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PE20070849A1 - Compuestos mimeticos de lisina modificados - Google Patents

Compuestos mimeticos de lisina modificados

Info

Publication number
PE20070849A1
PE20070849A1 PE2006001691A PE2006001691A PE20070849A1 PE 20070849 A1 PE20070849 A1 PE 20070849A1 PE 2006001691 A PE2006001691 A PE 2006001691A PE 2006001691 A PE2006001691 A PE 2006001691A PE 20070849 A1 PE20070849 A1 PE 20070849A1
Authority
PE
Peru
Prior art keywords
benzoylamine
pyrrolidin
acetyl
aryl
amino
Prior art date
Application number
PE2006001691A
Other languages
English (en)
Inventor
Bjarne Due Larsen
Jorgen Soberg Petersen
Ketil Jorgen Haugen
John A Butera
James K Hennan
Edward H Kerns
Evgueni Lvovich Piatnitski
Original Assignee
Zealand Pharma As
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38110525&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070849(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zealand Pharma As, Wyeth Corp filed Critical Zealand Pharma As
Publication of PE20070849A1 publication Critical patent/PE20070849A1/es

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

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Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE Y ES OX, OR2, NXR2 O NR2R3, DONDE X ES H O UN COMPUESTO DE FORMULA (a), (b), ENTRE OTROS, DONDE Z' ES H, (CH2)m-ARILO(C6-C20), (CH2)m-HETEROARILO DE 5 A 20 MIEMBROS, ENTRE OTROS, EN DONDE m ES DE 0 A 2; R5 ES H O ALQUILO(C1-C10) OPCIONALMENTE SUSTITUIDO CON NITRILO, SULFURO, CARBOXI, CETO, ENTRE OTROS; k ES DE 0 A 2; X' ES OR3, NR2R3 O UN MIMETICO DE LISINA; R2 Y R3 SON CADA UNO H, ALQUILO(C1-C10), CICLOALQUILO(C3-C20), ARILO(C6-C20), ENTRE OTROS; R1 ES H, ALQUILO(C1-C10), ARILO(C6-C20), ARALQUILO(C7-C20), ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON NH2, HIDRAZIDA, HALURO, NITRO, ENTRE OTROS SUSTITUYENTES. SON COMPUESTOS PREFERIDOS: ACIDO 1-(2-AMINO-ACETIL)-4-(4-NITRO-BENZOILAMINO)-PIRROLIDIN-2-CARBOXILICO, ACIDO 1-(2-AMINO-ACETIL)-4- BENZOILAMINO-PIRROLIDIN-2-CARBOXILICO, ACIDO 1-(2-AMINO-ACETIL)-4-(4-METIL-BENZOILAMINO)-PIRROLIDIN-2-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MIMETICOS DE LISINA SIENDO UTILES PARA EL TRATAMIENTO DE FIBRILACION AURICULAR, TAQUICARDIA VENTRICULAR, FIBRILACION VENTRICULAR, OSTEOPOROSIS, DIABETES TIPO I O II, ATEROSCLEROSIS, LEUCOPENIA
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