PE20080150A1 - PYRIDINONE DERIVATIVES N-ARIL AND N-HETEROARYL SUBSTITUTED AS ANTAGONISTS OF THE MELANIN-CONCENTRATING HORMONE (MCH) RECEPTOR - Google Patents
PYRIDINONE DERIVATIVES N-ARIL AND N-HETEROARYL SUBSTITUTED AS ANTAGONISTS OF THE MELANIN-CONCENTRATING HORMONE (MCH) RECEPTORInfo
- Publication number
- PE20080150A1 PE20080150A1 PE2007000677A PE2007000677A PE20080150A1 PE 20080150 A1 PE20080150 A1 PE 20080150A1 PE 2007000677 A PE2007000677 A PE 2007000677A PE 2007000677 A PE2007000677 A PE 2007000677A PE 20080150 A1 PE20080150 A1 PE 20080150A1
- Authority
- PE
- Peru
- Prior art keywords
- aril
- mch
- antagonists
- receptor
- halo
- Prior art date
Links
- 101800002739 Melanin-concentrating hormone Proteins 0.000 title abstract 4
- ORRDHOMWDPJSNL-UHFFFAOYSA-N melanin concentrating hormone Chemical compound N1C(=O)C(C(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CCSC)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(NC(=O)C(NC(=O)C(N)CC(O)=O)C(C)O)CCSC)CSSCC(C(=O)NC(CC=2C3=CC=CC=C3NC=2)C(=O)NC(CCC(O)=O)C(=O)NC(C(C)C)C(O)=O)NC(=O)C2CCCN2C(=O)C(CCCNC(N)=N)NC(=O)C1CC1=CC=C(O)C=C1 ORRDHOMWDPJSNL-UHFFFAOYSA-N 0.000 title abstract 4
- 102000047659 melanin-concentrating hormone Human genes 0.000 title abstract 4
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000005299 pyridinones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 AMINO Chemical class 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- FIULGFJIHJJXMT-UHFFFAOYSA-N [C]1[N]C=CC=C1 Chemical class [C]1[N]C=CC=C1 FIULGFJIHJJXMT-UHFFFAOYSA-N 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical group OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIRIDINONA N-ARIL Y N-HETEROARIL SUSTITUIDOS DE FORMULA (I) DONDE A ES FENILO O PIRIDINILO; R1 Y R2 SON CADA UNO H, ALQUILO(C1-C3), ALQUILCARBONILO(C1-C3), ALQUILOXI(C1-C3)-ALQUILO(C1-C3), ENTRE OTROS; R3 ES H, HALO, CN, OH, OXO, ENTRE OTROS; R4 Y R5 SON CADA UNO H, HALO, CN, OH, AMINO, ENTRE OTROS; k Y l SON CADA UNO DE 0 A 4; m ES DE 0 A 3; Y1 E Y3 SON CADA UNO UN ENLACE SIMPLE, NR7, O, S, SO O SO2, DONDE R7 ES H O ALQUILO(C1-C3); Y2 ES UN HIDROCARBURO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HALO, CN, OH, AMINO, TIO, ENTRE OTROS; B ES UN ANILLO DE 6 MIEMBROS QUE TIENE HASTA 3 ATOMOS DE N OPCIONALMENTE SUSTITUIDO CON HALO, CN, OH, OXO, TIO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS LOS COMPUESTOS DE FORMULA (i), (ii), ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE LA HORMONA CONCENTRADORA DE MELANINA (MCH) SIENDO UTILES EN EL TRATAMIENTO DE ANSIEDAD, DEPRESION, PSICOSISREFERS TO COMPOUNDS DERIVED FROM N-ARIL AND N-HETEROARIL PYRIDINONE SUBSTITUTED FROM FORMULA (I) WHERE A IS PHENYL OR PYRIDINYL; R1 AND R2 ARE EACH H, ALKYL (C1-C3), ALKYLCARBONyl (C1-C3), ALKYLOXY (C1-C3) -ALKYL (C1-C3), AMONG OTHERS; R3 IS H, HALO, CN, OH, OXO, AMONG OTHERS; R4 AND R5 ARE EACH H, HALO, CN, OH, AMINO, AMONG OTHERS; k AND l ARE EACH FROM 0 TO 4; m IS 0 TO 3; Y1 AND Y3 ARE EACH A SIMPLE LINK, NR7, O, S, SO OR SO2, WHERE R7 IS H OR ALKYL (C1-C3); Y2 IS A HYDROCARBON (C1-C6) OPTIONALLY SUBSTITUTED WITH HALO, CN, OH, AMINO, TIO, AMONG OTHERS; B IS A RING OF 6 MEMBERS THAT HAS UP TO 3 ATOMS OF N OPTIONALLY REPLACED WITH HALO, CN, OH, OXO, TIO, AMONG OTHERS. PREFERRED COMPOUNDS ARE THE COMPOUNDS OF FORMULA (i), (ii), AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE ANTAGONISTS OF THE MELANIN CONCENTRATING HORMONE (MCH) RECEPTOR, BEING USEFUL IN THE TREATMENT OF ANXIETY, DEPRESSION, PSYCHOSIS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06114917 | 2006-06-02 | ||
| EP06123263 | 2006-10-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080150A1 true PE20080150A1 (en) | 2008-04-11 |
Family
ID=38266244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000677A PE20080150A1 (en) | 2006-06-02 | 2007-05-31 | PYRIDINONE DERIVATIVES N-ARIL AND N-HETEROARYL SUBSTITUTED AS ANTAGONISTS OF THE MELANIN-CONCENTRATING HORMONE (MCH) RECEPTOR |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR061163A1 (en) |
| PE (1) | PE20080150A1 (en) |
| TW (1) | TW200811146A (en) |
| UY (1) | UY30378A1 (en) |
| WO (1) | WO2007141200A1 (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008041090A1 (en) * | 2006-10-06 | 2008-04-10 | Pfizer Limited | Malanin concentrating hormone receptor-1 antagonist pyridinones |
| CA2727055C (en) | 2008-01-11 | 2016-12-20 | Albany Molecular Research, Inc. | (1-azinone) -substituted pyridoindoles as mch antagonists |
| US8278316B2 (en) | 2009-03-09 | 2012-10-02 | Bristol-Myers Squibb Company | Aza pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists |
| EP2437599A4 (en) * | 2009-06-03 | 2012-10-31 | Glaxosmithkline Llc | Bis-pyridylpyridones as melanin-concentrating hormone receptor 1 antagonists |
| WO2010141545A1 (en) * | 2009-06-03 | 2010-12-09 | Glaxosmithkline Llc | Bis-pyridylpyridones as melanin-concentrating hormone receptor 1 antagonists |
| WO2011003012A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof |
| WO2011003007A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| EP2448585B1 (en) * | 2009-07-01 | 2014-01-01 | Albany Molecular Research, Inc. | Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof |
| WO2011003021A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| WO2011127643A1 (en) * | 2010-04-12 | 2011-10-20 | Merck Sharp & Dohme Corp. | Pyridone derivatives |
| EP2558094A4 (en) * | 2010-04-12 | 2013-09-25 | Merck Sharp & Dohme | PYRIDONE DERIVATIVES |
| US9359300B2 (en) | 2010-12-06 | 2016-06-07 | Confluence Life Sciences, Inc. | Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
| DK2648516T3 (en) | 2010-12-06 | 2019-01-02 | Aclaris Therapeutics Inc | SUBSTITUTED PYRIDINON-PYRIDINYL COMPOUNDS |
| US8993765B2 (en) | 2010-12-21 | 2015-03-31 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof |
| US8697700B2 (en) | 2010-12-21 | 2014-04-15 | Albany Molecular Research, Inc. | Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof |
| WO2013149362A1 (en) * | 2012-04-06 | 2013-10-10 | Glaxosmithkline Llc | 1-(dihydronaphthalenyl)pyridones as melanin-concentrating hormone receptor 1 antagonists |
| KR102057877B1 (en) | 2012-07-18 | 2019-12-20 | 노스 앤드 사우스 브라더 파마시 인베스트먼트 컴파니 리미티드 | Nitrogenous heterocyclic derivatives and their application in drugs |
| RS61724B1 (en) | 2013-06-07 | 2021-05-31 | Aclaris Therapeutics Inc | Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
| JP6454348B2 (en) | 2013-12-19 | 2019-01-16 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | Nitrogen heterocyclic derivatives and their applications in medicine |
| CN107698499A (en) * | 2016-08-08 | 2018-02-16 | 罗楹 | A kind of preparation method of oxynidone |
| CN116023327A (en) * | 2016-08-08 | 2023-04-28 | 北京康蒂尼药业股份有限公司 | Preparation method of hydroxynisone |
| JP2023509800A (en) * | 2020-01-10 | 2023-03-09 | コンシナンス セラピューティクス， インコーポレイテッド | Therapeutic combinations of drugs and methods of their use |
| JP2023519891A (en) | 2020-03-27 | 2023-05-15 | アクラリス セラピューティクス，インコーポレイテッド | Processes, Compositions, and Crystalline Forms of Substituted Pyridinone-Pyridinyl Compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1490064E (en) * | 2002-02-14 | 2009-12-28 | Pharmacia Corp | Substituted pyridinones as modulators of p38 map kinase |
| US7732456B2 (en) * | 2004-03-05 | 2010-06-08 | Banyu Pharmaceutical Co., Ltd. | Pyridone derivative |
| WO2007024004A1 (en) * | 2005-08-24 | 2007-03-01 | Banyu Pharmaceutical Co., Ltd. | Phenylpyridone derivative |
-
2007
- 2007-05-31 UY UY30378A patent/UY30378A1/en unknown
- 2007-05-31 PE PE2007000677A patent/PE20080150A1/en not_active Application Discontinuation
- 2007-06-01 AR ARP070102381A patent/AR061163A1/en not_active Application Discontinuation
- 2007-06-01 TW TW096119627A patent/TW200811146A/en unknown
- 2007-06-01 WO PCT/EP2007/055376 patent/WO2007141200A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007141200A1 (en) | 2007-12-13 |
| WO2007141200A8 (en) | 2008-03-27 |
| AR061163A1 (en) | 2008-08-06 |
| TW200811146A (en) | 2008-03-01 |
| UY30378A1 (en) | 2008-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |