PE20060618A1 - TRIAZOLOPYRIDINYLSULFANIL DERIVATIVES AS KINASE INHIBITORS MAP P38 - Google Patents
TRIAZOLOPYRIDINYLSULFANIL DERIVATIVES AS KINASE INHIBITORS MAP P38Info
- Publication number
- PE20060618A1 PE20060618A1 PE2005000916A PE2005000916A PE20060618A1 PE 20060618 A1 PE20060618 A1 PE 20060618A1 PE 2005000916 A PE2005000916 A PE 2005000916A PE 2005000916 A PE2005000916 A PE 2005000916A PE 20060618 A1 PE20060618 A1 PE 20060618A1
- Authority
- PE
- Peru
- Prior art keywords
- triazolopyridinylsulfanil
- kinase
- derivatives
- kinase inhibitors
- heterociclilo
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- SCVJRXQHFJXZFZ-KVQBGUIXSA-N 2-amino-9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purine-6-thione Chemical compound C1=2NC(N)=NC(=S)C=2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 SCVJRXQHFJXZFZ-KVQBGUIXSA-N 0.000 abstract 2
- -1 4-METHYLPHENYL Chemical class 0.000 abstract 2
- 239000004202 carbamide Substances 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 230000000414 obstructive effect Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE TRIAZOLOPIRIDINILSULFANILO DE FORMULA I, DONDE R1 ES CH3, S(O)pCH3, S(O)pCH2CH3, ENTRE OTROS; R1a ES CH3 O CH2CH3, ENTRE OTROS; R2 ES HETEROARILO, HETEROCICLILO, ARILO, ENTRE OTROS; R3 ES HETEROARILO, HETEROCICLILO, ARILO, ENTRE OTROS; R7 ES ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON OH, HALO, ALCOXI C1-C6, ENTRE OTROS; p ES 0, 1 O 2. SON COMPUESTOS PREFERIDOS: N-{3-TERC-BUTIL-1-[4-(METITIO)FENIL]-1H-PIRAZOL-5-IL}-N'-{2-[(3-ISOPROPIL[1,2,4]TRIAZOLO[4,3-a]PIRIDIN-6-IL)TIO]BENCIL}UREA, N-[3-TERC-BUTIL-1-(4-METILFENIL)-1H-PIRAZOL-5-IL]-N'-(2-{[3-(2)CLORO-4-HIDROXIFENIL)[1,2,4]TRIAZOLO[4,3-a]PIRIDIN-6-IL]TIO}BENCIL)UREA, ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA QUINASA ACTIVADA POR MITOGENOS p38 (MAPK p38, QUINASA p38 O p38), PARTICULARMENTE DE LA QUINASA p38 ALFA Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES OBSTRUCTIVAS O INFLAMATORIAS DE LAS VIAS RESPIRATORIAS, ENTRE OTRASREFERRING TO A TRIAZOLOPYRIDINYLSULFANIL DERIVATIVE COMPOUND OF FORMULA I, WHERE R1 IS CH3, S (O) pCH3, S (O) pCH2CH3, AMONG OTHERS; R1a IS CH3 OR CH2CH3, AMONG OTHERS; R2 IS HETEROARILO, HETEROCICLILO, ARILO, AMONG OTHERS; R3 IS HETEROARILO, HETEROCICLILO, ARILO, AMONG OTHERS; R7 IS C1-C6 ALKYL OPTIONALLY SUBSTITUTED WITH OH, HALO, C1-C6 ALCOXY, AMONG OTHERS; p IS 0, 1 OR 2. THE PREFERRED COMPOUNDS ARE: N- {3-TERC-BUTYL-1- [4- (METHYL) PHENYL] -1H-PYRAZOLE-5-IL} -N '- {2 - [(3 -ISOPROPYL [1,2,4] TRIAZOLO [4,3-a] PYRIDIN-6-IL) THIO] BENZYL} UREA, N- [3-TERC-BUTYL-1- (4-METHYLPHENYL) -1H-PIRAZOLE- 5-IL] -N '- (2 - {[3- (2) CHLORO-4-HYDROXYPHENYL) [1,2,4] TRIAZOLO [4,3-a] PYRIDIN-6-IL] THIO} BENZYL) UREA , AMONG OTHERS. SUCH COMPOUNDS ARE INHIBITORS OF THE PROTEIN KINASE ACTIVATED BY MYTOGEN p38 (MAPK p38, KINASE p38 OR p38), PARTICULARLY OF THE ALPHA p38 KINASE AND ARE USEFUL IN THE TREATMENT OF OBSTRUCTIVE OR INFLAMMATORY DISEASES IN THE VIAS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0418015A GB0418015D0 (en) | 2004-08-12 | 2004-08-12 | New compounds |
| US69155905P | 2005-06-17 | 2005-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060618A1 true PE20060618A1 (en) | 2006-07-14 |
Family
ID=33017410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000916A PE20060618A1 (en) | 2004-08-12 | 2005-08-09 | TRIAZOLOPYRIDINYLSULFANIL DERIVATIVES AS KINASE INHIBITORS MAP P38 |
Country Status (9)
| Country | Link |
|---|---|
| CN (1) | CN101006087B (en) |
| GB (1) | GB0418015D0 (en) |
| ME (1) | ME01360B (en) |
| NI (1) | NI200700039A (en) |
| PE (1) | PE20060618A1 (en) |
| RS (1) | RS50642B (en) |
| TW (1) | TWI295926B (en) |
| UA (1) | UA93032C2 (en) |
| ZA (1) | ZA200700923B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009098612A2 (en) * | 2008-02-04 | 2009-08-13 | Pfizer Limited | Polymorphic form of a [1, 2, 4] triazolo [4, 3-a] pyridine derivative for treating inflammatory diseases |
| WO2010094956A1 (en) * | 2009-02-17 | 2010-08-26 | Pulmagen Therapeutics (Inflammation) Limited. | Triazolopyridine derivatives as p38 map kinase inhibitors |
| GB201009731D0 (en) * | 2010-06-10 | 2010-07-21 | Pulmagen Therapeutics Inflamma | Kinase inhibitors |
| EP2788349B1 (en) * | 2011-12-09 | 2016-10-26 | Chiesi Farmaceutici S.p.A. | Kinase inhibitors |
| CN105646484A (en) * | 2016-03-01 | 2016-06-08 | 孙霖 | Crystal form B and preparation method |
| CN105693716A (en) * | 2016-03-01 | 2016-06-22 | 孙霖 | Crystal form A and preparing method |
-
2004
- 2004-08-12 GB GB0418015A patent/GB0418015D0/en not_active Ceased
-
2005
- 2005-08-09 UA UAA200701488A patent/UA93032C2/en unknown
- 2005-08-09 PE PE2005000916A patent/PE20060618A1/en not_active Application Discontinuation
- 2005-08-09 CN CN2005800274566A patent/CN101006087B/en not_active Expired - Fee Related
- 2005-08-09 ME MEP-2008-934A patent/ME01360B/en unknown
- 2005-08-09 TW TW94126968A patent/TWI295926B/en not_active IP Right Cessation
- 2005-08-09 RS RSP-2008/0599A patent/RS50642B/en unknown
-
2007
- 2007-01-31 ZA ZA200700923A patent/ZA200700923B/en unknown
- 2007-02-09 NI NI200700039A patent/NI200700039A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101006087B (en) | 2010-09-29 |
| ME01360B (en) | 2010-06-30 |
| CN101006087A (en) | 2007-07-25 |
| GB0418015D0 (en) | 2004-09-15 |
| TWI295926B (en) | 2008-04-21 |
| UA93032C2 (en) | 2011-01-10 |
| NI200700039A (en) | 2008-03-07 |
| RS50642B (en) | 2010-06-30 |
| ZA200700923B (en) | 2008-09-25 |
| TW200610529A (en) | 2006-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |