PE20070719A1 - NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF AKT ACTIVITY - Google Patents
NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF AKT ACTIVITYInfo
- Publication number
- PE20070719A1 PE20070719A1 PE2006001351A PE2006001351A PE20070719A1 PE 20070719 A1 PE20070719 A1 PE 20070719A1 PE 2006001351 A PE2006001351 A PE 2006001351A PE 2006001351 A PE2006001351 A PE 2006001351A PE 20070719 A1 PE20070719 A1 PE 20070719A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- inhibitors
- triazolo
- piperidin
- pyridin
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000005054 naphthyridines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 2
- FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical compound N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 abstract 1
- HTSNMAQKHKWFBA-UHFFFAOYSA-N 2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one Chemical compound N=1NC(N2C=1C=1C=CC=NC=1C=C2)=O HTSNMAQKHKWFBA-UHFFFAOYSA-N 0.000 abstract 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical class ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 abstract 1
- RAXXELZNTBOGNW-UHFFFAOYSA-O Imidazolium Chemical compound C1=C[NH+]=CN1 RAXXELZNTBOGNW-UHFFFAOYSA-O 0.000 abstract 1
- IAANPAZLOYJKJI-UHFFFAOYSA-N N=1N=C(N2C=1C=1C=CC=NC=1C=C2)N Chemical compound N=1N=C(N2C=1C=1C=CC=NC=1C=C2)N IAANPAZLOYJKJI-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 abstract 1
- YAMUAKCHMBKTCI-UHFFFAOYSA-N [1,2,4]triazolo[3,4-f][1,6]naphthyridine Chemical compound C1=CN=C2C=CN3C=NN=C3C2=C1 YAMUAKCHMBKTCI-UHFFFAOYSA-N 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003852 triazoles Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE NAFTIRIDINA DE FORMULA A DONDE a ES 0 O 1; b ES 0 O 1; m ES 0, 1 O 2; Q ES UN HETEROCICLILO TAL COMO TRIAZOL O IMIDAZOL, ENTRE OTROS; R1 ES H, OXO, HALO, COOH, OH, (C=O)aObALQUILO C1-C10, ENTRE OTROS; R4 Y R5 SON H, ALQUILO C1-C6, ALQUENILO C1-C6, ALQUINILO C1-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 9-FENIL-8-(4-{[4-(5-PIRIDIN-2-IL)-1H-1,2,4-TRIAZOL-3-IL))PIPERIDIN-1-IL)]METIL}FENIL)[1,2,4]TRIAZOLO[3,4-f]-1,6-NAFTIRIDIN-3-AMINA, 9-FENIL-8-(4-{[ 4-(5-PIRIDIN-2-IL-1H-1,2,4-TRIAZOL-3-IL))PIPERIDIN-1-IL]METIL}FENIL)[1,2,4]TRIAZOLO[3,4-f]-1,6-NAFTIRIDIN-3-OL, 3-(CLOROMETIL)-9-FENIL-8-(4-{[4-(4-PIRIDIN-2-IL-1H-IMIDAZOL-1-IL)PIPERIDIN-1-IL]METIL}FENIL)[1,2,4]TRIAZOLO[3,4-f]-1,6-NAFTIRIDINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE LA SERINA/TREONINA QUINASA Akt Y SON UTILES PARA EL TRATAMIENTO DE CANCERREFERRING TO A COMPOUND DERIVED FROM NAPHTHYRIDINE FROM FORMULA A WHERE a IS 0 OR 1; b IS 0 O 1; m IS 0, 1 O 2; Q IS A HETEROCICLYL SUCH AS TRIAZOLE OR IMIDAZOLE, AMONG OTHERS; R1 IS H, OXO, HALO, COOH, OH, (C = O) α-C1-C10ALKYL, AMONG OTHERS; R4 AND R5 ARE H, C1-C6 ALKYL, C1-C6 ALKYL, C1-C6 ALKYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 9-PHENYL-8- (4 - {[4- (5-PYRIDIN-2-IL) -1H-1,2,4-TRIAZOL-3-IL)) PIPERIDIN-1-IL)] METHYL } PHENYL) [1,2,4] TRIAZOLO [3,4-f] -1,6-NAPHTHYRIDIN-3-AMINE, 9-PHENYL-8- (4 - {[4- (5-PYRIDIN-2-IL -1H-1,2,4-TRIAZOL-3-IL)) PIPERIDIN-1-IL] METHYL} PHENYL) [1,2,4] TRIAZOLO [3,4-f] -1,6-NAPHTHYRIDIN-3- OL, 3- (CHLOROMETHYL) -9-PHENYL-8- (4 - {[4- (4-PYRIDIN-2-IL-1H-IMIDAZOL-1-IL) PIPERIDIN-1-IL] METHYL} PHENYL) [1 , 2,4] TRIAZOLO [3,4-f] -1,6-NAPHTHYRIDINE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE INHIBITORS OF THE ACTIVITY OF SERINE / THREONINE KINASE Akt AND ARE USEFUL FOR THE TREATMENT OF CANCER
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73418805P | 2005-11-07 | 2005-11-07 | |
| PCT/US2006/022079 WO2006135627A2 (en) | 2005-06-10 | 2006-06-07 | Inhibitors of akt activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070719A1 true PE20070719A1 (en) | 2007-08-10 |
Family
ID=38951408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001351A PE20070719A1 (en) | 2005-11-07 | 2006-11-03 | NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF AKT ACTIVITY |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR057843A1 (en) |
| DO (1) | DOP2006000242A (en) |
| GT (1) | GT200600476A (en) |
| PE (1) | PE20070719A1 (en) |
-
2006
- 2006-10-30 AR ARP060104743A patent/AR057843A1/en not_active Application Discontinuation
- 2006-11-03 DO DO2006000242A patent/DOP2006000242A/en unknown
- 2006-11-03 PE PE2006001351A patent/PE20070719A1/en not_active Application Discontinuation
- 2006-11-03 GT GT200600476A patent/GT200600476A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GT200600476A (en) | 2007-05-23 |
| AR057843A1 (en) | 2007-12-19 |
| DOP2006000242A (en) | 2007-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |