（ｈｊｖ）抗体
CN114075287B (zh) * 2020-08-18 2023-07-21 湖南远泰生物技术有限公司 人源化bcma抗体和bcma-car-t细胞

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002077006A1 (en) 2001-03-23 2002-10-03 Human Genome Sciences, Inc. Bone morphogenic protein polynucleotides, polypeptides, and antibodies
EP2954903A1 (en) 2005-02-16 2015-12-16 The General Hospital Corporation Use of bmp antagonists to regulate hepcidin-mediated iron metabolism
CA2742871C (en) * 2008-11-13 2018-10-23 Herb Lin Methods and compositions for regulating iron homeostasis by modulation of bmp-6
US20110070242A1 (en) * 2009-09-01 2011-03-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for Diagnosing and Treating Iron Dysregulation
AR093620A1 (es) 2012-12-17 2015-06-10 Lilly Co Eli Anticuerpos bmp-6

Also Published As

Publication number Publication date
SI2931748T1 (sl) 2017-01-31
HUE032431T2 (en) 2017-09-28
MA38161A1 (fr) 2017-12-29
RS55413B1 (sr) 2017-04-28
ME02515B (me) 2017-02-20
MX2015007831A (es) 2015-08-20
HK1209763A1 (en) 2016-04-08
CN104870473A (zh) 2015-08-26
SG11201504695QA (en) 2015-07-30
TN2015000277A1 (en) 2016-10-03
EA201590918A1 (ru) 2015-10-30
IL239242A0 (en) 2015-07-30
AR093620A1 (es) 2015-06-10
US8980582B2 (en) 2015-03-17
CA2892911C (en) 2017-02-28
JP6033459B2 (ja) 2016-11-30
BR112015012708A2 (pt) 2017-09-12
LT2931748T (lt) 2017-01-10
CL2015001639A1 (es) 2015-10-02
CY1118254T1 (el) 2017-06-28
US8795665B2 (en) 2014-08-05
EP2931748A1 (en) 2015-10-21
CN104870473B (zh) 2018-05-29
ES2608381T3 (es) 2017-04-10
WO2014099391A1 (en) 2014-06-26
US20140309404A1 (en) 2014-10-16
US20140170161A1 (en) 2014-06-19
PT2931748T (pt) 2016-11-02
HRP20161587T1 (hr) 2017-01-13
ZA201504282B (en) 2017-11-29
CA2892911A1 (en) 2014-06-26
EP2931748B1 (en) 2016-10-05
TW201439118A (zh) 2014-10-16
DK2931748T3 (da) 2017-01-02
AP2015008600A0 (en) 2015-07-31
AU2013363548A1 (en) 2015-05-28
PL2931748T3 (pl) 2017-05-31
JP2016501273A (ja) 2016-01-18
KR20150083918A (ko) 2015-07-20
PH12015501360A1 (en) 2015-09-02

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