PE20061162A1 - COMPOUNDS OLEFINIC DERIVATIVES OF 8-AZONIABICICLO [3.2.1] OCTANES - Google Patents
COMPOUNDS OLEFINIC DERIVATIVES OF 8-AZONIABICICLO [3.2.1] OCTANESInfo
- Publication number
- PE20061162A1 PE20061162A1 PE2005001395A PE2005001395A PE20061162A1 PE 20061162 A1 PE20061162 A1 PE 20061162A1 PE 2005001395 A PE2005001395 A PE 2005001395A PE 2005001395 A PE2005001395 A PE 2005001395A PE 20061162 A1 PE20061162 A1 PE 20061162A1
- Authority
- PE
- Peru
- Prior art keywords
- endo
- dimethyl
- octane
- bromide
- azoniabiciclo
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- -1 2-THENYL Chemical class 0.000 abstract 4
- 229940124225 Adrenoreceptor agonist Drugs 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- 206010006458 Bronchitis chronic Diseases 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 206010014561 Emphysema Diseases 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 abstract 1
- 229960004373 acetylcholine Drugs 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 208000007451 chronic bronchitis Diseases 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 abstract 1
- BDDIUTHMWNWMRJ-UHFFFAOYSA-N octane;hydrobromide Chemical compound Br.CCCCCCCC BDDIUTHMWNWMRJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE R2 Y R3 SON ALQUILO(C1-C6), CICLOALQUILO(C5-C6), 2-TIENILO, 2-PIRIDILO, ENTRE OTROS; X- ES UN ANION ASOCIADO CON LA CARGA POSITIVA DEL ATOMO DE N TAL COMO CLORURO, BROMURO, YODURO, SULFATO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: BROMURO DE (3-ENDO)-3-(2,2-DI-2-TIENILETENIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO, BROMURO DE (3-ENDO)-3-(2,2DIFENILETENIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO, 4-METILBENCENOSULFONATO DE (3-ENDO)-3-(2,2-DIFENILETENIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ADEMAS CONTIENE UN AGONISTA DEL ADRENORECEPTOR ß2, UN ANTIHISTAMINICO, UN ANTIALERGICO O UN ANTIINFLAMATORIO. DICHOS COMPUESTOS INHIBEN LA UNION DE ACETILCOLINA A SUS RECEPTORES MUSCARINICOS SIENDO UTILES EN EL TRATAMIENTO DE ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, BRONQUITIS CRONICA, ASMA, FIBROSIS PULMONAR, ENFISEMA PULMONARREFERS TO A COMPOUND OF FORMULA (I) WHERE R2 AND R3 ARE ALKYL (C1-C6), CYCLOALKYL (C5-C6), 2-THENYL, 2-PYRIDYL, AMONG OTHERS; X- IS AN ANION ASSOCIATED WITH THE POSITIVE CHARGE OF THE N ATOM SUCH AS CHLORIDE, BROMIDE, IODIDE, SULPHATE, AMONG OTHERS. THE PREFERRED COMPOUNDS ARE: (3-ENDO) -3- (2,2-DI-2-THYENYLETHENYL) -8,8-DIMETHYL-8-AZONIABYCLE [3.2.1] OCTANE BROMIDE, (3-ENDO) BROMIDE - 3- (2,2-DIPHENYLETHENYL) -8,8-DIMETHYL-8-AZONIABICYCLO [3.2.1] OCTANE, (3-ENDO) -3- (2,2-DIPHENYLETHENYL) -8,8-DIMETHYL- 4-METHYLBENZENOSULPHONATE 8-AZONIABICICLO [3.2.1] OCTANE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION THAT ALSO CONTAINS A ß2-ADRENORECEPTOR AGONIST, AN ANTIHISTAMINE, AN ANTI-ALLERGIC OR AN ANTI-INFLAMMATORY. SUCH COMPOUNDS INHIBIT THE BINDING OF ACETYLCHOLINE TO ITS MUSCARINAL RECEPTORS, BEING USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, CHRONIC BRONCHITIS, ASTHMA, PULMONARY FIBROSIS, PULMONARY EMPHYSEMA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63366904P | 2004-12-06 | 2004-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20061162A1 true PE20061162A1 (en) | 2006-10-14 |
Family
ID=36578446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005001395A PE20061162A1 (en) | 2004-12-06 | 2005-12-01 | COMPOUNDS OLEFINIC DERIVATIVES OF 8-AZONIABICICLO [3.2.1] OCTANES |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR054411A1 (en) |
| PE (1) | PE20061162A1 (en) |
| TW (1) | TW200633706A (en) |
| UY (1) | UY29244A1 (en) |
| WO (1) | WO2006062883A2 (en) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20050250A1 (en) | 2003-07-17 | 2005-04-08 | Glaxo Group Ltd | ANTAGONISTS OF ACETYLCHOLIN MUSCARINAL RECEPTORS |
| WO2005037280A1 (en) | 2003-10-14 | 2005-04-28 | Glaxo Group Limited | Muscarinic acetycholine receptor antagonists |
| AU2004281167A1 (en) | 2003-10-17 | 2005-04-28 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists field of the invention |
| PE20050489A1 (en) | 2003-11-04 | 2005-09-02 | Glaxo Group Ltd | ANTAGONISTS OF MUSCARINE ACETYLCHOLINE RECEPTORS |
| US7384946B2 (en) | 2004-03-17 | 2008-06-10 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
| PE20060259A1 (en) | 2004-04-27 | 2006-03-25 | Glaxo Group Ltd | QUINUCLIDINE COMPOUNDS AS ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR |
| WO2005112644A2 (en) | 2004-05-13 | 2005-12-01 | Glaxo Group Limited | Muscarinic acetylcholine receptor antagonists |
| US7932247B2 (en) | 2004-11-15 | 2011-04-26 | Glaxo Group Limited | M3 muscarinic acetylcholine receptor antagonists |
| JP2009504768A (en) | 2005-08-18 | 2009-02-05 | グラクソ グループ リミテッド | Muscarinic acetylcholine receptor antagonist |
| UY31636A1 (en) | 2008-02-06 | 2009-08-03 | DUE PHARMACOPHORES-MUSCARINIC ANTAGONISTS OF PDE4 | |
| AR070564A1 (en) | 2008-02-06 | 2010-04-21 | Glaxo Group Ltd | DERIVATIVES OF 1H-PIRAZOLO [3,4-B] PIRIDIN-5-ILO, PDE4 PHOSPHODIESTERASE INHIBITORS AND ACETILCOLINE MUSCARINIC RECEPTORS (MACHR) ANTAGONISTS, USEFUL IN THE TREATMENT AND / OR PROFILAXES AND PHYSPHOSITIZES, PHYSPHOSYSTEMS, AND PHARMOSES THAT UNDERSTAND THEM |
| TW201000476A (en) | 2008-02-06 | 2010-01-01 | Glaxo Group Ltd | Dual pharmacophores-PDE4-muscarinic antagonistics |
| ES2994042T3 (en) | 2009-02-26 | 2025-01-16 | Glaxo Group Ltd | Pharmaceutical formulations comprising 4-{(1 r)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol |
| GB0921075D0 (en) | 2009-12-01 | 2010-01-13 | Glaxo Group Ltd | Novel combination of the therapeutic agents |
| JP6267685B2 (en) | 2012-04-13 | 2018-01-24 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Aggregated particles |
| GB201222679D0 (en) | 2012-12-17 | 2013-01-30 | Glaxo Group Ltd | Pharmaceutical combination products |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2800478A (en) * | 1955-07-01 | 1957-07-23 | Smith Kline French Lab | 3-substituted-8-alkylnortropanes and the acid and quaternary ammonium salts thereof |
| GB1273823A (en) * | 1968-10-22 | 1972-05-10 | Soc Ind Fab Antibiotiques Sifa | New tropane derivatives their salts and process for preparation thereof |
| IL104068A (en) * | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Surfactant-free pharmaceutical aerosol formulation comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n- propane as propellant |
| US6624167B1 (en) * | 2000-08-04 | 2003-09-23 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
-
2005
- 2005-12-01 PE PE2005001395A patent/PE20061162A1/en not_active Application Discontinuation
- 2005-12-02 UY UY29244A patent/UY29244A1/en unknown
- 2005-12-05 TW TW094142713A patent/TW200633706A/en unknown
- 2005-12-05 WO PCT/US2005/043875 patent/WO2006062883A2/en not_active Ceased
- 2005-12-05 AR ARP050105078A patent/AR054411A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006062883A2 (en) | 2006-06-15 |
| TW200633706A (en) | 2006-10-01 |
| WO2006062883A3 (en) | 2007-03-29 |
| AR054411A1 (en) | 2007-06-27 |
| UY29244A1 (en) | 2006-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |