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PE20081195A1 - Derivado de 2-piridincarboxamida que tiene efecto activador de gk - Google Patents

Derivado de 2-piridincarboxamida que tiene efecto activador de gk

Info

Publication number
PE20081195A1
PE20081195A1 PE2007001346A PE2007001346A PE20081195A1 PE 20081195 A1 PE20081195 A1 PE 20081195A1 PE 2007001346 A PE2007001346 A PE 2007001346A PE 2007001346 A PE2007001346 A PE 2007001346A PE 20081195 A1 PE20081195 A1 PE 20081195A1
Authority
PE
Peru
Prior art keywords
methyl
thio
triazol
carboxamide
pyridin
Prior art date
Application number
PE2007001346A
Other languages
English (en)
Inventor
Noriaki Hashimoto
Masanori Asai
Teruyuki Nishimura
Sagara Yufu
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Publication of PE20081195A1 publication Critical patent/PE20081195A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

REFERIDA A UN DERIVADO DE PIRIDINCARBOXAMIDA DE FORMULA (I), DONDE R1 Y R2 SON ALQUILO C1-C6; X1 ES UN COMPUESTO: -O-(CH2)m-NR11R12 (II-1), DONDE R11 Y R12 SON H, ALQUILO C1-C6, ENTRE OTROS Y m ES UN ENTERO DE 1 A 3. SON COMPUESTOS PREFERIDOS: 3-({4-2-(DIMETILAMINO)ETOXI]FENIL}TIO)-N-(3-METIL-1,2,4-TIADIAZOL-5-IL)-6-(4-METIL-4H-1,2,4-TRIAZOL-3-IL)TIO]PIRIDIN-2-CARBOXAMIDA, 3-({4-[(1-METILAZETIDIN-3-IL)OXI]FENILTIO)-N-(3-METIL-1,2,4-TIADIAZOL-5-IL)-6-[(4-METIL-4H-1,2,4-TRIAZOL-3-IL)TIO]PIRIDIN-2-CARBOXAMIDA, N-(3-METIL-1,2,4-TIADIAZOL-5-IL)-6-[(4-METIL-4H-1,2,4-TRIAZOL-3-IL)TIO]-3-{[4-(2-PIRROLIDIN-1-ILETOXI)FENIL]TIO}PIRIDIN-2-CARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ACTIVADORES DE LA GLUCOQUINASA Y SON UTILES EN EL TRATAMIENTO DE LA DIABETES Y LA OBESIDAD
PE2007001346A 2006-10-06 2007-10-04 Derivado de 2-piridincarboxamida que tiene efecto activador de gk PE20081195A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006275824 2006-10-06

Publications (1)

Publication Number Publication Date
PE20081195A1 true PE20081195A1 (es) 2008-09-04

Family

ID=39282963

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001346A PE20081195A1 (es) 2006-10-06 2007-10-04 Derivado de 2-piridincarboxamida que tiene efecto activador de gk

Country Status (22)

Country Link
US (1) US8338460B2 (es)
EP (1) EP2077266B1 (es)
JP (1) JP5292100B2 (es)
KR (1) KR20090060426A (es)
CN (1) CN101522673A (es)
AR (1) AR063028A1 (es)
AU (1) AU2007307560B2 (es)
BR (1) BRPI0716590A2 (es)
CA (1) CA2667068C (es)
CL (1) CL2007002890A1 (es)
CO (1) CO6180507A2 (es)
CR (1) CR10673A (es)
GT (1) GT200900065A (es)
IL (1) IL197714A0 (es)
MA (1) MA30813B1 (es)
MX (1) MX2009003073A (es)
NO (1) NO20091793L (es)
PE (1) PE20081195A1 (es)
RU (1) RU2009117209A (es)
SV (1) SV2009003196A (es)
TW (1) TW200831504A (es)
WO (1) WO2008044777A1 (es)

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Publication number Priority date Publication date Assignee Title
PE20050194A1 (es) * 2003-02-13 2005-04-23 Banyu Pharma Co Ltd Derivados de piridina-2-carboxamida como activadores de glucoquinasa
AR063028A1 (es) 2006-10-06 2008-12-23 Banyu Pharma Co Ltd Derivados heterociclicos de piridin-2-carboxamida activadores de glucoquinasas, utiles para el tratamiento de diabetes y obesidad y composiciones farmaceuticas que los contienen.
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2009063821A1 (ja) 2007-11-12 2009-05-22 Banyu Pharmaceutical Co., Ltd. ヘテロアリールオキシキナゾリン誘導体
US8592428B2 (en) 2008-08-15 2013-11-26 Msd K. K. Acetyl pyrrolidinyl indole derivative
CA2734981A1 (en) * 2008-08-29 2010-03-04 Banyu Pharmaceutical Co., Ltd. Oxotetrahydrofuran-2-yl-benzimidazole derivative
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9527838B2 (en) 2012-12-17 2016-12-27 Merck Sharp & Dohme Corp. 2-pyridinecarboxamide derivatives, compositions containing such compounds, and methods of treatment
CN113045546A (zh) * 2021-03-25 2021-06-29 浙江天宇药业股份有限公司 一种吡咯替尼杂质、其制备方法及用途

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SE0102764D0 (sv) * 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
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EP1496052B1 (en) * 2002-03-26 2009-08-05 Banyu Pharmaceutical Co., Ltd. Novel aminobenzamide derivative
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AU2004215514B2 (en) * 2003-02-26 2010-03-04 Msd K.K. Heteroarylcarbamoylbenzene derivative
BRPI0412259B1 (pt) 2003-07-22 2019-08-20 Astex Therapeutics Limited Compostos de 1H-pirazol 3,4-dissubstituídos como moduladores de quinases dependentes de ciclina (CDK), seus usos, processo para a preparação dos mesmos e composição farmacêutica
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AR063028A1 (es) 2006-10-06 2008-12-23 Banyu Pharma Co Ltd Derivados heterociclicos de piridin-2-carboxamida activadores de glucoquinasas, utiles para el tratamiento de diabetes y obesidad y composiciones farmaceuticas que los contienen.

Also Published As

Publication number Publication date
US8338460B2 (en) 2012-12-25
GT200900065A (es) 2010-04-28
TW200831504A (en) 2008-08-01
CO6180507A2 (es) 2010-07-19
CL2007002890A1 (es) 2008-01-18
MX2009003073A (es) 2009-04-02
CN101522673A (zh) 2009-09-02
AU2007307560A1 (en) 2008-04-17
CR10673A (es) 2009-09-03
NO20091793L (no) 2009-05-05
BRPI0716590A2 (pt) 2012-12-25
JP5292100B2 (ja) 2013-09-18
RU2009117209A (ru) 2010-11-20
KR20090060426A (ko) 2009-06-12
AU2007307560B2 (en) 2012-10-04
EP2077266A4 (en) 2010-07-07
AR063028A1 (es) 2008-12-23
CA2667068C (en) 2012-03-27
SV2009003196A (es) 2009-07-28
JPWO2008044777A1 (ja) 2010-02-18
WO2008044777A1 (fr) 2008-04-17
US20080090799A1 (en) 2008-04-17
MA30813B1 (fr) 2009-10-01
EP2077266B1 (en) 2012-07-25
CA2667068A1 (en) 2008-04-17
EP2077266A1 (en) 2009-07-08
IL197714A0 (en) 2009-12-24

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