PE20141353A1 - Derivado de acido pirrolidin-3-ilacetico - Google Patents
Derivado de acido pirrolidin-3-ilaceticoInfo
- Publication number
- PE20141353A1 PE20141353A1 PE2014000266A PE2014000266A PE20141353A1 PE 20141353 A1 PE20141353 A1 PE 20141353A1 PE 2014000266 A PE2014000266 A PE 2014000266A PE 2014000266 A PE2014000266 A PE 2014000266A PE 20141353 A1 PE20141353 A1 PE 20141353A1
- Authority
- PE
- Peru
- Prior art keywords
- acid
- pyrrolidin
- alkyl
- methyl
- derivative
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 3
- -1 2,6-DICHLOROPHENYL Chemical class 0.000 abstract 2
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 206010009887 colitis Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE ACIDO PIRROLIDIN-3-ILACETICO DE FORMULA (1) DONDE R ES ALQUILO(C1-C6), CICLOALQUILO(C3-C8) O CICLOALQUENILO(C3-C8); X ES ALQUILO(C1-C6); Z E Y SON CADA UNO HALOGENO O ALQUILO(C1-C6); n ES 0 O 1. SON COMPUESTOS PREFERIDOS: ACIDO 2-[(3S,4R)-1-{[2-CLORO-6-(TRIFLUOROMETIL)FENIL]METIL}-3-{[1-(2-FLUOROPENTIL)PIPERIDIN-4-IL]CARBAMOIL}-4-METILPIRROLIDIN-3-IL]ACETICO; ACIDO 2-[(3S,4R)-1-[(2,6-DICLOROFENIL)METIL]-3-({1-[(4,4-DIFLUOROCICLOHEXIL)METIL]PIPERIDIN-4-IL}CARBAMOIL)-4-METILPIRROLIDIN-3-IL]ACETICO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN UN EFECTO INHIBIDOR EN LA RUTA DE FRACTALCINA-CX3CR1 SIENDO UTILES EN EL TRATAMIENTO DE COLITIS ULCEROSA, ENFERMEDAD DE CROHN
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011199482 | 2011-09-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20141353A1 true PE20141353A1 (es) | 2014-09-26 |
Family
ID=47883287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014000266A PE20141353A1 (es) | 2011-09-13 | 2012-09-11 | Derivado de acido pirrolidin-3-ilacetico |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP2757103B1 (es) |
| JP (1) | JP5829689B2 (es) |
| KR (1) | KR101963922B1 (es) |
| CN (1) | CN103764648B (es) |
| AR (1) | AR087788A1 (es) |
| AU (1) | AU2012309556B2 (es) |
| BR (1) | BR112014004267B1 (es) |
| CA (1) | CA2844617C (es) |
| CL (1) | CL2014000484A1 (es) |
| CY (1) | CY1117460T1 (es) |
| DK (1) | DK2757103T3 (es) |
| ES (1) | ES2564732T3 (es) |
| HR (1) | HRP20160166T1 (es) |
| HU (1) | HUE026824T2 (es) |
| IL (1) | IL230804A (es) |
| JO (1) | JO3082B1 (es) |
| ME (1) | ME02383B (es) |
| MX (1) | MX358494B (es) |
| MY (1) | MY169869A (es) |
| PE (1) | PE20141353A1 (es) |
| PH (1) | PH12014500212A1 (es) |
| PL (1) | PL2757103T3 (es) |
| PT (1) | PT2757103E (es) |
| RS (1) | RS54582B1 (es) |
| RU (1) | RU2615135C2 (es) |
| SG (1) | SG11201400163WA (es) |
| SI (1) | SI2757103T1 (es) |
| SM (1) | SMT201600071B (es) |
| TW (1) | TWI543975B (es) |
| UA (1) | UA112873C2 (es) |
| WO (1) | WO2013039057A1 (es) |
| ZA (1) | ZA201400918B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150129698A (ko) * | 2013-03-12 | 2015-11-20 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 피롤리딘-3-일 아세트산 유도체의 염 및 그의 결정 |
| WO2014142086A1 (ja) * | 2013-03-13 | 2014-09-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピロリジン－３－イル酢酸誘導体およびピペリジン－３－イル酢酸誘導体 |
| KR20250086780A (ko) | 2022-10-19 | 2025-06-13 | 아스트라제네카 아베 | Cx3cr1 조절제로서의 2,4,6-삼중치환된 1,3,5-트리아진 |
| WO2025219939A1 (en) | 2024-04-17 | 2025-10-23 | Astrazeneca Ab | Salts and polymorphs of cx3cr1 modulators |
| WO2025219947A1 (en) | 2024-04-18 | 2025-10-23 | Astrazeneca Ab | Thio-substituted 1,3,5-triazine cx3cr1 modulators |
| WO2025219950A1 (en) | 2024-04-18 | 2025-10-23 | Astrazeneca Ab | Small molecule cx3cr1 modulators |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4263391B2 (ja) | 2001-03-19 | 2009-05-13 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗ｃｘ３ｃｒ１抗体、抗フラクタルカイン抗体及びフラクタルカインの利用 |
| US20050143372A1 (en) | 2001-10-30 | 2005-06-30 | Shomir Ghosh | Compounds, pharmaceutical compositions and methods of use therefor |
| US20070142386A1 (en) * | 2003-10-07 | 2007-06-21 | Astrazeneca | New 2-substituted, 4-amino-thiazolo[4,5-d] pyrimidines, useful as chemokine receptor antagonists, esp. cx3cr1 |
| AR053347A1 (es) * | 2005-04-06 | 2007-05-02 | Astrazeneca Ab | Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos |
| UA90707C2 (en) | 2005-04-06 | 2010-05-25 | Астразенека Аб | Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives |
| AU2007300749B2 (en) | 2006-09-29 | 2011-08-25 | Astrazeneca Ab | Novel 5,7-disubstituted [1, 3] thiazolo [4, 5] pyrimidin-2 (3H)-amine derivatives and their use in therapy |
| TW200820973A (en) | 2006-09-29 | 2008-05-16 | Astrazeneca Ab | Novel compounds 480 |
| TW200831497A (en) * | 2006-10-12 | 2008-08-01 | Epix Delaware Inc | Carboxamide compounds and their use |
| HRP20160457T1 (hr) * | 2008-03-07 | 2016-05-20 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Derivati 1-benzil-3-hidroksimetilindazola i njihova uporaba u liječenju bolesti baziranih na ekspresiji mcp-1 i cx3cr1 |
| AR071036A1 (es) | 2008-03-26 | 2010-05-19 | Astrazeneca Ab | Derivados 5, 7-disustituidos de [1, 3]tiazolo[4, 5-d]pirimidin-2 (3h)-ona, una composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por el receptor cx3cr1. |
-
2012
- 2012-09-05 JO JOP/2012/0251A patent/JO3082B1/ar active
- 2012-09-05 TW TW101132401A patent/TWI543975B/zh not_active IP Right Cessation
- 2012-09-06 AR ARP120103280A patent/AR087788A1/es active IP Right Grant
- 2012-09-11 RS RS20160106A patent/RS54582B1/sr unknown
- 2012-09-11 BR BR112014004267-5A patent/BR112014004267B1/pt not_active IP Right Cessation
- 2012-09-11 MY MYPI2014700213A patent/MY169869A/en unknown
- 2012-09-11 CA CA2844617A patent/CA2844617C/en active Active
- 2012-09-11 KR KR1020147003630A patent/KR101963922B1/ko not_active Expired - Fee Related
- 2012-09-11 PE PE2014000266A patent/PE20141353A1/es active IP Right Grant
- 2012-09-11 ME MEP-2016-37A patent/ME02383B/me unknown
- 2012-09-11 WO PCT/JP2012/073171 patent/WO2013039057A1/ja not_active Ceased
- 2012-09-11 PL PL12831085T patent/PL2757103T3/pl unknown
- 2012-09-11 SG SG11201400163WA patent/SG11201400163WA/en unknown
- 2012-09-11 CN CN201280041634.0A patent/CN103764648B/zh not_active Expired - Fee Related
- 2012-09-11 SI SI201230463T patent/SI2757103T1/sl unknown
- 2012-09-11 PH PH1/2014/500212A patent/PH12014500212A1/en unknown
- 2012-09-11 RU RU2014107536A patent/RU2615135C2/ru active
- 2012-09-11 MX MX2014002210A patent/MX358494B/es active IP Right Grant
- 2012-09-11 HR HRP20160166TT patent/HRP20160166T1/hr unknown
- 2012-09-11 PT PT128310851T patent/PT2757103E/pt unknown
- 2012-09-11 AU AU2012309556A patent/AU2012309556B2/en not_active Ceased
- 2012-09-11 DK DK12831085.1T patent/DK2757103T3/en active
- 2012-09-11 ES ES12831085.1T patent/ES2564732T3/es active Active
- 2012-09-11 HU HUE12831085A patent/HUE026824T2/en unknown
- 2012-09-11 EP EP12831085.1A patent/EP2757103B1/en active Active
- 2012-09-11 JP JP2013533669A patent/JP5829689B2/ja not_active Expired - Fee Related
- 2012-11-09 UA UAA201401661A patent/UA112873C2/uk unknown
-
2014
- 2014-02-03 IL IL230804A patent/IL230804A/en active IP Right Grant
- 2014-02-06 ZA ZA2014/00918A patent/ZA201400918B/en unknown
- 2014-02-27 CL CL2014000484A patent/CL2014000484A1/es unknown
-
2016
- 2016-03-10 SM SM201600071T patent/SMT201600071B/xx unknown
- 2016-03-16 CY CY20161100224T patent/CY1117460T1/el unknown
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