PE20071137A1 - Derivados de 8-piracin-s-espiropirimidintriona oxaquinolina como agentes antibacterianos - Google Patents
Derivados de 8-piracin-s-espiropirimidintriona oxaquinolina como agentes antibacterianosInfo
- Publication number
- PE20071137A1 PE20071137A1 PE2006001657A PE2006001657A PE20071137A1 PE 20071137 A1 PE20071137 A1 PE 20071137A1 PE 2006001657 A PE2006001657 A PE 2006001657A PE 2006001657 A PE2006001657 A PE 2006001657A PE 20071137 A1 PE20071137 A1 PE 20071137A1
- Authority
- PE
- Peru
- Prior art keywords
- antibacterial agents
- spiropyrimidintriona
- oxaquinoline
- piracin
- derivatives
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE R1 ES PIRACINA OPCIONALMENTE SUSTITUIDA; R2 Y R3 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDOS; R4 Y R5 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C6), ETER, -(CH2)mARILO, BENCILO, -(CH2)mOPO3(Rp)2', OPCIONALMENTE SUSTITUIDOS, ENTRE OTROS; X E Y SON INDEPENDIENTEMENTE H, HALO, ALQUILO(C1-C6), -OR6', ETER, HETEROCICLICO, ENTRE OTROS. SON SELECCIONADOS: rel-(2S,4R,4aR)-9,10-DIFLUORO-2,4-DIMETIL-8-PIRACIN-2-IL-1,2,4,4a-TETRAHIDRO-2'H,6H-ESPIRO[1,4-OXACIN[4,3-a]QUINOLIN-5-5'-PIRIMIDIN]-2',4',6'(1'H,3'H)-TRIONA, (2S,4R,4aR)-9,10-DIFLUORO-2,4-DIMETIL-8-PIRACIN-2-IL-1,2,4,4a-TETRAHIDRO-2'H,6H-ESPIRO[1,4-OXACIN[4,3-a]QUINOLIN-5-5'-PIRIMIDIN]-2',4',6'(1'H,3'H)-TRIONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON AGENTES ANTIBACTERIANOS POR LO QUE SON UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75326205P | 2005-12-22 | 2005-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20071137A1 true PE20071137A1 (es) | 2008-01-10 |
Family
ID=37872452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001657A PE20071137A1 (es) | 2005-12-22 | 2006-12-20 | Derivados de 8-piracin-s-espiropirimidintriona oxaquinolina como agentes antibacterianos |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7557100B2 (es) |
| EP (2) | EP2620439A1 (es) |
| JP (1) | JP5513743B2 (es) |
| AR (1) | AR058701A1 (es) |
| CA (1) | CA2634644A1 (es) |
| DO (1) | DOP2006000268A (es) |
| GT (1) | GT200600520A (es) |
| NL (1) | NL2000373C2 (es) |
| PE (1) | PE20071137A1 (es) |
| TW (1) | TW200734344A (es) |
| UY (1) | UY30030A1 (es) |
| WO (1) | WO2007072151A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2552682T3 (es) | 2003-03-10 | 2015-12-01 | Merck Sharp & Dohme Corp. | Agentes antibacterianos novedosos |
| DOP2006000268A (es) * | 2005-12-22 | 2007-07-31 | Pfizer Prod Inc | Agentes antibacterianos |
| WO2009004382A2 (en) * | 2007-07-02 | 2009-01-08 | Astrazeneca Ab | 3-spiropyrimidinetrione-quinoline derivatives and their use as antibacterial agents |
| EP2164964B1 (en) * | 2007-07-06 | 2011-09-07 | Aarhus Universitet | Dehydrated chitosan nanoparticles |
| JP2010533701A (ja) | 2007-07-16 | 2010-10-28 | アストラゼネカ アクチボラグ | 抗菌剤として使用のスピロ縮合バルビツール酸誘導体 |
| AU2008316830B2 (en) * | 2007-10-25 | 2016-03-17 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
| KR101676886B1 (ko) * | 2008-10-14 | 2016-11-16 | 엔타시스 테라퓨틱스 리미티드 | 박테리아 감염의 치료를 위한 융합된 스피로시클릭 헤테로방향족 화합물 |
| US9040528B2 (en) | 2008-10-14 | 2015-05-26 | Astrazeneca Ab | Chemical compounds 542 |
| AU2009308181B2 (en) | 2008-10-24 | 2015-12-03 | Cempra Pharmaceuticals, Inc. | Methods for treating resistant diseases using triazole containing macrolides |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| ES2608285T3 (es) | 2009-09-10 | 2017-04-07 | Cempra Pharmaceuticals, Inc. | Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC |
| NZ602544A (en) | 2010-03-22 | 2014-11-28 | Cempra Pharmaceuticals Inc | Crystalline forms of a macrolide, and uses therefor |
| SI2571506T1 (sl) | 2010-05-20 | 2017-12-29 | Cempra Pharmaceuticals, Inc. | Postopki za pripravo makrolidov in ketolidov ter njihovih intermediatov |
| US9815863B2 (en) | 2010-09-10 | 2017-11-14 | Cempra Pharmaceuticals, Inc. | Hydrogen bond forming fluoro ketolides for treating diseases |
| SG11201405895UA (en) | 2012-03-27 | 2014-10-30 | Cempra Pharmaceuticals Inc | Parenteral formulations for administering macrolide antibiotics |
| US8952149B2 (en) * | 2012-09-26 | 2015-02-10 | Zoetis Llc | Tricyclic tetrahydroquinoline antibacterial agents |
| US8889671B2 (en) * | 2013-01-23 | 2014-11-18 | Astrazeneca Ab | Compounds and methods for treating bacterial infections |
| CN105163785A (zh) | 2013-03-14 | 2015-12-16 | 森普拉制药公司 | 用于治疗呼吸道疾病的方法及其制剂 |
| JP6675973B2 (ja) | 2013-03-15 | 2020-04-08 | センプラ ファーマシューティカルズ，インコーポレイテッド | マクロライド抗菌薬を調製するための集束的な方法 |
| WO2015181637A1 (en) | 2014-05-29 | 2015-12-03 | Entasis Therapeutics Limited | Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections |
| TW201722965A (zh) | 2015-08-16 | 2017-07-01 | 葛蘭素史密斯克藍智慧財產發展有限公司 | 用於抗菌應用之化合物 |
| EP4438117A3 (en) | 2017-07-28 | 2024-12-18 | Takeda Pharmaceutical Company Limited | Tyk2 inhibitors and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5011860A (en) | 1986-04-11 | 1991-04-30 | Schering Corporation | Aryl-substituted naphthyridine and pyridopyrazine derivatives and their use in treating hyperproliferative skin diseases |
| DE19502178A1 (de) | 1994-01-27 | 1995-08-03 | Hoechst Ag | Thiadiazolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Vorprodukte zur Herstellung von Flüssigkristallen |
| US6608081B2 (en) * | 1999-08-12 | 2003-08-19 | Ortho-Mcneil Pharmaceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| HRP20030332A2 (en) | 2000-10-26 | 2003-06-30 | Pfizer Prod Inc | Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors |
| EP1395585B1 (en) * | 2001-05-30 | 2006-01-04 | Warner-Lambert Company LLC | Antibacterial agents |
| WO2003091252A1 (en) | 2002-04-25 | 2003-11-06 | Bristol-Myers Squibb Company | Spirobarbituric acid derivatives useful as inhibitors of matrix metalloproteases |
| US7208490B2 (en) | 2002-10-07 | 2007-04-24 | Pharmacia & Upjohn Company Llc | Tricyclic tetrahydroquinoline antibacterial agents |
| CA2606847A1 (en) | 2005-05-09 | 2006-11-16 | Warner-Lambert Company Llc | Antibacterial agents |
| DOP2006000268A (es) * | 2005-12-22 | 2007-07-31 | Pfizer Prod Inc | Agentes antibacterianos |
-
2006
- 2006-11-29 DO DO2006000268A patent/DOP2006000268A/es unknown
- 2006-12-11 CA CA002634644A patent/CA2634644A1/en not_active Abandoned
- 2006-12-11 WO PCT/IB2006/003641 patent/WO2007072151A1/en not_active Ceased
- 2006-12-11 JP JP2008546665A patent/JP5513743B2/ja not_active Expired - Fee Related
- 2006-12-11 EP EP13151044.8A patent/EP2620439A1/en not_active Withdrawn
- 2006-12-11 EP EP06831728A patent/EP1971612A1/en not_active Withdrawn
- 2006-12-13 NL NL2000373A patent/NL2000373C2/nl not_active IP Right Cessation
- 2006-12-19 US US11/641,215 patent/US7557100B2/en not_active Expired - Fee Related
- 2006-12-19 UY UY30030A patent/UY30030A1/es not_active Application Discontinuation
- 2006-12-20 AR ARP060105669A patent/AR058701A1/es unknown
- 2006-12-20 GT GT200600520A patent/GT200600520A/es unknown
- 2006-12-20 PE PE2006001657A patent/PE20071137A1/es not_active Application Discontinuation
- 2006-12-21 TW TW095148255A patent/TW200734344A/zh unknown
-
2009
- 2009-07-15 US US12/503,123 patent/US20090275536A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009520804A (ja) | 2009-05-28 |
| NL2000373A1 (nl) | 2007-06-26 |
| UY30030A1 (es) | 2007-07-31 |
| US7557100B2 (en) | 2009-07-07 |
| TW200734344A (en) | 2007-09-16 |
| CA2634644A1 (en) | 2007-06-28 |
| NL2000373C2 (nl) | 2010-02-02 |
| WO2007072151A1 (en) | 2007-06-28 |
| EP1971612A1 (en) | 2008-09-24 |
| JP5513743B2 (ja) | 2014-06-04 |
| DOP2006000268A (es) | 2007-07-31 |
| EP2620439A1 (en) | 2013-07-31 |
| US20090275536A1 (en) | 2009-11-05 |
| AR058701A1 (es) | 2008-02-20 |
| GT200600520A (es) | 2007-07-17 |
| US20070197518A1 (en) | 2007-08-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |