PE20070488A1 - Proceso para la preparacion de compuestos derivados del ester del acido amino-acetico - Google Patents
Proceso para la preparacion de compuestos derivados del ester del acido amino-aceticoInfo
- Publication number
- PE20070488A1 PE20070488A1 PE2006001166A PE2006001166A PE20070488A1 PE 20070488 A1 PE20070488 A1 PE 20070488A1 PE 2006001166 A PE2006001166 A PE 2006001166A PE 2006001166 A PE2006001166 A PE 2006001166A PE 20070488 A1 PE20070488 A1 PE 20070488A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- formula
- preparation
- compounds
- amino
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 9
- 238000000034 method Methods 0.000 title abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 title 2
- 229960002449 glycine Drugs 0.000 title 1
- 235000013905 glycine and its sodium salt Nutrition 0.000 title 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 abstract 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical class CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- YXFVVABEGXRONW-CNRUNOGKSA-N tritiomethylbenzene Chemical compound [3H]CC1=CC=CC=C1 YXFVVABEGXRONW-CNRUNOGKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE COMPUESTOS DE FORMULA (III) DONDE R ES H, ALQUILO(C1-C7) O ALCOXI-ALQUILO(C1-C7); R1 ES H, ALQUILO(C1-C7), ALCOXI(C1-C7)-ALQUILO(C1-C6); R' ES H, ALQUILO(C1-C7) O ARALQUILO; QUE COMPRENDE: A) HACER REACCIONAR UN COMPUESTO DE FORMULA (I) CON UN COMPUESTO DE FORMULA (II) EN PRESENCIA DE UNA BASE TAL COMO TRIMETIL-AMINA Y UN SOLVENTE TAL COMO CLORURO DE METILENO O TOLUENO, DICHA REACCION SE LLEVA A CABO A UNA TEMPERATURA DE 0ºC A 40ºC Y SE OBTIENE UN COMPUESTO DE FORMULA (III). ES UN COMPUESTO PREFERIDO: ETIL-ESTER DEL ACIDO {[1-[4-METOXI-3-(3-METOXI-PROPOXI)-FENIL]-MET-(E)-ILIDEN]-AMINO}-ACETICO. SE REFIERE TAMBIEN A PROCEDIMIENTOS DE PREPARACION DE COMPUESTOS DE FORMULA (IV), (VI), ENTRE OTROS. DICHOS COMPUESTOS SON INTERMEDIARIOS PARA LA PREPARACION DE COMPUESTOS INHIBIDORES DE RENINA TAL COMO ALISQUIRENO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0519764.5A GB0519764D0 (en) | 2005-09-28 | 2005-09-28 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070488A1 true PE20070488A1 (es) | 2007-06-13 |
Family
ID=35394904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001166A PE20070488A1 (es) | 2005-09-28 | 2006-09-26 | Proceso para la preparacion de compuestos derivados del ester del acido amino-acetico |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7973175B2 (es) |
| EP (2) | EP1931629B1 (es) |
| JP (1) | JP2009509990A (es) |
| KR (1) | KR20080048042A (es) |
| CN (1) | CN101273012A (es) |
| AR (1) | AR057137A1 (es) |
| AT (1) | ATE492533T1 (es) |
| AU (1) | AU2006299097B2 (es) |
| BR (1) | BRPI0616707A2 (es) |
| CA (1) | CA2623495A1 (es) |
| DE (1) | DE602006019114D1 (es) |
| EC (1) | ECSP088319A (es) |
| ES (1) | ES2358536T3 (es) |
| GB (1) | GB0519764D0 (es) |
| GT (1) | GT200600427A (es) |
| IL (1) | IL189763A0 (es) |
| MA (1) | MA29852B1 (es) |
| MY (1) | MY143251A (es) |
| NO (1) | NO20082005L (es) |
| NZ (1) | NZ566429A (es) |
| PE (1) | PE20070488A1 (es) |
| PL (1) | PL1931629T3 (es) |
| PT (1) | PT1931629E (es) |
| RU (1) | RU2423348C2 (es) |
| TN (1) | TNSN08142A1 (es) |
| TW (1) | TW200730480A (es) |
| WO (1) | WO2007039183A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2062874B1 (en) | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Process and intermediates for the preparation of aliskiren |
| EP2189442B1 (en) | 2008-11-20 | 2014-10-01 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process and intermediates for the preparation of aliskiren |
| US8203005B2 (en) | 2009-10-29 | 2012-06-19 | Carbo Design Llc | Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren |
| CN101774986B (zh) * | 2010-01-06 | 2012-03-28 | 浙江天宇药业股份有限公司 | 一种制备阿利克伦及其中间体的方法 |
| CN101863796B (zh) * | 2010-05-12 | 2011-08-24 | 海南美兰史克制药有限公司 | 一种阿利克仑化合物及其制法 |
| EP2551260A1 (en) | 2011-07-28 | 2013-01-30 | Chemo Ibérica, S.A. | Chemical process for opening ring compounds |
| US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3421295A1 (de) | 1984-06-08 | 1985-12-12 | Basf Ag, 6700 Ludwigshafen | Neue pyrrolidincarbonsaeurederivative, verfahren zu ihrer herstellung |
| MY119161A (en) | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| US6730798B2 (en) | 2000-07-05 | 2004-05-04 | Speedel Pharma Ag | Process for the preparation of substituted octanoyl amides |
| DE10116816A1 (de) * | 2001-04-04 | 2002-10-17 | Basf Ag | Verfahren zur Herstellung von N-Benzylaminen |
| GB0419361D0 (en) | 2004-08-31 | 2004-10-06 | Novartis Ag | Organic compounds |
-
2005
- 2005-09-28 GB GBGB0519764.5A patent/GB0519764D0/en not_active Ceased
-
2006
- 2006-09-25 GT GT200600427A patent/GT200600427A/es unknown
- 2006-09-26 AU AU2006299097A patent/AU2006299097B2/en not_active Ceased
- 2006-09-26 PT PT06805861T patent/PT1931629E/pt unknown
- 2006-09-26 PL PL06805861T patent/PL1931629T3/pl unknown
- 2006-09-26 NZ NZ566429A patent/NZ566429A/en not_active IP Right Cessation
- 2006-09-26 MY MYPI20080623A patent/MY143251A/en unknown
- 2006-09-26 AT AT06805861T patent/ATE492533T1/de active
- 2006-09-26 CA CA002623495A patent/CA2623495A1/en not_active Abandoned
- 2006-09-26 PE PE2006001166A patent/PE20070488A1/es not_active Application Discontinuation
- 2006-09-26 RU RU2008116317/04A patent/RU2423348C2/ru not_active IP Right Cessation
- 2006-09-26 ES ES06805861T patent/ES2358536T3/es active Active
- 2006-09-26 KR KR1020087007396A patent/KR20080048042A/ko not_active Ceased
- 2006-09-26 WO PCT/EP2006/009323 patent/WO2007039183A1/en not_active Ceased
- 2006-09-26 AR ARP060104197A patent/AR057137A1/es not_active Application Discontinuation
- 2006-09-26 US US12/067,055 patent/US7973175B2/en not_active Expired - Fee Related
- 2006-09-26 EP EP06805861A patent/EP1931629B1/en not_active Not-in-force
- 2006-09-26 JP JP2008532650A patent/JP2009509990A/ja active Pending
- 2006-09-26 EP EP10178025A patent/EP2287153A1/en not_active Withdrawn
- 2006-09-26 CN CNA2006800353469A patent/CN101273012A/zh active Pending
- 2006-09-26 DE DE602006019114T patent/DE602006019114D1/de active Active
- 2006-09-26 BR BRPI0616707-1A patent/BRPI0616707A2/pt not_active IP Right Cessation
- 2006-09-27 TW TW095135800A patent/TW200730480A/zh unknown
-
2008
- 2008-02-25 IL IL189763A patent/IL189763A0/en unknown
- 2008-03-27 TN TNP2008000142A patent/TNSN08142A1/en unknown
- 2008-03-27 EC EC2008008319A patent/ECSP088319A/es unknown
- 2008-04-04 MA MA30815A patent/MA29852B1/fr unknown
- 2008-04-28 NO NO20082005A patent/NO20082005L/no not_active Application Discontinuation
-
2011
- 2011-05-26 US US13/116,349 patent/US20110230665A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2358536T3 (es) | 2011-05-11 |
| AR057137A1 (es) | 2007-11-21 |
| WO2007039183A1 (en) | 2007-04-12 |
| JP2009509990A (ja) | 2009-03-12 |
| IL189763A0 (en) | 2008-08-07 |
| RU2008116317A (ru) | 2009-11-10 |
| RU2423348C2 (ru) | 2011-07-10 |
| TW200730480A (en) | 2007-08-16 |
| US7973175B2 (en) | 2011-07-05 |
| US20110230665A1 (en) | 2011-09-22 |
| TNSN08142A1 (en) | 2009-07-14 |
| BRPI0616707A2 (pt) | 2011-06-28 |
| EP1931629A1 (en) | 2008-06-18 |
| AU2006299097B2 (en) | 2010-11-04 |
| CA2623495A1 (en) | 2007-04-12 |
| ATE492533T1 (de) | 2011-01-15 |
| DE602006019114D1 (de) | 2011-02-03 |
| EP2287153A1 (en) | 2011-02-23 |
| EP1931629B1 (en) | 2010-12-22 |
| KR20080048042A (ko) | 2008-05-30 |
| US20080255369A1 (en) | 2008-10-16 |
| MA29852B1 (fr) | 2008-10-03 |
| GB0519764D0 (en) | 2005-11-09 |
| ECSP088319A (es) | 2008-04-28 |
| MY143251A (en) | 2011-04-15 |
| PL1931629T3 (pl) | 2011-05-31 |
| NO20082005L (no) | 2008-06-24 |
| AU2006299097A1 (en) | 2007-04-12 |
| PT1931629E (pt) | 2011-03-09 |
| NZ566429A (en) | 2010-10-29 |
| GT200600427A (es) | 2007-04-30 |
| CN101273012A (zh) | 2008-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |