[go: up one dir, main page]

PE20060651A1 - Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa - Google Patents

Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa

Info

Publication number
PE20060651A1
PE20060651A1 PE2005000974A PE2005000974A PE20060651A1 PE 20060651 A1 PE20060651 A1 PE 20060651A1 PE 2005000974 A PE2005000974 A PE 2005000974A PE 2005000974 A PE2005000974 A PE 2005000974A PE 20060651 A1 PE20060651 A1 PE 20060651A1
Authority
PE
Peru
Prior art keywords
pirazole
pirazol
cr6r7
members
protein kinase
Prior art date
Application number
PE2005000974A
Other languages
English (en)
Inventor
Lee Andrew Funk
Lei Jia
Jerry Jialun Meng
Mason Alan Pairish
Michelle Bich Tran-Dube
Jingrong Jean Cui
Hong Shen
Mitchell David Nambu
Pei-Pei Kung
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35677463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20060651(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of PE20060651A1 publication Critical patent/PE20060651A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DE AMINOHETEROARILO SUSTITUIDOS CON PIRAZOL, DE FORMULA (I), EN DONDE Y ES N O CR12; A ES ARILO(C6-C12), HETEROARILO(DE 5 A 12 MIEMBROS), ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON UNO O MAS R3; R1 ES 1H-PIRAZOL-1-IL, 1H-PIRAZOL-3-IL, 1H-PIRAZOL-4-IL, OPCIONALMENTE SUSTITUIDO CON 1 A 3 GRUPOS R13; R2 ES H, HALOGENO, ENTRE OTROS; CADA R3 ES INDEPENDIENTEMENTE HALOGENO, ALQUILO(C1-C12), CICLOALQUILO(C3-C12), ARILO(C6-C12), HETEROALICICLICO(3 A 12 MIEMBROS), CN, NR4R5, -C(O)R4, -O(R6R7)nR4, ENTRE OTROS; R9 Y R10 SON INDEPENDIENTEMENTE H, ALQUILO(C1-C12), ENTRE OTROS; CADA R13 ES INDEPENDIENTEMENTE HALOGENO, ALQUILO(C1-C12), CICLOALQUILO(C3-C12), ARILO(C6-C12), HETEROALICICLICO(3 A 12 MIEMBROS), HETEROARILO(5 A 12 MIEMBROS), NR4R5, -C(O)R4, -O(R6R7)nR4, -(CR6R7)nOR4, -(CR6R7)nC(O)OR4, -(CR6R7)nC(O)NR4R5, -(CR6R7)n(HETEROALICICLICO O CICLOALQUILO DE 3 A 12 MIEMBROS), ENTRE OTROS; t ES DE 1 A 4. SON PREFERIDOS: 4-[(4-{6-AMINO-5-[1-(2,6-DICLORO-3-FLUOROFENIL)ETOXI]PIRIDIN-3-IL}-1H-PIRAZOL-1-IL)METIL]PIPERIDIN-4-OL, 2-{1-[2-AMINO-5-(1-PIPERIDIN-4-IL-1H-PIRAZOL-4-IL)-PIRIDIN-3-ILOXO]-ETIL}-4-FLUOROBENZONITRILO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA QUINASA c-MET, POR LO QUE SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS DEL CRECIMIENTO CELULAR ANORMAL, O CANCERES
PE2005000974A 2004-08-26 2005-08-24 Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa PE20060651A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60524404P 2004-08-26 2004-08-26
US69080305P 2005-06-14 2005-06-14

Publications (1)

Publication Number Publication Date
PE20060651A1 true PE20060651A1 (es) 2006-07-19

Family

ID=35677463

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000974A PE20060651A1 (es) 2004-08-26 2005-08-24 Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa

Country Status (43)

Country Link
US (1) US20060128724A1 (es)
EP (1) EP1784396B8 (es)
JP (1) JP4167295B2 (es)
KR (1) KR100869393B1 (es)
CN (1) CN101018780B (es)
AP (1) AP2332A (es)
AR (1) AR050529A1 (es)
AT (1) ATE492544T1 (es)
AU (1) AU2005276132B2 (es)
BR (1) BRPI0514537B8 (es)
CA (1) CA2577937C (es)
CR (2) CR8938A (es)
CY (1) CY1111138T1 (es)
DE (1) DE602005025499D1 (es)
DK (1) DK1784396T3 (es)
EA (1) EA011725B1 (es)
EC (1) ECSP077278A (es)
ES (1) ES2355923T3 (es)
GE (1) GEP20094845B (es)
GT (1) GT200500226A (es)
HN (1) HN2005000477A (es)
HR (1) HRP20110116T1 (es)
IL (1) IL181045A0 (es)
MA (1) MA28827B1 (es)
ME (1) ME01309B (es)
MX (1) MX2007002310A (es)
MY (1) MY139942A (es)
NI (1) NI200700058A (es)
NL (1) NL1029809C2 (es)
NO (1) NO338656B1 (es)
NZ (1) NZ552946A (es)
PA (1) PA8643201A1 (es)
PE (1) PE20060651A1 (es)
PL (1) PL1784396T3 (es)
PT (1) PT1784396E (es)
RS (1) RS51601B (es)
SI (1) SI1784396T1 (es)
SV (1) SV2006002208A (es)
TN (1) TNSN07071A1 (es)
TW (1) TWI300411B (es)
UY (1) UY29080A1 (es)
WO (1) WO2006021881A2 (es)
ZA (1) ZA200701281B (es)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2476667T3 (da) * 2003-02-26 2014-09-15 Sugen Inc Aminoheteroaryl-forbindelser som proteinkinase-inhibitorer
MX2007002312A (es) 2004-08-26 2007-04-16 Pfizer Compuestos de aminoheteroarilo enantiomericamente puros como inhibidores de proteina quinasa.
US20070072908A1 (en) * 2005-06-08 2007-03-29 Japan Tobacco Inc. Heterocyclic compounds
PT1963302E (pt) * 2005-12-05 2013-04-09 Pfizer Prod Inc Polimorfos de um inibidor de c-met/hgfr
PL1959955T3 (pl) * 2005-12-05 2011-04-29 Pfizer Prod Inc Sposób traktowania nieprawidłowego wzrostu komórek
WO2008051808A2 (en) 2006-10-23 2008-05-02 Sgx Pharmaceuticals, Inc. Bicyclic triazoles as protein kinase modulators
GB0621607D0 (en) * 2006-10-31 2006-12-06 Chroma Therapeutics Ltd Inhibitors of c-Met
MY148851A (en) 2006-12-14 2013-06-14 Bayer Ip Gmbh Dihydropyridine derivatives as useful as protein kinase inhibitors
US8551995B2 (en) * 2007-01-19 2013-10-08 Xcovery Holding Company, Llc Kinase inhibitor compounds
CA2683559C (en) * 2007-04-13 2019-09-24 Dana Farber Cancer Institute, Inc. Methods for treating cancer resistant to erbb therapeutics
US8263585B2 (en) 2007-05-04 2012-09-11 Novartis Ag Organic compounds
DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
JP5973131B2 (ja) 2007-09-13 2016-08-23 コデクシス， インコーポレイテッド アセトフェノンの還元のためのケトレダクターゼポリペプチド
AU2008315746A1 (en) 2007-10-25 2009-04-30 Astrazeneca Ab Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders
JP2011511005A (ja) 2008-02-04 2011-04-07 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド ２−アミノピリジン系キナーゼ阻害薬
AR070317A1 (es) 2008-02-06 2010-03-31 Osi Pharm Inc Furo (3,2-c) piridina y tieno (3,2-c) piridinas
US8268834B2 (en) * 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
KR20100134693A (ko) 2008-04-23 2010-12-23 교와 핫꼬 기린 가부시키가이샤 2-아미노퀴나졸린 유도체
KR101034351B1 (ko) * 2008-05-14 2011-05-16 한국화학연구원 신규 벤즈옥사졸로 치환된 피리딘 유도체 또는 이의약학적으로 허용가능한 염, 이의 제조방법 및 이를유효성분으로 함유하는 이상세포 성장 질환의 예방 및치료용 약학적 조성물
NZ590542A (en) 2008-06-19 2012-12-21 Xcovery Holding Co Llc Substituted pyridazine carboxamide compounds as kinase inhibitor compounds
JP2012509342A (ja) * 2008-11-20 2012-04-19 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド 置換ピロロ［２，３−ｂ］−ピリジンおよび−ピラジン
DE102009003975A1 (de) 2009-01-07 2010-07-08 Merck Patent Gmbh Benzothiazolonderivate
AU2010254053A1 (en) * 2009-05-28 2011-12-01 Vertex Pharmaceuticals Incorporated Substituted pyrazole inhibitors of c-Met protein kinase
EP2451802A1 (en) 2009-07-07 2012-05-16 Pathway Therapeutics, Inc. Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
DE102009056886A1 (de) 2009-12-03 2011-06-09 Bayer Schering Pharma Aktiengesellschaft cMet-Inhibitoren zur Behandlung der Endometriose
WO2011100502A1 (en) * 2010-02-11 2011-08-18 OSI Pharmaceuticals, LLC 7-aminofuropyridine derivatives
EA201290822A1 (ru) * 2010-02-22 2013-03-29 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Триазолоны в качестве ингибиторов синтазы жирных кислот
WO2011109593A1 (en) 2010-03-03 2011-09-09 OSI Pharmaceuticals, LLC Substituted-5-aminopyrrolo/pyrazolopyridines
EP2566858A2 (en) * 2010-05-04 2013-03-13 Pfizer Inc. Heterocyclic derivatives as alk inhibitors
US8513238B2 (en) * 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
WO2011143646A1 (en) 2010-05-14 2011-11-17 OSI Pharmaceuticals, LLC Fused bicyclic kinase inhibitors
AR081039A1 (es) 2010-05-14 2012-05-30 Osi Pharmaceuticals Llc Inhibidores biciclicos fusionados de quinasa
EA201690998A1 (ru) 2010-05-17 2017-01-30 Инкозен Терапьютикс Пвт. Лтд. НОВЫЕ СОЕДИНЕНИЯ 3,5-ДИЗАМЕЩЕННОГО-3H-ИМИДАЗО[4,5-b]ПИРИДИНА И 3,5-ДИЗАМЕЩЕННОГО-3H-[1,2,3]ТРИАЗОЛО[4,5-b]ПИРИДИНА КАК МОДУЛЯТОРЫ ПРОТЕИНКИНАЗ
CN101857594B (zh) * 2010-06-18 2013-04-03 南方医科大学 一种四氢吡啶并吲哚类化合物及其制备方法和应用
US20130315895A1 (en) 2010-07-01 2013-11-28 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
WO2012003544A1 (en) * 2010-07-09 2012-01-12 The Walter And Eliza Hall Institute Of Medical Research Protein kinase inhibitors and methods of treatment
CN101967140A (zh) * 2010-09-14 2011-02-09 郑州泰基鸿诺药物科技有限公司 氘代克里唑蒂尼及其衍生物、制备方法和应用
BR112013008523B1 (pt) 2010-10-08 2021-12-07 Xcovery Holdings, Inc Compostos de piridazina carboxamida substituídos e usos dos mesmos para tratar câncer, uma doença de proliferação, uma doença neurológica, uma doença psiquiátrica, obesidade, diabetes ou doença cardiovascular
US9145390B2 (en) 2011-03-03 2015-09-29 Concert Pharmaceuticals, Inc. Derivatives of pyrazole-substituted amino-heteroaryl compounds
ES2608967T3 (es) 2011-03-28 2017-04-17 Mei Pharma, Inc. (Aralquilamino sustituido en alfa y heteroarilalquilamino)pirimidinil y 1,3,5-triazinil benzimidazoles, composiciones farmacéuticas que los contienen, y estos compuestos para usar en el tratamiento de enfermedades proliferativas
JP2014513724A (ja) 2011-05-16 2014-06-05 オーエスアイ・ファーマシューティカルズ，エルエルシー 融合二環キナーゼ阻害剤
CN102850328B (zh) * 2011-07-01 2014-12-24 苏州东南药业股份有限公司 吡啶类化合物、其制备方法、包含该化合物的药物组合物及其用途
EP2739617A4 (en) * 2011-07-27 2015-01-28 Nanjing Allgen Pharma Co Ltd SPIROCYCLIC MOLECULES AS PROTEIN KINASE INHIBITORS
BR112014002141A2 (pt) 2011-08-02 2017-02-21 Pfizer crizotinib para uso no tratamento de câncer
WO2013041038A1 (en) * 2011-09-21 2013-03-28 Teligene Ltd. Pyridine compounds as inhibitors of kinase
CN103087050A (zh) * 2011-10-28 2013-05-08 山东轩竹医药科技有限公司 芳基激酶抑制剂
CA2863892C (en) 2012-03-06 2016-08-30 Pfizer Inc. Macrocyclic derivatives for the treatment of proliferative diseases
CN103304552B (zh) * 2012-03-09 2016-12-28 广东东阳光药业有限公司 取代的吡啶化合物及其使用方法和用途
WO2013138210A1 (en) * 2012-03-14 2013-09-19 Ning Xi Substituted cyclic compounds and methods of use
HK1207072A1 (en) 2012-03-16 2016-01-22 埃克希金医药品有限公司 3,5-diaminopyrazole kinase inhibitors
CN103319468B (zh) * 2012-03-21 2016-07-13 广东东阳光药业有限公司 取代的螺双环化合物及其使用方法和用途
WO2013144191A1 (de) 2012-03-29 2013-10-03 Bayer Intellectual Property Gmbh Substituierte 2 -amino - 3 - cyanopyridine als inhibitoren des natrium calcium austausches und ihre verwendung bei kardiovaskulären erkrankungen
EA026412B1 (ru) 2012-03-30 2017-04-28 Ризен Фармасьютикалз Са НОВЫЕ СОЕДИНЕНИЯ 3,5-ДИЗАМЕЩЕННОГО-3H-ИМИДАЗО[4,5-b]ПИРИДИНА И 3,5-ДИЗАМЕЩЕННОГО-3H-[1,2,3]ТРИАЗОЛО[4,5-b]ПИРИДИНА КАК МОДУЛЯТОРЫ c-MET ПРОТЕИНКИНАЗ
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
CN106349222B (zh) * 2012-04-22 2019-03-05 东南大学 克里唑替尼前药及其制备方法与用途
KR101582852B1 (ko) 2012-05-24 2016-01-07 서울대학교 산학협력단 타우 단백질 매개 신경 퇴행성 질환 치료제
WO2013181251A1 (en) 2012-05-29 2013-12-05 Ratiopharm Gmbh Crizotinib hydrochloride salt in crystalline
GB201211310D0 (en) * 2012-06-26 2012-08-08 Chroma Therapeutics Ltd CSF-1R kinase inhibitors
WO2014020467A2 (en) 2012-07-30 2014-02-06 Fresenius Kabi Oncology Ltd Process for the preparation of pyrazole substituted aminoheteroaryl compounds
JO3215B1 (ar) 2012-08-09 2018-03-08 Phenex Pharmaceuticals Ag حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy
AU2013307383A1 (en) * 2012-08-27 2015-03-26 Cemm - Forschungszentrum Fur Molekulare Medizin Gmbh Aminoheteroaryl compounds as MTH1 inhibitors
CN103720691A (zh) * 2012-10-11 2014-04-16 韩冰 一类治疗脑性瘫痪的化合物及其用途
WO2014060381A1 (de) 2012-10-18 2014-04-24 Bayer Cropscience Ag Heterocyclische verbindungen als schädlingsbekämpfungsmittel
WO2014081816A1 (en) * 2012-11-21 2014-05-30 Concert Pharmaceuticals, Inc. Fluoro-derivatives of pyrazole-substituted amino-heteroaryl compounds
EP2945938B1 (en) 2013-01-18 2018-03-07 F. Hoffmann-La Roche AG 3-substituted pyrazoles and use as dlk inhibitors
AU2014211856C1 (en) * 2013-02-02 2018-04-12 Centaurus Biopharma Co., Ltd. Substituted 2-aminopyridine protein kinase inhibitor
CN103992307B (zh) * 2013-02-16 2017-07-14 浙江九洲药物科技有限公司 一种克里唑替尼的制备方法
WO2014139391A1 (en) * 2013-03-11 2014-09-18 Teligene Ltd Substituted pyridine compounds as kinases inhibitors
US9765035B2 (en) 2013-03-14 2017-09-19 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
CA2903264A1 (en) 2013-03-14 2014-11-06 Epizyme, Inc. Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof
EP2970181B1 (en) 2013-03-14 2017-06-07 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US9120757B2 (en) 2013-03-14 2015-09-01 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
EP2970135B1 (en) 2013-03-14 2018-07-18 Epizyme, Inc. Pyrazole derivatives as prmt1 inhibitors and uses thereof
US9133189B2 (en) 2013-03-14 2015-09-15 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
US9447079B2 (en) 2013-03-14 2016-09-20 Epizyme, Inc. PRMT1 inhibitors and uses thereof
MX382991B (es) 2013-03-14 2025-03-13 Epizyme Inc Inhibidores de la arginina metiltransferasa y usos de los mismos.
EP2970131B1 (en) 2013-03-14 2017-11-15 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
CN104059054B (zh) * 2013-03-19 2018-11-20 浙江导明医药科技有限公司 用于治疗癌症的三级环状胺alk激酶抑制剂
WO2014203177A1 (en) * 2013-06-18 2014-12-24 Shilpa Medicare Limited Amorphous (r) -3- [1- (2, 6-dichloro-3-fluorophenyl) methoxy] -5- [1- (piperidin-4- yl) -1h-pyrazol-4-yl] pyridin-2-amine
CN104230890A (zh) * 2013-06-19 2014-12-24 信诺凯（北京）化工有限公司 吡啶-2-胺衍生物及其制法和药物组合物与用途
CN104650049B (zh) * 2013-08-28 2018-06-08 广东东阳光药业有限公司 取代的吡啶化合物及其使用方法和用途
KR101598664B1 (ko) 2013-09-04 2016-03-02 씨제이헬스케어 주식회사 피롤로피리다진 유도체를 포함하는 단백질 키나제 억제제
WO2015034729A1 (en) * 2013-09-05 2015-03-12 Calitor Sciences, Llc Substituted pyridine compounds and methods of use
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
WO2015046653A1 (ko) 2013-09-30 2015-04-02 한국화학연구원 신규한 트리아졸로 피라진 유도체 및 그의 용도
CA2943329A1 (en) 2014-03-24 2015-10-01 Genentech, Inc. Cancer treatment with c-met antagonists and correlation of the latter with hgf expression
WO2015172747A1 (en) * 2014-05-16 2015-11-19 Zhaoyin Wang Spirocyclic molecules as mth1 inhibitors
JP2017530950A (ja) 2014-08-25 2017-10-19 ファイザー・インコーポレイテッド 癌を処置するためのｐｄ−１アンタゴニストおよびａｌｋ阻害剤の併用
WO2016044576A1 (en) * 2014-09-17 2016-03-24 Epizyme, Inc. Salts, co-crystals, amorphous forms, and crystalline forms of an arginine methyltransferase inhibitor
CN104402868B (zh) * 2014-11-04 2016-08-24 郑州泰基鸿诺医药股份有限公司 氘代克里唑蒂尼晶型及其制备方法
ES2764299T3 (es) 2014-12-09 2020-06-02 Inst Nat Sante Rech Med Anticuerpos monoclonales humanos contra AXL
EA032473B1 (ru) 2014-12-23 2019-05-31 Аксикин Фармасьютикалз, Инк. 3,5-диаминопиразоловые ингибиторы киназы
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
WO2016145383A1 (en) * 2015-03-11 2016-09-15 Board Of Regents, University Of Texas System Mth1 inhibitors for treating disease
JP6966423B2 (ja) 2015-04-24 2021-11-17 グアンジョウ マキシノベル ファーマシューティカルズ カンパニー リミテッド 縮合環ピリミジンアミノ誘導体、その製造方法、中間体、薬学的組成物及び応用
CN106279112A (zh) * 2015-06-12 2017-01-04 浙江九洲药业股份有限公司 一种克里唑替尼中间体及其制备方法和应用
CA3000386A1 (en) 2015-09-30 2017-04-06 Merck Patent Gmbh Combination of a pd-1 axis binding antagonist and an alk inhibitor for treating alk-negative cancer
EP4019019B1 (en) 2016-05-20 2024-02-07 Biohaven Pharmaceutical Holding Company Ltd. Use of riluzole, riluzole prodrugs or riluzole analogs with immunotherapies to treat cancers
TWI646094B (zh) * 2016-06-01 2019-01-01 大陸商貝達藥業股份有限公司 Crystal form of inhibitory protein kinase active compound and application thereof
CN106632260B (zh) * 2016-09-29 2019-04-26 上海天慈生物谷生物工程有限公司 一种小分子激酶抑制剂的制备方法
CN117860758A (zh) 2017-05-23 2024-04-12 梅制药公司 联合疗法
US11351176B2 (en) 2017-08-14 2022-06-07 Mei Pharma, Inc. Combination therapy
CN110372664A (zh) * 2018-04-13 2019-10-25 华东理工大学 选择性jak2抑制剂及其应用
KR102207608B1 (ko) 2019-04-24 2021-01-26 윤종오 카르복실산으로 유기화된 규소 이온 복합체 및 복합체의 제조방법과 이를 이용한 제품
CN115745979B (zh) * 2021-11-11 2025-09-23 中国医学科学院医药生物技术研究所 一种蛋白靶向降解化合物及其用途
CN119451699A (zh) 2022-07-04 2025-02-14 中外制药株式会社 并用药物
EP4582104A1 (en) 2022-08-30 2025-07-09 Chugai Seiyaku Kabushiki Kaisha Combination drug

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI941572L (fi) * 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
DE69334255D1 (de) * 1992-02-06 2009-02-12 Novartis Vaccines & Diagnostic Marker für Krebs und biosynthetisches Bindeprotein dafür
US5863949A (en) * 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
PT821671E (pt) * 1995-04-20 2001-04-30 Pfizer Derivados do acido arilsulfonil hidroxamico como inibidores de mmp e tnf
US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
GB9518953D0 (en) * 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
CA2259222A1 (en) * 1996-06-27 1997-12-31 Pfizer Inc. Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors
JPH11236333A (ja) * 1997-12-30 1999-08-31 Pfizer Prod Inc 抗ガン剤として有用なイミダゾリン−４−オン誘導体
ATE321037T1 (de) * 1998-08-27 2006-04-15 Pfizer Prod Inc Als antikrebsmittel verwendbare alkinyl- substituierte chinolin-2-on-derivate
ES2237125T3 (es) * 1998-08-27 2005-07-16 Pfizer Products Inc. Derivados de quinolin-2-ona utiles como agentes anticancerigenos.
EP1006113A1 (en) * 1998-12-02 2000-06-07 Pfizer Products Inc. Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth
US6682736B1 (en) * 1998-12-23 2004-01-27 Abgenix, Inc. Human monoclonal antibodies to CTLA-4
JP3270834B2 (ja) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
ES2243228T3 (es) * 1999-02-11 2005-12-01 Pfizer Products Inc. Derivados quinolin-2-ona sustituidos con heteroarilo utiles como agentes anticancerigenos.
US6586447B1 (en) * 1999-04-01 2003-07-01 Pfizer Inc 3,3-disubstituted-oxindole derivatives useful as anticancer agents
EP1081137A1 (en) * 1999-08-12 2001-03-07 Pfizer Products Inc. Selective inhibitors of aggrecanase in osteoarthritis treatment
PT1106612E (pt) * 1999-11-30 2004-06-30 Pfizer Prod Inc Derivados de quinolina uteis para inibir a farnesil-proteina-transferase
HN2000000266A (es) * 2000-01-21 2001-05-21 Pfizer Prod Inc Compuesto anticanceroso y metodo de separacion de enantiomeros util para sintetizar dicho compuesto.
US6844357B2 (en) * 2000-05-01 2005-01-18 Pfizer Inc. Substituted quinolin-2-one derivatives useful as antiproliferative agents
SE0102438D0 (sv) * 2001-07-05 2001-07-05 Astrazeneca Ab New compounds
SE0102439D0 (sv) * 2001-07-05 2001-07-05 Astrazeneca Ab New compounds
AU2003206109A1 (en) * 2002-02-06 2003-09-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Catechol bioisosteres
AU2003246927A1 (en) * 2002-07-03 2004-01-23 Astex Technology Limited 3-`(hetero) arylmethoxy ! pyridines and their analogues as p38 map kinase inhibitors
WO2004013091A2 (en) * 2002-08-01 2004-02-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem 4-anilido substituted quinazolines and use thereof as inhibitors of epidermal growth factor receptor kinases
SE0203754D0 (sv) * 2002-12-17 2002-12-17 Astrazeneca Ab New compounds
DE10307845A1 (de) * 2003-02-25 2004-09-02 Bayer Cropscience Gmbh Heterocyclische Amide, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel
DK2476667T3 (da) * 2003-02-26 2014-09-15 Sugen Inc Aminoheteroaryl-forbindelser som proteinkinase-inhibitorer
MX2007002312A (es) * 2004-08-26 2007-04-16 Pfizer Compuestos de aminoheteroarilo enantiomericamente puros como inhibidores de proteina quinasa.

Also Published As

Publication number Publication date
PA8643201A1 (es) 2006-06-02
SI1784396T1 (sl) 2011-03-31
WO2006021881A3 (en) 2006-05-18
PT1784396E (pt) 2011-01-27
CR20120421A (es) 2012-09-14
GEP20094845B (en) 2009-11-25
TW200621751A (en) 2006-07-01
HRP20110116T1 (hr) 2011-03-31
DK1784396T3 (da) 2011-02-14
ZA200701281B (en) 2008-12-31
AP2007003906A0 (en) 2007-02-28
TWI300411B (en) 2008-09-01
JP2008510788A (ja) 2008-04-10
NZ552946A (en) 2010-09-30
WO2006021881A2 (en) 2006-03-02
ATE492544T1 (de) 2011-01-15
NL1029809C2 (nl) 2006-10-17
GT200500226A (es) 2006-04-10
NL1029809A1 (nl) 2006-02-28
MA28827B1 (fr) 2007-08-01
US20060128724A1 (en) 2006-06-15
CN101018780B (zh) 2012-01-11
CA2577937A1 (en) 2006-03-02
RS51601B (sr) 2011-08-31
CA2577937C (en) 2010-12-21
EP1784396A2 (en) 2007-05-16
IL181045A0 (en) 2007-07-04
EP1784396B1 (en) 2010-12-22
HN2005000477A (es) 2010-06-09
NO20071320L (no) 2007-05-29
CR8938A (es) 2007-08-14
BRPI0514537B8 (pt) 2021-05-25
KR100869393B1 (ko) 2008-11-21
AP2332A (en) 2011-12-05
ES2355923T3 (es) 2011-04-01
BRPI0514537A (pt) 2008-06-17
AU2005276132B2 (en) 2011-09-29
AU2005276132A1 (en) 2006-03-02
ME01309B (me) 2013-12-20
JP4167295B2 (ja) 2008-10-15
HK1105415A1 (en) 2008-04-03
EA011725B1 (ru) 2009-04-28
MX2007002310A (es) 2007-05-08
BRPI0514537B1 (pt) 2020-05-12
EP1784396B8 (en) 2011-04-20
AR050529A1 (es) 2006-11-01
NO338656B1 (no) 2016-09-26
KR20070038569A (ko) 2007-04-10
TNSN07071A1 (fr) 2008-06-02
DE602005025499D1 (de) 2011-02-03
SV2006002208A (es) 2006-10-04
NI200700058A (es) 2008-03-07
UY29080A1 (es) 2006-03-31
ECSP077278A (es) 2007-03-29
EA200700321A1 (ru) 2007-08-31
MY139942A (en) 2009-11-30
PL1784396T3 (pl) 2011-05-31
CN101018780A (zh) 2007-08-15
CY1111138T1 (el) 2015-06-11

Similar Documents

Publication Publication Date Title
PE20060651A1 (es) Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa
PE20040647A1 (es) Inhibidores de cinasas de tirosina
PE20090835A1 (es) Derivados de quinazolina como inhibidores de la pi3 quinasa
PE20060598A1 (es) Derivado heterociclo conteniendo nitrogeno como antagonista de quimiocina ccr5
PE20050874A1 (es) Compuestos de bencimidazolona que tienen actividad agonista del receptor 5-ht4
PE20080677A1 (es) Inhibidores de pirrolotriazina cinaza
PE20120034A1 (es) Compuestos derivados de n-fenilpirimidin-2-amina
PE20081845A1 (es) Nuevos derivados de aminopirimidina como inhibidores de plk1
PE20080345A1 (es) Derivados de piperazina como agonistas del receptor de gpr38
PE20081238A1 (es) Piperidinas sustituidas como antagonistas de hdm2
PE20050952A1 (es) Derivados de isoquinolina como inhibidores de b-raf
PE20051142A1 (es) Derivados de 4-benzimidazol-2-il-piridazin-3-ona, preparacion para los mismos
PE20060398A1 (es) Compuestos derivados de pirimidina como inhibidores de quinasa de proteina
RU2010103969A (ru) Соединения ди(ариламино)арила
PE20051171A1 (es) Inhibidores de proteina quinasas con estructura de 3-quinolincarbonitrilo
CL2010000204A1 (es) Compuestos intermediarios derivados de 4 amino-3-metoxibenzamida; compuesto intermediario n-{4-[4-(ciclopropilmetil)piperazin-1-il]ciclohexil}acetamida; compuesto intermediario 2-cloro-7-etil-7,8-dihidro-5-metil-8-(1-metiletil)-6(5h)-pteridinona, útiles en la preparación de dihidropteridinonas sustituidas (divisional sol. 2077-05).
CO5560573A2 (es) Derivados activos de amino-ftalazinona como inhibidores de quinasa, proceso para su preparacion y composiciones farmaceuticas que los contienen
PE20080059A1 (es) Quinazolinas para la inhibicion de pdk1
PE20060383A1 (es) Nuevos derivados amino de urea ciclicos como inhibidores de quinasa
DE602007004750D1 (de) Als inhibitoren von proteinkinasen geeignete aminopyridine und aminopyrimidine
PE20050132A1 (es) Piperazinas heterociclicas sustituidas
PE20090288A1 (es) Derivados de quinoxalina como inhibidores de la pi3 quinasa
PE20040720A1 (es) Derivados de benzodioxol
AR054834A1 (es) Derivados de 1,1-dioxido-2,3-dihidro-1,2-benzoisotiazol-6-il-1h-indazol-4-il-2,4 pirimidina diamina
PE20210373A1 (es) Compuestos de pirimidina y composiciones farmaceuticas para prevenir o tratar canceres que incluyen los mismos

Legal Events

Date Code Title Description
FG Grant, registration