PE20091826A1 - Derivados de la 2-trifluorometilnicotinamida como agentes para aumentar el hdl-colesterol - Google Patents
Derivados de la 2-trifluorometilnicotinamida como agentes para aumentar el hdl-colesterolInfo
- Publication number
- PE20091826A1 PE20091826A1 PE2009000468A PE2009000468A PE20091826A1 PE 20091826 A1 PE20091826 A1 PE 20091826A1 PE 2009000468 A PE2009000468 A PE 2009000468A PE 2009000468 A PE2009000468 A PE 2009000468A PE 20091826 A1 PE20091826 A1 PE 20091826A1
- Authority
- PE
- Peru
- Prior art keywords
- hydroxy
- cholesterol
- agents
- nicotinamide
- trifluoro
- Prior art date
Links
- 108010023302 HDL Cholesterol Proteins 0.000 title abstract 2
- PNXJWEQRIVLWBG-UHFFFAOYSA-N 2-(trifluoromethyl)pyridine-3-carboxamide Chemical class NC(=O)C1=CC=CN=C1C(F)(F)F PNXJWEQRIVLWBG-UHFFFAOYSA-N 0.000 title 1
- -1 2-CYCLOPROPYL-2-HYDROXY-PROPYL Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- GEAXLHPORCRESC-UHFFFAOYSA-N chlorocyclohexatriene Chemical class ClC1=CC=C=C[CH]1 GEAXLHPORCRESC-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- ORTQUHUGBDMJPG-UHFFFAOYSA-N n-(2-cyclopropyl-2-hydroxypropyl)-5-(3,4-dichlorophenyl)-6-(2,2,2-trifluoroethoxy)-2-(trifluoromethyl)pyridine-3-carboxamide Chemical compound C1CC1C(O)(C)CNC(=O)C(C(=NC=1OCC(F)(F)F)C(F)(F)F)=CC=1C1=CC=C(Cl)C(Cl)=C1 ORTQUHUGBDMJPG-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE 2-TRIFLUOROMETILNICOTINAMIDA DE FORMULA (I), DONDE R1 ES HIDROXIALQUILO INFERIOR, CICLOALQUILO SUSTITUIDO O NO POR HIDROXI, HIDROXIALQUILO INFERIOR, ENTRE OTROS; R2, R4 Y R8 SON CADA UNO H; R3 ES ALCOXIALQUILO INFERIOR, HALOALQUILO INFERIOR, HETEROALQUILO INFERIOR, ENTRE OTROS; R5, R6 Y R7 SON CADA UNO H, ALQUILO INFERIOR, HALOALCOXI INFERIOR, ENTRE OTROS. SON COMPUESTOS SELECCIONADOS: 5-(4-CLORO-FENIL)-N-(2-CICLOPROPIL-2-HIDROXI-PROPIL)-6-(2,2,2-TRIFLUORO-ETOXI)-2-TRIFLUOROMETIL-NICOTINAMIDA; N-(2-CICLOPROPIL-2-HIDROXI-PROPIL)-5-(3,4-DICLOROFENIL)-6-(2,2,2-TRIFLUORO-ETOXI)-2-TRIFLUOROMETIL-NICOTINAMIDA; 5-(3-CLORO-FENIL)-N-(CICLOPROPIL-2-HIDROXI-PROPIL)-6-(2,2,2-TRIFLUORO-ETOXI)-2-TRIFLUOROMETIL-NICOTINAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGENTES PARA AUMENTAR EL HDL-COLESTEROL SIENDO UTILES EN EL TRATAMIENTO DE HIPERCOLESTEROLEMIA, HIPERTRIGLICERIDEMIA, INFARTO DE MIOCARDIO, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08153792 | 2008-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091826A1 true PE20091826A1 (es) | 2009-11-25 |
Family
ID=40601113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000468A PE20091826A1 (es) | 2008-03-31 | 2009-03-30 | Derivados de la 2-trifluorometilnicotinamida como agentes para aumentar el hdl-colesterol |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7897621B2 (es) |
| EP (1) | EP2262770B1 (es) |
| JP (1) | JP5442711B2 (es) |
| KR (1) | KR101249668B1 (es) |
| CN (1) | CN101981009B (es) |
| AR (1) | AR071096A1 (es) |
| AU (1) | AU2009231375A1 (es) |
| CA (1) | CA2717537A1 (es) |
| ES (1) | ES2391371T3 (es) |
| IL (1) | IL208021A0 (es) |
| MX (1) | MX2010010000A (es) |
| PE (1) | PE20091826A1 (es) |
| TW (1) | TW200944504A (es) |
| WO (1) | WO2009121740A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102638979A (zh) * | 2009-09-21 | 2012-08-15 | 范德比尔特大学 | 作为mGluR5 正变构调节剂的邻苄基烟酰胺 |
| WO2012031817A1 (en) * | 2010-09-09 | 2012-03-15 | F. Hoffmann-La Roche Ag | Determination of abca1 protein levels in cells |
| US8410107B2 (en) | 2010-10-15 | 2013-04-02 | Hoffmann-La Roche Inc. | N-pyridin-3-yl or N-pyrazin-2-yl carboxamides |
| US8669254B2 (en) | 2010-12-15 | 2014-03-11 | Hoffman-La Roche Inc. | Pyridine, pyridazine, pyrimidine or pyrazine carboxamides as HDL-cholesterol raising agents |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0400208D0 (sv) | 2004-02-02 | 2004-02-02 | Astrazeneca Ab | Chemical compounds |
| CN101155781B (zh) | 2005-04-06 | 2012-11-07 | 霍夫曼-拉罗奇有限公司 | 作为cb1逆激动剂的吡啶-3-甲酰胺衍生物 |
| US7629346B2 (en) | 2006-06-19 | 2009-12-08 | Hoffmann-La Roche Inc. | Pyrazinecarboxamide derivatives as CB1 antagonists |
| US7781593B2 (en) | 2006-09-14 | 2010-08-24 | Hoffmann-La Roche Inc. | 5-phenyl-nicotinamide derivatives |
| EP2450350A1 (en) | 2006-10-04 | 2012-05-09 | F. Hoffmann-La Roche AG | 3-Pyridinecarboxamide and 2-pyrazinecarboxamide derivatives as HDL-cholesterol raising agents |
| EP2076499B1 (en) | 2006-10-04 | 2010-05-12 | F.Hoffmann-La Roche Ag | Pyrazine-2-carboxamide derivatives as cb2 receptor modulators |
-
2009
- 2009-03-16 US US12/404,364 patent/US7897621B2/en not_active Expired - Fee Related
- 2009-03-23 EP EP09727590A patent/EP2262770B1/en not_active Not-in-force
- 2009-03-23 CA CA2717537A patent/CA2717537A1/en not_active Abandoned
- 2009-03-23 WO PCT/EP2009/053343 patent/WO2009121740A1/en not_active Ceased
- 2009-03-23 KR KR1020107021707A patent/KR101249668B1/ko not_active Expired - Fee Related
- 2009-03-23 AU AU2009231375A patent/AU2009231375A1/en not_active Abandoned
- 2009-03-23 CN CN2009801105525A patent/CN101981009B/zh not_active Expired - Fee Related
- 2009-03-23 MX MX2010010000A patent/MX2010010000A/es active IP Right Grant
- 2009-03-23 JP JP2011502334A patent/JP5442711B2/ja not_active Expired - Fee Related
- 2009-03-23 ES ES09727590T patent/ES2391371T3/es active Active
- 2009-03-27 AR ARP090101099A patent/AR071096A1/es unknown
- 2009-03-30 TW TW098110488A patent/TW200944504A/zh unknown
- 2009-03-30 PE PE2009000468A patent/PE20091826A1/es not_active Application Discontinuation
-
2010
- 2010-09-06 IL IL208021A patent/IL208021A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2262770B1 (en) | 2012-08-01 |
| AU2009231375A1 (en) | 2009-10-08 |
| WO2009121740A1 (en) | 2009-10-08 |
| KR20100117142A (ko) | 2010-11-02 |
| CA2717537A1 (en) | 2009-10-08 |
| JP5442711B2 (ja) | 2014-03-12 |
| MX2010010000A (es) | 2010-09-30 |
| CN101981009B (zh) | 2013-09-11 |
| CN101981009A (zh) | 2011-02-23 |
| US20090247588A1 (en) | 2009-10-01 |
| US7897621B2 (en) | 2011-03-01 |
| AR071096A1 (es) | 2010-05-26 |
| TW200944504A (en) | 2009-11-01 |
| ES2391371T3 (es) | 2012-11-23 |
| KR101249668B1 (ko) | 2013-04-01 |
| IL208021A0 (en) | 2010-12-30 |
| EP2262770A1 (en) | 2010-12-22 |
| JP2011516444A (ja) | 2011-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |