PE20110562A1 - Produccion y almacenamiento mejorados de proteinas en plantas - Google Patents
Produccion y almacenamiento mejorados de proteinas en plantasInfo
- Publication number
- PE20110562A1 PE20110562A1 PE2010001207A PE2010001207A PE20110562A1 PE 20110562 A1 PE20110562 A1 PE 20110562A1 PE 2010001207 A PE2010001207 A PE 2010001207A PE 2010001207 A PE2010001207 A PE 2010001207A PE 20110562 A1 PE20110562 A1 PE 20110562A1
- Authority
- PE
- Peru
- Prior art keywords
- seed
- deficiency
- protein
- seed storage
- proteins
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108010016634 Seed Storage Proteins Proteins 0.000 abstract 4
- 230000007812 deficiency Effects 0.000 abstract 2
- 230000009261 transgenic effect Effects 0.000 abstract 2
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 108700026244 Open Reading Frames Proteins 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 208000008425 Protein deficiency Diseases 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000031787 nutrient reservoir activity Effects 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 229940083466 soybean lecithin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8251—Amino acid content, e.g. synthetic storage proteins, altering amino acid biosynthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8222—Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
- C12N15/823—Reproductive tissue-specific promoters
- C12N15/8234—Seed-specific, e.g. embryo, endosperm
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nutrition Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
REFERIDA A UNA PLANTA TRANSGENICA, CARACTERIZADA PORQUE COMPRENDE: A) UNA DEFICIENCIA DE UNA O MAS PROTEINAS DE ALMACENAMIENTO DE SEMILLA, DONDE LA DEFICIENCIA SE TRADUCE EN UNA REDUCCION DE LA MENOS DE AL MENOS 50% EN PROTEINA DE ALMACENAMIENTO DE SEMILLA ENDOGENA EN COMPARACION CON AQUELLA SILVESTRE; B) UN POLINUCLEOTIDO HETEROLOGO QUE COMPRENDE UN PROMOTOR DE PROTEINA DE ALMACENAMIENTO DE SEMILLA, UN MARCO DE LECTURA ABIERTO QUE COMPRENDE UNA SECUENCIA DE SENAL ER ENLAZADO OPERABLEMENTE AL PROMOTOR DE PROTEINA DE ALMACENAMIENTO DE SEMILLA. DICHA PLANTA TRANSGENICA ES CAPAZ DE PRODUCIR UNA PROTEINA HETEROLOGA A UN NIVEL QUE ES MAYOR A 5% DEL PESO SECO TOTAL DE LA SEMILLA. DICHA SEMILLA ES SOYA Y LA DEFICIENCIA DE PROTEINA DE ALMACENAMIENTO ES DE UNO O MAS DE INHIBIDOR DE TRIPSINA KUNITZ, LECITINA DE SOYA, PROTEINA DE UNION A GLUCOSA, ENTRE OTROS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7661608P | 2008-06-28 | 2008-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110562A1 true PE20110562A1 (es) | 2011-08-11 |
Family
ID=41444990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010001207A PE20110562A1 (es) | 2008-06-28 | 2009-06-29 | Produccion y almacenamiento mejorados de proteinas en plantas |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20100313307A1 (es) |
| EP (1) | EP2307547A4 (es) |
| JP (1) | JP2011526155A (es) |
| KR (1) | KR20110044211A (es) |
| CN (1) | CN102137932A (es) |
| AP (1) | AP2011005557A0 (es) |
| AR (1) | AR072391A1 (es) |
| AU (1) | AU2009261943A1 (es) |
| BR (1) | BRPI0914824A2 (es) |
| CA (1) | CA2729375A1 (es) |
| CL (1) | CL2010001598A1 (es) |
| CO (1) | CO6341485A2 (es) |
| CU (1) | CU20100263A7 (es) |
| DO (1) | DOP2010000399A (es) |
| EA (1) | EA201170104A1 (es) |
| EC (1) | ECSP11010793A (es) |
| IL (1) | IL210210A0 (es) |
| MX (1) | MX2010014541A (es) |
| PE (1) | PE20110562A1 (es) |
| WO (2) | WO2009158694A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8741591B2 (en) | 2009-10-09 | 2014-06-03 | The Research Foundation For The State University Of New York | pH-insensitive glucose indicator protein |
| DK2622069T3 (en) | 2010-10-01 | 2016-02-22 | Novozymes Inc | Beta-glucosidasevarianter and polynucleotides encoding them |
| JP5809810B2 (ja) * | 2011-02-22 | 2015-11-11 | 本田技研工業株式会社 | タンパク質の植物細胞内への蓄積方法 |
| CA2859490A1 (en) | 2012-04-05 | 2013-10-10 | Basf Plant Science Company Gmbh | Fungal resistant plants expressing hydrophobin |
| BR112015009201A2 (pt) * | 2012-10-31 | 2017-11-14 | Danisco Us Inc | composição compreendeendo um polipeptídeo recombinante, ácido nucleico codificando o mesmo, célula hospedeira, bem como métodos para produzir uma beta-glucosidase e para hidrolisar um substrato de biomassa lignocelulósica |
| KR101449155B1 (ko) * | 2012-12-06 | 2014-10-13 | 주식회사 바이오앱 | 식물체에서 목적 단백질의 번역 효율을 증진시키기 위한 염기서열 |
| CN106480089A (zh) * | 2016-12-30 | 2017-03-08 | 上海交通大学 | 一种提高大豆含硫氨基酸含量及降低过敏原蛋白的方法 |
| CN109486851B (zh) * | 2018-10-12 | 2022-04-01 | 武汉禾元生物科技股份有限公司 | 一种提高胚乳生物反应器中重组蛋白表达水平的方法 |
| CN109220805A (zh) * | 2018-11-05 | 2019-01-18 | 贵州大学 | 一种红豆树组培苗瓶外生根方法 |
| IL265841A (en) * | 2019-04-03 | 2020-10-28 | Yeda Res & Dev | A plant that expresses animal milk proteins |
| KR102213745B1 (ko) | 2019-04-16 | 2021-02-09 | 주식회사 바이오앱 | 돼지 유행성 설사병 바이러스 백신 조성물 및 이의 제조 방법 |
| CN110122333A (zh) * | 2019-06-17 | 2019-08-16 | 西安同人五凤农业有限公司 | 一种凤凰木种子促进发芽生根的方法 |
| WO2020256372A1 (ko) | 2019-06-17 | 2020-12-24 | 주식회사 바이오앱 | 아프리카 돼지열병의 진단을 위한 항원 생산용 재조합 벡터 및 이의 용도 |
| US11326176B2 (en) * | 2019-11-22 | 2022-05-10 | Mozza Foods, Inc. | Recombinant micelle and method of in vivo assembly |
| US12359212B2 (en) | 2019-11-22 | 2025-07-15 | Mozza Foods, Inc. | Recombinant micelle and method of in vivo assembly |
| US20230380373A1 (en) * | 2020-10-28 | 2023-11-30 | Pioneer Hi-Bred International, Inc. | Leghemoglobin in soybean |
| WO2022093977A1 (en) * | 2020-10-30 | 2022-05-05 | Fortiphyte, Inc. | Pathogen resistance in plants |
| KR102630105B1 (ko) * | 2020-11-26 | 2024-01-29 | 전남대학교산학협력단 | Cel12A 단백질을 포함하는 셀룰로오스 분해용 조성물 및 이의 제조방법 |
| WO2023027402A1 (ko) | 2021-08-27 | 2023-03-02 | 주식회사 바이오앱 | 아프리카 돼지열병 바이러스 유래 항원 단백질을 포함하는 아프리카 돼지열병의 예방용 백신 |
| WO2023076272A1 (en) * | 2021-10-25 | 2023-05-04 | The Regents Of The University Of California | Vectors and methods for improved dicot plant transformation frequency |
| AU2023272468A1 (en) | 2022-05-14 | 2024-11-14 | Novonesis Plant Biosolutions A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
| KR20250014003A (ko) * | 2023-07-18 | 2025-02-03 | 메디프로젠 주식회사 | 저장단백질 함량이 저감된 콩 형질전환체 및 이의 용도 |
| KR102726138B1 (ko) | 2023-10-17 | 2024-11-14 | 대한민국 | 백시니아 바이러스 재조합 a33r 단백질 및 이를 포함하는 오르소폭스바이러스 항체 진단 키트 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2092069A1 (en) * | 1992-03-27 | 1993-09-28 | Asako Iida | An expression plasmid for seeds |
| US6326527B1 (en) * | 1993-08-25 | 2001-12-04 | Dekalb Genetics Corporation | Method for altering the nutritional content of plant seed |
| US5850016A (en) * | 1996-03-20 | 1998-12-15 | Pioneer Hi-Bred International, Inc. | Alteration of amino acid compositions in seeds |
| ATE347604T1 (de) * | 1996-06-14 | 2006-12-15 | Du Pont | Suppressi0n spezifischer klassen von soja- sojasamenproteingenen |
| JP3451284B2 (ja) * | 2000-06-15 | 2003-09-29 | 名古屋大学長 | ファイトスルフォカイン前駆体遺伝子のプロモーター |
| US7615624B2 (en) * | 2000-06-23 | 2009-11-10 | Syngenta Participations Ag | Arabidopsis derived promoters for regulation of plant expression |
| US6855871B2 (en) * | 2000-08-21 | 2005-02-15 | Pioneer Hi-Bred International, Inc. | Methods of increasing polypeptide accumulation in plants |
| JP4565231B2 (ja) * | 2000-08-22 | 2010-10-20 | 独立行政法人農業生物資源研究所 | 外来遺伝子産物を植物の種子中に高度に蓄積させる方法 |
| AU2002244071A1 (en) * | 2001-02-14 | 2002-08-28 | Ventria Bioscience | Expression system for seed proteins |
| EP1402038A2 (en) * | 2001-06-22 | 2004-03-31 | Syngenta Participations AG | Identification and characterization of plant genes |
| WO2004027070A2 (de) * | 2002-09-03 | 2004-04-01 | Sungene Gmbh & Co. Kgaa | Transgene expressionskassetten zur expression von nukleinsäuren in nicht-reproduktiven blütengeweben von pflanzen |
| CA2410702A1 (en) * | 2002-11-26 | 2004-05-26 | Illimar Altosaar | Production of human granulocyte macrophage-colony stimulating factor (gm-csf) in the seeds of transgenic rice plants |
| EP1668137B8 (en) * | 2003-08-27 | 2012-03-21 | ORF Liftaekni HF. | Enhancing accumulation of heterologous polypeptides in plant seeds through targeted suppression of endogenous storage proteins |
| BRPI0508518A (pt) * | 2004-03-08 | 2007-08-14 | Syngenta Participations Ag | proteìna e promotor de semente de milho rica em glutamina |
| EP1896593A4 (en) * | 2005-05-09 | 2010-07-28 | Univ Fraser Simon | IMPROVED VEGETATIVE PROTEIN PRODUCTION IN TRANSGENIC PLANT CELLS USING SEED-SPECIFIC PROMOTERS |
-
2009
- 2009-06-28 US US12/493,231 patent/US20100313307A1/en not_active Abandoned
- 2009-06-28 WO PCT/US2009/048989 patent/WO2009158694A1/en not_active Ceased
- 2009-06-29 BR BRPI0914824A patent/BRPI0914824A2/pt not_active IP Right Cessation
- 2009-06-29 CA CA2729375A patent/CA2729375A1/en not_active Abandoned
- 2009-06-29 JP JP2011516781A patent/JP2011526155A/ja not_active Withdrawn
- 2009-06-29 CN CN2009801330877A patent/CN102137932A/zh active Pending
- 2009-06-29 AU AU2009261943A patent/AU2009261943A1/en not_active Abandoned
- 2009-06-29 AP AP2011005557A patent/AP2011005557A0/xx unknown
- 2009-06-29 AR ARP090102400A patent/AR072391A1/es not_active Application Discontinuation
- 2009-06-29 EP EP09771247A patent/EP2307547A4/en not_active Withdrawn
- 2009-06-29 EA EA201170104A patent/EA201170104A1/ru unknown
- 2009-06-29 KR KR1020117002119A patent/KR20110044211A/ko not_active Withdrawn
- 2009-06-29 PE PE2010001207A patent/PE20110562A1/es not_active Application Discontinuation
- 2009-06-29 WO PCT/US2009/049097 patent/WO2009158716A1/en not_active Ceased
- 2009-06-29 MX MX2010014541A patent/MX2010014541A/es not_active Application Discontinuation
-
2010
- 2010-12-22 DO DO2010000399A patent/DOP2010000399A/es unknown
- 2010-12-23 IL IL210210A patent/IL210210A0/en unknown
- 2010-12-28 CU CU20100263A patent/CU20100263A7/es unknown
- 2010-12-28 CL CL2010001598A patent/CL2010001598A1/es unknown
-
2011
- 2011-01-27 CO CO11009269A patent/CO6341485A2/es not_active Application Discontinuation
- 2011-01-28 EC EC2011010793A patent/ECSP11010793A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2010001598A1 (es) | 2011-07-15 |
| ECSP11010793A (es) | 2011-07-29 |
| AP2011005557A0 (en) | 2011-02-28 |
| BRPI0914824A2 (pt) | 2015-12-01 |
| MX2010014541A (es) | 2011-07-29 |
| WO2009158716A1 (en) | 2009-12-30 |
| CA2729375A1 (en) | 2009-12-30 |
| EP2307547A4 (en) | 2011-06-22 |
| CN102137932A (zh) | 2011-07-27 |
| EP2307547A1 (en) | 2011-04-13 |
| WO2009158694A1 (en) | 2009-12-30 |
| KR20110044211A (ko) | 2011-04-28 |
| CO6341485A2 (es) | 2011-11-21 |
| EA201170104A1 (ru) | 2011-08-30 |
| DOP2010000399A (es) | 2012-11-15 |
| JP2011526155A (ja) | 2011-10-06 |
| CU20100263A7 (es) | 2012-06-21 |
| AU2009261943A1 (en) | 2009-12-30 |
| US20100313307A1 (en) | 2010-12-09 |
| AR072391A1 (es) | 2010-08-25 |
| IL210210A0 (en) | 2011-03-31 |
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