PE20080432A1 - CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS - Google Patents
CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODSInfo
- Publication number
- PE20080432A1 PE20080432A1 PE2007000999A PE2007000999A PE20080432A1 PE 20080432 A1 PE20080432 A1 PE 20080432A1 PE 2007000999 A PE2007000999 A PE 2007000999A PE 2007000999 A PE2007000999 A PE 2007000999A PE 20080432 A1 PE20080432 A1 PE 20080432A1
- Authority
- PE
- Peru
- Prior art keywords
- pyridyl
- amino
- substituted
- phenyl
- compositions
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000005829 chemical entities Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 CARBOXYL Chemical group 0.000 abstract 2
- 102000003505 Myosin Human genes 0.000 abstract 2
- 108060008487 Myosin Proteins 0.000 abstract 2
- DUAJIKVIRGATIW-UHFFFAOYSA-N trinitrogen(.) Chemical class [N]=[N+]=[N-] DUAJIKVIRGATIW-UHFFFAOYSA-N 0.000 abstract 2
- VVUSJBSGROBYOY-UHFFFAOYSA-N CC(CCNC1=C(C=CC=C1)C1=CC=C(C=N1)C(=O)NCC=1C=NC=CC1)C Chemical compound CC(CCNC1=C(C=CC=C1)C1=CC=C(C=N1)C(=O)NCC=1C=NC=CC1)C VVUSJBSGROBYOY-UHFFFAOYSA-N 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 150000001409 amidines Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- KDVFRXTWJDZBAJ-UHFFFAOYSA-N n-methyl-6-phenyl-2-(2-phenylethylamino)pyridine-3-carboxamide Chemical compound CNC(=O)C1=CC=C(C=2C=CC=CC=2)N=C1NCCC1=CC=CC=C1 KDVFRXTWJDZBAJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA X, DONDE W1 ES N, CR6; W2 ES N, CR4, SIEMPRE QUE AMBOS W1 Y W2 NO SON N; R1 Y R4 SON CADA UNO H, CIANO, HALO, HIDROXI, AZIDO, ENTRE OTROS; Z1 ES H, ARILO SUSTITUIDO O NO, HETEROARILO, ENTRE OTROS; Z2 ES H, CARBOXILO, AMIDINO SUSTITUIDO O NO, ACILO, ENTRE OTROS; Z3 ES H, HALOGENO, ALQUILO SUSTITUIDO O NO; R3 ES H, ALQUILO SUSTITUIDO O NO; R6 ES H, ACILO, CIANO, HALO, AZIDO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-METIL-{6-FENIL-2-[(2-FENILETIL)AMINO]-(3-PIRIDIL)}CARBOXAMIDA; {2-[(3-METILBUTIL)AMINO]-6-FENIL-(3-PIRIDIL)}-N-(3-PIRIDILMETIL)CARBOXAMIDA; 2-{[(METILSULFONIL)AMINO]METIL}PIPERIDIL-6-FENIL-2-[(2-(2-PIRIDIL)ETIL)AMINO](3-PIRIDIL)CETONA; ENTRE OTROS. REFERIDA TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS MODULAN MIOSINA DEL MUSCULO LISO Y/O MIOSINA NO MUSCULAR UTILES EN EL TRATAMIENTO DE HIPERTENSION, ASMA, GLAUCOMA, DERRAME CEREBRAL, ENTRE OTROSREFERS TO A COMPOUND OF FORMULA X, WHERE W1 IS N, CR6; W2 IS N, CR4, PROVIDED THAT BOTH W1 AND W2 ARE NOT N; R1 AND R4 ARE EACH H, CYANE, HALO, HYDROXY, AZIDO, AMONG OTHERS; Z1 IS H, ARYL, SUBSTITUTED OR NOT, HETEROARYL, AMONG OTHERS; Z2 IS H, CARBOXYL, AMIDINE SUBSTITUTED OR NOT, ACIL, AMONG OTHERS; Z3 IS H, HALOGEN, ALKYL SUBSTITUTED OR NOT; R3 IS H, RENTAL SUBSTITUTED OR NOT; R6 IS H, ACILO, CYANE, HALO, AZIDO, AMONG OTHERS. PREFERRED COMPOUNDS ARE: N-METHYL- {6-PHENYL-2 - [(2-PHENYLETHYL) AMINO] - (3-PYRIDYL)} CARBOXAMIDE; {2 - [(3-METHYLBUTYL) AMINO] -6-PHENYL- (3-PYRIDYL)} - N- (3-PYRIDYLMETHYL) CARBOXAMIDE; 2 - {[(METHYLSULFONYL) AMINO] METHYL} PIPERIDYL-6-PHENYL-2 - [(2- (2-PYRIDYL) ETHYL) AMINO] (3-PYRIDYL) KETONE; AMONG OTHERS. ALSO REFERRED TO A PREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS MODULATE SMOOTH MUSCLE MYOSIN AND / OR NON-MUSCULAR MYOSIN USEFUL IN THE TREATMENT OF HYPERTENSION, ASTHMA, GLAUCOMA, BRAIN SPILL, AMONG OTHERS
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83501006P | 2006-08-01 | 2006-08-01 | |
| US83490306P | 2006-08-01 | 2006-08-01 | |
| US83518306P | 2006-08-01 | 2006-08-01 | |
| US83490106P | 2006-08-01 | 2006-08-01 | |
| US83490406P | 2006-08-01 | 2006-08-01 | |
| US83523606P | 2006-08-02 | 2006-08-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080432A1 true PE20080432A1 (en) | 2008-05-29 |
Family
ID=38997696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000999A PE20080432A1 (en) | 2006-08-01 | 2007-08-01 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR062176A1 (en) |
| PE (1) | PE20080432A1 (en) |
| TW (1) | TW200823188A (en) |
| WO (1) | WO2008016643A2 (en) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7919511B2 (en) | 2006-08-01 | 2011-04-05 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| US7939534B2 (en) | 2006-08-01 | 2011-05-10 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| US7932270B2 (en) | 2006-08-01 | 2011-04-26 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| US7939548B2 (en) | 2006-08-02 | 2011-05-10 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
| EP2202228B1 (en) | 2007-10-15 | 2014-12-10 | Takeda Pharmaceutical Company Limited | Amide compounds and use of the same |
| EP2440204B1 (en) | 2009-06-12 | 2013-12-18 | Bristol-Myers Squibb Company | Nicotinamide compounds useful as kinase modulators |
| HRP20160967T1 (en) | 2009-10-06 | 2016-10-07 | Millennium Pharmaceuticals, Inc. | Heterocyclic compounds useful as pdk1 inhibitors |
| US8377970B2 (en) | 2009-10-08 | 2013-02-19 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel |
| US8993612B2 (en) | 2009-10-08 | 2015-03-31 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer |
| WO2014134391A1 (en) | 2013-02-28 | 2014-09-04 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| TW201444798A (en) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors |
| WO2015010832A1 (en) * | 2013-07-22 | 2015-01-29 | Syngenta Participations Ag | Microbiocidal heterocyclic derivatives |
| JP2017214290A (en) * | 2014-09-12 | 2017-12-07 | 田辺三菱製薬株式会社 | Aromatic carboxylic acid amide compound |
| EP3319968A1 (en) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| RS62639B1 (en) | 2015-07-06 | 2021-12-31 | Alkermes Inc | Hetero-halo inhibitors of histone deacetylase |
| GB201604970D0 (en) | 2016-03-23 | 2016-05-04 | Syngenta Participations Ag | Improvements in or relating to organic compounds |
| TWI770104B (en) | 2017-01-11 | 2022-07-11 | 美商羅登醫療公司 | Bicyclic inhibitors of histone deacetylase |
| JOP20180011A1 (en) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | Perulo derivatives [1, 2-b] pyridazine |
| PL3664802T3 (en) | 2017-08-07 | 2022-07-11 | Alkermes, Inc. | Bicyclic inhibitors of histone deacetylase |
| TWI721483B (en) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | Pyrrolo[1,2-b]pyridazine derivatives |
| BR112022008753A2 (en) * | 2019-11-06 | 2022-07-19 | Remedy Plan Inc | CANCER TREATMENTS TARGETED TO CANCER STEM CELLS |
| CN111393376B (en) * | 2020-05-11 | 2022-05-13 | 安徽赛迪生物科技有限公司 | Synthetic method of 2-chloropyrimidine-4-formic acid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4140853A (en) * | 1975-04-18 | 1979-02-20 | Schering Aktiengesellschaft | Process for the preparation of aminopyridines |
| EP1740573A1 (en) * | 2004-04-22 | 2007-01-10 | Eli Lilly And Company | Amides as bace inhibitors |
-
2007
- 2007-07-31 WO PCT/US2007/017186 patent/WO2008016643A2/en not_active Ceased
- 2007-08-01 AR ARP070103397A patent/AR062176A1/en unknown
- 2007-08-01 TW TW096128145A patent/TW200823188A/en unknown
- 2007-08-01 PE PE2007000999A patent/PE20080432A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008016643A2 (en) | 2008-02-07 |
| AR062176A1 (en) | 2008-10-22 |
| WO2008016643A3 (en) | 2008-06-19 |
| TW200823188A (en) | 2008-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20080432A1 (en) | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | |
| JP4663984B2 (en) | Thiadiazolyl piperazine derivatives useful for the treatment or prevention of pain | |
| JP5956999B2 (en) | Heteroaryl compounds and uses thereof | |
| WO2008002596A3 (en) | Adenosine a2a receptor antagonists | |
| TW200800899A (en) | Novel compounds | |
| MX2009004900A (en) | Thiazole and oxazole-substituted arylamides. | |
| EA200802007A1 (en) | COMPOUNDS POTENTIATING AMPA RECEPTOR AND APPLICATION OF THE SPECIFIED COMPOUNDS IN MEDICINE | |
| JP2011527334A5 (en) | ||
| NO20076450L (en) | Heterocyclic compounds as nicotinic acid receptor agonists for the treatment of dyslipidemia | |
| TW200738729A (en) | Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia | |
| DK1716152T3 (en) | Condensed heterocyclic compounds and their use as metabotropic receptor antagonists in the treatment of gastrointestinal disorders | |
| BR0207526A (en) | Compound, pharmaceutical composition, and methods for treating pain, migraine, depression, anxiety, schizophrenia, parkinson's disease, or stroke | |
| NZ547615A (en) | Quinoline derivatives and use thereof as mycobacterial inhibitors | |
| MX2012004848A (en) | Tricyclic heterocyclic compounds. | |
| NO20091596L (en) | Benzoylamino Heterocyclic Compounds as Glucokinase (GLK) Activators | |
| PL1735278T3 (en) | Histamine h3 receptor agents, preparation and therapeutic uses | |
| KR20120123691A (en) | Pharmaceutical compositions for the treatment of pain and other indicatons | |
| WO2008056259A3 (en) | Oxazole derivatives as positive allosteric modulators of metabotropic glutamate receptors | |
| MY148375A (en) | Delta and epsilon crystal forms of imatinib mesylate | |
| NO20092464L (en) | Solid forms of racemic ilaprazole | |
| EA200501595A1 (en) | AZABICYCLIC DERIVATIVES AS ANTAGONISTS OF MUSCARINE RECEPTOR | |
| TN2009000452A1 (en) | [4-(6-fluoro-7-methylamino-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl] -5-chloro-thiophen-2-yl-sulfonylurea salts, in different crystalline forms, pharmaceutical compositions thereof | |
| RU2450010C2 (en) | SUBSTITUTED IMIDAZO{2,1-b}THIAZOLES AND APPLICATION THEREOF FOR MAKING DRUG PREPARATIONS | |
| EA200900245A1 (en) | HEMOKIN RECEPTOR ACTIVITY MODULATORS, CRYSTAL FORMS AND METHOD FOR THEIR RECEPTION | |
| DK1750703T3 (en) | Method of reducing gastrointestinal toxicity caused by the administration of tegafur |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |