PE20091753A1 - Conjugados antagonistas peptidicos analogos a la bombesina - Google Patents
Conjugados antagonistas peptidicos analogos a la bombesinaInfo
- Publication number
- PE20091753A1 PE20091753A1 PE2009000339A PE2009000339A PE20091753A1 PE 20091753 A1 PE20091753 A1 PE 20091753A1 PE 2009000339 A PE2009000339 A PE 2009000339A PE 2009000339 A PE2009000339 A PE 2009000339A PE 20091753 A1 PE20091753 A1 PE 20091753A1
- Authority
- PE
- Peru
- Prior art keywords
- leu
- xaa211
- gln7
- his12
- val10
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/086—Bombesin; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
REFERIDA A UN CONJUGADO PEPTIDICO ANALOGO A LA BOMBESINA DE FORMULA [A-(B)n]x-C (I), DONDE x ES UN ENTERO DE 1 A 3; n ES UN ENTERO DE 1 A 6; A ES UN QUELANTE PARA METALES TAL COMO DOTA-, EDTA-, TRITA-, ENTRE OTROS, QUE COMPRENDE AL MENOS UN RADIONUCLIDO DE METAL TAL COMO 67Ga, 64Cu, 51Cr; ENTRE OTROS; B ES UN SEPARADOR CONECTADO AL N-TERMINAL DE C REPRESENTADO POR LA FORMULA (B1-B2); B1 ES UNA UNION COVALENTE, UN AMINOACIDO NATURAL, UNA DIAMINA LINEAL O UNA DIAMINA CICLICA; B2 ES UNA UNION COVALENTE, UN AMINOACIDO NATURAL, UN AMINOACIDO NO NATURAL, UN ACIDO CARBOXILICO CICLICO O UN ACIDO CARBOXILICO LINEAL; C ES UN ANTAGONISTA PEPTIDICO ANALOGO A LA BOMBESINA CON LA SECUENCIA C-1 A C-4; C-1 ES Xaa16-Gln7-Trp8-Ala9-Val10-Xaa211-His12-Xaa313-Xaa414-ZH; Xaa1 ES D-Fe, D-Cpa, D-Tyr, ENTRE OTROS; Xaa2 ES Gli O BETA-Ala; Xaa3 ES UNA ESTATINA, 4-Am, 5-MeHpA, ENTRE OTROS; Xaa4 ES Leu, Cpa, Met, ENTRE OTROS; Z ES NH U O; C-2 ES Xaa16-Gln7-Trp8-Ala9-Val10-Xaa211-His12-Leu PSI (CHOH-CH2)-(CH2)2-CH3; C-3 ES Xaa16-Gln7-Trp8-Ala9-Val10-Xaa211-His12-Xaa513-Xaa614-ZH; Xaa5 ES Leu PSI-CH2NH-; Xaa6 ES Cys, Phe, Trp, ENTRE OTROS; C-4 ES Xaa16-Gln7-Trp8-Ala9-Val10-Xaa211-His12-Xaa7; Xaa7 ES Leu-O-ALQUILO O Leu-NH-ALQUILO. TAMBIEN ESTA REFERIDA A UN RADIOFARMACO QUE SE UNE A LOS RECEPTORES DE BOMBESINA, PARTICULARMENTE, AL RECEPTOR DEL PEPTIDO LIBERADOR DE GASTRINA (GRP) Y SON UTILES COMO AGENTES DE DIAGNOSTICO POR IMAGENES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08075180A EP2100900A1 (en) | 2008-03-07 | 2008-03-07 | Bombesin analog peptide antagonist conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091753A1 true PE20091753A1 (es) | 2009-12-13 |
Family
ID=39677415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000339A PE20091753A1 (es) | 2008-03-07 | 2009-03-06 | Conjugados antagonistas peptidicos analogos a la bombesina |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US9035023B2 (es) |
| EP (2) | EP2100900A1 (es) |
| JP (1) | JP5784911B2 (es) |
| KR (2) | KR101734553B1 (es) |
| CN (1) | CN101965358B (es) |
| AR (1) | AR070809A1 (es) |
| AU (1) | AU2009221204C1 (es) |
| BR (1) | BRPI0909823B1 (es) |
| CA (1) | CA2717427C (es) |
| CL (1) | CL2009000537A1 (es) |
| CO (1) | CO6290707A2 (es) |
| CR (1) | CR11671A (es) |
| CY (1) | CY1118687T1 (es) |
| DK (1) | DK2252628T3 (es) |
| DO (1) | DOP2010000269A (es) |
| EC (1) | ECSP10010467A (es) |
| ES (1) | ES2615805T3 (es) |
| HU (1) | HUE032980T2 (es) |
| MX (1) | MX2010009843A (es) |
| NZ (1) | NZ587795A (es) |
| PA (1) | PA8818501A1 (es) |
| PE (1) | PE20091753A1 (es) |
| PL (1) | PL2252628T3 (es) |
| PT (1) | PT2252628T (es) |
| RU (1) | RU2523531C2 (es) |
| SI (1) | SI2252628T1 (es) |
| SV (1) | SV2010003660A (es) |
| TW (1) | TWI515011B (es) |
| UA (1) | UA103314C2 (es) |
| UY (1) | UY31693A (es) |
| WO (1) | WO2009109332A1 (es) |
| ZA (1) | ZA201006385B (es) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2380597A1 (en) | 2010-04-20 | 2011-10-26 | Technische Universität München | Cyclopeptide derivatives and uses thereof |
| EP2380596A1 (en) | 2010-04-20 | 2011-10-26 | Technische Universität München | Cyclopentapeptide derivatives and uses thereof |
| EP2643024A1 (en) * | 2010-11-22 | 2013-10-02 | Piramal Imaging SA | 177lutetium-labeled bombesin analogs for radiotherapy |
| WO2012156511A1 (en) * | 2011-05-19 | 2012-11-22 | Universitätsspital Basel | Bombesin receptor targeting peptide incorporating a 1, 2, 3-triazole group in the backbone for preparing in vivo diagnostic and therapeutic agents |
| CA3114832A1 (en) | 2012-09-25 | 2014-04-03 | Advanced Accelerator Applications International Sa | Grpr-antagonists for detection, diagnosis and treatment of grpr-positive cancer |
| EP2740726A1 (en) | 2012-12-07 | 2014-06-11 | 3B Pharmaceuticals GmbH | Neurotensin receptor ligands |
| WO2014164988A1 (en) * | 2013-03-13 | 2014-10-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tetrahydroxamate chelators of zirconium89 and niobium90 for use in diagnostic applications |
| WO2015119763A1 (en) * | 2014-02-06 | 2015-08-13 | Immunomedics, Inc. | Al-f-18-labeled, al-f-19-labeled and ga-68-labeled gastrin-releasing peptide receptor (grpr)-antagonists for imaging of prostate cancer |
| CN106573959B (zh) | 2014-06-06 | 2022-03-25 | 慕尼黑工业大学 | 修饰的环五肽及其用途 |
| CA2949936C (en) | 2014-06-10 | 2022-10-18 | 3B Pharmaceuticals Gmbh | Conjugate comprising a neurotensin receptor ligand and use thereof |
| EP2954934A1 (en) | 2014-06-11 | 2015-12-16 | 3B Pharmaceuticals GmbH | Conjugate comprising a neurotensin receptor ligand and use thereof |
| EP2954933A1 (en) | 2014-06-10 | 2015-12-16 | 3B Pharmaceuticals GmbH | Conjugate comprising a neurotensin receptor ligand |
| EP3220946B1 (en) | 2014-06-16 | 2021-06-09 | Codexis, Inc. | Compositions and methods for attenuating and preventing intestinal inflammation due to the presence of peptidic food antigens in an intestine |
| CN104610431B (zh) * | 2014-11-26 | 2017-12-15 | 南京市第一医院 | 一种多肽及其应用 |
| WO2017106798A2 (en) | 2015-12-16 | 2017-06-22 | Nepetx, Llc | Compositions and methods for treating gluten intolerance and disorders arising therefrom |
| EP3279197A1 (en) | 2016-08-03 | 2018-02-07 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Diagnosis, treatment and prevention of neurotensin receptor-related conditions |
| US11241511B2 (en) | 2016-12-29 | 2022-02-08 | The General Hospital Corporation | HER3 peptides for imaging and radiotherapy |
| PT3568205T (pt) | 2017-01-12 | 2023-10-26 | Radiomedix Inc | Tratamento de células de cancro que sobrexpressam recetores de somatostatina com a utilização de derivados de ocreótido quelado a radioisótopos |
| CN110891614A (zh) * | 2017-05-05 | 2020-03-17 | 融合制药公司 | Igf-1r单克隆抗体及其用途 |
| RU2681318C1 (ru) * | 2017-11-24 | 2019-03-06 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Способ получения иммуносупрессорного пептида Abu-TGIRIS-Abu, меченного ионом Gd3+ |
| US20210402016A1 (en) * | 2018-11-13 | 2021-12-30 | Provincial Health Services Authority | Radiolabeled bombesin-derived compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders |
| JP2022541752A (ja) | 2019-07-08 | 2022-09-27 | ３ベー ファーマシューティカルズ ゲーエムベーハー | 線維芽細胞活性化タンパク質リガンドを含む化合物およびその使用 |
| EP3763726A1 (en) | 2019-07-08 | 2021-01-13 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| IL293008A (en) * | 2019-12-19 | 2022-07-01 | Univ Muenchen Tech | Modified peptides that are antagonistic to grpr for cancer imaging and therapy |
| WO2021250240A1 (en) | 2020-06-12 | 2021-12-16 | Orano | Diaza-18-crown-6 derivative useful for chelating radium, conjugate and radium chelate comprising the same, and uses thereof |
| EP3973999A1 (en) * | 2020-09-28 | 2022-03-30 | Orano Med | Conjugate or its salt comprising a gastrin-releasing peptide receptor antagonist and uses thereof |
| WO2022123462A1 (en) | 2020-12-09 | 2022-06-16 | 3B Pharmaceuticals Gmbh | Radiolabelled prostate specific membrane antigen (psma) inhibitors and use thereof |
| EP4050018A1 (en) | 2021-01-07 | 2022-08-31 | 3B Pharmaceuticals GmbH | Compounds comprising a fibroblast activation protein ligand and use thereof |
| US20250339569A1 (en) | 2021-12-17 | 2025-11-06 | 3B Pharmaceuticals Gmbh | Carbonic anhydrase ix ligands |
| IL315057A (en) | 2022-03-25 | 2024-10-01 | Provincial Health Services Authority | Radiolabeled compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders |
| KR20250057886A (ko) | 2022-09-07 | 2025-04-29 | 쓰리비 파마슈티컬스 게엠베하 | 전립선 특이적 막 항원 (psma) 리간드 및 그의 용도 |
| CN117919452A (zh) * | 2023-03-09 | 2024-04-26 | 中国科学院宁波材料技术与工程研究所 | 一种亚细胞器主动靶向成像探针及其制备方法 |
| WO2024212808A1 (zh) * | 2023-04-10 | 2024-10-17 | 湖南中晟全肽生物科技股份有限公司 | 蛙皮素类多肽化合物及其用途 |
| EP4455159A1 (en) | 2023-04-25 | 2024-10-30 | 3B Pharmaceuticals GmbH | Gastric inhibitory peptide receptor ligands with bio-distribution modifier |
| WO2025054727A1 (en) * | 2023-09-13 | 2025-03-20 | Provincial Health Services Authority | Radiolabeled compounds for in vivo imaging of gastrin-releasing peptide receptor (grpr) and treatment of grpr-related disorders |
| CN120019818A (zh) * | 2023-11-20 | 2025-05-20 | 湖南中晟全肽生物科技股份有限公司 | 一种多肽偶联药物及其制备方法和用途 |
| WO2025109003A1 (en) | 2023-11-21 | 2025-05-30 | 3B Pharmaceuticals Gmbh | P-cadherin ligands |
| WO2025119203A1 (zh) * | 2023-12-05 | 2025-06-12 | 烟台蓝纳成生物技术有限公司 | 一种异二聚体放射性核素偶联药物、制备及其应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4885363A (en) | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| US5021556A (en) | 1987-07-22 | 1991-06-04 | Neorx Corporation | Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides |
| US5075099A (en) | 1988-05-31 | 1991-12-24 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| US5686410A (en) * | 1989-07-20 | 1997-11-11 | Novartis Ag | Polypeptide derivatives |
| AU638043B2 (en) * | 1989-07-20 | 1993-06-17 | Novartis Ag | Labeled polypeptide derivatives |
| US5367080A (en) | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
| US5369094A (en) | 1990-11-29 | 1994-11-29 | The Administrators Of The Tulane Educational Fund | Polypeptide bombesin antagonists |
| US5965107A (en) | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| CA2346154A1 (en) | 2001-05-02 | 2002-11-02 | University Of Missouri | Gastrin receptor-avid peptide conjugates |
| JP2002506424A (ja) | 1997-04-22 | 2002-02-26 | キュレイター オブ ザ ユニバーシィティ オブ ミズーリ | ガストリン受容体−親和性ペプチド結合体 |
| US5886142A (en) | 1997-05-20 | 1999-03-23 | Thomas Jefferson University | Radiolabeled thrombus imaging agents |
| PL341762A1 (en) | 1997-12-24 | 2001-05-07 | Vertex Pharma | Precursors of aspartil protease inhibitors |
| AU2012199A (en) | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
| AU2010299A (en) | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs os aspartyl protease inhibitors |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| GR1003661B (el) * | 2000-05-25 | 2001-09-05 | Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων (Εκεφε) "Δημοκριτος"... | ΣΥΝΘΕΣΗ, ΒΙΟΛΟΓΙΚΗ ΚΑΙ ΠΡΟΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΑΝΑΛΟΓΩΝ ΤΗΣ (D-Phe6, Leu-NHEt13, des-Met14)-ΒΟΜΒΕΣΙΝΗΣ (6-14)ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΠΑ ΡΑΓΩΓΑ ΤΟΥ 1,4,8,11-ΤΕΤΡΑΑΖΑΕΝΔΕΚΑΝΙΟΥ(1,4,8,11-TETRAAZAUNDECAN E)ΚΑΙ ΕΠΙΣΗΜΑΣΜΕΝΩΝ ΜΕ ΤΕΧΝΗΤΙΟ-99M- ΓΙΑ ΕΦΑΡΜΟΓΗ ΣΤΗΝ ΟΓΚΟΛΟΓ |
| AU2001223816A1 (en) * | 2000-12-20 | 2002-07-01 | Warner-Lambert Company Llc | Novel uses of non-peptide bombesin receptor antagonists for treating anxiety and panic disorders |
| US20080008649A1 (en) | 2003-01-13 | 2008-01-10 | Bracco Imaging S.P.A. | Gastrin Releasing Peptide Compounds |
| US7850947B2 (en) | 2003-01-13 | 2010-12-14 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| US7922998B2 (en) * | 2003-01-13 | 2011-04-12 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| EP1654005A4 (en) * | 2003-07-24 | 2011-06-15 | Bracco Imaging Spa | STABLE RADIOPHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR PREPARATION |
| WO2007109475A2 (en) | 2006-03-16 | 2007-09-27 | Bracco Imaging S.P.A. | Chelation of metals to thiol groups using in situ reduction of disulfide-containing compounds by phosphines |
| EP2643024A1 (en) * | 2010-11-22 | 2013-10-02 | Piramal Imaging SA | 177lutetium-labeled bombesin analogs for radiotherapy |
-
2008
- 2008-03-07 EP EP08075180A patent/EP2100900A1/en not_active Withdrawn
-
2009
- 2009-02-27 KR KR1020107022308A patent/KR101734553B1/ko active Active
- 2009-02-27 CA CA2717427A patent/CA2717427C/en active Active
- 2009-02-27 AU AU2009221204A patent/AU2009221204C1/en active Active
- 2009-02-27 PL PL09717301T patent/PL2252628T3/pl unknown
- 2009-02-27 WO PCT/EP2009/001403 patent/WO2009109332A1/en not_active Ceased
- 2009-02-27 JP JP2010549043A patent/JP5784911B2/ja active Active
- 2009-02-27 DK DK09717301.7T patent/DK2252628T3/en active
- 2009-02-27 HU HUE09717301A patent/HUE032980T2/en unknown
- 2009-02-27 RU RU2010140846/04A patent/RU2523531C2/ru active
- 2009-02-27 PT PT97173017T patent/PT2252628T/pt unknown
- 2009-02-27 KR KR1020167029634A patent/KR20160128425A/ko not_active Withdrawn
- 2009-02-27 UA UAA201011560A patent/UA103314C2/ru unknown
- 2009-02-27 SI SI200931607A patent/SI2252628T1/sl unknown
- 2009-02-27 US US12/921,209 patent/US9035023B2/en active Active
- 2009-02-27 EP EP09717301.7A patent/EP2252628B1/en active Active
- 2009-02-27 BR BRPI0909823-2A patent/BRPI0909823B1/pt active IP Right Grant
- 2009-02-27 NZ NZ587795A patent/NZ587795A/en unknown
- 2009-02-27 ES ES09717301.7T patent/ES2615805T3/es active Active
- 2009-02-27 MX MX2010009843A patent/MX2010009843A/es not_active Application Discontinuation
- 2009-02-27 CN CN200980107992.5A patent/CN101965358B/zh active Active
- 2009-03-06 PE PE2009000339A patent/PE20091753A1/es not_active Application Discontinuation
- 2009-03-06 PA PA20098818501A patent/PA8818501A1/es unknown
- 2009-03-06 TW TW098107446A patent/TWI515011B/zh active
- 2009-03-06 AR ARP090100799A patent/AR070809A1/es not_active Application Discontinuation
- 2009-03-06 UY UY0001031693A patent/UY31693A/es not_active Application Discontinuation
- 2009-03-06 CL CL2009000537A patent/CL2009000537A1/es unknown
-
2010
- 2010-09-06 CO CO10110036A patent/CO6290707A2/es not_active Application Discontinuation
- 2010-09-06 ZA ZA2010/06385A patent/ZA201006385B/en unknown
- 2010-09-07 CR CR11671A patent/CR11671A/es not_active Application Discontinuation
- 2010-09-07 SV SV2010003660A patent/SV2010003660A/es not_active Application Discontinuation
- 2010-09-07 DO DO2010000269A patent/DOP2010000269A/es unknown
- 2010-09-07 EC EC2010010467A patent/ECSP10010467A/es unknown
-
2015
- 2015-03-27 US US14/671,106 patent/US20150265733A1/en not_active Abandoned
-
2017
- 2017-02-07 CY CY20171100170T patent/CY1118687T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20091753A1 (es) | Conjugados antagonistas peptidicos analogos a la bombesina | |
| UY32902A (es) | Nuevos agonistas de npr-b | |
| MX2022000251A (es) | Compuestos que comprenden un ligando de proteina de activacion de fibroblasto y uso del mismo. | |
| HRP20120621T1 (hr) | Sna“ni analozi kompstatina | |
| PE20091783A1 (es) | Anticuerpos anti-factor d humanizados | |
| MX2023007869A (es) | Compuestos que comprenden un ligando de proteina de activacion de fibroblasto y uso del mismo. | |
| PE20121393A1 (es) | Analogo peptidico de oxintomodulina | |
| CO6150201A2 (es) | Anticuerpo humanizado contra beta amiloide | |
| RU2013154047A (ru) | Пептидные лекарственные препараты с повышенной эффективностью против инсулинорезистентности | |
| PE20110306A1 (es) | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) | |
| AR080904A2 (es) | Coagonistas del receptor de glucagon /glp - 1 | |
| MX2015006868A (es) | Metodos para la elaboracion de conjugados a partir de proteinas que contienen disulfuro. | |
| PE20120331A1 (es) | Agentes medicinales unidos a dipeptido | |
| PE20161153A1 (es) | Insulina de accion prolongada y uso de la misma | |
| MX2010004571A (es) | Composiciones y metodos que comprenden peptidos y proteasas de aminoacidos basicos. | |
| NZ600732A (en) | Oxyntomodulin peptide analogue | |
| AR081339A1 (es) | Conjugados peptidicos | |
| CA2651990C (en) | Improved antimicrobial peptides | |
| MX2016008355A (es) | Anticuerpos que comprenden extensiones de polipeptidos de cadena ligera en el extremo c y conjugados y metodos de uso de estos. | |
| MX369282B (es) | Composiciones para el cuidado oral, prebioticas, que contienen aminoacidos. | |
| PE20140260A1 (es) | Compuestos antidiabeticos | |
| ATE404225T1 (de) | Radiofluorierte peptide | |
| AR075933A1 (es) | Composiciones polipeptidas y de inmunizacion conteniendo polipeptidos positivos gram y metodos de uso | |
| MX2015005867A (es) | Moleculas de transporte especificas de proteoglicano c4s. | |
| EA200702012A1 (ru) | Пептиды механо-фактора роста и их применение |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |