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PE20121336A1 - Nuevos compuestos triciclicos - Google Patents

Nuevos compuestos triciclicos

Info

Publication number
PE20121336A1
PE20121336A1 PE2012000745A PE2012000745A PE20121336A1 PE 20121336 A1 PE20121336 A1 PE 20121336A1 PE 2012000745 A PE2012000745 A PE 2012000745A PE 2012000745 A PE2012000745 A PE 2012000745A PE 20121336 A1 PE20121336 A1 PE 20121336A1
Authority
PE
Peru
Prior art keywords
triazolo
alpha
methyl
tricyclic compounds
pyrazin
Prior art date
Application number
PE2012000745A
Other languages
English (en)
Inventor
Neil Wishart
Maria A Argiriadi
David J Calderwood
Anna M Ericsson
Bryan A Fiamengo
Kristine E Frank
Michael Friedman
Dawn M George
Eric R Goedken
Nathan S Josephsohn
Biqin C Li
Michael J Morytko
Kent D Stewart
Jeffrey W Voss
Grier A Wallace
Lu Wang
Kevin R Woller
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44070404&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20121336(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of PE20121336A1 publication Critical patent/PE20121336A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract

REFERIDA A UN COMPUESTO TRICICLICO DE FORMULA (I), DONDE T ES N, CR6, O, NR6, S; U ES N O CR4; X ES CR3 O NR3; Y ES N O C; R1, R2 Y R5 SON H, DEUTERIO, HALOGENO, NO2, ENTRE OTROS; R3 ES H, CICLOALQUILO C5-C12, ALQUILO C1-C8, ENTRE OTROS; R4 Y R6 SON H, HALOGENO, DEUTERIO, CF3, CHF2, CH2F, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-(1-((6H-PIRROLO[2,3-e][1,2,4]TRIAZOLO[4,3-ALFA]PIRAZIN-1-IL)METIL)CICLOBUTIL)-2-CIANOACETAMIDA, (S)-1-((1-(CICLOPROPILSULFONIL)PIRROLIDIN-3-IL)METIL)-6H-PIRROLO[2,3-e][1,2,4]TRIAZOLO[4,3-ALFA]PIRAZINA, (S)-5-(3-((6H-PIRROLO[2,3-e][1,2,4]TRIAZOLO[4,3-ALFA]PIRAZIN-1-IL)METIL)PIRROLIDIN-1-IL)PIRAZIN-2-CARBONITRILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES, ENFERMEDADES AUTOINMUNES, CANCER, ENTRE OTROS
PE2012000745A 2009-12-01 2010-12-01 Nuevos compuestos triciclicos PE20121336A1 (es)

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