PE20110407A1 - Composicion farmaceutica que comprende una sal de estroncio, vitamina d y una ciclodextrina - Google Patents
Composicion farmaceutica que comprende una sal de estroncio, vitamina d y una ciclodextrinaInfo
- Publication number
- PE20110407A1 PE20110407A1 PE2010001074A PE2010001074A PE20110407A1 PE 20110407 A1 PE20110407 A1 PE 20110407A1 PE 2010001074 A PE2010001074 A PE 2010001074A PE 2010001074 A PE2010001074 A PE 2010001074A PE 20110407 A1 PE20110407 A1 PE 20110407A1
- Authority
- PE
- Peru
- Prior art keywords
- strontium
- vitamin
- cyclodextrin
- pharmaceutical composition
- beta
- Prior art date
Links
- 229920000858 Cyclodextrin Polymers 0.000 title abstract 5
- 229940088594 vitamin Drugs 0.000 title abstract 3
- 239000011782 vitamin Substances 0.000 title abstract 3
- 229930003231 vitamin Natural products 0.000 title abstract 3
- 235000013343 vitamin Nutrition 0.000 title abstract 3
- 150000003722 vitamin derivatives Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title abstract 2
- 159000000008 strontium salts Chemical class 0.000 title abstract 2
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 239000001116 FEMA 4028 Substances 0.000 abstract 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 abstract 1
- 229960004853 betadex Drugs 0.000 abstract 1
- 229940097362 cyclodextrins Drugs 0.000 abstract 1
- 239000007938 effervescent tablet Substances 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- MLCQLNYCRIEWMX-ZZMNMWMASA-L strontium (2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-olate Chemical compound [Sr+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] MLCQLNYCRIEWMX-ZZMNMWMASA-L 0.000 abstract 1
- XXUZFRDUEGQHOV-UHFFFAOYSA-J strontium ranelate Chemical compound [Sr+2].[Sr+2].[O-]C(=O)CN(CC([O-])=O)C=1SC(C([O-])=O)=C(CC([O-])=O)C=1C#N XXUZFRDUEGQHOV-UHFFFAOYSA-J 0.000 abstract 1
- 229940079488 strontium ranelate Drugs 0.000 abstract 1
- XUBXWWLLZIPPHW-DFWYDOINSA-L strontium;(2s)-2-aminopentanedioate Chemical compound [Sr+2].[O-]C(=O)[C@@H](N)CCC([O-])=O XUBXWWLLZIPPHW-DFWYDOINSA-L 0.000 abstract 1
- LVZZABGEQTZXHP-UHFFFAOYSA-L strontium;propanedioate Chemical compound [Sr+2].[O-]C(=O)CC([O-])=O LVZZABGEQTZXHP-UHFFFAOYSA-L 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERA A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) SAL DE ESTRONCIO SELECCIONADA DE RANELATO DE ESTRONCIO, MALONATO DE ESTRONCIO, L-ASCORBATO DE ESTRONCIO, GLUTAMATO DE ESTRONCIO, ENTRE OTROS, B) VITAMINA D TAL COMO COLECALCIFEROL EN UNA DOSIFICACION DE 1000 UI, C) BETA-CICLODEXTRINA SUSTITUIDA SELECCIONADA DE HPBCD (HIDROXIPROPIL-BETA.CICLODEXTRINAS), SBECD (SULFOBUTILETER-BETA-CICLODEXTRINAS), ENTRE OTRAS Y D) UNO O VARIOS EXCIPIENTES O VEHICULOS INERTES. LA RELACION MASICA ENTRE LA CANTIDAD DE VITAMINA D Y CICLODEXTRINA ESTA COMPRENDIDA ENTRE 1/40 Y 1/800. DICHA COMPOSICION ESTA EN FORMA DE COMPRIMIDOS PARA TRAGAR, PARA MASTICAR, COMPRIMIDOS EFERVESCENTES O EN FORMA DE GRANULOS PARA SOBRE SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDADES OSEAS O DE LA ARTROSIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0905706A FR2953139B1 (fr) | 2009-11-27 | 2009-11-27 | Composition pharmaceutique comprenant un sel de strontium, de la vitamine d et une cyclodextrine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110407A1 true PE20110407A1 (es) | 2011-07-02 |
Family
ID=41719206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010001074A PE20110407A1 (es) | 2009-11-27 | 2010-11-19 | Composicion farmaceutica que comprende una sal de estroncio, vitamina d y una ciclodextrina |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20110130370A1 (es) |
| EP (1) | EP2335704A1 (es) |
| JP (1) | JP2011111458A (es) |
| KR (1) | KR101278935B1 (es) |
| CN (1) | CN102078620A (es) |
| AP (1) | AP2010005490A0 (es) |
| AR (1) | AR079160A1 (es) |
| AU (1) | AU2010241527B2 (es) |
| BR (1) | BRPI1004685A2 (es) |
| CA (1) | CA2723119C (es) |
| CL (1) | CL2010001260A1 (es) |
| CO (1) | CO6280058A1 (es) |
| CU (1) | CU20100230A7 (es) |
| EA (1) | EA018460B1 (es) |
| EC (1) | ECSP10010622A (es) |
| FR (1) | FR2953139B1 (es) |
| GE (1) | GEP20135734B (es) |
| HN (1) | HN2010002518A (es) |
| IL (1) | IL209348A0 (es) |
| MA (1) | MA32363B1 (es) |
| MX (1) | MX2010012566A (es) |
| MY (1) | MY158261A (es) |
| NZ (1) | NZ589513A (es) |
| PE (1) | PE20110407A1 (es) |
| SG (1) | SG171542A1 (es) |
| SV (1) | SV2010003744A (es) |
| TW (1) | TW201200136A (es) |
| UA (1) | UA105766C2 (es) |
| UY (1) | UY33039A (es) |
| WO (1) | WO2011064474A1 (es) |
| ZA (1) | ZA201008230B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1993559T1 (sl) | 2006-02-03 | 2017-01-31 | Opko Renal, Llc | Zdravljenje nezadostnosti in pomanjkanja vitamina D s 25-hidroksivitaminon D2 in 25-hidroksivitaminom D3 |
| DK3357496T3 (da) | 2006-06-21 | 2020-05-11 | Opko Ireland Global Holdings Ltd | Terapi ved brug af vitamin d-repletteringsmiddel og vitamin d-hormonsubstitutionsmiddel |
| PT2148661E (pt) | 2007-04-25 | 2013-03-06 | Proventiv Therapeutics Llc | Composições orais de libertação controlada compreendendo um composto de vitamina d e veículo ceroso |
| PT2148684E (pt) | 2007-04-25 | 2013-04-19 | Cytochroma Inc | Método de tratamento para a insuficiência e deficiência de vitamina d |
| NZ625712A (en) | 2009-11-27 | 2016-02-26 | Genzyme Corp | An amorphous and a crystalline form of genz 112638 hemitartrate as inhibitor of glucosylceramide synthase |
| US11672809B2 (en) | 2010-03-29 | 2023-06-13 | Eirgen Pharma Ltd. | Methods and compositions for reducing parathyroid levels |
| CN102525975B (zh) * | 2011-12-14 | 2013-06-19 | 天津药物研究院药业有限责任公司 | 雷奈酸锶口腔崩解片及其制备方法 |
| CN102626420B (zh) * | 2012-04-13 | 2014-06-25 | 深圳大学 | 一种含有锶、钙和维生素d的混合制剂 |
| ES2505716T3 (es) * | 2013-01-21 | 2015-09-04 | Galenicum Health S.L. | Composiciones farmacéuticas que comprenden una sal de ácido |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| CN103142623B (zh) * | 2013-03-21 | 2014-04-16 | 青岛正大海尔制药有限公司 | 骨化三醇和雷尼酸锶的混悬颗粒及其制备方法 |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| EP3235822B1 (en) * | 2014-12-19 | 2020-01-29 | Nagasaki University | Novel bisphosphonic acid derivative and application for same |
| WO2017182237A1 (en) | 2016-03-28 | 2017-10-26 | Opko Ireland Global Holdings, Limited | Methods of vitamin d treatment |
| US10463636B2 (en) * | 2016-09-30 | 2019-11-05 | Deanna J. Nelson | Pharmaceutical quality strontium L-lactate |
| IL270162B2 (en) * | 2017-04-25 | 2025-07-01 | Buck Inst Res Aging | ?-ketoglutarate (akg) and (i) a vitamin a compound, or (ii) a vitamin d compound, for use in delaying onset or delaying progression of frailty |
| WO2019004984A2 (en) * | 2017-05-29 | 2019-01-03 | Biofarma Ilac Sanayi Ve Ticaret A.S. | PHARMACEUTICAL FORMULATION COMPRISING CHOLECALCIFEROL |
| CN109276710A (zh) * | 2018-11-23 | 2019-01-29 | 中国医学科学院药用植物研究所海南分所 | 一种增加骨密度的组合物及其制备方法和用途 |
| CN112370429A (zh) * | 2019-10-21 | 2021-02-19 | 广州富诺营养科技有限公司 | 一种直压型有机钙维生素d3咀嚼片及其制备方法 |
| CN114452259A (zh) * | 2021-07-28 | 2022-05-10 | 安徽旺盛添加剂有限公司 | 一种维生素d微囊钙片及其制备方法 |
| WO2024246793A1 (en) * | 2023-05-31 | 2024-12-05 | Haleon Us Holdings Llc | Active ingredient complex and method of making thereof |
| CN119055788A (zh) * | 2023-05-31 | 2024-12-03 | 葛兰素史克消费保健（美国）控股有限责任公司 | 活性成分络合物及其制备方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS52130904A (en) * | 1976-04-26 | 1977-11-02 | Teijin Ltd | Stabilization of vitamin d# |
| HU177586B (en) * | 1978-12-19 | 1981-11-28 | Chinoin Gyogyszer Es Vegyeszet | New process for preparing stable inclusion complexes of vitamine d with cyclodextrin |
| US4727064A (en) * | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| FR2651497B1 (fr) | 1989-09-01 | 1991-10-25 | Adir | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| CN1110275A (zh) * | 1994-04-06 | 1995-10-18 | 福建省药品检验所 | 一种维生素D与羟丙基-β-环糊精的包合物 |
| FR2749759B1 (fr) | 1996-06-17 | 1999-11-26 | Adir | Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose |
| WO2001036490A2 (en) * | 1999-11-12 | 2001-05-25 | Pitha & Pitha Llc | Crystalline mixtures of partial methyl ethers of beta-cyclodextrin and related compounds |
| WO2001048024A1 (en) * | 1999-12-23 | 2001-07-05 | Cerestar Holding B.V. | Stabilized cyclodextrin complexes |
| JP2003268005A (ja) * | 2002-03-14 | 2003-09-25 | Medorekkusu:Kk | 包接体の製造法 |
| WO2004098618A2 (en) * | 2003-05-07 | 2004-11-18 | Osteologix A/S | Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions |
| PL1622629T3 (pl) * | 2003-05-07 | 2013-12-31 | Osteologix As | Kompozycja do kontrolowanego uwalniania zawierająca sól strontu |
| ES2275218T3 (es) | 2003-05-07 | 2007-06-01 | Osteologix A/S | Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos. |
| JPWO2004106600A1 (ja) * | 2003-05-30 | 2006-07-20 | 三井化学株式会社 | 人工毛髪用繊維 |
| JP2007525472A (ja) * | 2003-07-04 | 2007-09-06 | ニコメド ダンマーク エイピーエス | 経口使用のための副甲状腺ホルモン（ｐｔｈ）含有医薬組成物 |
| WO2005123130A2 (en) * | 2004-06-17 | 2005-12-29 | Osteologix A/S | Improved treatments of rheumatic and arthritic diseases comprising combinations of a 5-lipoxygenase inhibitor |
| CA2571449C (en) * | 2004-06-25 | 2015-12-08 | John Nikolaj Hvarre Christensen | Compositions comprising strontium and vitamin d and uses thereof |
| CN101018586B (zh) * | 2004-06-25 | 2014-08-27 | 莫克瓦洛Spf有限公司 | 含锶和维生素d的组合物及其用途 |
| EP1865929A2 (en) * | 2005-03-28 | 2007-12-19 | Bioresponse, L.L.C. | Diindolylmethane-based compositions and methods of use thereof for promoting oral mucosal and bone health |
| DE102005017775A1 (de) * | 2005-04-13 | 2006-10-19 | Schering Ag | Komplexe aus Vitamin D-Verbindungen oder deren Analoga mit einem 5Z,7E,10(19)-Trien-System und methlierten Derivaten des ß-Cyclodextrins |
| US20070218111A1 (en) * | 2006-03-16 | 2007-09-20 | Western Holdings, Llc | Strontium compositions for bones |
| CN1823764A (zh) * | 2006-03-27 | 2006-08-30 | 重庆医药工业研究院有限责任公司 | 一种含有雷奈酸锶和维生素d药物组合物 |
| FR2899895B1 (fr) | 2006-04-12 | 2010-09-17 | Servier Lab | Nouveaux sels de strontium d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| KR100822133B1 (ko) * | 2006-11-06 | 2008-04-15 | 한미약품 주식회사 | 비타민 ｄ 또는 이의 유도체의 고체분산체 및비스포스포네이트를 포함하는, 골다공증 예방 또는 치료용복합제제 |
-
2009
- 2009-11-27 FR FR0905706A patent/FR2953139B1/fr not_active Expired - Fee Related
-
2010
- 2010-11-11 MA MA33348A patent/MA32363B1/fr unknown
- 2010-11-15 SG SG201008356-6A patent/SG171542A1/en unknown
- 2010-11-16 IL IL209348A patent/IL209348A0/en unknown
- 2010-11-17 ZA ZA2010/08230A patent/ZA201008230B/en unknown
- 2010-11-17 CL CL2010001260A patent/CL2010001260A1/es unknown
- 2010-11-18 AU AU2010241527A patent/AU2010241527B2/en not_active Ceased
- 2010-11-18 MX MX2010012566A patent/MX2010012566A/es not_active Application Discontinuation
- 2010-11-18 UY UY0001033039A patent/UY33039A/es unknown
- 2010-11-19 CO CO10145569A patent/CO6280058A1/es not_active Application Discontinuation
- 2010-11-19 PE PE2010001074A patent/PE20110407A1/es not_active Application Discontinuation
- 2010-11-19 MY MYPI2010005459A patent/MY158261A/en unknown
- 2010-11-22 EC EC2010010622A patent/ECSP10010622A/es unknown
- 2010-11-23 CA CA2723119A patent/CA2723119C/fr not_active Expired - Fee Related
- 2010-11-23 US US12/927,733 patent/US20110130370A1/en not_active Abandoned
- 2010-11-24 NZ NZ589513A patent/NZ589513A/en not_active IP Right Cessation
- 2010-11-24 CN CN2010105599459A patent/CN102078620A/zh active Pending
- 2010-11-24 UA UAA201014025A patent/UA105766C2/uk unknown
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- 2010-11-25 BR BRPI1004685-2A patent/BRPI1004685A2/pt not_active IP Right Cessation
- 2010-11-25 AR ARP100104358A patent/AR079160A1/es not_active Application Discontinuation
- 2010-11-26 EP EP10290628A patent/EP2335704A1/fr not_active Withdrawn
- 2010-11-26 KR KR1020100118714A patent/KR101278935B1/ko not_active Expired - Fee Related
- 2010-11-26 HN HN2010002518A patent/HN2010002518A/es unknown
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- 2010-11-26 JP JP2010263698A patent/JP2011111458A/ja active Pending
- 2010-11-26 WO PCT/FR2010/000787 patent/WO2011064474A1/fr not_active Ceased
- 2010-12-01 AP AP2010005490A patent/AP2010005490A0/xx unknown
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