[go: up one dir, main page]

PE20080678A1 - Eteres heterociclicos substituidos y sus uso en trastornos del cns - Google Patents

Eteres heterociclicos substituidos y sus uso en trastornos del cns

Info

Publication number
PE20080678A1
PE20080678A1 PE2007000983A PE2007000983A PE20080678A1 PE 20080678 A1 PE20080678 A1 PE 20080678A1 PE 2007000983 A PE2007000983 A PE 2007000983A PE 2007000983 A PE2007000983 A PE 2007000983A PE 20080678 A1 PE20080678 A1 PE 20080678A1
Authority
PE
Peru
Prior art keywords
heterociclic
ethers
substituted
alkyl
methyl
Prior art date
Application number
PE2007000983A
Other languages
English (en)
Inventor
Joanne J Bronson
Mark J Silva
Kevin W Gillman
Michael F Parker
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20080678A1 publication Critical patent/PE20080678A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 ES H, ALQUILO; R2 ES H, ALQUILO; R3 ES H, ALQUILO; Ar1 ES FENILO, PIRIDINILO, ENTRE OTROS; Ar2 ES PIRIDINILO, PIRIMIDINILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-(4-METOXIFENIL)-6-(((4-FENILPIPERIDIN-4-IL)METOXI)METIL)-4-(TRIFLUORMETIL)PIRIDINA; 1-METIL-4-(6-(((4-FENILPIPERIDIN-4-IL)METOXI)METIL)-4-(TRIFLUOROMETIL)PIRIDIN-2-IL)PIPERAZINA; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DESCRITOS SON INHIBIDORES DE LA REABSORCION DE NEUROQUININA-1, UTILES EN EL TRATAMIENTO BULIMIA, TRASTORNO DE PANICO, DEPRESION, ANSIEDAD Y DEMAS RELACIONADOS
PE2007000983A 2006-07-27 2007-07-26 Eteres heterociclicos substituidos y sus uso en trastornos del cns PE20080678A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83365206P 2006-07-27 2006-07-27

Publications (1)

Publication Number Publication Date
PE20080678A1 true PE20080678A1 (es) 2008-06-26

Family

ID=38895951

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000983A PE20080678A1 (es) 2006-07-27 2007-07-26 Eteres heterociclicos substituidos y sus uso en trastornos del cns

Country Status (16)

Country Link
US (1) US20080027056A1 (es)
EP (1) EP2069328A2 (es)
JP (1) JP2009544726A (es)
KR (1) KR20090043497A (es)
CN (1) CN101495470A (es)
AR (1) AR062113A1 (es)
AU (1) AU2007276744A1 (es)
BR (1) BRPI0714615A2 (es)
CA (1) CA2659192A1 (es)
CL (1) CL2007002201A1 (es)
MX (1) MX2009000762A (es)
NO (1) NO20090193L (es)
PE (1) PE20080678A1 (es)
TW (1) TW200817361A (es)
WO (1) WO2008014247A2 (es)
ZA (1) ZA200900613B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090018163A1 (en) * 2007-07-11 2009-01-15 Bristol-Myers Squibb Company Substituted Heterocyclic Ethers and Their Use in CNS Disorders
US8026257B2 (en) * 2007-07-11 2011-09-27 Bristol-Myers Squibb Company Substituted heterocyclic ethers and their use in CNS disorders
US7632861B2 (en) * 2007-11-13 2009-12-15 Bristol-Myers Squibb Company Substituted heterocyclic ethers and their use in CNS disorders
WO2009096941A1 (en) * 2008-01-28 2009-08-06 Bristol-Myers Squibb Company Substituted heterocyclic ethers and their use in cns disorders
SG187286A1 (en) 2011-07-29 2013-02-28 Smart Communications Inc System and method for activating a mobile device to initiate a communication

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69327541T2 (de) * 1992-10-28 2000-08-10 Merck Sharp & Dohme Ltd., Hoddesdon 4-arylmethyloxymethyl piperidine als tachykinin antagonisten
JP4592077B2 (ja) * 2002-07-03 2010-12-01 シェーリング コーポレイション 嘔吐、抑鬱、不安および咳の処置のためのニューロキニン−１（ｎｋ−１）アンタゴニストとしての１−アミド−４−フェニル−４−ベンジルオキシメチル−ピペリジン誘導体および関連化合物
JP2006502157A (ja) * 2002-09-09 2006-01-19 アストラゼネカ・アクチエボラーグ ナフチルエーテル化合物及びそれらの使用
US20070249607A1 (en) * 2006-04-17 2007-10-25 Bristol-Myers Squibb Company Nk-1 and serotonin transporter inhibitors

Also Published As

Publication number Publication date
WO2008014247A2 (en) 2008-01-31
JP2009544726A (ja) 2009-12-17
NO20090193L (no) 2009-01-29
ZA200900613B (en) 2010-04-28
KR20090043497A (ko) 2009-05-06
CN101495470A (zh) 2009-07-29
MX2009000762A (es) 2009-01-28
EP2069328A2 (en) 2009-06-17
TW200817361A (en) 2008-04-16
BRPI0714615A2 (pt) 2013-06-18
CA2659192A1 (en) 2008-01-31
AR062113A1 (es) 2008-10-15
AU2007276744A1 (en) 2008-01-31
WO2008014247A3 (en) 2008-03-20
CL2007002201A1 (es) 2008-02-08
US20080027056A1 (en) 2008-01-31

Similar Documents

Publication Publication Date Title
EA200901379A1 (ru) Производные никотиновой кислоты как модуляторы метаботропных глутаматных рецепторов 5 подтипа
PE20061436A1 (es) Derivados de amida sustituida como inhibidores de proteina quinasa
EA200801996A1 (ru) 2-замещенные производные 4-бензилфталазинонов в качестве гистаминовых h1- и h3-антагонистов
PE20100087A1 (es) Compuestos y composiciones como inhibidores de cinasa
PE20090444A1 (es) Eteres heterociclicos sustituidos y su uso en trastornos del snc
PE20081845A1 (es) Nuevos derivados de aminopirimidina como inhibidores de plk1
AR062965A1 (es) Compuestos moduladores de receptores de glutamatometabotropicos mglur5, composiciones farmaceuticas que los contienen y usos terapeuticos en trastornos gastrointestinales, neurologicos y psiquiatricos agudos y cronicos
PE20161066A1 (es) Derivados de piperidinil-indol como inhibidores del factor de complemento b y usos de los mismos
PE20142294A1 (es) Compuestos de indol e indazol que activan la ampk
PE20121050A1 (es) Compuestos de n-(1-(4-(1h-pirazol-5-il)ftalazin-1-il)piperidin-4-il)-benzamida sustituidos como antagonistas de la trayectoria hedgehog
PE20131377A1 (es) Triazina-oxadiazoles
PE20140192A1 (es) Derivados de bencimidazol como inhibidores de cinasa pi3
PE20050681A1 (es) PIRIDO[2,3-d] PIRIMIDINA-2,4-DIAMINAS COMO INHIBIDORES DE PDE 2
DE602005014086D1 (de) Pyrimidinderivate als orexin-rezeptorantagonisten
PE20091204A1 (es) Derivados de 2-aminoquinolina como antagonistas del receptor de 5-ht5a
PE20110433A1 (es) Antagonistas de la via hedgehog de ftalazina disustituida
CO6140060A2 (es) Derivados de aminocicloalquil 1,2,4-triazol como moduladores de mglur5
PE20141598A1 (es) Derivados de dihidro-benzo-oxazina y dihidro-pirido-oxazina
EA201171062A1 (ru) Алкиламидные соединения и их применение
PE20091450A1 (es) INHIBIDORES DE LA ESTEAROIL-CoA-DESATURASA
AR060813A1 (es) Moduladores de mglur5 iii
DK2203444T3 (da) Faste former af (S)-ethyl-2-amino-3-(4-(2-amino-6-((R)-1-(4-chlor-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluorethoxy)pyrimidin-4-yl)phenyl)propanoat
PE20151535A1 (es) Derivado de dihidropiridazin-3,5-diona
PE20080678A1 (es) Eteres heterociclicos substituidos y sus uso en trastornos del cns
PE20140968A1 (es) Derivados de benzamida sustituida

Legal Events

Date Code Title Description
FC Refusal