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PE20071169A1 - Preparacion de gamma-aminoacidos que tienen afinidad por la proteina alfa-2-delta - Google Patents

Preparacion de gamma-aminoacidos que tienen afinidad por la proteina alfa-2-delta

Info

Publication number
PE20071169A1
PE20071169A1 PE2006001658A PE2006001658A PE20071169A1 PE 20071169 A1 PE20071169 A1 PE 20071169A1 PE 2006001658 A PE2006001658 A PE 2006001658A PE 2006001658 A PE2006001658 A PE 2006001658A PE 20071169 A1 PE20071169 A1 PE 20071169A1
Authority
PE
Peru
Prior art keywords
alkyl
cycloalkyl
compound
alpha
gamma
Prior art date
Application number
PE2006001658A
Other languages
English (en)
Inventor
Margaret Claire Evans
Lloyd Charles Franklin
Lorraine Michelle Murtagh
Thomas Norman Nanninga
Bruce Allen Pearlman
James Edward Saenz
Niamh Josephine Willis
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20071169A1 publication Critical patent/PE20071169A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO QUE CONSISTE: PONER EN CONTACTO UN COMPUESTO DE FORMULA 7 DONDE R6 ES ALQUILO C1-C6, ALQUENILO C2-C6, CICLOALQUILO C3-C7, ENTRE OTROS CON UNA ENZIMA QUE HIDROLIZA DIASTEREOSELECTIVAMENTE PARA OBTENER UN COMPUESTO DE FORMULA 10 DONDE R1 Y R2 SON CADA UNO H, ALQUILO C1-C3, CON LA CONDICION QUE R1 Y R2 NO SEAN AMBOS H; R3 ES ALQUILO C1-C6, ALQUENILO C2-C6, CICLOALQUILO C3-C6, ARILO, ENTRE OTROS; R8 ES ALQUILO C1-C6, ALQUENILO C2-C6, CICLOALQUILO C3-C7, HALOALQUILO C1-C6, HALOALQUENILO, ENTRE OTROS. LA ENZIMA UTILIZADA ES LIPASA DE BURKHOLDERIA CEPACIA O THERMOMYCES LANUGINOSUS. SON COMPUESTOS PREFERIDOS: ESTER 2-METILPENTILICO DEL ACIDO (R)-METANOSULFONICO; ESTER DIETILICO DEL ACIDO (2'R)-2-CIANO-2-(2'-METILPENTIL)SUCCINICO; ACIDO (3S,5R)-3-AMINOMETIL-5-METILOCTANOICO; ENTRE OTROS. DICHOS COMPUESTOS SE UNEN A LA SUBUNIDAD ALFA-2-DELTA DE UN CANAL DE CALCIO UTILES EN EL TRATAMIENTO DE SINDROME DE PIERNAS INQUIETAS Y TRASTORNOS NEURODEGENERATIVOS, PSIQUIATRICOS Y DEL SUENO
PE2006001658A 2005-12-21 2006-12-20 Preparacion de gamma-aminoacidos que tienen afinidad por la proteina alfa-2-delta PE20071169A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75283905P 2005-12-21 2005-12-21

Publications (1)

Publication Number Publication Date
PE20071169A1 true PE20071169A1 (es) 2007-11-30

Family

ID=37903526

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001658A PE20071169A1 (es) 2005-12-21 2006-12-20 Preparacion de gamma-aminoacidos que tienen afinidad por la proteina alfa-2-delta

Country Status (28)

Country Link
US (2) US20070141684A1 (es)
EP (2) EP2017259A3 (es)
JP (1) JP2009520492A (es)
KR (1) KR20080068932A (es)
CN (1) CN101341117A (es)
AP (1) AP2008004485A0 (es)
AR (1) AR058559A1 (es)
AU (1) AU2006327872A1 (es)
BR (1) BRPI0620467A2 (es)
CA (1) CA2633358A1 (es)
CR (1) CR10080A (es)
DO (1) DOP2006000286A (es)
EA (1) EA200801393A1 (es)
EC (1) ECSP088551A (es)
GT (1) GT200600524A (es)
IL (1) IL191840A0 (es)
MA (1) MA30139B1 (es)
ME (1) ME00005B (es)
NL (1) NL2000374C2 (es)
NO (1) NO20082989L (es)
NZ (1) NZ568971A (es)
PE (1) PE20071169A1 (es)
RS (1) RS20080279A (es)
TN (1) TNSN08272A1 (es)
TW (1) TW200736201A (es)
UY (1) UY30031A1 (es)
WO (1) WO2007072159A1 (es)
ZA (1) ZA200804780B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102099482B (zh) * 2008-05-21 2014-04-16 桑多斯股份公司 5-甲基-3-硝基甲基-己酸酯的立体选择性酶水解方法
WO2011144742A1 (en) 2010-05-21 2011-11-24 Chemilia Ab Novel pyrimidine derivatives
FR2966734B1 (fr) * 2010-10-29 2014-07-18 Max Rombi Composition comprenant au moins une enzyme proteolytique pour son utilisation pour empecher la synthese des triglycerides
EP2688883B1 (en) 2011-03-24 2016-05-18 Noviga Research AB Pyrimidine derivatives
CN102249833B (zh) * 2011-05-27 2013-12-11 中国科学院化学研究所 一种制备手性γ-氨基酸及其衍生物的方法
WO2017155025A1 (ja) * 2016-03-10 2017-09-14 第一三共株式会社 酵素による光学分割を用いた光学活性吉草酸誘導体の製造方法
CN108192932B (zh) * 2017-12-26 2020-09-29 上海皓元生物医药科技有限公司 一种手性醇的酶催化制备方法
CN112877219A (zh) * 2021-01-29 2021-06-01 江西科技师范大学 一种高浓度胆固醇培养基及其制备方法和应用
CN119462461B (zh) * 2024-12-06 2025-11-04 万华化学集团股份有限公司 一种维生素a异构化的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
US5618710A (en) 1990-08-03 1997-04-08 Vertex Pharmaceuticals, Inc. Crosslinked enzyme crystals
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035298A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing gum containing medicament active agents
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US6642398B2 (en) * 1999-06-10 2003-11-04 Warner-Lambert Company Mono-and disubstituted 3-propyl gamma-aminobutyric acids
KR100694735B1 (ko) * 1999-06-10 2007-03-14 워너-램버트 캄파니 엘엘씨 일치환 및 이치환된 3-프로필 감마-아미노부티르산
EP2172197A1 (en) 2002-12-13 2010-04-07 Warner-Lambert Company LLC Octanoic acid derivative to treat fibromyalgia and other pains
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)

Also Published As

Publication number Publication date
ECSP088551A (es) 2008-07-30
NL2000374C2 (nl) 2010-02-09
WO2007072159A1 (en) 2007-06-28
NZ568971A (en) 2010-04-30
BRPI0620467A2 (pt) 2011-11-16
TW200736201A (en) 2007-10-01
JP2009520492A (ja) 2009-05-28
ZA200804780B (en) 2009-05-27
AR058559A1 (es) 2008-02-13
EA200801393A1 (ru) 2009-12-30
IL191840A0 (en) 2008-12-29
EP2017259A3 (en) 2011-04-13
KR20080068932A (ko) 2008-07-24
UY30031A1 (es) 2007-07-31
NL2000374A1 (nl) 2007-06-25
GT200600524A (es) 2007-12-03
DOP2006000286A (es) 2007-07-31
CR10080A (es) 2008-07-10
US20090299093A1 (en) 2009-12-03
EP1973867A1 (en) 2008-10-01
WO2007072159B1 (en) 2008-08-21
MEP0708A (xx) 2010-02-10
AU2006327872A1 (en) 2007-06-28
EP2017259A2 (en) 2009-01-21
TNSN08272A1 (fr) 2009-10-30
ME00005B (me) 2010-06-10
CN101341117A (zh) 2009-01-07
AP2008004485A0 (en) 2008-06-30
RS20080279A (sr) 2009-07-15
CA2633358A1 (en) 2007-06-28
US20070141684A1 (en) 2007-06-21
NO20082989L (no) 2008-09-19
MA30139B1 (fr) 2009-01-02

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