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PE20090595A1 - Derivados de quinoliniloxipiperidina y pirrolidina como antagonistas del receptor h1 - Google Patents

Derivados de quinoliniloxipiperidina y pirrolidina como antagonistas del receptor h1

Info

Publication number
PE20090595A1
PE20090595A1 PE2008001370A PE2008001370A PE20090595A1 PE 20090595 A1 PE20090595 A1 PE 20090595A1 PE 2008001370 A PE2008001370 A PE 2008001370A PE 2008001370 A PE2008001370 A PE 2008001370A PE 20090595 A1 PE20090595 A1 PE 20090595A1
Authority
PE
Peru
Prior art keywords
alkyl
piperidinyl
oxy
butyl
quinolinyloxipiperidine
Prior art date
Application number
PE2008001370A
Other languages
English (en)
Inventor
Paul Martin Gore
Ashley Paul Hancock
Simon Teanby Hodgson
Panayiotis Alexandrou Procopiou
Sadie Vile
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20090595A1 publication Critical patent/PE20090595A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDA A COMPUESTOS DERIVADOS DE QUINOLINILOXIPIPERIDINA Y PIRROLIDINA DE FORMULA (I) DONDE R1 ES ALQUILO(C1-C6) DE CADENA LINEAL; R2 ES -ALQUILEN(C1-C6)-R3-R4 EN EL QUE EL ALQUILENO ES DE CADENA LINEAL Y ESTA OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C3), O ES UN ANILLO DE 5 A 7 MIEMBROS QUE CONTIENE SO2; R3 ES -SO2-, -NR5SO2-, -SO2NR6-, ENTRE OTROS, DONDE R5 Y R6 SON CADA UNO H O ALQUILO(C1-C6); R4 ES ALQUILO(C1-C6), CICLOALQUILO(C5-C7), ENTRE OTROS; a ES 1 O 2. SON COMPUESTOS PREFERIDOS: 6-BUTIL-8-({1-[2-(ETILSULFONIL)ETIL]-4-PIPERIDINIL}OXI)QUINOLINA, N-(3-{4-[(6-PENTIL-8-QUINOLINIL)OXI]-1-PIPERIDINIL}PROPIL)ETANOSULFONAMIDA, N-(4-{4-[(6-BUTIL-8-QUINOLINIL)OXI]-1-PIPERIDINIL}BUTIL)METANOSULFONAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE HISTAMINA H1 SIENDO UTILES EN EL TRATAMIENTO DE RINITIS ALERGICA, ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA
PE2008001370A 2007-08-15 2008-08-13 Derivados de quinoliniloxipiperidina y pirrolidina como antagonistas del receptor h1 PE20090595A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95594107P 2007-08-15 2007-08-15
US8258508P 2008-07-22 2008-07-22

Publications (1)

Publication Number Publication Date
PE20090595A1 true PE20090595A1 (es) 2009-06-06

Family

ID=40351220

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001370A PE20090595A1 (es) 2007-08-15 2008-08-13 Derivados de quinoliniloxipiperidina y pirrolidina como antagonistas del receptor h1

Country Status (8)

Country Link
US (2) US20110281909A1 (es)
EP (1) EP2185542A2 (es)
JP (1) JP2010535845A (es)
AR (1) AR067927A1 (es)
CL (1) CL2008002384A1 (es)
PE (1) PE20090595A1 (es)
TW (1) TW200922581A (es)
WO (1) WO2009021965A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009050204A1 (en) * 2007-10-16 2009-04-23 Glaxo Group Limited Quinoline derivatives used to treat inflammatory and allergic diseases
WO2012045729A1 (en) 2010-10-05 2012-04-12 Glaxo Group Limited Imidazo [1, 2 -a] pyridine and pyrazolo [1, 5 -a] pyridine derivatives as trpv1 antagonists
WO2012072512A1 (en) 2010-11-29 2012-06-07 Glaxo Group Limited N-cyclobutyl-imidazopyridine or -pyrazolopyridine carboxamides as trpv1 antagonists
WO2012139963A1 (en) 2011-04-11 2012-10-18 Glaxo Group Limited N- cyclobutyl - imidazopyridine - methylamine as trpv1 antagonists
WO2014022752A1 (en) 2012-08-03 2014-02-06 Amgen Inc. Macrocycles as pim inhibitors
US9643946B2 (en) 2013-02-28 2017-05-09 Sk Chemicals Co., Ltd. Tricyclic compound and use thereof
WO2015028976A2 (en) * 2013-08-30 2015-03-05 Mahesh Kandula Compounds and methods for the treatment of inflammatory diseases
US10377775B2 (en) 2014-12-04 2019-08-13 Shin-Etsu Chemical Co., Ltd. Method for producing polyalkylene glycol derivative having amino group at end
JP6460937B2 (ja) * 2014-12-04 2019-01-30 信越化学工業株式会社 末端にアミノ基を有するポリアルキレングリコール誘導体の製造方法
US9708350B2 (en) 2014-12-04 2017-07-18 Shin-Etsu Chemical Co., Ltd. Method for producing polyalkylene glycol derivative having amino group at end, polymerization initiator for use in the same, and alcohol compound as raw material for the polymerization initiator
JP2024500567A (ja) * 2020-12-11 2024-01-09 アヴァカ ファーマ プライベート リミテッド フェキソフェナジンを含む組成物

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3632329A1 (de) * 1986-09-24 1988-03-31 Bayer Ag Substituierte phenylsulfonamide
FR2737892B1 (fr) * 1995-08-17 1997-10-24 Fournier Ind & Sante Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique
AU2001234690A1 (en) 2000-02-01 2001-08-14 Cor Therapeutics, Inc. 2-(1h)-quinolone and 2-(1h)-quinoxalone inhibitors of factor xa
ATE341545T1 (de) 2001-07-16 2006-10-15 Astrazeneca Ab Quinolin-derivate und ihre verwendung als inhibitoren der tyrosine kinase
AU2002347359A1 (en) 2001-12-05 2003-06-17 Astrazeneca Ab Quinoline derivatives
AU2002347336A1 (en) 2001-12-05 2003-06-17 Astrazeneca Ab Quinoline derivatives
AU2002365665A1 (en) 2001-12-05 2003-06-17 Astrazeneca Ab Pharmaceutical compositions comprising benzofuranyl substituted 3-cyanoquinoline derivatives and their use for the treatment of solid tumours
WO2003047585A1 (en) 2001-12-05 2003-06-12 Astrazeneca Ab Pharmaceutical compositions comprising benzofuranyl substituted 3-cyanoquinoline derivatives and their use for the treatment of solid tumours
WO2003047582A1 (en) 2001-12-05 2003-06-12 Astrazeneca Ab Quinoline derivatives as antitumour agents
WO2003105850A1 (en) 2002-06-18 2003-12-24 Abbott Laboratories 2-aminoquinolines as melanin concentrating hormone receptor antagonists
GB0215823D0 (en) 2002-07-09 2002-08-14 Astrazeneca Ab Quinazoline derivatives
US20040033959A1 (en) 2002-07-19 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Pharmaceutical compositions for hepatitis C viral protease inhibitors
AR041198A1 (es) * 2002-10-11 2005-05-04 Otsuka Pharma Co Ltd Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen
WO2004078748A2 (en) 2003-02-28 2004-09-16 Bayer Pharmaceuticals Corporation Novel bicyclic urea derivatives useful in the treatment of cancer and other disorders
DE10316081A1 (de) * 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
PT2213661E (pt) 2003-09-26 2011-12-15 Exelixis Inc Moduladores de c-met e métodos de uso
FR2865205B1 (fr) * 2004-01-16 2006-02-24 Sanofi Synthelabo Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique
GB0407025D0 (en) 2004-03-29 2004-04-28 Glaxo Group Ltd Novel compounds
JP5314244B2 (ja) 2004-10-27 2013-10-16 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
US20080161305A1 (en) 2005-04-06 2008-07-03 Exelixis, Inc. C-Met Modulators and Methods of Use
WO2006110516A1 (en) 2005-04-11 2006-10-19 Abbott Laboratories Acylhydrazide p2x7 antagonists and uses thereof

Also Published As

Publication number Publication date
WO2009021965A3 (en) 2009-04-16
US7884114B2 (en) 2011-02-08
US20110281909A1 (en) 2011-11-17
US20090270355A1 (en) 2009-10-29
WO2009021965A2 (en) 2009-02-19
JP2010535845A (ja) 2010-11-25
EP2185542A2 (en) 2010-05-19
CL2008002384A1 (es) 2009-07-17
TW200922581A (en) 2009-06-01
AR067927A1 (es) 2009-10-28

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Legal Events

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