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PE20090759A1 - Derivados heteroarilo de benzodioxanos heterociclo-fusionados antidepresivos - Google Patents

Derivados heteroarilo de benzodioxanos heterociclo-fusionados antidepresivos

Info

Publication number
PE20090759A1
PE20090759A1 PE2008000918A PE2008000918A PE20090759A1 PE 20090759 A1 PE20090759 A1 PE 20090759A1 PE 2008000918 A PE2008000918 A PE 2008000918A PE 2008000918 A PE2008000918 A PE 2008000918A PE 20090759 A1 PE20090759 A1 PE 20090759A1
Authority
PE
Peru
Prior art keywords
methyl
benzoxazin
piperidin
benzodioxanes
antidepressants
Prior art date
Application number
PE2008000918A
Other languages
English (en)
Inventor
Amedeo A Failli
Deborah Evrard
Yanfang Li
Nicole T Hatzenbuhler
Juliann Mogish
Iwan S Gunawan
Antonina Nikitenko
Ping Zhou
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20090759A1 publication Critical patent/PE20090759A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDO DERIVADOS HETEROARILO DE BENZODIOXANOS HETEROCICLO-FISIONADO DE FORMULA (I): DONDE G ES ATOMO DE C DE CONFIGURACION R O S, QUE CONTIENE UN H; R1 ES H, HIDROXI, HALO, ENTRE OTROS; X-Y1 ES DE PREFERENCIA N=C(CH3)-CH=CH-; A-B SON DE PREFERENCIA 6-{(N-IL-PIPERIDIN-4-IL)OXI}-2H-1,4-BENZOXAZIN-3(4H)-ONA; 6-{(N-IL-PIPERIDIN-4-IL)METIL}-2H-1,4-BENZOXAZIN-3(4H)-ONA; 6-{(N-IL-PIPERIDIN-4-IL)OXI}-4-METIL-2H-1,4-BENZOXAZIN-3(4H)-ONA; ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6-[(1-{[(2S)-8-METIL-2,3-DIHIDRO[1,4]DIOXINO[2,3-f]QUINOLIN-2-IL]METIL}PIPERIDIN-4-IL)OXI]-2H-1,4-BENZOXAZIN-3(4H)-ONA SAL DEL CLORHIDRATO; 6-[(1-{[(2S)-8-METIL-2,3-DIHIDRO[1,4]DIOXINO[2,3-f]QUINOLIN-2-IL]METIL}PIPERIDIN-4-IL)METIL]-2H-1,4-BENZOXAZIN-3(4H)-ONA; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE DEPRESION, ANSIEDAD, TRASTORNO DE PANICO, ENTRE OTROS
PE2008000918A 2007-05-30 2008-05-29 Derivados heteroarilo de benzodioxanos heterociclo-fusionados antidepresivos PE20090759A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94076507P 2007-05-30 2007-05-30

Publications (1)

Publication Number Publication Date
PE20090759A1 true PE20090759A1 (es) 2009-07-20

Family

ID=39720304

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000918A PE20090759A1 (es) 2007-05-30 2008-05-29 Derivados heteroarilo de benzodioxanos heterociclo-fusionados antidepresivos

Country Status (7)

Country Link
US (1) US20090042874A1 (es)
AR (1) AR066760A1 (es)
CL (1) CL2008001563A1 (es)
PA (1) PA8781801A1 (es)
PE (1) PE20090759A1 (es)
TW (1) TW200904446A (es)
WO (1) WO2008150848A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2639065T5 (es) 2009-06-25 2023-01-30 Alkermes Pharma Ireland Ltd Compuestos heterocíclicos para el tratamiento de trastornos neurológicos y psicológicos
US8536328B2 (en) 2010-05-04 2013-09-17 Alkermes Pharma Ireland Limited Process for synthesizing oxidized lactam compounds
EP2585066B1 (en) 2010-06-24 2018-09-26 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
CN104356063A (zh) * 2014-10-16 2015-02-18 华东师范大学 7-羟基-3,4-二氢-2-(1h)喹诺酮的制备方法
WO2016100823A1 (en) 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands
US10633336B2 (en) 2014-12-19 2020-04-28 The Broad Institute, Inc. Dopamine D2 receptor ligands
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
CN111909170B (zh) * 2020-09-11 2022-08-12 吉林奥来德光电材料股份有限公司 一种有机电致发光化合物、其制备方法以及包含该有机电致发光化合物的有机电致发光器件
WO2025099127A1 (en) 2023-11-10 2025-05-15 Wella Germany Gmbh New telescoping syntheses of 6-hydroxy-benzomorpholine (3,4-dihydro-2h-1,4-benzoxazin-6-ol)

Family Cites Families (23)

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US6319241B1 (en) * 1998-04-30 2001-11-20 Medtronic, Inc. Techniques for positioning therapy delivery elements within a spinal cord or a brain
US6421566B1 (en) * 1998-04-30 2002-07-16 Medtronic, Inc. Selective dorsal column stimulation in SCS, using conditioning pulses
US6941171B2 (en) * 1998-07-06 2005-09-06 Advanced Bionics Corporation Implantable stimulator methods for treatment of incontinence and pain
US6407092B1 (en) * 1999-04-23 2002-06-18 Pharmacia & Upjohn Company Tetracyclic azepinoindole compounds
US6516227B1 (en) * 1999-07-27 2003-02-04 Advanced Bionics Corporation Rechargeable spinal cord stimulator system
FR2801885B1 (fr) * 1999-12-06 2002-01-11 Adir Nouveaux derives (dihydro)benzoxaziniques et (dihydro) benzothiaziniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6885888B2 (en) * 2000-01-20 2005-04-26 The Cleveland Clinic Foundation Electrical stimulation of the sympathetic nerve chain
US6697676B2 (en) * 2000-12-21 2004-02-24 Medtronic, Inc. Medical electrical lead having an expandable electrode assembly
US6735472B2 (en) * 2001-01-26 2004-05-11 Pacesetter, Inc. Method of defibrillating a heart with electrode configurations including a left ventricular defibrillation electrode
US6458802B1 (en) * 2001-03-14 2002-10-01 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline
US6821981B2 (en) * 2001-04-26 2004-11-23 Wyeth Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists
US6861427B2 (en) * 2001-04-26 2005-03-01 Wyeth Azabicyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoline as 5-HT1A antagonists
BR0209901A (pt) * 2001-05-17 2004-07-13 Wyeth Corp Processos para a sìntese de derivados de 2,3-dihidro-1,4-dioxino-[2,3-f] quinolina
US6800637B2 (en) * 2002-09-12 2004-10-05 Wyeth Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
US6939877B2 (en) * 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
US6911445B2 (en) * 2002-09-12 2005-06-28 Wyeth Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
US7135479B2 (en) * 2002-09-12 2006-11-14 Wyeth Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
US7153849B2 (en) * 2002-09-12 2006-12-26 Wyeth Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans
GB0227240D0 (en) * 2002-11-21 2002-12-31 Glaxo Group Ltd Compounds
US7160888B2 (en) * 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
US7414052B2 (en) * 2004-03-30 2008-08-19 Wyeth Phenylaminopropanol derivatives and methods of their use
US20060062725A1 (en) * 2004-08-09 2006-03-23 Valliant John F Methods for preparing metal-carborane complexes for radioimaging and radiotherapy
WO2008042735A1 (en) * 2006-09-29 2008-04-10 Wyeth Tetrahydroquinoline, indoline, and related aniline derivatives of heterocycle-fused benzodioxan methylamines

Also Published As

Publication number Publication date
AR066760A1 (es) 2009-09-09
WO2008150848A1 (en) 2008-12-11
US20090042874A1 (en) 2009-02-12
TW200904446A (en) 2009-02-01
CL2008001563A1 (es) 2008-10-10
PA8781801A1 (es) 2009-01-23

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