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PE20080349A1 - Estructuras de cristal de inhibidores sglt2 y procesos para preparar los mismos - Google Patents

Estructuras de cristal de inhibidores sglt2 y procesos para preparar los mismos

Info

Publication number
PE20080349A1
PE20080349A1 PE2007000845A PE2007000845A PE20080349A1 PE 20080349 A1 PE20080349 A1 PE 20080349A1 PE 2007000845 A PE2007000845 A PE 2007000845A PE 2007000845 A PE2007000845 A PE 2007000845A PE 20080349 A1 PE20080349 A1 PE 20080349A1
Authority
PE
Peru
Prior art keywords
prepare
processes
agent
sglt2 inhibitor
glass structures
Prior art date
Application number
PE2007000845A
Other languages
English (en)
Inventor
Jack Z Gougoutas
Hildegard Lobinger
Srividya Ramakrishnan
Prashant Deshpande
Jeffrey T Bien
Chiajen Lai
Chenchi Wang
Peter Riebel
John Anthony Grosso
Alexandra A Nirschl
Janak Singh
John D Dimarco
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38581970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080349(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20080349A1 publication Critical patent/PE20080349A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE REFIERE A UNA ESTRUCTURA CRISTALINA DE FORMULA I, CARACTERIZADA PORQUE COMPRENDE UNA ESTRUCTURA SELECCIONADA DEL GRUPO QUE CONSISTE DE (S)-PG (FORMA SC-3), R-PG (FORMA SD-3), ETOH (FORMA SA-1), ESTRUCTURA DE ETILENGLICOL (EG) (FORMA SB-1), ENTRE OTROS. REFERIDA TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA EN COMBINACION CON UNO O MAS AGENTES TERAPEUTICOS SELECCIONADOS DEL GRUPO QUE CONSISTE DE UN AGENTE ANTI-DIABETICO, ANTI-OBSESIDAD, ANTI-HIPERTENSIVO,ANTI-ATEROESCLEROTICO Y UN AGENTE REDUCTOR DE LIPIDOS. DICHO COMPUESTO ES INHIBIDOR DE SGLT2 UTIL EN EL TRATAMIENTO DE DIABETES, RETINOPATIA DIABETICA, NEFROPATIA DIABETICA, RETARDO DE CICATRIZACION DE HERIDAS, ENTRE OTROS
PE2007000845A 2006-06-28 2007-07-02 Estructuras de cristal de inhibidores sglt2 y procesos para preparar los mismos PE20080349A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81711806P 2006-06-28 2006-06-28
US11/765,481 US7919598B2 (en) 2006-06-28 2007-06-20 Crystal structures of SGLT2 inhibitors and processes for preparing same

Publications (1)

Publication Number Publication Date
PE20080349A1 true PE20080349A1 (es) 2008-04-25

Family

ID=38581970

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2007000845A PE20080349A1 (es) 2006-06-28 2007-07-02 Estructuras de cristal de inhibidores sglt2 y procesos para preparar los mismos
PE2011001791A PE20120776A1 (es) 2006-06-28 2007-07-02 Estructuras cristalinas de dapagliflozin y sus procesos de preparacion

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2011001791A PE20120776A1 (es) 2006-06-28 2007-07-02 Estructuras cristalinas de dapagliflozin y sus procesos de preparacion

Country Status (32)

Country Link
US (3) US7919598B2 (es)
EP (4) EP2457918A3 (es)
JP (6) JP5313889B2 (es)
KR (1) KR101493102B1 (es)
CN (2) CN103145773B (es)
AR (1) AR061730A1 (es)
AU (1) AU2007265246B2 (es)
BR (3) BRPI0713544B8 (es)
CA (3) CA2924318C (es)
CL (1) CL2007001915A1 (es)
CO (1) CO6160299A2 (es)
CY (1) CY1115738T1 (es)
DK (1) DK2069374T4 (es)
EA (4) EA020428B1 (es)
ES (3) ES2659862T5 (es)
HR (1) HRP20141007T4 (es)
IL (5) IL195882A (es)
MX (3) MX339143B (es)
MY (2) MY148566A (es)
NO (2) NO346828B1 (es)
NZ (4) NZ589195A (es)
PE (2) PE20080349A1 (es)
PH (1) PH12012500168B1 (es)
PL (1) PL2069374T5 (es)
PT (1) PT2069374E (es)
RS (1) RS53638B2 (es)
SG (2) SG172741A1 (es)
SI (1) SI2069374T2 (es)
TW (4) TWI421245B (es)
UA (1) UA96765C2 (es)
WO (1) WO2008002824A1 (es)
ZA (1) ZA200810475B (es)

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