[go: up one dir, main page]

PE20070246A1 - Compuestos de pirazolina sustituidos como moduladores del receptor cb1 y su preparacion - Google Patents

Compuestos de pirazolina sustituidos como moduladores del receptor cb1 y su preparacion

Info

Publication number
PE20070246A1
PE20070246A1 PE2006000848A PE2006000848A PE20070246A1 PE 20070246 A1 PE20070246 A1 PE 20070246A1 PE 2006000848 A PE2006000848 A PE 2006000848A PE 2006000848 A PE2006000848 A PE 2006000848A PE 20070246 A1 PE20070246 A1 PE 20070246A1
Authority
PE
Peru
Prior art keywords
preparation
pyrazoline compounds
compounds substituted
receiver modulators
modulators
Prior art date
Application number
PE2006000848A
Other languages
English (en)
Inventor
Maria Rosa Cuberes-Altisen
Original Assignee
Dr Esteve Labor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35311564&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070246(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dr Esteve Labor filed Critical Dr Esteve Labor
Publication of PE20070246A1 publication Critical patent/PE20070246A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

REFERIDA A UN COMPUESTO DE PIRAZOLINA DE FORMULA I, DONDE R1 ES FENILO MONOSUSTITUIDO CON HALOGENO, CH2F, CF3, CN, ENTRE OTROS; R2 ES FENILO MONOSUSTITUIDO CON HALOGENO, CHF2, CN, ENTRE OTROS; R3 ES UN GRUPO CICLOALIFATICO SATURADO O INSATURADO, OPCIONALMENTE SUSTITUIDO QUE CONTIENE AL MENOS UN HETEROATOMO COMO MIEMBRO DE ANILLO, QUE PUEDE ESTAR CONDENSADO CON UN SISTEMA CICLICO MONO O POLICICLICO, -NR4R5, ENTRE OTROS; R4 Y R5 SON H, ARILO, -SO2-R6, ENTRE OTROS; R6 ES ARILO, HETEROARILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS TIENEN AFINIDAD POR LOS RECEPTORES CANNABINOIDES, PARTICULARMENTE POR LOS RECEPTORES CB1, Y SON UTILES PARA EL TRATAMIENTO DE TRANSTORNOS DEL SISTEMA NERVIOSO, SISTEMA INMUNITARIO, GASTROINTESTINAL, ENTRE OTROS
PE2006000848A 2005-07-15 2006-07-14 Compuestos de pirazolina sustituidos como moduladores del receptor cb1 y su preparacion PE20070246A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05384005A EP1757587A1 (en) 2005-07-15 2005-07-15 Substituted pyrazoline compounds, their preparation and use as medicaments
US70548105P 2005-08-05 2005-08-05

Publications (1)

Publication Number Publication Date
PE20070246A1 true PE20070246A1 (es) 2007-05-30

Family

ID=35311564

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000848A PE20070246A1 (es) 2005-07-15 2006-07-14 Compuestos de pirazolina sustituidos como moduladores del receptor cb1 y su preparacion

Country Status (7)

Country Link
US (1) US20070015810A1 (es)
EP (2) EP1757587A1 (es)
AT (1) ATE523495T1 (es)
ES (1) ES2372307T3 (es)
PE (1) PE20070246A1 (es)
TW (1) TW200745043A (es)
WO (1) WO2007009695A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200533657A (en) * 2004-02-17 2005-10-16 Esteve Labor Dr Substituted pyrazoline compounds, their preparation and use as medicaments
EP1743892A1 (en) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
CA2666193A1 (en) 2006-08-08 2008-02-14 Sanofi-Aventis Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, medicaments comprising these compounds, and their use
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP2042175A1 (en) * 2007-09-21 2009-04-01 Laboratorios del Dr. Esteve S.A. Dose regimens of CB1-Receptor ligands in the treatment of obesity
WO2009097995A1 (de) * 2008-02-07 2009-08-13 Sanofi-Aventis Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
UY31968A (es) 2008-07-09 2010-01-29 Sanofi Aventis Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
EP2151234A1 (en) * 2008-07-28 2010-02-10 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical formulation comprising a CB1-receptor compound in a solid solution and/or solid dispersion
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
MX2012001729A (es) 2009-08-26 2012-06-13 Sanofi Sa Nuevos hidratos cristalinos de fluoroglicosido heteroaromatico, productos farmaceuticos que comprenden estos compuestos, y su empleo.
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683700B1 (de) 2011-03-08 2015-02-18 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
JP2017028024A (ja) * 2015-07-17 2017-02-02 富士通株式会社 部品搭載基板、部品内蔵基板、部品搭載基板の製造方法および部品内蔵基板の製造方法
EP3468545A4 (en) 2016-06-08 2020-07-22 President and Fellows of Harvard College METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME AND FRAGILE X SYNDROME
AU2019272778B2 (en) 2018-05-22 2024-10-03 President And Fellows Of Harvard College Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment
EP3801512A4 (en) 2018-05-29 2022-01-19 President and Fellows of Harvard College COMPOSITIONS AND METHODS FOR REDUCING TOUCH DYSFUNCTION, ANXIETY AND SOCIAL DISABILITY
US12077512B2 (en) 2019-03-25 2024-09-03 President And Fellows Of Harvard College Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment
EP3972595A4 (en) * 2019-05-22 2023-08-02 President and Fellows of Harvard College Human tactile prepulse inhibition assay

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2613720B1 (fr) * 1987-04-10 1990-01-19 Esteve Labor Dr Derives d'aryl-heteroaryl carbinols avec activite analgesique
FR2742147B1 (fr) * 1995-12-06 1998-02-27 Esteve Labor Dr Procede de separation de carbinols
AU7966198A (en) * 1997-06-13 1998-12-30 Smithkline Beecham Corporation Novel pyrazole and pyrazoline substituted compounds
ES2130079B1 (es) * 1997-07-10 2000-01-16 Esteve Labor Dr Resolucion de aminas
ES2130083B1 (es) * 1997-08-04 2000-01-16 Esteve Labor Dr Procedimiento para la obtencion de los enantiomeros de cizolirtina.
ES2150353B1 (es) * 1998-04-15 2001-07-01 Esteve Labor Dr Tienilazolilalcoxietanaminas, su preparacion y su aplicacion como medicamentos.
ES2137138B1 (es) * 1998-05-29 2000-09-16 Esteve Labor Dr Derivados de pirazolinas, su preparacion y su aplicacion como medicamentos.
CA2373510A1 (en) * 1999-05-12 2000-11-23 Ortho-Mcneil Pharmaceutical, Inc. Pyrazole carboxamides useful for the treatment of obesity and other disorders
KR20030008153A (ko) * 2000-06-22 2003-01-24 파모스 코포레이션 신규 비-향정신성 카나비노이드
AU2001275798A1 (en) * 2000-08-01 2002-02-13 Ono Pharmaceutical Co., Ltd. 3,4-dihydroisoquinoline derivative compounds and drugs containing these compounds as the active ingredient
CA2422708C (en) * 2001-03-22 2010-10-26 Solvay Pharmaceuticals B.V. 4,5-dihydro-1h-pyrazole derivatives having cb1-antagonistic activity
ES2183720B1 (es) * 2001-06-18 2004-01-16 Esteve Labor Dr Procedimiento para la preparacion de derivados de 1,5-diaril-3-trifluorometil-delta2-pirazolinas racemicas y enantiomericamente puras.
ES2180449B1 (es) * 2001-07-06 2004-01-16 Esteve Labor Dr Derivados de aril (o heteroaril) azolilcarbinoles para el tratamiento de la incontinencia urinaria.
US6509367B1 (en) * 2001-09-22 2003-01-21 Virginia Commonwealth University Pyrazole cannabinoid agonist and antagonists
TW200302726A (en) * 2002-01-31 2003-08-16 Ono Pharmaceutical Co Nitrogen-containing bicyclic compound and medicament containing same as active ingredient
US20050137251A1 (en) * 2002-03-18 2005-06-23 Aaron Garzon Dexanabinol and dexanabinol analogs regulate inflammation related genes
BR0313743A (pt) * 2002-08-23 2005-07-05 Chiron Corp Benzimidazol quinolinonas e usos destas
SE0300010D0 (sv) * 2003-01-07 2003-01-07 Astrazeneca Ab Novel Compounds
US20060172019A1 (en) * 2003-03-07 2006-08-03 Ralston Stuart H Cannabinoid receptor inverse agonists and neutral antagonists as therapeutic agents for the treatment of bone disorders
BRPI0412259B1 (pt) * 2003-07-22 2019-08-20 Astex Therapeutics Limited Compostos de 1H-pirazol 3,4-dissubstituídos como moduladores de quinases dependentes de ciclina (CDK), seus usos, processo para a preparação dos mesmos e composição farmacêutica
US7745476B2 (en) * 2004-01-30 2010-06-29 Solvay Pharmaceuticals B.V. 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity
TW200533657A (en) * 2004-02-17 2005-10-16 Esteve Labor Dr Substituted pyrazoline compounds, their preparation and use as medicaments
ITMI20041033A1 (it) * 2004-05-24 2004-08-24 Neuroscienze S C A R L Composti farmaceutici
WO2006044556A2 (en) * 2004-10-14 2006-04-27 Galileo Pharmaceuticals, Inc. Dual inhibitors of lipoxygenase for treating diabetes
EP1807063A2 (en) * 2004-10-25 2007-07-18 Solvay Pharmaceuticals GmbH Pharmaceutical compositions comprising cb1 cannabinoid receptor antagonists and potassium channel openers for the treatment of diabetes mellitus type i, obesity and related conditions

Also Published As

Publication number Publication date
EP1757587A1 (en) 2007-02-28
ATE523495T1 (de) 2011-09-15
EP1910299A1 (en) 2008-04-16
US20070015810A1 (en) 2007-01-18
EP1910299B1 (en) 2011-09-07
TW200745043A (en) 2007-12-16
ES2372307T3 (es) 2012-01-18
WO2007009695A1 (en) 2007-01-25

Similar Documents

Publication Publication Date Title
PE20070246A1 (es) Compuestos de pirazolina sustituidos como moduladores del receptor cb1 y su preparacion
MY140826A (en) Substituted pyrazoline compounds, their preparation and use as medicaments.
MX2010003949A (es) N-fenil-bipirrolidina carboxamidas sustituidas y uso terapeutico de las mismas.
ME01532B (me) Jedinjenja
CR9514A (es) Antagonistas de npy, preparacion y usos
MX2010003948A (es) N-fenil-birrolidin ureas sustituidas y uso terapeutico de las mismas.
EA200901157A1 (ru) Конденсированные кольцевые гетероциклические модуляторы киназы
MA31855B1 (fr) Carboxamides de n-phényl-bipyrrolidine substitués et leur utilisation thérapeutique
MX2010004003A (es) N-fenil-pirrolidinilmetlipirrolidin amidas sustituidas y uso terapeutico de las mismas.
MX2010006206A (es) Derivados de oxindol substituidos por 5-halogeno y el uso de los mismos para el tratamiento de enfermedades dependientes de la vasopresina.
MX2009010374A (es) Derivados de tetrahidro-naftalenamina sustituidos con heterociclilo, su preparacion y su uso como medicamentos.
BRPI0807804A2 (pt) " arilciclopentenos substituídos como agentes terapêuticos ".
WO2007009720A3 (en) Prodrugs of pyrazoline compounds, their preparation and use as medicaments
TN2011000223A1 (en) Substituted tetrahydropyran spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof
TW200738699A (en) 4-Substituted pyrazoline compounds, their preparation and use as medicaments
TW200745042A (en) Substituted pyrazoline compounds, their preparation and use as medicaments
EA200970969A1 (ru) Применение 4-циклопропилметокси-n-(3,5-дихлор-1-оксидопиридин-4-ил)-5-(метокси)пиридин-2-карбоксамида для лечения травм спинного мозга
MX2008013477A (es) Compuestos biciclicos de tetrahidropirrol.
EA201590350A1 (ru) Комбинации с пептидом с циклизованной основной цепью
TW200734335A (en) Compounds
TW200738640A (en) Substituted pyrazoline compounds, their preparation and use as medicaments
ES2328328A1 (es) Polimorfo alfa de una pirazolina sustituida, su preparacion y su uso como medicamento
WO2007009711A3 (en) Octahydropentalene-substituted pyrazoline compounds, their preparation and use as medicaments
TH149042A (th) การเตรียมเตตระไฮโดรไพแรน สไปโร ไพโรลิดิโนนที่ถูกแทนที่ และพิเพอริดิโนน และการใช้ประโยชน์ในการรักษาของมัน
ECSP066764A (es) Compuestos de pirazolina sustituidos, su preparación y su uso como medicamentos

Legal Events

Date Code Title Description
FA Abandonment or withdrawal