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PE20081548A1 - N-[2-(2,1,3-BENZOTIADIAZOL-5-ILAMINO)-6-(2,6-DICLOROFENIL)PIRIDO[2,3-d]PIRIMIDIN-7-IL]-N'-(1,1-DIMETILETIL)-UREA Y DERIVADOS - Google Patents

N-[2-(2,1,3-BENZOTIADIAZOL-5-ILAMINO)-6-(2,6-DICLOROFENIL)PIRIDO[2,3-d]PIRIMIDIN-7-IL]-N'-(1,1-DIMETILETIL)-UREA Y DERIVADOS

Info

Publication number
PE20081548A1
PE20081548A1 PE2008000043A PE2008000043A PE20081548A1 PE 20081548 A1 PE20081548 A1 PE 20081548A1 PE 2008000043 A PE2008000043 A PE 2008000043A PE 2008000043 A PE2008000043 A PE 2008000043A PE 20081548 A1 PE20081548 A1 PE 20081548A1
Authority
PE
Peru
Prior art keywords
dimethylethyl
pyrimidin
dichlorophenyl
urea
benzotiadiazol
Prior art date
Application number
PE2008000043A
Other languages
English (en)
Inventor
Bernard Bourrie
Pierre Casellas
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38268928&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081548(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20081548A1 publication Critical patent/PE20081548A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

REFERIDA AL COMPUESTO N-[2-(2,1,3-BENZOTIADIAZOL-5-ILAMINO)-6-(2,6-DICLOROFENIL)PIRIDO[2,3-d]PIRIMIDIN-7-IL]-N'-(1,1-DIMETILETIL)-UREA, UNA SAL, HIDRATO O SOLVATO DEL MISMO. DICHO COMPUESTO PUEDE ADMINISTRARSE JUNTO CON UNO O VARIOS COMPUESTOS TALES COMO DAUNORUBICINA Y CITOSINA ARABINOSIDA, EN FORMA ORAL Y/O INTRAVENOSA PARA EL TRATAMIENTO DE LA LEUCEMIA, PRINCIPALMENTE, LEUCEMIA MIELOIDE
PE2008000043A 2006-12-28 2008-01-02 N-[2-(2,1,3-BENZOTIADIAZOL-5-ILAMINO)-6-(2,6-DICLOROFENIL)PIRIDO[2,3-d]PIRIMIDIN-7-IL]-N'-(1,1-DIMETILETIL)-UREA Y DERIVADOS PE20081548A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0611492A FR2910813B1 (fr) 2006-12-28 2006-12-28 Nouvelle utilisation therapeutique pour le traitement des leucemies

Publications (1)

Publication Number Publication Date
PE20081548A1 true PE20081548A1 (es) 2009-01-04

Family

ID=38268928

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000043A PE20081548A1 (es) 2006-12-28 2008-01-02 N-[2-(2,1,3-BENZOTIADIAZOL-5-ILAMINO)-6-(2,6-DICLOROFENIL)PIRIDO[2,3-d]PIRIMIDIN-7-IL]-N'-(1,1-DIMETILETIL)-UREA Y DERIVADOS

Country Status (39)

Country Link
US (1) US8236811B2 (es)
EP (1) EP2107906B1 (es)
JP (1) JP5317987B2 (es)
KR (1) KR101458233B1 (es)
CN (1) CN101568338B (es)
AR (1) AR064550A1 (es)
AT (1) ATE534392T1 (es)
AU (1) AU2007347370B2 (es)
BR (1) BRPI0720963A2 (es)
CA (1) CA2672716C (es)
CL (1) CL2007003846A1 (es)
CO (1) CO6190610A2 (es)
CR (1) CR10881A (es)
CY (1) CY1112443T1 (es)
DK (1) DK2107906T3 (es)
EA (1) EA016873B1 (es)
EC (1) ECSP099449A (es)
ES (1) ES2377843T3 (es)
FR (1) FR2910813B1 (es)
GT (1) GT200900168A (es)
HR (1) HRP20120170T1 (es)
JO (1) JO2748B1 (es)
MA (1) MA31100B1 (es)
MX (1) MX2009007054A (es)
MY (1) MY148515A (es)
NI (1) NI200900129A (es)
NO (1) NO20092496L (es)
NZ (1) NZ577991A (es)
PE (1) PE20081548A1 (es)
PL (1) PL2107906T3 (es)
PT (1) PT2107906E (es)
RS (1) RS52162B (es)
SI (1) SI2107906T1 (es)
SV (1) SV2009003315A (es)
TN (1) TN2009000234A1 (es)
TW (1) TWI433678B (es)
UA (1) UA97505C2 (es)
WO (1) WO2008102075A2 (es)
ZA (1) ZA200904478B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2948568B1 (fr) * 2009-07-30 2012-08-24 Sanofi Aventis Formulation pharmaceutique
EP2638911A1 (en) * 2012-03-14 2013-09-18 Sanofi Novel combinations for treating acute myeloid leukaemia or chronic myeloid leukaemia
KR102349893B1 (ko) * 2013-12-13 2022-01-10 노파르티스 아게 제약 투여 형태
US20230136218A1 (en) * 2019-09-23 2023-05-04 President And Fellows Of Harvard College Methods and compositions for treating acute myeloid leukemia

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1171218A (en) 1967-11-09 1969-11-19 Parke Davis & Co New Heterocyclic Amine Compounds and Methods for their Production
IL115256A0 (en) 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
PT790997E (pt) 1994-11-14 2000-06-30 Warner Lambert Co 6-aril pirido¬2,3-d|pirimidinas e naftiridinas para inibir a proliferacao celular mediada pela quinase da tirosina proteica
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
US5620981A (en) 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
CA2386474A1 (en) 1999-09-20 2001-03-29 Takeda Chemical Industries, Ltd. Melanin concentrating hormone antagonist
AP2002002586A0 (en) * 2000-01-25 2002-09-30 Warner Lambert Co Pyrido[2,3-d] pyrimidine-2,7-diamine kinase inhibitors.
JP2003528101A (ja) 2000-03-06 2003-09-24 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ５−アルキルピリド［２，３−ｄ］ピリミジンチロシンキナーゼ阻害剤
WO2002012238A2 (en) 2000-08-04 2002-02-14 Warner-Lambert Company 2-(4-PYRIDYL)AMINO-6-DIALKOXYPHENYL-PYRIDO[2,3-d]PYRIMIDIN-7-ONES
US20030105115A1 (en) * 2001-06-21 2003-06-05 Metcalf Chester A. Novel pyridopyrimidines and uses thereof
US20050009849A1 (en) 2003-01-03 2005-01-13 Veach Darren R. Pyridopyrimidine kinase inhibitors
TW200502236A (en) 2003-03-28 2005-01-16 Hoffmann La Roche Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
WO2005105097A2 (en) 2004-04-28 2005-11-10 Gpc Biotech Ag Pyridopyrimidines for treating inflammatory and other diseases
FR2873118B1 (fr) 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
PE20060569A1 (es) 2004-07-16 2006-06-22 Boehringer Ingelheim Int Compuestos de indol carbonilamino como inhibidores de la polimerasa ne5b del vhc
FR2887882B1 (fr) * 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.

Also Published As

Publication number Publication date
CY1112443T1 (el) 2015-12-09
EP2107906A2 (fr) 2009-10-14
ZA200904478B (en) 2010-08-25
MY148515A (en) 2013-04-30
EA200970639A1 (ru) 2010-04-30
UA97505C2 (ru) 2012-02-27
WO2008102075A2 (fr) 2008-08-28
CL2007003846A1 (es) 2009-01-23
DK2107906T3 (da) 2012-03-19
CO6190610A2 (es) 2010-08-19
NO20092496L (no) 2009-07-23
KR101458233B1 (ko) 2014-11-04
ECSP099449A (es) 2009-07-31
CA2672716A1 (fr) 2008-08-28
PL2107906T3 (pl) 2012-04-30
AU2007347370B2 (en) 2013-05-23
EA016873B1 (ru) 2012-08-30
CR10881A (es) 2009-08-12
CN101568338B (zh) 2011-11-23
EP2107906B1 (fr) 2011-11-23
RS52162B (sr) 2012-08-31
HK1138189A1 (en) 2010-08-20
NZ577991A (en) 2012-01-12
GT200900168A (es) 2010-03-19
US8236811B2 (en) 2012-08-07
PT2107906E (pt) 2012-03-05
TWI433678B (zh) 2014-04-11
MX2009007054A (es) 2009-08-12
ES2377843T3 (es) 2012-04-02
FR2910813B1 (fr) 2009-02-06
HRP20120170T1 (hr) 2012-03-31
ATE534392T1 (de) 2011-12-15
BRPI0720963A2 (pt) 2014-03-18
AU2007347370A1 (en) 2008-08-28
NI200900129A (es) 2011-12-13
US20090298790A1 (en) 2009-12-03
MA31100B1 (fr) 2010-01-04
JP2010514743A (ja) 2010-05-06
AR064550A1 (es) 2009-04-08
TN2009000234A1 (fr) 2010-10-18
WO2008102075A3 (fr) 2008-12-11
SV2009003315A (es) 2010-02-05
SI2107906T1 (sl) 2012-03-30
JO2748B1 (en) 2014-03-15
CA2672716C (fr) 2013-05-28
JP5317987B2 (ja) 2013-10-16
KR20090103899A (ko) 2009-10-01
CN101568338A (zh) 2009-10-28
TW200833343A (en) 2008-08-16
FR2910813A1 (fr) 2008-07-04

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