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PE20120110A1 - [1,2,4]triazolo[1,5-a]piridinas como inhibidores de cinasa - Google Patents

[1,2,4]triazolo[1,5-a]piridinas como inhibidores de cinasa

Info

Publication number
PE20120110A1
PE20120110A1 PE2011001470A PE2011001470A PE20120110A1 PE 20120110 A1 PE20120110 A1 PE 20120110A1 PE 2011001470 A PE2011001470 A PE 2011001470A PE 2011001470 A PE2011001470 A PE 2011001470A PE 20120110 A1 PE20120110 A1 PE 20120110A1
Authority
PE
Peru
Prior art keywords
triazolo
pyridines
kinase inhibitors
phenylamine
pyridin
Prior art date
Application number
PE2011001470A
Other languages
English (en)
Inventor
Caroline Leriche
Eric Auclair
Jacques Le Roux
David Middlemiss
Original Assignee
Fovea Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42229029&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120110(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fovea Pharmaceuticals filed Critical Fovea Pharmaceuticals
Publication of PE20120110A1 publication Critical patent/PE20120110A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE [1,2,4]TRIAZOLO[1,5-a]PIRIDINAS DE FORMULA (I) DONDE A1 Y A2 SON CADA UNO N O C; R1 Y R2 SON CADA UNO H, ALQUILO(C1-C4), ARILO, HALOGENO, ENTRE OTROS; R3 ES H, ALQUILO(C1-C4), CICLOALQUILO, ARILO, CN, ENTRE OTROS; X ES UN ENLACE O (CH2)aW(CH2)b, (CH2)aW(CH2)bY(CH2)c, ENTRE OTROS, EN DONDE a, b Y c SON CADA UNO DE 0 A 3; W E Y SON CADA UNO -CO-, -O-, -SO2-, -CH2-, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: CLORHIDRATO DE 4-CLORO-3-{2-[4-(2-PIRROLIDIN-1-IL-ETOXI)-FENILAMINO]-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-6-IL}-FENOL; CLORHIDRATO DE 4-CLORO-3-{8-METIL-2-[4-(2-PIRROLIDIN-1-IL-ETOXI)-FENILAMINO]-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-6-IL}-FENOL; 4-CLORO-3-{2-[4-(2-MORFOLIN-4-IL-ETOXI)-FENILAMINO]-[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-6-IL}-FENOL; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE CINASA SIENDO UTILES EN EL TRATAMIENTO DE INFARTO DE MIOCARDIO, CANCER, ARTRITIS, RETINOPATIA, GLAUCOMA
PE2011001470A 2009-02-13 2010-02-09 [1,2,4]triazolo[1,5-a]piridinas como inhibidores de cinasa PE20120110A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09360013 2009-02-13

Publications (1)

Publication Number Publication Date
PE20120110A1 true PE20120110A1 (es) 2012-02-20

Family

ID=42229029

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001470A PE20120110A1 (es) 2009-02-13 2010-02-09 [1,2,4]triazolo[1,5-a]piridinas como inhibidores de cinasa

Country Status (24)

Country Link
US (1) US20120041195A1 (es)
EP (1) EP2396324A1 (es)
JP (1) JP2012517971A (es)
KR (1) KR20110116160A (es)
CN (1) CN102317288A (es)
AR (1) AR075411A1 (es)
BR (1) BRPI1008850A2 (es)
CA (1) CA2751517A1 (es)
CL (1) CL2011001947A1 (es)
CO (1) CO6420343A2 (es)
CR (1) CR20110386A (es)
DO (1) DOP2011000248A (es)
EA (1) EA201101188A1 (es)
EC (1) ECSP11011250A (es)
HN (1) HN2011002095A (es)
IL (1) IL214426A0 (es)
MX (1) MX2011008549A (es)
NI (1) NI201100151A (es)
NZ (1) NZ594508A (es)
PE (1) PE20120110A1 (es)
SG (1) SG173610A1 (es)
TN (1) TN2011000379A1 (es)
WO (1) WO2010092041A1 (es)
ZA (1) ZA201105896B (es)

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BRPI1009637A2 (pt) 2009-06-05 2019-04-30 Cephalon, Inc composto, composição e uso de um composto
EP2343297A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
EP2343295A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridine derivates
EP2343294A1 (en) 2009-11-30 2011-07-13 Bayer Schering Pharma AG Substituted triazolopyridines
UY33452A (es) * 2010-06-16 2012-01-31 Bayer Schering Pharma Ag Triazolopiridinas sustituidas
TW201204723A (en) * 2010-06-22 2012-02-01 Fovea Pharmaceuticals Heterocyclic compounds, their preparation and their therapeutic application
JP5989091B2 (ja) * 2011-04-21 2016-09-07 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ トリアゾロピリジン類
WO2012160029A1 (en) 2011-05-23 2012-11-29 Bayer Intellectual Property Gmbh Substituted triazolopyridines
UA112096C2 (uk) 2011-12-12 2016-07-25 Байєр Інтеллектуал Проперті Гмбх Заміщені триазолопіридини та їх застосування як інгібіторів ttk
KR20130091464A (ko) 2012-02-08 2013-08-19 한미약품 주식회사 타이로신 카이네이즈 억제 활성을 갖는 트리아졸로피리딘 유도체
JP6166289B2 (ja) 2012-03-14 2017-07-19 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 置換イミダゾピリダジン
EA027544B1 (ru) 2012-07-10 2017-08-31 Байер Фарма Акциенгезельшафт Способ получения замещенных триазолопиридинов
WO2014020043A1 (en) 2012-08-02 2014-02-06 Bayer Pharma Aktiengesellschaft Combinations for the treatment of cancer
HUE033131T2 (en) 2013-06-11 2017-11-28 Bayer Pharma AG Derivatives of substituted triazolopyridines
US20230055321A1 (en) * 2019-11-22 2023-02-23 Medshine Discovery Inc. Pyrimidopyrrole spiro compounds and derivatives thereof as dna-pk inhibitors

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US7268136B2 (en) * 2002-12-18 2007-09-11 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
BRPI0406809A (pt) 2003-01-17 2005-12-27 Warner Lambert Co Heterociclos substituìdos de 2-aminopiridina como inibidores da proliferação celular
CN1897950A (zh) * 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
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Also Published As

Publication number Publication date
EP2396324A1 (en) 2011-12-21
US20120041195A1 (en) 2012-02-16
WO2010092041A1 (en) 2010-08-19
MX2011008549A (es) 2011-12-06
IL214426A0 (en) 2011-09-27
SG173610A1 (en) 2011-09-29
CO6420343A2 (es) 2012-04-16
EA201101188A1 (ru) 2012-04-30
HN2011002095A (es) 2014-01-06
CR20110386A (es) 2011-12-02
CN102317288A (zh) 2012-01-11
CA2751517A1 (en) 2010-08-19
ZA201105896B (en) 2012-03-28
ECSP11011250A (es) 2011-10-31
NI201100151A (es) 2012-10-03
NZ594508A (en) 2013-12-20
DOP2011000248A (es) 2011-10-31
BRPI1008850A2 (pt) 2016-03-15
CL2011001947A1 (es) 2012-03-16
KR20110116160A (ko) 2011-10-25
TN2011000379A1 (en) 2013-03-27
JP2012517971A (ja) 2012-08-09
AR075411A1 (es) 2011-03-30

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