PE20090629A1 - Pirazinas y piperidinas piperazinil sustituidas como antagonistas del receptor 5-ht7 - Google Patents
Pirazinas y piperidinas piperazinil sustituidas como antagonistas del receptor 5-ht7Info
- Publication number
- PE20090629A1 PE20090629A1 PE2008001449A PE2008001449A PE20090629A1 PE 20090629 A1 PE20090629 A1 PE 20090629A1 PE 2008001449 A PE2008001449 A PE 2008001449A PE 2008001449 A PE2008001449 A PE 2008001449A PE 20090629 A1 PE20090629 A1 PE 20090629A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- ethyl
- phenyl
- receptor
- bencensulfonamide
- Prior art date
Links
- -1 PIPERAZINYL Chemical group 0.000 title abstract 4
- 239000005557 antagonist Substances 0.000 title abstract 2
- 108091005436 5-HT7 receptors Proteins 0.000 title 1
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical group C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052731 fluorine Inorganic materials 0.000 abstract 3
- 239000011737 fluorine Substances 0.000 abstract 3
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 3
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical group C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003053 piperidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIRAZINAS Y PIPERIDINAS PIPERAZINIL DE FORMULA (I) DONDE A ES -C(H)= O -N=; R1 ES FENILO OPCIONALMENTE SUSTITUIDO CON FLUOR O CLORO, PIRAZOL-4-ILO OPCIONALMENTE SUSTITUIDO CON METILO O ETILO, IMIDAZOLILO, ENTRE OTROS; R2 ES H O METILO; m ES DE 0 A 2; R3 ES H, FLUOR, HIDROXI, METOXI, ENTRE OTROS; R4 ES FLUOR, CLORO, METILO, METOXI, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: CLORHIDRATO DE N-{2-[3'-(4-METOXIMETIL-FENIL)-2,3,5,6-TETRAHIDRO-[1,2']BIPIRAZINIL-4-IL]-ETIL}-N-METIL-BENCENSULFONAMIDA, CLORHIDRATO DE 4-FLUORO-N-{2-[3'-(4-METOXIMETIL-FENIL)-2,3,5,6-TETRAHIDRO-[1,2']BIPIRAZINIL-4-IL]-ETIL}-N-METIL-BENCENSULFONAMIDA, CLORHIDRATO DE N-{2-[3'-(4-FLUORO-FENIL)-2,3,5,6-TETRAHIDRO-[1,2']BIPIRAZINIL-4-IL]-ETIL}-4-METOXI-N-METIL-BENCENSULFONAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS SELECTIVOS DEL RECEPTOR 5-TH7 SIENDO UTILES EN EL TRATAMIENTO DE MIGRANA
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96834407P | 2007-08-28 | 2007-08-28 | |
| US4875208P | 2008-04-29 | 2008-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090629A1 true PE20090629A1 (es) | 2009-05-16 |
Family
ID=39873874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001449A PE20090629A1 (es) | 2007-08-28 | 2008-08-27 | Pirazinas y piperidinas piperazinil sustituidas como antagonistas del receptor 5-ht7 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8048884B2 (es) |
| EP (1) | EP2188268B1 (es) |
| JP (1) | JP5290293B2 (es) |
| KR (1) | KR101148616B1 (es) |
| CN (1) | CN101790522B (es) |
| AR (1) | AR068111A1 (es) |
| AT (1) | ATE520673T1 (es) |
| AU (1) | AU2008293715B2 (es) |
| BR (1) | BRPI0816468A2 (es) |
| CA (1) | CA2694911C (es) |
| CY (1) | CY1111848T1 (es) |
| DK (1) | DK2188268T3 (es) |
| EA (1) | EA017809B1 (es) |
| HR (1) | HRP20110624T1 (es) |
| MX (1) | MX2010002352A (es) |
| PE (1) | PE20090629A1 (es) |
| PL (1) | PL2188268T3 (es) |
| PT (1) | PT2188268E (es) |
| SI (1) | SI2188268T1 (es) |
| TW (1) | TW200914020A (es) |
| WO (1) | WO2009029439A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI118473B (fi) | 2006-02-17 | 2007-11-30 | Outotec Oyj | Menetelmä kuparin talteenottamiseksi kuparisulfidimalmista |
| US7910588B2 (en) * | 2007-10-12 | 2011-03-22 | Eli Lilly And Company | 5-HT7 receptor antagonists |
| EP2558458B1 (de) | 2010-04-16 | 2017-09-06 | Bayer Intellectual Property GmbH | Neue heterocyclische verbindungen als schädlingsbekämpfungsmittel |
| AU2012323038B2 (en) | 2011-10-11 | 2016-09-08 | Ucb Pharma, S.A. | 2-oxo-piperidinyl derivatives |
| FR2995605B1 (fr) | 2012-09-18 | 2014-09-19 | Sanofi Sa | Derives de macrolides, leur preparation et leur application therapeutique. |
| CA2932051A1 (en) | 2013-12-20 | 2015-06-25 | Laboratorios Del Dr. Esteve, S.A. | Piperazine derivatives having multimodal activity against pain |
| CN110475773B (zh) | 2017-03-03 | 2025-06-24 | 琳达·佳慧·余 | 8-苯基异喹啉及其医药组合物用于治疗肠易激综合征 |
| KR102014335B1 (ko) * | 2017-12-01 | 2019-08-26 | 한국과학기술연구원 | 5-ht7 수용체의 조절제로 작용하는 아릴피라졸릴피페라진 또는 아릴피라졸릴다이아제페인의 유도체 및 이를 포함하는 중추신경계 질환 치료 또는 예방용 약학 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1149195C (zh) * | 1999-02-10 | 2004-05-12 | 伊莱利利公司 | 5－ht1f激动剂 |
| US20030008880A1 (en) * | 2001-05-02 | 2003-01-09 | Pfizer Inc. | 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity |
| US7153858B2 (en) * | 2003-01-31 | 2006-12-26 | Epix Delaware, Inc. | Arylpiperazinyl compounds |
| CA2514656A1 (en) * | 2003-01-31 | 2004-08-12 | Pfizer Products Inc. | 5ht7 antagonists and inverse agonists |
-
2008
- 2008-08-01 TW TW097129418A patent/TW200914020A/zh unknown
- 2008-08-19 BR BRPI0816468 patent/BRPI0816468A2/pt not_active Application Discontinuation
- 2008-08-19 HR HR20110624T patent/HRP20110624T1/hr unknown
- 2008-08-19 PT PT08798144T patent/PT2188268E/pt unknown
- 2008-08-19 AT AT08798144T patent/ATE520673T1/de active
- 2008-08-19 CA CA2694911A patent/CA2694911C/en not_active Expired - Fee Related
- 2008-08-19 EA EA201070321A patent/EA017809B1/ru not_active IP Right Cessation
- 2008-08-19 KR KR1020107004378A patent/KR101148616B1/ko not_active Expired - Fee Related
- 2008-08-19 MX MX2010002352A patent/MX2010002352A/es active IP Right Grant
- 2008-08-19 CN CN2008801048354A patent/CN101790522B/zh not_active Expired - Fee Related
- 2008-08-19 PL PL08798144T patent/PL2188268T3/pl unknown
- 2008-08-19 JP JP2010523034A patent/JP5290293B2/ja not_active Expired - Fee Related
- 2008-08-19 US US12/447,546 patent/US8048884B2/en not_active Expired - Fee Related
- 2008-08-19 AU AU2008293715A patent/AU2008293715B2/en not_active Ceased
- 2008-08-19 DK DK08798144.5T patent/DK2188268T3/da active
- 2008-08-19 SI SI200830392T patent/SI2188268T1/sl unknown
- 2008-08-19 EP EP08798144A patent/EP2188268B1/en not_active Not-in-force
- 2008-08-19 WO PCT/US2008/073543 patent/WO2009029439A1/en not_active Ceased
- 2008-08-27 AR ARP080103721A patent/AR068111A1/es unknown
- 2008-08-27 PE PE2008001449A patent/PE20090629A1/es not_active Application Discontinuation
-
2011
- 2011-09-20 CY CY20111100910T patent/CY1111848T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008293715A1 (en) | 2009-03-05 |
| TW200914020A (en) | 2009-04-01 |
| CN101790522A (zh) | 2010-07-28 |
| CN101790522B (zh) | 2012-06-27 |
| US8048884B2 (en) | 2011-11-01 |
| KR101148616B1 (ko) | 2012-05-21 |
| EP2188268B1 (en) | 2011-08-17 |
| CA2694911A1 (en) | 2009-03-05 |
| CA2694911C (en) | 2013-05-07 |
| BRPI0816468A2 (pt) | 2015-03-24 |
| HRP20110624T1 (hr) | 2011-09-30 |
| PL2188268T3 (pl) | 2011-12-30 |
| DK2188268T3 (da) | 2011-10-03 |
| US20100075976A1 (en) | 2010-03-25 |
| JP5290293B2 (ja) | 2013-09-18 |
| MX2010002352A (es) | 2010-08-04 |
| EA201070321A1 (ru) | 2010-08-30 |
| PT2188268E (pt) | 2011-10-03 |
| CY1111848T1 (el) | 2015-10-07 |
| EP2188268A1 (en) | 2010-05-26 |
| JP2010537994A (ja) | 2010-12-09 |
| EA017809B1 (ru) | 2013-03-29 |
| ATE520673T1 (de) | 2011-09-15 |
| SI2188268T1 (sl) | 2011-11-30 |
| AU2008293715B2 (en) | 2013-09-19 |
| AR068111A1 (es) | 2009-11-04 |
| KR20100038117A (ko) | 2010-04-12 |
| WO2009029439A1 (en) | 2009-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |