PE20070220A1 - Proceso para la sintesis de moduladores del receptor de progesterona - Google Patents
Proceso para la sintesis de moduladores del receptor de progesteronaInfo
- Publication number
- PE20070220A1 PE20070220A1 PE2006000913A PE2006000913A PE20070220A1 PE 20070220 A1 PE20070220 A1 PE 20070220A1 PE 2006000913 A PE2006000913 A PE 2006000913A PE 2006000913 A PE2006000913 A PE 2006000913A PE 20070220 A1 PE20070220 A1 PE 20070220A1
- Authority
- PE
- Peru
- Prior art keywords
- procedure
- synthesis
- oxindol
- cycloalkyl
- alkyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000002379 progesterone receptor modulator Substances 0.000 title 1
- 229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical compound C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 abstract 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- HGBGVEOXPHGSOS-UHFFFAOYSA-N 7-fluoro-1h-indole-2,3-dione Chemical compound FC1=CC=CC2=C1NC(=O)C2=O HGBGVEOXPHGSOS-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical compound C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- MFRIHAYPQRLWNB-UHFFFAOYSA-N sodium tert-butoxide Chemical compound [Na+].CC(C)(C)[O-] MFRIHAYPQRLWNB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE UN OXINDOL DE FORMULA I DONDE R1 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, CICLOALQUILO C3-C8, HETEROCICLO, ENTRE OTROS; R2, R3, R4 Y R5 SON CADA UNO H, HALOGENO, ALQUILO C1-C6, CICLOALQUILO C3-C6, ARILO, HETEROARILO, ENTRE OTROS; QUE COMPRENDE: A) COMBINAR UNA ISATINA TAL COMO 7-FLUOROISATINA Y ETILENGLICOL; B) HACER REACCIONAR LA SOLUCION DEL PASO A) CON HIDRAZINA ACUOSA; C) AISLAR DICHO OXINDOL. LAS IMPUREZAS FORMADAS EN EL PROCEDIMIENTO, SON TRATADAS CON ACIDO INORGANICO TAL COMO CuBr-(CH3)2S EN PRESENCIA DE UNA BASE SELECCIONADA DE TER-BUTOXIDO DE POTASIO O SODIO PARA OBTENER OXINDOLES. DICHO PROCEDIMIENTO PROPORCIONA REACTIVOS ECONOMICOS, ALTOS RENDIMIENTOS Y PURIFICACIONES SIMPLES, ESPECIALMENTE A GRAN ESCALA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70401005P | 2005-07-29 | 2005-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070220A1 true PE20070220A1 (es) | 2007-03-19 |
Family
ID=37430943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000913A PE20070220A1 (es) | 2005-07-29 | 2006-07-26 | Proceso para la sintesis de moduladores del receptor de progesterona |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7754895B2 (es) |
| AR (1) | AR054876A1 (es) |
| GT (1) | GT200600334A (es) |
| PE (1) | PE20070220A1 (es) |
| TW (1) | TW200740771A (es) |
| WO (1) | WO2007016355A2 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070213526A1 (en) * | 2006-03-07 | 2007-09-13 | Wyeth | Purification of progesterone receptor modulators |
| US20080051585A1 (en) * | 2006-08-17 | 2008-02-28 | Wyeth | Process for the preparation of indolin-2-one derivatives useful as PR modulators |
| US20080319204A1 (en) * | 2007-06-25 | 2008-12-25 | Wyeth | Process for the synthesis of progesterone receptor modulators |
| JP2010534240A (ja) * | 2007-07-23 | 2010-11-04 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ | ボロン酸の反応性の調節系 |
| AU2010247391A1 (en) | 2009-05-15 | 2011-12-01 | Novartis Ag | Benzoxazolone derivatives as aldosterone synthase inhibitors |
| CA2761858A1 (en) | 2009-05-15 | 2010-11-18 | Novartis Ag | 5-pyridin-3-yl-1,3-dihydro-indol-2-on derivatives and their use as modulators of aldosterone synthase and/or cyp11b1 |
| US8803420B2 (en) | 2010-01-15 | 2014-08-12 | Idemitsu Kosan Co., Ltd. | Organic electroluminescence device |
| US8557980B2 (en) | 2010-02-18 | 2013-10-15 | The Board Of Trustees Of The University Of Illinois | Methods for forming protected organoboronic acids |
| CN110003077B (zh) * | 2018-01-04 | 2022-03-15 | 南京农业大学 | 一种含吡咯烷二酮和苯胺基团的丁酰苯肼类化合物、制备方法及应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW550257B (en) | 1999-01-16 | 2003-09-01 | Sinon Corp | A process for preparing 2-oxindole |
| US5973165A (en) * | 1999-03-17 | 1999-10-26 | Sinon Corporation | Process for preparing 2-oxindole |
| AT408223B (de) | 1999-12-27 | 2001-09-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von oxindolen |
| US20040186160A1 (en) * | 2002-12-13 | 2004-09-23 | Sugen, Inc. | Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors |
| AR049631A1 (es) | 2004-04-27 | 2006-08-23 | Wyeth Corp | Proceso de acoplamiento para la generacion de derivados reactivos de pirrol -2- carbonitrilo n- sustituidos con contenido de boro para producir biarilos |
| AU2005238520B2 (en) | 2004-04-27 | 2011-09-08 | Wyeth | Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same |
| AU2005237520B2 (en) | 2004-04-27 | 2012-01-19 | Wyeth | Purification of progesterone receptor modulators |
| GT200500185A (es) | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
| GT200500183A (es) | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
| WO2006044415A2 (en) * | 2004-10-12 | 2006-04-27 | Decode Genetics, Inc. | Carboxylic acid peri - substituted bicyclics for occlusive artery disease |
| AR056994A1 (es) | 2005-04-29 | 2007-11-07 | Wyeth Corp | Proceso para preparar isatinas con control de formacion de subproductos |
| CN101166722A (zh) | 2005-04-29 | 2008-04-23 | 惠氏公司 | 制备3,3-二取代的羟吲哚和硫代羟吲哚的方法 |
-
2006
- 2006-07-26 PE PE2006000913A patent/PE20070220A1/es not_active Application Discontinuation
- 2006-07-27 US US11/494,425 patent/US7754895B2/en not_active Expired - Fee Related
- 2006-07-27 TW TW095127522A patent/TW200740771A/zh unknown
- 2006-07-27 WO PCT/US2006/029446 patent/WO2007016355A2/en not_active Ceased
- 2006-07-27 GT GT200600334A patent/GT200600334A/es unknown
- 2006-07-27 AR ARP060103255A patent/AR054876A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GT200600334A (es) | 2007-03-14 |
| WO2007016355A2 (en) | 2007-02-08 |
| TW200740771A (en) | 2007-11-01 |
| AR054876A1 (es) | 2007-07-25 |
| US20070027327A1 (en) | 2007-02-01 |
| US7754895B2 (en) | 2010-07-13 |
| WO2007016355A3 (en) | 2007-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |