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PE20061082A1 - Sales de la n-[2-({(3r)-1-[trans-4-hidroxi-4-(6-metoxipiridin-3-il)-ciclohexil]pirrodilin-3-il}amino)-2-oxoetil]-3-(trifluorometil)benzamida - Google Patents

Sales de la n-[2-({(3r)-1-[trans-4-hidroxi-4-(6-metoxipiridin-3-il)-ciclohexil]pirrodilin-3-il}amino)-2-oxoetil]-3-(trifluorometil)benzamida

Info

Publication number
PE20061082A1
PE20061082A1 PE2005001365A PE2005001365A PE20061082A1 PE 20061082 A1 PE20061082 A1 PE 20061082A1 PE 2005001365 A PE2005001365 A PE 2005001365A PE 2005001365 A PE2005001365 A PE 2005001365A PE 20061082 A1 PE20061082 A1 PE 20061082A1
Authority
PE
Peru
Prior art keywords
salt
acid
refers
metoxypyridin
oxoethyl
Prior art date
Application number
PE2005001365A
Other languages
English (en)
Inventor
Chu-Biao Xue
Brian W Metcalf
Hao Feng
Joseph Glenn
Hui-Yin Harry Li
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of PE20061082A1 publication Critical patent/PE20061082A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE REFIERE A SALES DE LA N-[2-({(3R)-1-[TRANS-4-HIDROXI-4-(6-METOXIPIRIDIN-3-IL)-CICLOHEXIL]PIRRODILIN-3-IL}AMINO)-2-OXOETIL]-3-(TRIFLUOROMETIL)BENZAMIDA DE FORMULA I DONDE DICHA SAL SE SELECCIONA DE UNA SAL DEL ACIDO BIS METANOSULFONICO, ACIDO BIS ETANOSULFONICO, ACIDO CANFORICO. DICHA SAL PUEDE ESTAR EN FORMA CRISTALINA O ANHIDRA Y SE CARACTERIZA PORQUE PRESENTA UN PICO ENDOTERMICO DE 166°C DETERMINADO POR UN TERMOGRAMA DE CALORIMETRIA DIFERENCIAL DE BARRIDO (DSC) Y UN PATRON DE DIFRACCION DE POLVO DE RAYOS X CON PICOS QUE COMPRENDEN ENTRE 8,7° A 21,8°. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION QUE COMPRENDE COMBINAR EL COMPUESTO DE FORMULA I CON UN ACIDO METANOSULFONCIO EN UN SOLVENTE CRISTALIZANTE QUE COMPRENDE AGUA, ALCOHOL Y CETONA Y PRECIPITAR DICHA SAL DE DICHO SOLVENTE CRISTALIZANTE. SE REFIERE TAMBIEN A UN COMPOSICION FARMACEUTICA QUE COMPRENDE DICHA SAL Y QUE ACTUA A NIVEL DEL RECEPTOR DE QUIMIOCINAS CCR2 SIENDO UTIL EN EL TRATAMIENTO DE ENFERMEDADES REUMATOIDEAS, ATEROSCLEROSIS, LUPUS, DOLOR NEUROPATICO
PE2005001365A 2004-11-22 2005-11-22 Sales de la n-[2-({(3r)-1-[trans-4-hidroxi-4-(6-metoxipiridin-3-il)-ciclohexil]pirrodilin-3-il}amino)-2-oxoetil]-3-(trifluorometil)benzamida PE20061082A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63014604P 2004-11-22 2004-11-22
US69963705P 2005-07-15 2005-07-15

Publications (1)

Publication Number Publication Date
PE20061082A1 true PE20061082A1 (es) 2006-12-08

Family

ID=36647947

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001365A PE20061082A1 (es) 2004-11-22 2005-11-22 Sales de la n-[2-({(3r)-1-[trans-4-hidroxi-4-(6-metoxipiridin-3-il)-ciclohexil]pirrodilin-3-il}amino)-2-oxoetil]-3-(trifluorometil)benzamida

Country Status (10)

Country Link
US (1) US20060111404A1 (es)
EP (1) EP1819694A2 (es)
JP (1) JP2008520722A (es)
AR (1) AR051965A1 (es)
CA (1) CA2587919A1 (es)
PA (1) PA8653301A1 (es)
PE (1) PE20061082A1 (es)
TW (1) TW200633703A (es)
UY (1) UY29219A1 (es)
WO (1) WO2006073592A2 (es)

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ATE555087T1 (de) * 2002-11-27 2012-05-15 Incyte Corp 3-aminopyrrolidinderivate als modulatoren von chemokinrezeptoren
GEP20084505B (en) * 2003-12-18 2008-10-10 Incyte Corp 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
AP2006003849A0 (en) * 2004-06-28 2006-12-31 Incyte Corp 3-Aminocyclopentanecarboxamides as modulators of chemokine receptors
WO2007143600A2 (en) 2006-06-05 2007-12-13 Incyte Corporation Sheddase inhibitors combined with cd30-binding immunotherapeutics for the treatment of cd30 positive diseases
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
CA2687931C (en) 2007-05-31 2016-05-24 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists and uses thereof
WO2009130915A1 (ja) 2008-04-25 2009-10-29 株式会社日本触媒 ポリアクリル酸（塩）系吸水性樹脂およびその製造方法
EP2376475B1 (en) * 2008-12-10 2015-09-02 Janssen Pharmaceutica NV 4-azetidinyl-1-heteroaryl-cyclohexanol antagonists of ccr2
CN103724328B (zh) 2008-12-19 2015-10-14 贝林格尔.英格海姆国际有限公司 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺
CN102300884B (zh) 2009-02-06 2014-05-14 株式会社日本触媒 聚丙烯酸(盐)系吸水性树脂及其制备方法
EP2419417B1 (en) * 2009-04-16 2015-03-25 Janssen Pharmaceutica NV 4-azetidinyl-1-heteroaryl-cyclohexane antagonists of ccr2
NZ595432A (en) * 2009-04-17 2013-12-20 Janssen Pharmaceutica Nv 4-azetidinyl-1-phenyl-cyclohexane antagonists of ccr2
WO2010121036A1 (en) * 2009-04-17 2010-10-21 Janssen Pharmaceutica Nv 4-azetidinyl-1-heteroatom linked-cyclohexane antagonists of ccr2
KR101151415B1 (ko) * 2009-07-10 2012-06-01 양지화학 주식회사 Ｃｃｒ２ 길항제로서의 피페라지닐에틸 3-아미노피롤리딘 유도체
JP5619011B2 (ja) 2009-08-27 2014-11-05 株式会社日本触媒 ポリアクリル酸（塩）系吸水性樹脂およびその製造方法
CN102548654A (zh) 2009-09-29 2012-07-04 株式会社日本触媒 颗粒状吸水剂及其制造方法
PL2513093T3 (pl) 2009-12-17 2015-03-31 Centrexion Therapeutics Corp Nowi antagoniści receptora CCR2 i ich zastosowanie
EP2576538B1 (en) 2010-06-01 2015-10-28 Boehringer Ingelheim International GmbH New CCR2 antagonists
KR101743280B1 (ko) * 2010-06-17 2017-06-02 얀센 파마슈티카 엔.브이. Ccr2의 사이클로헥실-아제티디닐 길항제
CN107936189B (zh) 2013-08-28 2021-06-01 株式会社日本触媒 聚丙烯酸(盐)系吸水性树脂粉末及其制品
CN109608661B (zh) 2013-08-28 2021-09-10 株式会社日本触媒 凝胶粉碎装置、及聚丙烯酸(盐)系吸水性树脂粉末的制造方法、以及吸水性树脂粉末
KR102622891B1 (ko) 2015-05-21 2024-01-08 케모센트릭스, 인크. Ccr2 조절제
AU2016287584B2 (en) 2015-07-02 2020-03-26 Centrexion Therapeutics Corporation (4-((3R,4R)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate
KR102677442B1 (ko) 2017-09-25 2024-06-20 케모센트릭스, 인크. 케모카인 수용체 2(ccr2) 길항제 및 pd-1/pd-l1 억제제를 사용하는 병용 요법
US20190269664A1 (en) 2018-01-08 2019-09-05 Chemocentryx, Inc. Methods of treating solid tumors with ccr2 antagonists
ES2991280T3 (es) 2018-01-08 2024-12-03 Chemocentryx Inc Antagonistas de CCR2 para el tratamiento del linfoma cutáneo de linfocitos T

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ATE555087T1 (de) * 2002-11-27 2012-05-15 Incyte Corp 3-aminopyrrolidinderivate als modulatoren von chemokinrezeptoren

Also Published As

Publication number Publication date
CA2587919A1 (en) 2006-07-13
AR051965A1 (es) 2007-02-21
EP1819694A2 (en) 2007-08-22
WO2006073592A3 (en) 2006-09-28
US20060111404A1 (en) 2006-05-25
WO2006073592A2 (en) 2006-07-13
PA8653301A1 (es) 2006-11-09
UY29219A1 (es) 2006-04-28
TW200633703A (en) 2006-10-01
JP2008520722A (ja) 2008-06-19

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