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PE20080011A1 - Derivados de diazepina y combinaciones farmaceuticas que los comprenden - Google Patents

Derivados de diazepina y combinaciones farmaceuticas que los comprenden

Info

Publication number
PE20080011A1
PE20080011A1 PE2007000326A PE2007000326A PE20080011A1 PE 20080011 A1 PE20080011 A1 PE 20080011A1 PE 2007000326 A PE2007000326 A PE 2007000326A PE 2007000326 A PE2007000326 A PE 2007000326A PE 20080011 A1 PE20080011 A1 PE 20080011A1
Authority
PE
Peru
Prior art keywords
diazepine
quinoline
decahydrocyclopenta
bromo
halogen
Prior art date
Application number
PE2007000326A
Other languages
English (en)
Inventor
Sharon Rosenzweig-Lipson
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38510419&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080011(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20080011A1 publication Critical patent/PE20080011A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

REFERIDA A UNA COMPOSICION QUE COMPRENDE: a) UN FARMACO ANTIPSICOTICO TIPICO O ATIPICO, b) OPCIONALMENTE, UN PORTADOR O VEHICULO FARMACEUTICAMENTE ACEPTABLE Y c) UN DERIVADO DIAZEPINO DE FORMULA (I), DONDE LA LINEA PUNTEADA REPRESENTA UN ENLACE SIMPLE O DOBLE; n ES 1 O 2; m ES 0 O 1; R1 Y R2 SON HALOGENO, CN, R, OR, ENTRE OTROS; R ES H O ALQUILO C1-C6; R3 Y R4 JUNTO CON LOS ATOMOS DE CARBONO A LOS CUALES ESTAN LIGADOS, FORMAN UN ANILLO DE 4 A 8 MIEMBROS, SATURADO O INSATURADO Y QUE OPCIONALMENTE ESTA SUSTITUIDO CON HALOGENO, R U OR; R5 Y R6 SON R. SON COMPUESTOS DE FORMULA (I) FAVORITOS: 2-BROMO-4,5,6,7,9,9a,10,11,12,13,14,14a-DODECAHIDROCICLOHEPTA[c][1,4]DIAZEPINO[6,7,1-ij]QUINOLINA, 2-BROMO-4,5,6,7,9,,9a,10,11,12,12a-DECAHIDROCICLOPENTA[c][1,4]DIAZEPINO[6,7,1-ij]QUINOLINA, 2-CLORO-4,5,6,7,9,9a,10,11,12,12a-DECAHIDROCICLOPENTA[c][1,4]DIAZEPINO[6,7,1-ij]QUINOLINA, ENTRE OTROS. EL AGENTE ANTIPSICOTICO ES CLORPROMAZINA, TIORIDAZINA, MESORIDAZINA, RISPERIDONA, OLANZAPINA, ENTRE OTROS. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE TRASTORNOS PSICOTICOS
PE2007000326A 2006-03-24 2007-03-23 Derivados de diazepina y combinaciones farmaceuticas que los comprenden PE20080011A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78544906P 2006-03-24 2006-03-24
US78839206P 2006-03-31 2006-03-31

Publications (1)

Publication Number Publication Date
PE20080011A1 true PE20080011A1 (es) 2008-03-11

Family

ID=38510419

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000326A PE20080011A1 (es) 2006-03-24 2007-03-23 Derivados de diazepina y combinaciones farmaceuticas que los comprenden

Country Status (18)

Country Link
US (1) US20070238725A1 (es)
EP (1) EP1998780A2 (es)
JP (1) JP2009531432A (es)
KR (1) KR20080107429A (es)
AR (1) AR060086A1 (es)
AU (1) AU2007230981A1 (es)
BR (1) BRPI0709129A2 (es)
CA (1) CA2644639A1 (es)
CR (1) CR10255A (es)
EC (1) ECSP088761A (es)
IL (1) IL193799A0 (es)
MX (1) MX2008012093A (es)
NO (1) NO20083790L (es)
PA (1) PA8720601A1 (es)
PE (1) PE20080011A1 (es)
RU (1) RU2008140136A (es)
TW (1) TW200806321A (es)
WO (1) WO2007111983A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200500317A (es) * 2004-11-05 2006-10-27 Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
AR054849A1 (es) * 2005-07-26 2007-07-18 Wyeth Corp Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
TW200734334A (en) * 2006-01-13 2007-09-16 Wyeth Corp Treatment of substance abuse
US20070225277A1 (en) * 2006-03-24 2007-09-27 Wyeth Treatment of pain
TW200806300A (en) * 2006-03-24 2008-02-01 Wyeth Corp New therapeutic combinations for the treatment of depression
PE20080126A1 (es) * 2006-03-24 2008-04-07 Wyeth Corp Metodos para tratar trastornos cognitivos y otros afines
CL2008002777A1 (es) * 2007-09-21 2010-01-22 Wyeth Corp Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario.
KR102275505B1 (ko) * 2015-04-27 2021-07-08 아레나 파마슈티칼스, 인크. 5-ht2c 수용체 효능제 및 조성물 및 사용 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914250A (en) * 1974-08-01 1975-10-21 American Home Prod 1,4-Diazepino{8 6,5,4-jk{9 carbazoles
AU2002227170A1 (en) * 2000-11-03 2002-05-15 Wyeth Cycloalkyl(b)(1,4)diazepino(6,7,1-hi)indoles and derivatives
TWI312781B (en) * 2002-04-25 2009-08-01 [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TW200307540A (en) * 2002-04-25 2003-12-16 Wyeth Corp [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
EP1587789B1 (en) * 2003-01-16 2008-09-03 Acadia Pharmaceuticals Inc. Selective serotonin 2a/2c receptor inverse agonists as therapeutics for neurodegenerative diseases
JP2007504181A (ja) * 2003-09-04 2007-03-01 ハー・ルンドベック・アクチエゼルスカベット セロトニン再取り込み阻害剤およびロキサピンの併用

Also Published As

Publication number Publication date
BRPI0709129A2 (pt) 2011-06-28
MX2008012093A (es) 2008-10-03
ECSP088761A (es) 2008-10-31
US20070238725A1 (en) 2007-10-11
AR060086A1 (es) 2008-05-21
KR20080107429A (ko) 2008-12-10
EP1998780A2 (en) 2008-12-10
AU2007230981A1 (en) 2007-10-04
WO2007111983A8 (en) 2007-12-21
CR10255A (es) 2008-11-26
WO2007111983A2 (en) 2007-10-04
TW200806321A (en) 2008-02-01
IL193799A0 (en) 2009-09-22
CA2644639A1 (en) 2007-10-04
PA8720601A1 (es) 2008-11-19
WO2007111983A3 (en) 2008-05-29
RU2008140136A (ru) 2010-04-27
JP2009531432A (ja) 2009-09-03
NO20083790L (no) 2008-10-21

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