PE20070612A1 - NEW CYSTEINE PROTEASE INHIBITORS - Google Patents
NEW CYSTEINE PROTEASE INHIBITORSInfo
- Publication number
- PE20070612A1 PE20070612A1 PE2006001057A PE2006001057A PE20070612A1 PE 20070612 A1 PE20070612 A1 PE 20070612A1 PE 2006001057 A PE2006001057 A PE 2006001057A PE 2006001057 A PE2006001057 A PE 2006001057A PE 20070612 A1 PE20070612 A1 PE 20070612A1
- Authority
- PE
- Peru
- Prior art keywords
- saturated
- benzohydrazide
- alkylen
- methylpropyl
- pyrimidinyl
- Prior art date
Links
- 239000002852 cysteine proteinase inhibitor Substances 0.000 title 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002430 hydrocarbons Chemical group 0.000 abstract 2
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 2
- 230000000078 anti-malarial effect Effects 0.000 abstract 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- XFPNCCPMCDQTME-UHFFFAOYSA-N n'-(5-bromo-2-cyanopyrimidin-4-yl)-n'-(2-methylpropyl)-3-[(4-propylpiperazin-1-yl)methyl]benzohydrazide Chemical compound C1CN(CCC)CCN1CC1=CC=CC(C(=O)NN(CC(C)C)C=2C(=CN=C(N=2)C#N)Br)=C1 XFPNCCPMCDQTME-UHFFFAOYSA-N 0.000 abstract 1
- IZHHMTCAVBKJJX-UHFFFAOYSA-N n'-(5-chloro-2-cyanopyrimidin-4-yl)-4-[[4-[3-(diethylamino)propyl]piperazin-1-yl]methyl]-n'-(2-methylpropyl)benzohydrazide Chemical compound C1CN(CCCN(CC)CC)CCN1CC1=CC=C(C(=O)NN(CC(C)C)C=2C(=CN=C(N=2)C#N)Cl)C=C1 IZHHMTCAVBKJJX-UHFFFAOYSA-N 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R4 ES HALOGENO, R2 ES FENIL-(ALQUILEN-C1-C3)-X, PIRIDIL-FENIL-ALQUILEN C1-C3-X, FENIL-ALQUILEN C1-C3-X-RJ, DONDE FENILO ESTA OPCIONALMENTE SUSTITUIDO POR CF3; RJ ES Z, -ALQUILEN C1-C4-Z, -C(O)Z; X Y Z SON CADA UNO GRUPO HIDROCARBONADO MONOCICLICO SATURADO DE 4 MIEMBROS QUE CONTIENE N, GRUPO HIDROCARBONADO SATURADO MONOCICLICO, PARCIALMENTE SATURADO O AROMATICO DE 6 ATOMOS, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N'-(5-BROMO-2-CIANO-4-PIRIMIDINIL)-N'-(2-METILPROPIL)-3-[(4-PROPIL-1-PIPERAZINIL)METIL]BENZOHIDRAZIDA; N'-(5-CLORO-2-CIANO-4-PIRIMIDINIL)-4-({4-[3-(DIETILAMINO)PROPIL]-1-PIPERAZINIL}METIL)-N'-(2-METILPROPIL)BENZOHIDRAZIDA; 4-(1-AZETIDINILMETIL)-N'-(5-BROMO-2-CIANO-PIRIMIDINIL)-N'-(2-METILPROPIL)BENZOHIDRAZIDA. REFERIDA TAMBIEN A UN PROCESO Y UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE PROTEASA CON ACTIVIDAD ANTIMALARICAREFERS TO A COMPOUND OF FORMULA I, WHERE R4 IS HALOGEN, R2 IS PHENYL- (ALKYLEN-C1-C3) -X, PYRIDYL-PHENYL-ALKYLEN C1-C3-X, PHENYL-ALKYLEN C1-C3-X-RJ, WHERE FENILO IS OPTIONALLY REPLACED BY CF3; RJ IS Z, -C1-C4-Z ALKYLENE, -C (O) Z; X AND Z ARE EACH SATURATED SATURATED SATURATED HYDROCARBON GROUP OF 4 MEMBERS CONTAINING N, SATURATED SATURATED HYDROCARBON GROUP, PARTIALLY SATURATED OR AROMATIC OF 6 ATOMS, AMONG OTHERS. PREFERRED COMPOUNDS ARE: N '- (5-BROMO-2-CYANO-4-PYRIMIDINYL) -N' - (2-METHYLPROPYL) -3 - [(4-PROPYL-1-PIPERAZINYL) METHYL] BENZOHYDRAZIDE; N '- (5-CHLORO-2-CYANO-4-PYRIMIDINYL) -4 - ({4- [3- (DIETHYLAMINO) PROPYL] -1-PIPERAZINYL} METHYL) -N' - (2-METHYLPROPYL) BENZOHYDRAZIDE; 4- (1-AZETHYDINYLMETHYL) -N '- (5-BROMO-2-CYANE-PYRIMIDINYL) -N' - (2-METHYLPROPYL) BENZOHYDRAZIDE. ALSO REFERRED TO A PROCESS AND A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE PROTEASE INHIBITORS WITH ANTIMALARIC ACTIVITY
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05381043 | 2005-09-02 | ||
| EP06110666 | 2006-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070612A1 true PE20070612A1 (en) | 2007-06-23 |
Family
ID=37770277
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001056A PE20070332A1 (en) | 2005-09-02 | 2006-08-31 | HETEROARYL-NITRILE COMPOUNDS SUBSTITUTED AS INHIBITORS OF CYSTEINE PROTEASES |
| PE2006001057A PE20070612A1 (en) | 2005-09-02 | 2006-08-31 | NEW CYSTEINE PROTEASE INHIBITORS |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001056A PE20070332A1 (en) | 2005-09-02 | 2006-08-31 | HETEROARYL-NITRILE COMPOUNDS SUBSTITUTED AS INHIBITORS OF CYSTEINE PROTEASES |
Country Status (4)
| Country | Link |
|---|---|
| AR (2) | AR055624A1 (en) |
| PE (2) | PE20070332A1 (en) |
| TW (2) | TW200804351A (en) |
| WO (3) | WO2007025774A2 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2030621A1 (en) * | 2007-08-21 | 2009-03-04 | Glaxo Group Limited | Novel substituted pyrimidines as cysteine protease inhibitors |
| EP2077841A1 (en) * | 2006-10-30 | 2009-07-15 | Glaxo Group Limited | Novel substituted pyrimidines as cysteine protease inhibitors |
| KR20100023948A (en) | 2007-06-08 | 2010-03-04 | 닛뽕 케미파 가부시키가이샤 | Therapeutic or prophylactic agent for cerebral aneurysm |
| JPWO2009054454A1 (en) | 2007-10-24 | 2011-03-03 | 国立大学法人 東京医科歯科大学 | Modulator of signal transduction of Toll-like receptor containing cathepsin inhibitor as an active ingredient |
| DE102008063561A1 (en) * | 2008-12-18 | 2010-08-19 | Bayer Cropscience Ag | Hydrazides, process for their preparation and their use as herbicides and insecticides |
| CN102267964B (en) * | 2011-06-15 | 2014-06-18 | 浙江师范大学 | 3-hydroxy-2,3-dihydro-benzofuran derivatives as well as synthesis method and application thereof |
| WO2019190117A1 (en) * | 2018-03-28 | 2019-10-03 | 한림제약(주) | 2-cyanopyrimidin-4-yl carbamate or urea derivative or salt thereof, and pharmaceutical composition including same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR036375A1 (en) * | 2001-08-30 | 2004-09-01 | Novartis Ag | PIRROLO [2,3-D] PIRIMIDINE -2- CARBONITRILE COMPOUNDS, A PROCESS FOR THEIR PREPARATION, A PHARMACEUTICAL COMPOSITION AND THE USE OF SUCH COMPOUNDS FOR THE PREPARATION OF MEDICINES |
-
2006
- 2006-08-31 WO PCT/EP2006/008578 patent/WO2007025774A2/en not_active Ceased
- 2006-08-31 TW TW095132087A patent/TW200804351A/en unknown
- 2006-08-31 WO PCT/EP2006/008579 patent/WO2007025775A2/en not_active Ceased
- 2006-08-31 TW TW095132088A patent/TW200804352A/en unknown
- 2006-08-31 AR ARP060103810A patent/AR055624A1/en not_active Application Discontinuation
- 2006-08-31 AR ARP060103809A patent/AR057110A1/en not_active Application Discontinuation
- 2006-08-31 WO PCT/EP2006/008580 patent/WO2007025776A2/en not_active Ceased
- 2006-08-31 PE PE2006001056A patent/PE20070332A1/en not_active Application Discontinuation
- 2006-08-31 PE PE2006001057A patent/PE20070612A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007025775A2 (en) | 2007-03-08 |
| WO2007025776A2 (en) | 2007-03-08 |
| TW200804352A (en) | 2008-01-16 |
| PE20070332A1 (en) | 2007-05-11 |
| TW200804351A (en) | 2008-01-16 |
| AR055624A1 (en) | 2007-08-29 |
| AR057110A1 (en) | 2007-11-14 |
| WO2007025774A3 (en) | 2007-04-26 |
| WO2007025776A3 (en) | 2007-05-03 |
| WO2007025774A2 (en) | 2007-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |