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PE20061134A1 - COMPOUNDS DERIVED FROM PYRIMIDINE FUSED AS INHIBITORS OF TYROSINE KINASE - Google Patents

COMPOUNDS DERIVED FROM PYRIMIDINE FUSED AS INHIBITORS OF TYROSINE KINASE

Info

Publication number
PE20061134A1
PE20061134A1 PE2005001389A PE2005001389A PE20061134A1 PE 20061134 A1 PE20061134 A1 PE 20061134A1 PE 2005001389 A PE2005001389 A PE 2005001389A PE 2005001389 A PE2005001389 A PE 2005001389A PE 20061134 A1 PE20061134 A1 PE 20061134A1
Authority
PE
Peru
Prior art keywords
inhibitors
tyrosine kinase
pyrrolo
pyrimidin
chloro
Prior art date
Application number
PE2005001389A
Other languages
Spanish (es)
Inventor
Tomoyasu Ishikawa
Takahiko Taniguchi
Masaki Seto
Hiroshi Banno
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2005/010451 external-priority patent/WO2005118588A1/en
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20061134A1 publication Critical patent/PE20061134A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE W ES C(R1) O N, DONDE R1 ES H, O UN GRUPO OPCIONALMENTE SUSTITUIDO UNIDO A TRAVES DE UN C, N U O; A ES ARILO(C6-C18) O HETEROARILO(C5-C6) OPCIONALMENTE SUSTITUIDO; X1 ES O, S, SO, SO2, ENTRE OTROS; R2 ES H, GRUPO OPCIONALMENTE SUSTITUIDO UNIDO A TRAVES DE UN C O S, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-{2-[4-({3-CLORO-4-[(3-FLUOROBENCIL)OXI]FENIL}AMINO)-5H-PIRROLO[3,2-d]PIRIMIDIN-5-IL]ETOXI}ETANOL, 2-{2-[4-({3-CLORO-4-[3-(TRIFLUOROMETIL)FENOXI]FENIL}AMINO)-5H-PIRROLO[3,2-d]PIRIMIDIN-5-IL]ETOXI}ETANOL, N-{2-[4-({3-CLORO-4-[3-(TRIFLUOROMETIL)FENOXI]FENIL}AMINO)-5H-PIRROLO[3,2-d]PIRIMIDIN-5-IL]ETIL}-3-HIDROXI-3-METILBUTANAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE TIROSINA QUINASA SIENDO UTILES EN EL TRATAMIENTO DE CANCERREFERS TO A COMPOUND OF FORMULA (I) WHERE W IS C (R1) O N, WHERE R1 IS H, OR AN OPTIONALLY SUBSTITUTE GROUP JOINED THROUGH A C, N OR O; A IS ARYL (C6-C18) OR HETEROARYL (C5-C6) OPTIONALLY SUBSTITUTED; X1 IS O, S, SO, SO2, AMONG OTHERS; R2 IS H, OPTIONALLY SUBSTITUTED GROUP JOINED THROUGH A C OR S, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 2- {2- [4 - ({3-CHLORO-4 - [(3-FLUOROBENZYL) OXY] PHENYL} AMINO) -5H-PYRROLO [3,2-d] PYRIMIDIN-5-IL] ETOXY } ETHANOL, 2- {2- [4 - ({3-CHLORO-4- [3- (TRIFLUORomethyl) PHENOXY] PHENYL} AMINO) -5H-PYRROLO [3,2-d] PYRIMIDIN-5-IL] ETHOXY} ETHANOL, N- {2- [4 - ({3-CHLORO-4- [3- (TRIFLUORomethyl) PHENOXY] PHENYL} AMINO) -5H-PYRROLO [3,2-d] PYRIMIDIN-5-IL] ETHYL} - 3-HYDROXY-3-METHYLBUTANAMIDE, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SAID COMPOUNDS ARE INHIBITORS OF TYROSINE KINASE, BEING USEFUL IN THE TREATMENT OF CANCER

PE2005001389A 2005-03-02 2005-11-30 COMPOUNDS DERIVED FROM PYRIMIDINE FUSED AS INHIBITORS OF TYROSINE KINASE PE20061134A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005058231 2005-03-02
PCT/JP2005/010451 WO2005118588A1 (en) 2004-06-02 2005-06-01 Fused heterocyclic compound

Publications (1)

Publication Number Publication Date
PE20061134A1 true PE20061134A1 (en) 2006-12-14

Family

ID=37715933

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001389A PE20061134A1 (en) 2005-03-02 2005-11-30 COMPOUNDS DERIVED FROM PYRIMIDINE FUSED AS INHIBITORS OF TYROSINE KINASE

Country Status (2)

Country Link
AR (1) AR051782A1 (en)
PE (1) PE20061134A1 (en)

Also Published As

Publication number Publication date
AR051782A1 (en) 2007-02-07

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