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PE20142337A1 - Sales de 5-[(1r)-2-({2-[4-(2,2-difluoro-2-feniletoxi)fenil]etil}amino)-1-hidroxietil]-8-hidroxiquinolin-2(1h)-ona - Google Patents

Sales de 5-[(1r)-2-({2-[4-(2,2-difluoro-2-feniletoxi)fenil]etil}amino)-1-hidroxietil]-8-hidroxiquinolin-2(1h)-ona

Info

Publication number
PE20142337A1
PE20142337A1 PE2014001393A PE2014001393A PE20142337A1 PE 20142337 A1 PE20142337 A1 PE 20142337A1 PE 2014001393 A PE2014001393 A PE 2014001393A PE 2014001393 A PE2014001393 A PE 2014001393A PE 20142337 A1 PE20142337 A1 PE 20142337A1
Authority
PE
Peru
Prior art keywords
phenyletoxy
difluoro
hydroxyethyl
phenyl
salts
Prior art date
Application number
PE2014001393A
Other languages
English (en)
Inventor
Duran Carlos Puig
Carrera Francesc Carrera
Garcia Juan Bautista Perez
Valls Enrique Moyes
Hereu Iolanda Marchueta
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of PE20142337A1 publication Critical patent/PE20142337A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

REFERIDA A UNA SAL DE ADICION CRISTALINA DE 5-[(1R)-2-({2-[4-(2,2-DIFLUORO-2-FENILETOXI)FENIL]ETIL}AMINO)-1-HIDROXIETIL]-8-HIDROXIQUINOLIN-2(1H)-ONA Y UN ACIDO DICARBOXILICO, SULFONICO O UNA SULFIMIDA DEL MISMO. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHA SAL Y PUEDE CONTENER OTRO AGENTE TERAPEUTICO TAL COMO UN CORTICOSTEROIDE, UN AGENTE ANTICOLINERGICO Y/O UN INHIBIDOR DE PDE4, DONDE EL CORTICOSTEROIDE ES PREDNISOLONA, BUDESONIDA, TRIAMCINOLONA, ENTRE OTROS, EL ANTICOLINERGICO ES SALES DE OXITROPIO, DE IPRATOPRIO, REVATROPATO, ENTRE OTROS Y EL INHIBIDOR DE PDE4 ES BENAFENTRINA, AROFILINA, ROLIPRAM, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES RESPIRATORIAS ASOCIADAS A LA ACTIVIDAD DEL RECEPTOR ADRENERGICO BETA2
PE2014001393A 2012-04-02 2013-03-28 Sales de 5-[(1r)-2-({2-[4-(2,2-difluoro-2-feniletoxi)fenil]etil}amino)-1-hidroxietil]-8-hidroxiquinolin-2(1h)-ona PE20142337A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12382134.0A EP2647627A1 (en) 2012-04-02 2012-04-02 Salts of 5-[(1r)-2-({2-[4-(2,2-difluoro-2-phenylethoxy)phenyl] ethyl}amino)-1-hydroxyethyl]-8-hydroxyquinolin-2(1h)-one.
US201261641465P 2012-05-02 2012-05-02

Publications (1)

Publication Number Publication Date
PE20142337A1 true PE20142337A1 (es) 2015-01-09

Family

ID=45926486

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014001393A PE20142337A1 (es) 2012-04-02 2013-03-28 Sales de 5-[(1r)-2-({2-[4-(2,2-difluoro-2-feniletoxi)fenil]etil}amino)-1-hidroxietil]-8-hidroxiquinolin-2(1h)-ona

Country Status (20)

Country Link
US (1) US20150065471A1 (es)
EP (2) EP2647627A1 (es)
JP (1) JP2015516386A (es)
KR (1) KR20150002613A (es)
CN (1) CN104245673A (es)
AR (1) AR090592A1 (es)
AU (1) AU2013245085A1 (es)
CA (1) CA2862957A1 (es)
CL (1) CL2014002558A1 (es)
CO (1) CO7081156A2 (es)
CR (1) CR20140462A (es)
EA (1) EA201401084A1 (es)
HK (1) HK1201833A1 (es)
IL (1) IL234742A0 (es)
MX (1) MX2014010799A (es)
PE (1) PE20142337A1 (es)
PH (1) PH12014502210A1 (es)
SG (1) SG11201405592TA (es)
UY (1) UY34722A (es)
WO (1) WO2013149959A1 (es)

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EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
PL3332767T3 (pl) * 2014-09-15 2019-10-31 Verona Pharma Plc Płynna formulacja wziewna zawierająca RPL554
GB201502260D0 (en) * 2015-02-11 2015-04-01 Verona Pharma Plc Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound
US10227271B2 (en) 2015-03-30 2019-03-12 Dow Global Technologies Llc Integrated C3—C4 hydrocarbon dehydrogenation process
CN104820028B (zh) * 2015-04-21 2020-12-08 重庆医药工业研究院有限责任公司 一种用液相色谱法分离测定阿普斯特及其对映异构体的方法
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CN110407769B (zh) * 2018-04-27 2022-11-08 复旦大学 3,4-二氢-苯并[f][1,4]硫氮杂䓬-5(2H)-酮类化合物及其药物用途

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Also Published As

Publication number Publication date
EA201401084A1 (ru) 2015-05-29
MX2014010799A (es) 2014-09-25
HK1201833A1 (en) 2015-09-11
EP2647627A1 (en) 2013-10-09
EP2834219A1 (en) 2015-02-11
CA2862957A1 (en) 2013-10-10
CR20140462A (es) 2014-10-31
SG11201405592TA (en) 2014-10-30
CN104245673A (zh) 2014-12-24
JP2015516386A (ja) 2015-06-11
CL2014002558A1 (es) 2014-11-28
PH12014502210A1 (en) 2015-01-12
IL234742A0 (en) 2014-11-30
UY34722A (es) 2013-09-30
AU2013245085A1 (en) 2014-09-11
WO2013149959A1 (en) 2013-10-10
AR090592A1 (es) 2014-11-26
KR20150002613A (ko) 2015-01-07
US20150065471A1 (en) 2015-03-05
CO7081156A2 (es) 2014-10-10

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