[go: up one dir, main page]

PE20070362A1 - COMPOUNDS DERIVED FROM INDAZOLE-4-IL-2,4-PYRIMIDINDIAMINE AS INHIBITORS OF TYROSINE KINASE (KINASE Syk) - Google Patents

COMPOUNDS DERIVED FROM INDAZOLE-4-IL-2,4-PYRIMIDINDIAMINE AS INHIBITORS OF TYROSINE KINASE (KINASE Syk)

Info

Publication number
PE20070362A1
PE20070362A1 PE2006000835A PE2006000835A PE20070362A1 PE 20070362 A1 PE20070362 A1 PE 20070362A1 PE 2006000835 A PE2006000835 A PE 2006000835A PE 2006000835 A PE2006000835 A PE 2006000835A PE 20070362 A1 PE20070362 A1 PE 20070362A1
Authority
PE
Peru
Prior art keywords
pyrimidindiamine
kinase
inhibitors
bencisotiazol
dihidro
Prior art date
Application number
PE2006000835A
Other languages
Spanish (es)
Inventor
Sebastien Andre Campos
Lee Andrew Harrison
Vipulkumar Kantibhai Patel
Giovanni Vitulli
Nigel James Parr
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0514580A external-priority patent/GB0514580D0/en
Priority claimed from GB0524785A external-priority patent/GB0524785D0/en
Priority claimed from GB0601728A external-priority patent/GB0601728D0/en
Priority claimed from GB0606763A external-priority patent/GB0606763D0/en
Priority claimed from GB0610513A external-priority patent/GB0610513D0/en
Priority claimed from GB0610924A external-priority patent/GB0610924D0/en
Priority claimed from GB0611488A external-priority patent/GB0611488D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20070362A1 publication Critical patent/PE20070362A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE R1 Y R2 SON CADA UNO H, ALQUILO(C1-C6) O CH2-CICLOALQUILO(C3-C7); R3 ES ALQUILO(C1-C3) O ALQUILO(C2-C3) SUSTITUIDO CON OH O ALCOXI(C1-C3); X ES HALOGENO. SON COMPUESTOS PREFERIDOS: N2-(1,1-DIOXIDO-2,3-DIHIDRO-1,2-BENCISOTIAZOL-6-IL)-N4-ETIL-5-FLUORO-N4-1H-INDAZOL-4-IL-2,4-PIRIMIDINDIAMINA, 5-CLORO-N2-(1,1-DIOXIDO-2,3-DIHIDRO-1,2-BENCISOTIAZOL-6-IL)-N4-ETIL-N4-1H-INDAZOL-4-IL-2,4-PIRIMIDINDIAMINA, 5-BROMO-N2-(1,1-DIOXIDO-2,3-DIHIDRO-1,2-BENCISOTIAZOL-6-IL)-N4-ETIL-N4-1H-INDAZOL-4-IL-2,4-PIRIMIDINDIAMINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA TIROSINA QUINASA (QUINASA Syk) SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS INFLAMATORIOS Y ALERGICOS TALES COMO ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, ASMA, COLITIS ULCEROSA, ENFERMEDAD DE CROHNREFERS TO COMPOUNDS OF FORMULA (I) WHERE R1 AND R2 ARE EACH H, ALKYL (C1-C6) OR CH2-CYCLOALKYL (C3-C7); R3 IS ALKYL (C1-C3) OR ALKYL (C2-C3) SUBSTITUTED WITH OH OR ALCOXY (C1-C3); X IS HALOGEN. THE PREFERRED COMPOUNDS ARE: N2- (1,1-DIOXIDO-2,3-DIHIDRO-1,2-BENCISOTIAZOL-6-IL) -N4-ETIL-5-FLUORO-N4-1H-INDAZOL-4-IL-2, 4-PYRIMIDINDIAMINE, 5-CHLORO-N2- (1,1-DIOXIDO-2,3-DIHIDRO-1,2-BENCISOTIAZOL-6-IL) -N4-ETIL-N4-1H-INDAZOL-4-IL-2, 4-PYRIMIDINDIAMINE, 5-BROMO-N2- (1,1-DIOXIDO-2,3-DIHIDRO-1,2-BENCISOTIAZOL-6-IL) -N4-ETIL-N4-1H-INDAZOL-4-IL-2, 4-PYRIMIDINDIAMINE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. THESE COMPOUNDS ARE INHIBITORS OF TYROSINE KINASE (KINASE Syk), BEING USEFUL IN THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS SUCH AS CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ASTHMA, ULCEROUS COLIHNTIS, CROSS DISEASE

PE2006000835A 2005-07-15 2006-07-13 COMPOUNDS DERIVED FROM INDAZOLE-4-IL-2,4-PYRIMIDINDIAMINE AS INHIBITORS OF TYROSINE KINASE (KINASE Syk) PE20070362A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0514580A GB0514580D0 (en) 2005-07-15 2005-07-15 Novel compounds
GB0524785A GB0524785D0 (en) 2005-12-05 2005-12-05 Novel compounds
GB0601728A GB0601728D0 (en) 2006-01-27 2006-01-27 Novel Compounds
GB0606763A GB0606763D0 (en) 2006-04-03 2006-04-03 Novel compounds
GB0610513A GB0610513D0 (en) 2006-05-26 2006-05-26 Novel compounds
GB0610924A GB0610924D0 (en) 2006-06-02 2006-06-02 Novel compounds
GB0611488A GB0611488D0 (en) 2006-06-09 2006-06-09 Novel compounds

Publications (1)

Publication Number Publication Date
PE20070362A1 true PE20070362A1 (en) 2007-04-23

Family

ID=37022880

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000835A PE20070362A1 (en) 2005-07-15 2006-07-13 COMPOUNDS DERIVED FROM INDAZOLE-4-IL-2,4-PYRIMIDINDIAMINE AS INHIBITORS OF TYROSINE KINASE (KINASE Syk)

Country Status (4)

Country Link
AR (1) AR054834A1 (en)
PE (1) PE20070362A1 (en)
TW (1) TW200740805A (en)
WO (1) WO2007009681A1 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007085540A1 (en) * 2006-01-27 2007-08-02 Glaxo Group Limited 1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives
AU2008277446A1 (en) 2007-07-16 2009-01-22 Astrazeneca Ab Pyrimidine derivatives 934
EP2489663A1 (en) 2011-02-16 2012-08-22 Almirall, S.A. Compounds as syk kinase inhibitors
GB201104153D0 (en) 2011-03-11 2011-04-27 Glaxo Group Ltd Novel compounds
EP2707357B1 (en) 2011-05-10 2017-01-18 Merck Sharp & Dohme Corp. Pyridyl aminopyridines as syk inhibitors
EP2706852B1 (en) 2011-05-10 2018-08-22 Merck Sharp & Dohme Corp. Bipyridylaminopyridines as syk inhibitors
KR20140028062A (en) 2011-05-10 2014-03-07 머크 샤프 앤드 돔 코포레이션 Aminopyrimidines as syk inhibitors
WO2013052394A1 (en) 2011-10-05 2013-04-11 Merck Sharp & Dohme Corp. 2-pyridyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
US8987456B2 (en) 2011-10-05 2015-03-24 Merck Sharp & Dohme Corp. 3-pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors
EP2763974B1 (en) 2011-10-05 2016-09-14 Merck Sharp & Dohme Corp. Phenyl carboxamide-containing spleen tyrosine kinase (syk) inhibitors
US9242984B2 (en) 2012-06-20 2016-01-26 Merck Sharp & Dohme Corp. Pyrazolyl derivatives as Syk inhibitors
US9487504B2 (en) 2012-06-20 2016-11-08 Merck Sharp & Dohme Corp. Imidazolyl analogs as syk inhibitors
WO2013192098A1 (en) 2012-06-22 2013-12-27 Merck Sharp & Dohme Corp. SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS
US9416111B2 (en) 2012-06-22 2016-08-16 Merck Sharp & Dohme Corp. Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors
US9353066B2 (en) 2012-08-20 2016-05-31 Merck Sharp & Dohme Corp. Substituted phenyl-Spleen Tyrosine Kinase (Syk) inhibitors
WO2014048065A1 (en) 2012-09-28 2014-04-03 Merck Sharp & Dohme Corp. Triazolyl derivatives as syk inhibitors
CN103864764A (en) * 2012-12-11 2014-06-18 齐鲁制药有限公司 Indazole-substituted pyrimidinamine derivative, and preparation method and use thereof
WO2014093191A1 (en) 2012-12-12 2014-06-19 Merck Sharp & Dohme Corp. AMINO-PYRIMIDINE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS
EP2934525B1 (en) 2012-12-21 2019-05-08 Merck Sharp & Dohme Corp. Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors
WO2014176210A1 (en) 2013-04-26 2014-10-30 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
US9499534B2 (en) 2013-04-26 2016-11-22 Merck Sharp & Dohme Corp. Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors
US9783531B2 (en) 2013-12-20 2017-10-10 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
EP3083560B1 (en) 2013-12-20 2021-10-27 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
US9822107B2 (en) 2013-12-20 2017-11-21 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
EP3116506B1 (en) 2014-03-13 2019-04-17 Merck Sharp & Dohme Corp. 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
BR112021018168B1 (en) 2019-03-21 2023-11-28 Onxeo PHARMACEUTICAL COMPOSITION, COMBINATION AND KIT COMPRISING A DBAIT MOLECULE AND A KINASE INHIBITOR FOR THE TREATMENT OF CANCER
CN114761006A (en) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) Methods of treating cancer resistant to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999031073A1 (en) * 1997-12-15 1999-06-24 Yamanouchi Pharmaceutical Co., Ltd. Novel pyrimidine-5-carboxamide derivatives
CA2400447C (en) * 2000-02-17 2008-04-22 Amgen Inc. Kinase inhibitors
WO2003030909A1 (en) * 2001-09-25 2003-04-17 Bayer Pharmaceuticals Corporation 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
TWI329105B (en) * 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
DK1534286T3 (en) * 2002-07-29 2010-04-26 Rigel Pharmaceuticals Inc Methods for treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
GB0305929D0 (en) * 2003-03-14 2003-04-23 Novartis Ag Organic compounds
EP1660458B1 (en) * 2003-08-15 2012-01-25 Novartis AG 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders

Also Published As

Publication number Publication date
TW200740805A (en) 2007-11-01
AR054834A1 (en) 2007-07-18
WO2007009681A1 (en) 2007-01-25

Similar Documents

Publication Publication Date Title
PE20070362A1 (en) COMPOUNDS DERIVED FROM INDAZOLE-4-IL-2,4-PYRIMIDINDIAMINE AS INHIBITORS OF TYROSINE KINASE (KINASE Syk)
PE20090288A1 (en) QUINOXALINE DERIVATIVES AS PI3 KINASE INHIBITORS
DOP2006000210A (en) AMIDA PYRIMIDINE COMPOUNDS AS PGDS INHIBITORS
MY154895A (en) Pyrimidine hydrazide compounds as pgds inhibitors
PE20160869A1 (en) NOVEL DERIVATIVES OF AMINO PYRIMIDINE
CY1122500T1 (en) PHARMACEUTICAL COMPOSITION CONTAINING GLUTARIMIDE DERIVATIVES, AND ITS USE FOR THE TREATMENT OF EOSINOPHILIC DISEASES
PE20220934A1 (en) AMINOQUINAZOLINE DERIVATIVES AS P2X PURINORECEPTOR 3 (P2X3) INHIBITORS
CL2012001221A1 (en) Compounds derived from 4 - (1h-pyrrol-1-yl) pyrimidin -2-ylamino and 4 - (1h-pyrazol-1-yl) -pyrimidin-2-ylamino, kinase inhibitors; an isomeric compound; pharmaceutical composition; Useful in the treatment of asthma, chronic obstructive pulmonary disease, ulcerative colitis, Crohn's disease, bronchitis, dermatitis, among others.
PE20120321A1 (en) INDAZOLES SUBSTITUTED WITH OXAZOLE AS PI3-KINASE INHIBITORS
PH12012501122A1 (en) Pteridinones as inhibitors of polo-like kinase
NO20090723L (en) Condensed heterocyclic derivatives and methods of use
MA35285B1 (en) indazoles
PE20121352A1 (en) HETEROARYL DERIVATIVES CONTAINING N AS INHIBITORS OF KINASE JAK3
NO20076502L (en) Pyrrolopyridines useful as inhibitors of protein kinase
PE20131464A1 (en) QUINAZOLIN-4 (3H) -ONE DERIVATIVES USED AS PI3 KINASE INHIBITORS
NO20081315L (en) Benzokinazoline derivatives and their use in the treatment of bone disorders
EA201190158A1 (en) Derivatives of benzofuranyl for use as glucose kinase inhibitors
AR065247A1 (en) NAPADISYLATE AND / OR HEMINAPADISYLATE SALT OF 5- (2 - {[6- (2,2-DIFLUORO-2-PHENYLETOXI) HEXIL] AMINO] -1-HYDROXYYLATE) -8-HYDROXYCHINOLIN-2 (1H) -ONA, COMPOSITIONS PHARMACEUTICS THAT CONTAIN THEM AND USES IN THE TREATMENT OF ASTHMA AND OTHER PULMONARY DISEASES.
ATE538100T1 (en) AMINOTETRAHYDROINDAZOLOACETIC ACIDS
NO20070445L (en) Pyrimidine.
EA200801996A1 (en) 2-SUBSTITUTED DERIVATIVES OF 4-BENZIL-PHTHALASINONES AS HISTAMINE H1-AND H3-ANTAGONISTS
MX2011013884A (en) Heterocyclic sulfonamides, uses and pharmaceutical compositions thereof.
ATE463483T1 (en) 6-SUBSTITUTED ISOQUINOLINE DERIVATIVES AS ROCK-1 INHIBITORS
PE20091035A1 (en) DERIVATIVES OF 2-AMINOPYRIMIDINE
PE20110584A1 (en) DERIVATIVES OF IMIDAZO [1,2-a] PYRIMIDINE AS MET INHIBITORS, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND THEIR PREPARATION PROCEDURE

Legal Events

Date Code Title Description
FC Refusal