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PE20091036A1 - Derivado de quinolina como antagonista del receptor p2x7 - Google Patents

Derivado de quinolina como antagonista del receptor p2x7

Info

Publication number
PE20091036A1
PE20091036A1 PE2008001976A PE2008001976A PE20091036A1 PE 20091036 A1 PE20091036 A1 PE 20091036A1 PE 2008001976 A PE2008001976 A PE 2008001976A PE 2008001976 A PE2008001976 A PE 2008001976A PE 20091036 A1 PE20091036 A1 PE 20091036A1
Authority
PE
Peru
Prior art keywords
compound
antagonist
receptor
formula
refers
Prior art date
Application number
PE2008001976A
Other languages
English (en)
Inventor
Simon David Guile
Toby Thompson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20091036A1 publication Critical patent/PE20091036A1/es

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

SE REFIERE AL COMPUESTO 6-CLORO-N-[(1-HIDROXICICLOHEPTIL)METIL]-2-{(3S)-3-[(2-HIDROXIETIL)AMINO]-PIRROLIDIN-1-IL}QUINOLINA-5-CARBOXAMIDA DE FORMULA (I). SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION QUE COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) EN CONDICIONES DE AMINACION REDUCTORA, DONDE PG ES UN GRUPO PROTECTOR; Y B) FORMAR OPCIONALMENTE UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL COMPUESTO. DICHO COMPUESTO ES ANTAGONISTA DEL RECEPTOR P2X7 SIENDO UTIL EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, ENFERMEDAD DE CROHN
PE2008001976A 2007-11-30 2008-11-26 Derivado de quinolina como antagonista del receptor p2x7 PE20091036A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99126507P 2007-11-30 2007-11-30

Publications (1)

Publication Number Publication Date
PE20091036A1 true PE20091036A1 (es) 2009-08-15

Family

ID=40676391

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001976A PE20091036A1 (es) 2007-11-30 2008-11-26 Derivado de quinolina como antagonista del receptor p2x7

Country Status (9)

Country Link
US (1) US8106073B2 (es)
EP (1) EP2225222B1 (es)
JP (1) JP2011505356A (es)
AR (1) AR069508A1 (es)
AT (1) ATE524458T1 (es)
ES (1) ES2370960T3 (es)
PE (1) PE20091036A1 (es)
TW (1) TW200932229A (es)
WO (1) WO2009070116A1 (es)

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EP2139879B1 (en) * 2007-03-22 2012-07-11 AstraZeneca AB Quinoline derivatives for the treatment of inflammatory diseases
PE20091036A1 (es) 2007-11-30 2009-08-15 Astrazeneca Ab Derivado de quinolina como antagonista del receptor p2x7
WO2011084368A1 (en) 2009-12-17 2011-07-14 Merck Sharp & Dohme Corp. Quinoline amide m1 receptor positive allosteric modulators
WO2012110190A1 (en) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163456A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
WO2012163792A1 (en) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Novel p2x7r antagonists and their use
CN103687860B (zh) 2011-07-22 2016-06-08 埃科特莱茵药品有限公司 作为p2x7受体拮抗剂的杂环酰胺衍生物
BR112014017735B1 (pt) 2012-01-20 2022-06-28 Idorsia Pharmaceuticals Ltd Compostos derivados de amida heterocíclicos como antagonistas do receptor de p2x7, composição farmacêutica, e, uso de um composto
ES2618056T3 (es) 2012-12-12 2017-06-20 Actelion Pharmaceuticals Ltd. Derivados de indol carboxamida como antagonistas del receptor P2X7
AR094053A1 (es) 2012-12-18 2015-07-08 Actelion Pharmaceuticals Ltd Derivados de indol carboxamida como antagonistas del receptor p2x₇
ES2616114T3 (es) 2013-01-22 2017-06-09 Actelion Pharmaceuticals Ltd. Derivados de amida heterocíclica como antagonistas del receptor P2X7
ES2616883T3 (es) 2013-01-22 2017-06-14 Actelion Pharmaceuticals Ltd. Derivados amida heterocíclicos como antagonistas del receptor P2X7
CA2948888A1 (en) * 2014-06-05 2015-12-10 Merck Patent Gmbh Novel quinoline derivatives and their use in neurodegenerative diseases
WO2020227159A2 (en) 2019-05-03 2020-11-12 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity

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JP2011505356A (ja) 2011-02-24
EP2225222A4 (en) 2010-12-01
HK1148002A1 (en) 2011-08-26
ES2370960T3 (es) 2011-12-26
US8106073B2 (en) 2012-01-31
EP2225222B1 (en) 2011-09-14
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