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PE20090895A1 - TRIAZOLE DERIVATIVES AS JAK QUINASE INHIBITORS - Google Patents

TRIAZOLE DERIVATIVES AS JAK QUINASE INHIBITORS

Info

Publication number
PE20090895A1
PE20090895A1 PE2008001287A PE2008001287A PE20090895A1 PE 20090895 A1 PE20090895 A1 PE 20090895A1 PE 2008001287 A PE2008001287 A PE 2008001287A PE 2008001287 A PE2008001287 A PE 2008001287A PE 20090895 A1 PE20090895 A1 PE 20090895A1
Authority
PE
Peru
Prior art keywords
alkyl
pyrazole
alkenyl
methyl
jak
Prior art date
Application number
PE2008001287A
Other languages
Spanish (es)
Inventor
Lynsie Almeida
Brian Aquila
Claudio Edmundo Chuaqui
Huiping Guan
Shan Huang
Stephanos Ioannidis
Michelle Lamb
Bo Peng
Jie Shi
Mei Su
Quibin Su
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40304964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090895(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20090895A1 publication Critical patent/PE20090895A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

REFERIDO A UN COMPUESTO DERIVADO DE TRIAZOL DE FORMULA (I): DONDE EL ANILLO A ES HETEROCICLILO OPCIONALMENTE SUSTITUIDO SOBRE EL C CON UNO O MAS R2; EL ANILLO B ES SELECCIONADO DE CARBOCICLO Y HETEROCICLILO OPCIONALMENTE SUSTITUIDO SOBRE EL C CON UNO O MAS R4; X ES -O-, -NH- Y -S-; R1 ES HALO, -CN, ALQUILO(C1-C6), ENTRE OTROS; R2 ES -CN, ALQUILO(C1-C6), ALQUENILO(C2-C6), ENTRE OTROS; R3 ES ALQUILO(C1-C6), ALQUENILO(C2-C6); ALQUINILO(C2-C6), ENTRE OTROS; R4 ES ALQUILO(C1-C6), ALQUENILO (C2-C6), CARBOCILILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (S)-N2-(1-(5-FLUOROPIRIDIN-2-IL)ETIL)-N4-(5-METIL-1H-PIRAZOL-3-IL)-6-(4-METILPIPERAZIN-1-IL)-1,3,5-TRIAZINA-2,4-DIAMINA, (S)-N2-(1-(5-FLUOROPIRIMIDIN-2-IL)ETIL)N4-(5-METIL-1H-PIRAZOL-3-IL)-6-MORFOLIN-1,3,5-TRIAZINA-2,4-DIAMINA, 4-(1-(5-FLUOROPIRIDIN-2-IL)ETOXI)-N-(5-METIL-1H-PIRAZOL-3-IL)-6-MORFOLIN-1,3,5-TRIAZIN-2-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA FORMULACION Y A UN METODO DE PREPARACION. DICHO COMPUESTO TIENE ACTIVIDAD INHIBITORIA DE JAK QUINASA Y ES UTIL EN EL TRATAMIENTO DE TRASTORNOS MIELOPROLIFERATIVOS Y EL CANCERREFERRING TO A COMPOUND DERIVED FROM TRIAZOLE OF FORMULA (I): WHERE THE RING A IS HETEROCYCLYL OPTIONALLY SUBSTITUTED ON THE C WITH ONE OR MORE R2; RING B IS SELECTED FROM CARBOCYCLE AND HETEROCYCLYL OPTIONALLY SUBSTITUTED ON C WITH ONE OR MORE R4; X IS -O-, -NH- AND -S-; R1 IS HALO, -CN, (C1-C6) ALKYL, AMONG OTHERS; R2 IS -CN, ALKYL (C1-C6), ALKENYL (C2-C6), AMONG OTHERS; R3 IS ALKYL (C1-C6), ALKENYL (C2-C6); ALKINYL (C2-C6), AMONG OTHERS; R4 IS ALKYL (C1-C6), ALKENYL (C2-C6), CARBOCILYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: (S) -N2- (1- (5-FLUOROPYRIDIN-2-IL) ETHYL) -N4- (5-METHYL-1H-PYRAZOLE-3-IL) -6- (4-METHYLPIPERAZIN-1- IL) -1,3,5-TRIAZINE-2,4-DIAMINE, (S) -N2- (1- (5-FLUOROPYRIMIDIN-2-IL) ETHYL) N4- (5-METHYL-1H-PYRAZOLE-3- IL) -6-MORPHOLIN-1,3,5-TRIAZINE-2,4-DIAMINE, 4- (1- (5-FLUOROPYRIDIN-2-IL) ETHOXY) -N- (5-METHYL-1H-PYRAZOLE-3 -IL) -6-MORFOLIN-1,3,5-TRIAZIN-2-AMINE, AMONG OTHERS. IT ALSO REFERS TO A FORMULATION AND A METHOD OF PREPARATION. SAID COMPOUND HAS JAK KINASE INHIBITORY ACTIVITY AND IS USEFUL IN THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS AND CANCER

PE2008001287A 2007-07-31 2008-07-31 TRIAZOLE DERIVATIVES AS JAK QUINASE INHIBITORS PE20090895A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95315807P 2007-07-31 2007-07-31

Publications (1)

Publication Number Publication Date
PE20090895A1 true PE20090895A1 (en) 2009-08-08

Family

ID=40304964

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001287A PE20090895A1 (en) 2007-07-31 2008-07-31 TRIAZOLE DERIVATIVES AS JAK QUINASE INHIBITORS

Country Status (6)

Country Link
AR (1) AR069899A1 (en)
CL (1) CL2008002243A1 (en)
PE (1) PE20090895A1 (en)
TW (1) TW200906818A (en)
UY (1) UY31254A1 (en)
WO (1) WO2009016410A2 (en)

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CA2755394C (en) 2009-03-13 2021-10-19 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
AU2010259002B2 (en) * 2009-06-08 2014-03-20 Nantbio, Inc. Triazine derivatives and their therapeutical applications
EP2440053A4 (en) * 2009-06-09 2012-10-31 California Capital Equity Llc Benzyl substituted triazine derivatives and their therapeutical applications
KR101712035B1 (en) 2009-06-29 2017-03-03 아지오스 파마슈티컬스 아이엔씨. Therapeutic compounds and compositions
CA2793835C (en) 2009-10-21 2021-07-20 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
CN108451955B (en) 2011-05-03 2022-02-01 安吉奥斯医药品有限公司 Pyruvate kinase activators for therapy
CN102827073A (en) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 Therapeutically active compositions and application methods thereof
CN102827170A (en) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 Active treatment compositions and use method thereof
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
AR091858A1 (en) * 2012-07-25 2015-03-04 Sova Pharmaceuticals Inc CISTATIONIN-g-LIASA INHIBITORS (CSE)
NZ706999A (en) 2012-10-15 2018-12-21 Agios Pharmaceuticals Inc Inhibitors of mutant isocitrate dehydrogenase and therapeutical uses thereof
CN105517996B (en) * 2013-07-11 2019-03-26 安吉奥斯医药品有限公司 Therapeutical active compound and its application method
WO2015003355A2 (en) * 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
WO2015003360A2 (en) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
JP6529492B2 (en) 2013-07-11 2019-06-12 アジオス ファーマシューティカルズ， インコーポレイテッド 2,4- or 4,6-Diaminopyrimidine Compounds as IDH2 Mutant Inhibitors for the Treatment of Cancer
US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
AU2015229214B2 (en) 2014-03-14 2019-07-11 Les Laboratoires Servier Pharmaceutical compositions of therapeutically active compounds
ES2708344T3 (en) 2015-01-16 2019-04-09 Bayer Cropscience Ag Procedure for the preparation of 4-cyanoperidine hydrochloride
EP4344703A1 (en) 2015-06-11 2024-04-03 Agios Pharmaceuticals, Inc. Methods of using pyruvate kinase activators
MX390531B (en) 2015-10-15 2025-03-20 Servier Lab COMBINATION THERAPY TO TREAT MALIGNANT TUMORS.
MA43000B1 (en) 2015-10-15 2021-11-30 Celgene Corp Combination therapy for the treatment of malignant tumors
EP3676264A1 (en) * 2017-08-28 2020-07-08 Acurastem Inc. Pikfyve kinase inhibitors
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
CA3103624A1 (en) * 2018-06-22 2019-12-26 Aduro Biotech, Inc. Triazine compounds and uses thereof
CN109020951B (en) * 2018-08-24 2020-06-02 大连理工大学 Naphthalimide derivatives containing trisubstituted cyanuric chloride and their synthesis methods and applications
CN114761013A (en) 2019-09-27 2022-07-15 迪斯克医药公司 Methods of treating myelofibrosis and related disorders
JP2023528223A (en) 2020-05-13 2023-07-04 ディスク・メディシン・インコーポレイテッド Anti-Hemoduvelin (HJV) Antibodies for Treating Myelofibrosis
CN111454214B (en) * 2020-05-27 2023-04-07 龙曦宁（上海）医药科技有限公司 Synthetic method of 2-methoxy-1-pyrimidineethylamine hydrochloride

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030032035A (en) * 2000-09-15 2003-04-23 버텍스 파마슈티칼스 인코포레이티드 Pyrazole compounds useful as protein kinase inhibitors
MXPA03005610A (en) * 2000-12-21 2003-10-06 Vertex Pharma Pyrazole compounds useful as protein kinase inhibitors.
US7179826B2 (en) * 2002-03-15 2007-02-20 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
US20080287437A1 (en) * 2005-05-16 2008-11-20 Astrazeneca Ab Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors
HRP20120824T1 (en) * 2005-10-28 2012-11-30 Astrazeneca Ab 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer

Also Published As

Publication number Publication date
WO2009016410A3 (en) 2009-07-02
CL2008002243A1 (en) 2009-08-21
WO2009016410A2 (en) 2009-02-05
AR069899A1 (en) 2010-03-03
TW200906818A (en) 2009-02-16
UY31254A1 (en) 2009-04-30

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