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PE20130234A1 - Derivados de heteroaril imidazolona como inhibidores de jak - Google Patents

Derivados de heteroaril imidazolona como inhibidores de jak

Info

Publication number
PE20130234A1
PE20130234A1 PE2012002212A PE2012002212A PE20130234A1 PE 20130234 A1 PE20130234 A1 PE 20130234A1 PE 2012002212 A PE2012002212 A PE 2012002212A PE 2012002212 A PE2012002212 A PE 2012002212A PE 20130234 A1 PE20130234 A1 PE 20130234A1
Authority
PE
Peru
Prior art keywords
imidazo
dihydro
alkyl
carbonitrile
oxo
Prior art date
Application number
PE2012002212A
Other languages
English (en)
Inventor
Paul Robert Eastwood
Rodriguez Jacob Gonzales
Castillo Elena Gomez
Tana Jordi Bach
Original Assignee
Almirall Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43028230&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20130234(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Almirall Sa filed Critical Almirall Sa
Publication of PE20130234A1 publication Critical patent/PE20130234A1/es

Links

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/04—Ortho-condensed systems

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  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE HETEROARIL IMIDAZOLONA DE FORMULA (I) DONDE m Y p SON CADA UNO DE 0 A 3; Z Y V SON CADA UNO N O C; W ES N O CR3; W' ES N O CR2; W'' ES N O CR4; X E Y SON CADA UNO N O CR5; Y' ES N O CR5, EN DONDE R1, R2, R3, R4 Y R5 SON CADA UNO H, HALOGENO, CN, ALQUILO(C1-C6), ALQUENILO(C2-C4), CICLOALQUILO(C3-C10), ENTRE OTROS; R6, R7, R9 Y R10 SON CADA UNO H, HIDROXIALQUILO(C1-C4), ALQUIL(C1-C4)-O-ALQUILO(C1-C4), ENTRE OTROS; R8 Y R11 SON CADA UNO H, HALOGENO, ALQUILO(C1-C6), ALQUINILO(C2-C4), ARILO(C5-C14), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-[8-OXO-9-(TETRAHIDRO-2H-PIRAN-4-IL)-8,9-DIHIDRO-7H-PURIN-2-IL]IMIDAZO[1,2-a]PIRIDINA-6-CARBONITRILO; 3-[3-(2-METILCICLOHEXIL)-2-OXO-2,3-DIHIDRO-1H-IMIDAZO[4,5-b]PIRIDIN-5-IL]IMIDAZO[1,2-a]PIRIDINA-6-CARBONITRILO; 3-{9-[(4R)-8-FLUORO-3,4-DIHIDRO-2H-CROMEN-4-IL]-8-OXO-8,9-DIHIDRO-7H-PURIN-2-IL}IMIDAZO[1,2-a]PIRIDINA-6-CARBONITRILO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE JAK1, JAK2 Y JAK3 SIENDO UTILES EN EL TRATAMIENTO DE POLICITEMIA VERA, MIELOFIBROSIS, ARTRITIS REUMATOIDE, ESCLEROSIS MULTIPLE
PE2012002212A 2010-06-15 2011-06-14 Derivados de heteroaril imidazolona como inhibidores de jak PE20130234A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10382174A EP2397482A1 (en) 2010-06-15 2010-06-15 Heteroaryl imidazolone derivatives as jak inhibitors
US36505910P 2010-07-16 2010-07-16

Publications (1)

Publication Number Publication Date
PE20130234A1 true PE20130234A1 (es) 2013-03-07

Family

ID=43028230

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012002212A PE20130234A1 (es) 2010-06-15 2011-06-14 Derivados de heteroaril imidazolona como inhibidores de jak

Country Status (22)

Country Link
US (1) US20130089512A1 (es)
EP (2) EP2397482A1 (es)
JP (1) JP2013528630A (es)
KR (1) KR20130113331A (es)
CN (1) CN102933583A (es)
AR (1) AR081932A1 (es)
AU (1) AU2011267385A1 (es)
BR (1) BR112012032234A2 (es)
CA (1) CA2802588A1 (es)
CL (1) CL2012003564A1 (es)
CO (1) CO6640257A2 (es)
CR (1) CR20120634A (es)
EA (1) EA201201677A1 (es)
GT (1) GT201200321A (es)
MX (1) MX2012014017A (es)
PE (1) PE20130234A1 (es)
PH (1) PH12012502334A1 (es)
SG (1) SG186163A1 (es)
TW (1) TW201201811A (es)
UY (1) UY33454A (es)
WO (1) WO2011157397A1 (es)
ZA (1) ZA201207636B (es)

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